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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:tyrosinemia type I pathway
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Accession:PW:0001608 term browser browse the term
Definition:Type I tyrosinemia results from defects in the fumarylacetoacetate hydrolase (FAH) enzyme that catalyzes the last step in the tyrosine degradation pathway.
Synonyms:exact_synonym: hepatorenal tyrosinemia pathway;   tyrosinemia type I disease pathway
 related_synonym: SMP:00218


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tyrosinemia type I pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 ISO SMPDB SMP:00218 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 ISO SMPDB SMP:00218 NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Comt catechol-O-methyltransferase ISO SMPDB SMP:00218 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Dbh dopamine beta-hydroxylase ISO SMPDB SMP:00218 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Dct dopachrome tautomerase ISO SMPDB SMP:00218 NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Ddc dopa decarboxylase ISO SMPDB SMP:00218 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Fah fumarylacetoacetate hydrolase ISO SMPDB SMP:00218 NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:138,548,834...138,571,505 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO SMPDB SMP:00218 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 ISO SMPDB SMP:00218 NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase ISO SMPDB SMP:00218 NCBI chr 6:16,598,325...16,617,590
Ensembl chr 6:10,845,771...10,864,877 		JBrowse link
G Hgd homogentisate 1, 2-dioxygenase ISO SMPDB SMP:00218 NCBI chr11:76,592,202...76,643,776
Ensembl chr11:63,086,752...63,138,323 		JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase ISO SMPDB SMP:00218 NCBI chr12:39,042,246...39,053,596
Ensembl chr12:33,381,231...33,392,766 		JBrowse link
G Maoa monoamine oxidase A ISO SMPDB SMP:00218 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mif macrophage migration inhibitory factor ISO SMPDB SMP:00218 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase ISO SMPDB SMP:00218 NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,384,923...83,386,556 		JBrowse link
G Tat tyrosine aminotransferase ISO SMPDB SMP:00218 NCBI chr19:54,856,604...54,867,168
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tyr tyrosinase ISO SMPDB SMP:00218 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      nervous system disease pathway 761
        brain disease pathway 350
          inborn error of brain metabolic pathway 319
            tyrosinemia pathway 29
              tyrosinemia type I pathway 17
Path 2
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      nutritional and metabolic disease pathway 709
        metabolic disease pathway 666
          inborn error of metabolism pathway 530
            inborn error of amino acid metabolism pathway 229
              tyrosinemia pathway 29
                tyrosinemia type I pathway 17
paths to the root