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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Nematode Infections
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Accession:DOID:9002992 term browser browse the term
Definition:Infections by nematodes, general or unspecified.
Synonyms:exact_synonym: Nematode Infection
 primary_id: MESH:D009349;   RDO:0005956
For additional species annotation, visit the Alliance of Genome Resources.


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Nematode Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP protein:increased expression:liver (rat) RGD PMID:12621079 RGD:2306675 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 severity ISO RGD PMID:27697499 RGD:40400689 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il33 interleukin 33 ISO associated with Nippostrongylus brasiliensis infection; mRNA:increased expression:lung RGD PMID:22331917 RGD:40400742 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4 interleukin 4 IEP mRNA:increased expression:spleen RGD PMID:17570971 RGD:2317296 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Muc13 mucin 13, cell surface associated ISO protein:increased expression:cecum, glycocalyx RGD PMID:21155842 RGD:7364766 NCBI chr11:70,185,757...70,223,012
Ensembl chr11:70,185,757...70,211,701
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming IEP
ISO
mRNA:increased expression:intestine RGD PMID:16689826, PMID:20138044 RGD:2303607, RGD:7349349 NCBI chr 1:214,663,929...214,693,197 JBrowse link
G Muc3 mucin 3, intestinal IEP mRNA:increased expression:intestine RGD PMID:16689826 RGD:2303607 NCBI chr12:22,535,663...22,584,775 JBrowse link
G Muc4 mucin 4, cell surface associated IEP
ISO
mRNA:increased expression:intestine
protein:increased expression:cecum, glycocalyx
RGD PMID:16689826, PMID:21155842 RGD:2303607, RGD:7364766 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming resistance ISO
IEP
mRNA:increased expression:cecum RGD PMID:20138044, PMID:22269441 RGD:7349349, RGD:7364747 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 susceptibility ISO RGD PMID:11850627 RGD:737789 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP mRNA:increased expression:liver (rat) RGD PMID:20695884 RGD:5130965 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
angiostrongyliasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl1 interleukin 1 receptor-like 1 treatment ISO mRNA:increased expression:brain: RGD PMID:24657070, PMID:23148283 RGD:11561855, RGD:40400713 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:brain: RGD PMID:23148283, PMID:24076431 RGD:40400713, RGD:40400715 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il5 interleukin 5 ISO RGD PMID:8361777 RGD:11354948 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Mag myelin-associated glycoprotein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr 1:89,345,325...89,360,905
Ensembl chr 1:89,345,429...89,360,733
JBrowse link
G Mbp myelin basic protein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr 8:128,824,420...128,854,492
Ensembl chr 8:128,824,508...128,850,358
JBrowse link
filariasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl1 interleukin 1 receptor-like 1 ISO RGD PMID:27592711 RGD:40400889 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Prg2 proteoglycan 2 ISO RGD PMID:24626328 RGD:40903014 NCBI chr 3:72,385,678...72,389,245
Ensembl chr 3:72,385,666...72,389,276
JBrowse link
Hookworm Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl1 interleukin 1 receptor-like 1 ISO RGD PMID:22329990 RGD:39938827 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il33 interleukin 33 ISO mRNA,protein:increased expression:Bronchoalveolar lavage, epithelium, macrophage RGD PMID:22329990 RGD:39938827 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Tff2 trefoil factor 2 ISO RGD PMID:22329990 RGD:39938827 NCBI chr20:9,872,669...9,876,008
Ensembl chr20:9,872,680...9,876,008
JBrowse link
onchocerciasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 severity ISO protein:increased expression:serum RGD PMID:22805723 RGD:8549600 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G RT1-Ba RT1 class II, locus Ba susceptibility ISO DNA:polymorphisms: :HLA-DQA1*0401, HLA-DQA1*0102,HLA-DQA1*0103; RGD PMID:22117902 RGD:8547660 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
JBrowse link
G RT1-Ha RT1 class II, locus Ha ISO RGD PMID:8854084 RGD:6480649 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461
JBrowse link
Onchocerciasis, Ocular term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor type 1 ISO RGD PMID:19168746 RGD:8662882 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:11884755 RGD:7794682 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
Strongylida Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase ISO RGD PMID:23630966 RGD:32716404 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671
JBrowse link
G Il3 interleukin 3 ISO RGD PMID:20500666 RGD:5686890 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il33 interleukin 33 ISO mRNA:increased expression:lung RGD PMID:22331917 RGD:40400742 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Plau plasminogen activator, urokinase IMP RGD PMID:18022622 RGD:6484141 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
strongyloidiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 treatment ISO RGD PMID:16129701 RGD:8655932 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il5 interleukin 5 severity ISO RGD PMID:9824515 RGD:11354934 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
toxascariasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tslp thymic stromal lymphopoietin ISO mRNA:increased expression:multiple (mouse) RGD PMID:24327787 RGD:38596353 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
Toxocara Canis Infection (Canine Roundworms) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 ISO protein:increased expression:plasma, respiratory system fluid/secretion RGD PMID:16168564 RGD:7248410 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
toxocariasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 treatment ISO RGD PMID:26732352 RGD:11534298 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 ISO RGD PMID:25773181 RGD:40902825 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
JBrowse link
trichinosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO RGD PMID:23465441 RGD:11049476 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Lta lymphotoxin alpha ISO RGD PMID:19564380 RGD:8548805 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Slc17a8 solute carrier family 17 member 8 IEP protein:increased expression:dorsal horn of spinal cord, dorsal root ganglion RGD PMID:22160634 RGD:9999169 NCBI chr 7:30,215,231...30,274,993
Ensembl chr 7:30,216,104...30,274,984
JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO protein:decreased expression:jejunum (mouse) RGD PMID:16336502 RGD:38676482 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:19564380 RGD:8548805 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tslp thymic stromal lymphopoietin disease_progression ISO RGD PMID:23024277 RGD:38596337 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
trichostrongyloidiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 IEP mRNA:increased expression:duodenum (rat) RGD PMID:21698235 RGD:11561920 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
trichuriasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:20864659 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20864659 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Tslp thymic stromal lymphopoietin susceptibility ISO RGD PMID:19273626 RGD:38549593 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16123
    disease by infectious agent 1824
      parasitic infectious disease 255
        parasitic helminthiasis infectious disease 78
          Nematode Infections 38
            Adenophorea Infections + 8
            Larva Migrans + 3
            Secernentea Infections + 22
            capillariasis 0
            thelaziasis 0
paths to the root