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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Liver Reperfusion Injury
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Accession:DOID:9002159 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the liver, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: Hepatic Ischemia-Reperfusion Injury;   Hepatic Reperfusion Injury;   Liver Ischemia-Reperfusion Injury
 primary_id: RDO:9000016
For additional species annotation, visit the Alliance of Genome Resources.



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Liver Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing treatment IDA RGD PMID:23762489 RGD:8695935 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adm adrenomedullin treatment IEP
ISO
mRNA,protein:increased expression:liver,plasma: RGD PMID:19212187 PMID:19212187 RGD:7364958, RGD:7364958 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP mRNA:increased expression:liver RGD PMID:21431875 RGD:10402078 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member treatment ISO
IEP
protein:altered expression:liver (mouse)
protein:altered expression:liver (rat)
RGD PMID:30671488 PMID:29589772 RGD:15036807, RGD:14975297 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Bad BCL2-associated agonist of cell death treatment IEP mRNA:increased expression:liver
associated with Non-alcoholic Fatty Liver Disease
RGD PMID:22647552 PMID:22847887 RGD:10053673, RGD:10053710 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP mRNA:increased expression:liver
associated with Non-alcoholic Fatty Liver Disease
RGD PMID:22647552 PMID:22847887 PMID:21092002 RGD:10053673, RGD:10053710, RGD:5134995 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA
IEP
associated with Non-alcoholic Fatty Liver Disease RGD PMID:22847887 PMID:21092002 RGD:10053710, RGD:5134995 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IEP associated with Non-alcoholic Fatty Liver Disease RGD PMID:22847887 RGD:10053710 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G C3 complement C3 treatment IEP RGD PMID:19854450 RGD:11040888 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Casp12 caspase 12 treatment IEP RGD PMID:29428101 RGD:13782166 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp8 caspase 8 treatment IEP
ISO
RGD PMID:23423194 PMID:15300206 RGD:8661760, RGD:14695087 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:23364428 RGD:13782358 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 severity
treatment
IEP
ISO
mRNA, protein:increased expression:liver, serum (rat) RGD PMID:9500701 PMID:27229110 PMID:10630515 RGD:8549627, RGD:14995460, RGD:14995929 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 treatment
severity
ISO RGD PMID:28623253 PMID:28623253 RGD:14995305, RGD:14995305 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 severity ISO RGD PMID:27229110 RGD:14995460 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd14 CD14 molecule IDA RGD PMID:22564590 RGD:7183676 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd40 CD40 molecule treatment IMP RGD PMID:14741776 RGD:8547795 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cfh complement factor H treatment IEP
ISO
mRNA,protein:decreased expression:liver,plasma: RGD PMID:19212187 PMID:19212187 RGD:7364958, RGD:7364958 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 treatment IDA RGD PMID:21092002 RGD:5134995 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 treatment ISO RGD PMID:18041715 RGD:27095942 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA:decreased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Elane elastase, neutrophil expressed IMP RGD PMID:10588515 RGD:10450560 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:25769561 RGD:15090809 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epor erythropoietin receptor IEP protein:increased phosphorylation:liver: RGD PMID:25769561 RGD:15090809 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G F3 coagulation factor III, tissue factor treatment IMP RGD PMID:11750579 RGD:11341708 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fadd Fas associated via death domain treatment IEP RGD PMID:23423194 RGD:8661760 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor treatment IMP
IEP
protein:increased expression:liver RGD PMID:17235585 PMID:16222447 PMID:18561025 RGD:2290283, RGD:1600351, RGD:14700680 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand treatment IMP RGD PMID:18561025 RGD:14700680 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fga fibrinogen alpha chain IEP mRNA:increased expression:liver (rat) RGD PMID:23503399 RGD:9685021 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fn1 fibronectin 1 IDA RGD PMID:12651615 RGD:7205470 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IDA associated with nonalcoholic fatty liver disease RGD PMID:28807209 RGD:13792730 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstm1 glutathione S-transferase mu 1 IEP mRNA:decreased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H2ax H2A.X variant histone treatment IEP RGD PMID:23792534 RGD:8693718 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmgb1 high mobility group box 1 treatment IMP
IEP
mRNA, protein:increased expression, altered localization:serum, hepatocyte, cytoplasm
protein:increased oxidation:liver
RGD PMID:24578610 PMID:21431875 PMID:22514737 RGD:10402068, RGD:10402078, RGD:10402175 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:20446775 RGD:10755725 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hp haptoglobin treatment IEP RGD PMID:17187421 PMID:21699906 RGD:1626366, RGD:11041815 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP
IEP
associated with Intestinal Reperfusion Injury;protein:increased expression:liver RGD PMID:7884306 PMID:8780571 RGD:11520784, RGD:14402044 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 severity ISO RGD PMID:28938192 RGD:14985248 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma treatment IDA RGD PMID:22381173 RGD:12791280 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:21911118 RGD:7364839 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 treatment IEP
ISO
RGD PMID:25919765 PMID:14999688 RGD:14696667, RGD:14696668 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il18bp interleukin 18 binding protein IEP mRNA,protein:increased expression:liver RGD PMID:25919765 RGD:14696667 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
JBrowse link
G Il1a interleukin 1 alpha treatment IEP
IDA
mRNA:increased expression:lung
protein:increased expression:serum
RGD PMID:19595018 PMID:19283466 PMID:9840148 RGD:2314952, RGD:6907377, RGD:11059517 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta IDA associated with Cholestasis RGD PMID:21468628 RGD:7175318 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO
IMP
rat model treated with human protein RGD PMID:9000676 PMID:12451245 RGD:6909138, RGD:8551710 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 treatment IDA RGD PMID:24752458 RGD:11062134 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 treatment IDA RGD PMID:22288937 RGD:10403073 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Lbp lipopolysaccharide binding protein IEP mRNA, protein:increased expression:liver RGD PMID:12134092 RGD:9685192 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEP protein:increased activity:liver: RGD PMID:11679968 RGD:10412680 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mfn2 mitofusin 2 treatment IEP mRNA, protein:decreased expression:liver (rat) RGD PMID:27363631 PMID:24898700 RGD:12910833, RGD:13204829 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir155 microRNA 155 ISO RGD PMID:28640790 RGD:21079442 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir21 microRNA 21 IEP RNA:increased expression:liver RGD PMID:29187695 RGD:41410824 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:liver
RNA:increased expression:serum,liver
RGD PMID:19104939 PMID:28646120 RGD:13831297, RGD:21408574 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mir34a microRNA 34a IEP miRNA:increased expression:liver RGD PMID:28963950 RGD:14695005 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Mmp15 matrix metallopeptidase 15 IEP mRNA:increased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP associated with Fatty Liver;mRNA, protein:decreased expression, decreased activity:liver RGD PMID:17255325 RGD:8547976 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Muc1 mucin 1, cell surface associated IEP mRNA, protein:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G Muc3 mucin 3 IEP mRNA, protein:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522
JBrowse link
G Muc4 mucin 4, cell surface associated IEP mRNA:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr11:68,008,245...68,053,229 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IEP RGD PMID:22288937 PMID:31952110 RGD:10403073, RGD:21201304 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:28966130 RGD:13450941 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:12605111 PMID:18507760 RGD:11100021, RGD:11100046 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Serpinc1 serpin family C member 1 treatment IEP
ISO
RGD PMID:24726586 PMID:8589354 RGD:10450597, RGD:11038771 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 IEP protein:increased activity:plasma (rat) RGD PMID:12353078 RGD:8547901 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:16367929 RGD:1580273 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Sirt1 sirtuin 1 treatment IEP RGD PMID:24557422 RGD:9497542 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor IEP RGD PMID:19595018 RGD:2314952 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sod1 superoxide dismutase 1 treatment ISO human gene in a rat model RGD PMID:16555330 PMID:11779401 RGD:8655889, RGD:1581095 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod3 superoxide dismutase 3 treatment ISO human gene in a rat model RGD PMID:11779401 RGD:1581095 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:19545665 RGD:11038676 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tfpi tissue factor pathway inhibitor ISO RGD PMID:9921794 RGD:11062061 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tlr2 toll-like receptor 2 treatment ISO
IEP
RGD PMID:16038046 PMID:25769561 RGD:15090805, RGD:15090809 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 treatment
severity
IEP
ISO
mRNA:increased expression:liver
protein:increased expression:membrane raft:
RGD PMID:21431875 PMID:27064547 PMID:23395256 PMID:22797797 PMID:21693218 RGD:10402078, RGD:14697698, RGD:14697699, RGD:14697702, RGD:5685379 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor treatment IEP
IMP
protein:increased expression:serum (rat) RGD PMID:24726586 PMID:17164725 PMID:15457564 PMID:10454827 PMID:21125813 More... RGD:10450597, RGD:14696803, RGD:14985257, RGD:14985258, RGD:14995447, RGD:14995473, RGD:15039406, RGD:2325259 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased localization:mitochondrion RGD PMID:23423194 RGD:8661760 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tradd TNFRSF1A-associated via death domain treatment IEP RGD PMID:23423194 RGD:8661760 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Ucp2 uncoupling protein 2 IEP mRNA:increased expression:liver RGD PMID:22195248 RGD:7175309 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Vegfa vascular endothelial growth factor A IEP RGD PMID:26451003 RGD:15036791 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase treatment IEP RGD PMID:24768926 RGD:13209011 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18109
    Nutritional and Metabolic Diseases 6747
      disease of metabolism 6747
        acquired metabolic disease 2143
          Reperfusion Injury 723
            Liver Reperfusion Injury 79
Path 2
Term Annotations click to browse term
  disease 18109
    disease of anatomical entity 17480
      gastrointestinal system disease 6530
        hepatobiliary disease 2716
          liver disease 2614
            Liver Injury 492
              Liver Reperfusion Injury 79
paths to the root