allergic disease - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	allergic disease	go back to main search page
Accession:	DOID:1205	browse the term
Definition:	An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods. (DO)
Synonyms:	exact_synonym:	allergic hypersensitivity disease; allergic reaction; allergic reactions; allergies; allergy; hypersensitivities; hypersensitivity; hypersensitivity reaction type I disease
	related_synonym:	eye allergy
	primary_id:	MESH:D006967
	xref:	EFO:0003785; EFO:0005751; ICD10CM:T78.40; MONDO:0005271; NCI:C3114
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants Sort by:
Rat (618) Mouse (612) Human (7034) Chinchilla (526) Bonobo (602) Dog (583) Squirrel (552) Pig (582) Green Monkey (585) Naked Mole-rat (528) All
Genes (612) QTL (3) Strains (3)

allergic disease

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily F member 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433

G

angiotensin I converting enzyme

susceptibility

DNA:deletion:intron:IVS16+1464-1751del (human)

RGD

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensinogen

susceptibility

DNA:polymorphism: :p.M235T (human)

RGD

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aldo-keto reductase family 1 member B1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

Rho GTPase activating protein 28

susceptibility

associated with acute lymphoblastic leukemia;DNA:SNP::rs9958628(human)

RGD

NCBI chr 9:107,832,584...107,998,030
Ensembl chr 9:107,833,330...107,998,000

G

BCL2-related protein A1

RGD

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

caspase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

C-C motif chemokine ligand 11

CTD Direct Evidence: marker/mechanism

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 12

CTD Direct Evidence: marker/mechanism

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 17

CTD Direct Evidence: marker/mechanism

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 19

CTD Direct Evidence: marker/mechanism

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism

PMID:15585374 PMID:21625544

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 24

CTD Direct Evidence: marker/mechanism

NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893

G

C-C motif chemokine ligand 3

CTD Direct Evidence: marker/mechanism

PMID:15585374 PMID:23624239

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

CTD Direct Evidence: marker/mechanism

PMID:15585374 PMID:21625544

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 7

CTD Direct Evidence: marker/mechanism

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 6

CTD Direct Evidence: marker/mechanism

NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603

G

C-C motif chemokine receptor 9

CTD Direct Evidence: marker/mechanism

NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969

G

CD14 molecule

resistance

DNA:polymorphism:promoter:c. -159C>T (human)

RGD

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD274 molecule

CTD Direct Evidence: marker/mechanism

PMID:20488241 PMID:23624239

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD40 ligand

CTD Direct Evidence: marker/mechanism

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

C-type lectin domain family 4, member A3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817

G

copper metabolism domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501

G

C-X3-C motif chemokine ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 3

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 9

CTD Direct Evidence: marker/mechanism

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

C-X-C motif chemokine receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

G

cytochrome P450, family 1, subfamily a, polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cysteinyl leukotriene receptor 1

severity

DNA:SNP: :927T>C (human)

RGD

NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121

G

desmoglein 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443

G

Fc gamma receptor 3A

treatment

associated with Purpura, Thrombocytopenic, Idiopathic

RGD

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

forkhead box P3

CTD Direct Evidence: marker/mechanism

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

glutathione S-transferase mu 1

susceptibility

DNA:deletion: :

RGD

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

susceptibility

DNA:polymorphism:exon:p.I105V (rs1695) (human)

RGD

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

haptoglobin

CTD Direct Evidence: marker/mechanism

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

intercellular adhesion molecule 1

associated with Giardiasis;protein:increased expression:serum

RGD

PMID:7524984 PMID:15587302

RGD:8158114, RGD:8547689

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:10886234 PMID:21625544

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 13

DNA:SNP:promoter, 3' utr:-1055C>T, 4738G>A (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21625544 PMID:11588017

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 16

CTD Direct Evidence: marker/mechanism

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

G

interleukin 17A

CTD Direct Evidence: marker/mechanism

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

CTD Direct Evidence: marker/mechanism

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

CTD Direct Evidence: marker/mechanism

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 1 receptor type 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

interleukin 2

RGD

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 2 receptor subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054

G

interleukin 4

CTD Direct Evidence: marker/mechanism

PMID:16095146 PMID:21625544

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5 receptor subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544

G

interleukin 6

CTD Direct Evidence: marker/mechanism

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

CTD Direct Evidence: marker/mechanism

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

integrin subunit beta 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

kininogen 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

lymphotoxin alpha

DNA:polymorphism, haplotype
associated with Nasal Polyps

RGD

PMID:11591192 PMID:22545387

RGD:8548785, RGD:8548802

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

mitogen-activated protein kinase kinase 6

CTD Direct Evidence: therapeutic

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

macrophage migration inhibitory factor

DNA:polymorphisms:promoter:

RGD

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

myosin light chain kinase

CTD Direct Evidence: marker/mechanism

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

platelet factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

pro-platelet basic protein

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

G

RT1 class II, locus Ba

susceptibility

DNA:polymorphism (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms (human)

CTD
RGD

PMID:8725357 PMID:15853900 PMID:10202362 PMID:16112029

RGD:5147651, RGD:5147866, RGD:5147826

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

susceptibility

DNA:polymorphism (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms (human)

CTD
RGD

PMID:8725357 PMID:20684489 PMID:10202362 PMID:16112029 PMID:10689122 More...

RGD:5147606, RGD:5147866, RGD:5147826, RGD:5147814, RGD:5147651

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class II, locus Da

RGD

NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455

G

RT1 class II, locus Db1

susceptibility

DNA:polymorphism (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms (human)

CTD
RGD

PMID:8725357 PMID:15853900 PMID:16112029 PMID:10689122

RGD:5147651, RGD:5147826, RGD:5147814

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

selectin P

CTD Direct Evidence: marker/mechanism

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

secreted phosphoprotein 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

tachykinin, precursor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transporter 1, ATP binding cassette subfamily B member

DNA:polymorphism, haplotype: :p.V333I (human)

RGD

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

transforming growth factor, beta 1

CTD Direct Evidence: marker/mechanism

PMID:19138248 PMID:21625544

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

PMID:16095146 PMID:21625544

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

CTD Direct Evidence: marker/mechanism

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

allergic asthma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 26

treatment

RGD

NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335

G

cysteinyl leukotriene receptor 1

treatment

RGD

NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121

G

eosinophil peroxidase

protein:increased expression:urine:

RGD

NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952

G

interleukin 25

treatment

RGD

NCBI chr15:28,408,766...28,412,157
Ensembl chr15:28,408,842...28,411,893

G

RT1 class II, locus B

susceptibility

DNA:polymorphism:

RGD

G

RT1 class II, locus Db1

susceptibility

RGD

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

RT1 class II, locus Ha

susceptibility

DNA:polymorphism:

RGD

NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244

G

RT1 class II, locus Hb, pseudogene 1

susceptibility

DNA:polymorphism:

NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618

G

triggering receptor expressed on myeloid cells 1

exacerbates

RGD

PMID:21592044 PMID:21592044

RGD:126928124, RGD:126928124

NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203

allergic bronchopulmonary aspergillosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 17

associated with Cystic Fibrosis

RGD

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine receptor 1

RGD

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

RGD

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CF transmembrane conductance regulator

DNA:mutations: :

RGD

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

intercellular adhesion molecule 1

RGD

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 alpha

RGD

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

mannose binding lectin 2

susceptibility

Chronic Necrotizing Pulmonary Aspergillosis; DNA:missense mutation:exon:p.R52C (human)
DNA:SNP:intron:1011G>A(human)

RGD

PMID:11474427 PMID:16487239

RGD:4889577, RGD:8693711

NCBI chr 1:228,016,439...228,024,736

G

RT1 class II, locus Bb

susceptibility

associated with cystic fibrosis; DNA:polymorphisms: :DQB1*06:02, DQB1*02:01(human)

RGD

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class II, locus Db1

susceptibility

associated with cystic fibrosis; DNA:polymorphisms: :

RGD

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

toll-like receptor 9

susceptibility

DNA:SNP:promoter:g.-1237T>C rs5743836 (human)

RGD

PMID:18275280 PMID:18936185

RGD:5130863, RGD:5130858

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

G

tumor necrosis factor

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

susceptibility

DNA:snps:5' utr, exon:g.-609G>T rs4149570, g.36A>G rs767455 (human)

RGD

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

allergic conjunctivitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 11

mRNA:increased expression:conjunctiva

RGD

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

RGD

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

mRNA:increased expression:conjunctiva

RGD

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

protein:increased expression:conjunctiva

RGD

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine receptor 3

RGD

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

intercellular adhesion molecule 1

RGD

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

RGD

PMID:12234900 PMID:16123425

RGD:8142386, RGD:8142391

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

treatment

protein:increased expression:tear

RGD

PMID:22092652 PMID:16914468 PMID:15144463 PMID:19060266

RGD:7364837, RGD:11041889, RGD:7365076, RGD:7365027

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

associated with Allergic Rhinitis;DNA:SNPs, haplotype:promoter, exon:-1112C>T (rs1800925), p.R130Q (rs20541) (human)

RGD

PMID:9191598 PMID:22023794

RGD:8549533, RGD:8549595

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 beta

treatment

RGD

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

treatment

human protein in a mouse model

RGD

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 4 receptor

susceptibility

associated with rhinitis; DNA:SNP: : rs2107356 (human)

RGD

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interferon regulatory factor 1

RGD

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

LCK proto-oncogene, Src family tyrosine kinase

protein:increased phosphorylation:T cell

RGD

NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794

G

mucin 1, cell surface associated

severity

RGD

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

mucin 2, oligomeric mucus/gel-forming

severity

RGD

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

mucin 4, cell surface associated

severity

RGD

PMID:17177679 PMID:11581187

RGD:7349351, RGD:7349400

NCBI chr11:68,008,245...68,053,242

G

phospholipase A2 group IIA

protein:increased expression:body fluid or substance

RGD

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

G

transforming growth factor, beta 1

treatment

RGD

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 2

associated with Staphylococcal Infections;

RGD

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

mRNA,protein:increased expression:conjunctiva:

RGD

PMID:21820713 PMID:16023216 PMID:21391988

RGD:7777131, RGD:7794849, RGD:7794770

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 9

mRNA,protein:decreased expression:conjunctiva:

RGD

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

G

tenascin C

DNA:SNPs: :multiple (human)

RGD

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

allergic contact dermatitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 6

CTD Direct Evidence: marker/mechanism

NCBI chr10:95,142,805...95,212,087
Ensembl chr10:95,142,966...95,211,530

G

asparaginase and isoaspartyl peptidase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:206,006,103...206,027,115
Ensembl chr 1:206,006,109...206,027,108

G

BCL2, apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone morphogenetic protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

calcitonin receptor like receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

caspase 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

C-C motif chemokine ligand 17

RGD

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 19

CTD Direct Evidence: marker/mechanism

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine ligand 5

protein:increased expression:ear (mouse)

RGD

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine receptor 1

RGD

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17374397 PMID:10899907

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 3

RGD

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

C-C motif chemokine receptor 5

mRNA:increased expression:skin, lymph node (rat)

RGD

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

CD36 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD3 delta subunit of T-cell receptor complex

CTD Direct Evidence: marker/mechanism

NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809

G

cell death-inducing DFFA-like effector c

CTD Direct Evidence: marker/mechanism

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

cytokine inducible SH2-containing protein

CTD Direct Evidence: marker/mechanism

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

contactin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:134,841,268...135,214,460
Ensembl chr 4:134,842,266...135,125,613

G

cAMP responsive element modulator

CTD Direct Evidence: marker/mechanism

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

cathepsin C

CTD Direct Evidence: marker/mechanism

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

C-X-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

CTD Direct Evidence: marker/mechanism

PMID:11312644 PMID:19022366

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

embigin

CTD Direct Evidence: marker/mechanism

NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050

G

ETS proto-oncogene 2, transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

G

coagulation factor XIII A1 chain

CTD Direct Evidence: marker/mechanism

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

G

fibrinogen-like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207

G

Fms related receptor tyrosine kinase 1

mRNA:protein:skin:

RGD

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

FYN binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629

G

G protein-coupled receptor kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

G

hydroxysteroid 11-beta dehydrogenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

IFI30, lysosomal thiol reductase

CTD Direct Evidence: marker/mechanism

NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175

G

interferon gamma

CTD Direct Evidence: marker/mechanism

PMID:11312644 PMID:12484431 PMID:15347381

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

immunoglobulin superfamily, member 6

CTD Direct Evidence: marker/mechanism

NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722

G

interleukin 10

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15347381 PMID:23760007

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

treatment

mRNA:increased expression:skin
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:27585668 PMID:9781803 PMID:12874202

RGD:8655902, RGD:8655940

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 18 binding protein

treatment

RGD

NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963

G

interleukin 1 alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 2

CTD Direct Evidence: marker/mechanism

PMID:11312644 PMID:22245253

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 2 receptor subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 4

CTD Direct Evidence: marker/mechanism

PMID:12484431 PMID:21804303

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

CTD Direct Evidence: marker/mechanism

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interaction protein for cytohesin exchange factors 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:43,237,903...43,451,735
Ensembl chr 1:43,269,202...43,427,969

G

integrin subunit alpha M

CTD Direct Evidence: marker/mechanism

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

junctional adhesion molecule 2

RGD

NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063

G

junctional adhesion molecule 3

RGD

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

kinase insert domain receptor

mRNA:protein:skin:

RGD

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kynurenine 3-monooxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

melanocortin 1 receptor

RGD

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

mesenchyme homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

microRNA 155

treatment

RGD

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 21

treatment

RGD

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

marker of proliferation Ki-67

RGD

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 3

mRNA:increased expression:skin, lymph node

RGD

PMID:16977379 PMID:10359808

RGD:2325935, RGD:8693317

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

mRNA:increased expression:skin, lymph node

RGD

PMID:16977379 PMID:10359808 PMID:10415717

RGD:2325935, RGD:8693317, RGD:8547869

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mannose receptor, C type 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

max dimerization protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

G

nicotinamide phosphoribosyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

N-acetyltransferase 1

susceptibility

DNA:polymorphism: :

RGD

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

susceptibility

DNA:polymorphisms: :

RGD

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

ninjurin 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

nuclear mitotic apparatus protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855

G

8-oxoguanine DNA glycosylase

RGD

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

pleckstrin homology-like domain, family A, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

G

Pim-1 proto-oncogene, serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

plasminogen activator, tissue type

CTD Direct Evidence: marker/mechanism

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

peroxiredoxin 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066

G

glutaminyl-peptide cyclotransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:15,964,656...15,996,730
Ensembl chr 6:15,964,657...15,996,711

G

RAB32, member RAS oncogene family

CTD Direct Evidence: marker/mechanism

NCBI chr 1:4,946,193...4,961,003
Ensembl chr 1:4,945,036...4,960,934

G

regulator of G-protein signaling 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984

G

spermidine/spermine N1-acetyl transferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

selectin E

CTD Direct Evidence: marker/mechanism

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

solute carrier family 2 member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 7 member 5

CTD Direct Evidence: marker/mechanism

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

suppressor of cytokine signaling 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

suppressor of cytokine signaling 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

secreted phosphoprotein 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310

G

SH3 and cysteine rich domain

CTD Direct Evidence: marker/mechanism

NCBI chr 8:111,530,800...111,653,228
Ensembl chr 8:111,530,800...111,654,008

G

transporter 2, ATP binding cassette subfamily B member

susceptibility

RGD

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

G

toll-like receptor 4

RGD

PMID:20711192 PMID:18725520

RGD:7777133, RGD:7794737

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 7

CTD Direct Evidence: marker/mechanism

NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754

G

thymosin, beta 10

CTD Direct Evidence: marker/mechanism

NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 6

CTD Direct Evidence: marker/mechanism

PMID:16033404 PMID:17374397

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

thymic stromal lymphopoietin

treatment

RGD

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

uridine phosphorylase 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462

G

vascular endothelial growth factor A

mRNA:protein:skin:

RGD

PMID:7876550 PMID:7876550

RGD:7421586, RGD:7421586

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

allergic cutaneous vasculitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

colony stimulating factor 3

treatment

associated with Severe Congenital Neutropenia;

RGD

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

allergic rhinitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

severity

DNA:snp:exon:c.1236C>T (human)

RGD

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

angiotensin I converting enzyme

no_association

DNA:deletion:intron:IVS16+1464-1751del (human)

RGD

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

BCL2, apoptosis regulator

mRNA, protein:increased expression:nasal mucosa (rat)

RGD

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 11

treatment

RGD

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 26

protein:increased expression:oronasal secretion (human)

RGD

NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335

G

CD40 molecule

protein:increased expression:lymphocyte

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD40 ligand

protein:increased expression:lymphocyte

RGD

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

claudin 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

claudin 7

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171

G

cytotoxic T-lymphocyte-associated protein 4

treatment

RGD

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

coagulation factor II, thrombin

protein:increased expression:nasal mucus

RGD

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

Fc gamma receptor 3A

susceptibility

DNA:polymorphism:exon:p.F158V(rs396991)(human)

RGD

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

glutamate ionotropic receptor AMPA type subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor AMPA type subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

heme oxygenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

histamine receptor H 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

interferon gamma

treatment

associated with Asthma
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:29871060 PMID:12787306 PMID:18510219

RGD:7829803, RGD:10755770

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:36127783 PMID:23883806 PMID:23253209

RGD:7364793, RGD:7364818

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

susceptibility
no_association

DNA:polymorphism:exon:c. 2044G>A (human)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds:p.R130Q (rs20541) (human)
DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human)
DNA:SNP:promoter:-1512A>C (rs1881457) (human)

PMID:17091279 PMID:22852128 PMID:12928861 PMID:23996716

RGD:4152796, RGD:8549518, RGD:8549516, RGD:8549501

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 13 receptor subunit alpha 2

protein:increased expression:serum

RGD

NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381

G

interleukin 17A

susceptibility

DNA:snp:promoter:c.-444A>G (human)
mRNA:increased expression:peripheral blood mononuclear cell (human)

RGD

PMID:22507625 PMID:21535180

RGD:9068429, RGD:5147409

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

severity
no_association

DNA:SNP:promoter:-137G>C (rs187238) (human)
DNA:SNP:promoter:-140C>G (rs360721) (human)

RGD

PMID:22840759 PMID:22840759

RGD:8655914, RGD:8655914

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

protein:increased expression:nasal mucus

RGD

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

RGD

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:36127783 PMID:9893928 PMID:24620662 PMID:8908280 PMID:14653048

RGD:7829796, RGD:11522769, RGD:7829827, RGD:7829802

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

treatment

RGD

PMID:23934070 PMID:24620662

RGD:11354976, RGD:11522769

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

integrin subunit beta 2

treatment

RGD

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

mannose receptor, C type 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

mucin 1, cell surface associated

severity

mRNA,protein:decreased expression:nasal mucosa

RGD

PMID:31425778 PMID:31425778 PMID:31425778

RGD:127345100, RGD:127345100, RGD:127345100

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

mucin 1, cell surface associated; TALEN induced mutant 1, Cgen

severity

RGD

G

mucin 5AC, oligomeric mucus/gel-forming

mRNA, protein:increased expression:nasal cavity epithelium

RGD

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

nucleotide-binding oligomerization domain containing 2

mRNA:increased expression:nasal mucosa (human)

RGD

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

occludin

CTD Direct Evidence: marker/mechanism

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

paraoxonase 1

severity

protein:decreased activity:plasma (human)

RGD

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

protein kinase cGMP-dependent 1

protein:increased expression:nasal cavity epithelium

RGD

NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RT1 class Ib, locus M3, gene 1

RGD

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

secretoglobin family 1A member 1

mRNA:decreased expression:nasal mucosa, lung

RGD

NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610

G

secretoglobin, family 3A, member 2

susceptibility

DNA:SNP: :rs7726552 (human)

RGD

NCBI chr18:35,932,840...35,935,762
Ensembl chr18:35,932,840...35,935,762

G

serpin family E member 1

mRNA:increased expression:nasal mucosa (mouse)

RGD

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

tachykinin receptor 1

mRNA:increased expression:nasal mucosa

RGD

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

transforming growth factor, beta 1

treatment

RGD

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 2

severity

DNA:polymorphism:cds:p.R753Q(human)
protein:increased expression:neutrophil:
mRNA:decreased expression:nasal mucosa:

RGD

PMID:22402138 PMID:22555057 PMID:18381801 PMID:18219831

RGD:7800732, RGD:8552993, RGD:8552972, RGD:7800742

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

severity
treatment
susceptibility
no_association

DNA:polymorphism:cds:p.D299G(human)
protein:increased expression:nasal lavage,leukocyte, bone marrow:
protein:decreased expression:nasal mucosa:
DNA:SNP: :rs1927911(human)
DNA:polymorphism: :4216G>C(human)

RGD

PMID:22402138 PMID:22555057 PMID:22577387 PMID:17069098 PMID:23639307 More...

RGD:7800732, RGD:8552993, RGD:7800740, RGD:7800738, RGD:7800736, RGD:4145354

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 9

protein:decreased expression:nasal mucosa:

RGD

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

Allergic Rhinoconjunctivitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily C, polypeptide 6

treatment

associated with Eosinophilic Esophagitis; DNA:polymorphisms::

RGD

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

interleukin 3

susceptibility

DNA:SNP: :rs40401(human)

RGD

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

Anaphylaxis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

disease_progression

RGD

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

angiotensinogen

RGD

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

asparaginase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:131,176,727...131,196,268
Ensembl chr 6:131,176,874...131,196,268

G

Bruton tyrosine kinase

treatment

RGD

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

calcium binding protein, spermatid associated 1

treatment

RGD

NCBI chr14:20,096,962...20,099,024
Ensembl chr14:20,096,899...20,099,181

G

chymase 1

protein:increased expression:lung, mast cell (human)

RGD

NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233

G

Fc gamma receptor 2A

susceptibility

associated with Agammaglobulinemia;DNA:mutation:splice junction:

RGD

PMID:23545275 PMID:26396093

RGD:11040993, RGD:11040995

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

GRB2-related adaptor protein 2

ameliorates

RGD

NCBI chr 7:112,117,142...112,190,880
Ensembl chr 7:112,117,142...112,190,877

G

histone deacetylase 3

RGD

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

haptoglobin

RGD

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

interleukin 4

mRNA:increased expression:lung, intestine, spleen
associated with cystic echinococcosis; protein:increased expression:blood

RGD

PMID:24468678 PMID:28095662

RGD:10402796, RGD:14696684

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

kininogen 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

leukotriene B4 receptor

CTD Direct Evidence: marker/mechanism

NCBI chr15:29,263,199...29,265,716

G

NLR family, pyrin domain containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

prostaglandin-endoperoxide synthase 1

RGD

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

RGD

PMID:18480553 PMID:17822719

RGD:2300247, RGD:1642600

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

vascular cell adhesion molecule 1

RGD

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

arthus reaction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Bruton tyrosine kinase

treatment

RGD

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

complement factor D

RGD

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

C-X3-C motif chemokine receptor 1

RGD

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

Fc gamma receptor 2A

treatment

RGD

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

aspergillosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

advanced glycosylation end product-specific receptor

DNA:SNP:promoter:-374T>A (human)

RGD

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

C-C motif chemokine ligand 19

associated with Neutropenia;mRNA:increased expression:lung

RGD

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine receptor 7

associated with Neutropenia

RGD

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

CD209d molecule

RGD

NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171

G

CF transmembrane conductance regulator

severity

RGD

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

C-type lectin domain family 1, member A

susceptibility

ClinVar Annotator: match by term: Aspergillosis, susceptibility to
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
OMIM

NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:162,877,346...162,901,247

G

C-type lectin domain containing 7A

ClinVar Annotator: match by term: Aspergillosis, susceptibility to
CTD Direct Evidence: marker/mechanism

ClinVar
OMIM
CTD

PMID:19864674 PMID:20807886 PMID:24033266 PMID:25741868

NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897

G

C-reactive protein

treatment

RGD

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

interleukin 15

DNA:polymorphism (human)

RGD

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

mannose binding lectin 1

susceptibility

RGD

NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174

G

mannose binding lectin 2

susceptibility

RGD

NCBI chr 1:228,016,439...228,024,736

G

S100 calcium binding protein B

DNA:SNP: :427C>T (human)

RGD

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

toll-like receptor 1

susceptibility

DNA:SNPs: :p.R80T, p.N248S (human)

RGD

NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125

G

toll-like receptor 2

mRNA:increased expression:lung

RGD

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 6

susceptibility

DNA:SNP: :p.S249P (human)

RGD

NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685

aspirin-induced respiratory disease

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium voltage-gated channel auxiliary subunit gamma 6

susceptibility

DNA:SNP,haplotype:rs192808(human)

RGD

NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341

G

C-C motif chemokine receptor 3

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20485159 PMID:20022477

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

cysteinyl leukotriene receptor 1

CTD Direct Evidence: marker/mechanism

PMID:16502481 PMID:17641958 PMID:20485159

NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121

G

cysteinyl leukotriene receptor 2

DNA:SNPs: :-819T>G, 2078C>T, 2534A>G (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16502481 PMID:20485159 PMID:15970796

NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136

G

FA complementation group C

DNA:haplotype::rs4647416(human)

RGD

NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376

G

interleukin 4

susceptibility

DNA:SNPs:promoter,5'UTR,intron:multiple

RGD

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

leukotriene C4 synthase

CTD Direct Evidence: marker/mechanism

PMID:9393345 PMID:9466979 PMID:10970818 PMID:20485159

NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651

G

membrane spanning 4-domains A2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310

G

periostin

CTD Direct Evidence: marker/mechanism

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

prostaglandin D2 receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213

G

prostaglandin E receptor 2

ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to
CTD Direct Evidence: marker/mechanism

PMID:15496426 PMID:16502481

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin I2 receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979

G

prostaglandin-endoperoxide synthase 2

protein:increased expression:mast cell
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16502481 PMID:20485159 PMID:9487340

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RT1 class II, locus Ba

susceptibility

RGD

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

susceptibility

RGD

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class II, locus Db1

susceptibility

RGD

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

RT1 class II, locus Hb, pseudogene 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618

G

transporter 2, ATP binding cassette subfamily B member

RGD

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

G

T-box transcription factor 21

ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to
CTD Direct Evidence: marker/mechanism

PMID:15806396 PMID:16502481

NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831

G

thromboxane A2 receptor

susceptibility

DNA:polymorphism: :795T>C (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16502481 PMID:20485159 PMID:15898979

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

asthma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

protein:increased expression:blood, lymphocyte

RGD

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

RGD

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

no_association

RGD

PMID:19771478 PMID:16008680

RGD:5128835, RGD:5128831

NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423

G

angiotensin I converting enzyme

susceptibility

DNA:polymorphism (human)

RGD

PMID:19484664 PMID:19383228

RGD:4140913, RGD:4140919

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acyl-CoA synthetase long-chain family member 3

DNA:hypermethylation:promoter

RGD

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

adenosine deaminase

susceptibility

DNA:polymorphisms (human)

RGD

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

ADAM metallopeptidase domain 33

susceptibility
no_association
disease_progression

mRNA:increased expression:lung
DNA:polymorphism: :p.M764T (human)
DNA:SNPs:introns,exon:7575G>A, 11188A>T, 12433T>C (human)
mRNA:increased expression:bronchus
DNA:SNPs (human)
DNA:SNPs: :multiple (human)

RGD
GAD

PMID:19635592 PMID:17961406 PMID:16893396 PMID:15118671 PMID:17339047 More...

RGD:4145360, RGD:4145379, RGD:4145382, RGD:1331525, RGD:4145380, RGD:4145359, RGD:4145378

NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461

G

ADAM metallopeptidase domain 8

severity

mRNA:increased expression:bronchus
mRNA:increased expression:respiratory tract

RGD

PMID:17339047 PMID:20194813 PMID:19373511

RGD:4145380, RGD:5128872, RGD:5128878

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

adenylate cyclase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

ADCYAP receptor type I

CTD Direct Evidence: marker/mechanism

NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700

G

alcohol dehydrogenase 5 (class III), chi polypeptide

susceptibility

protein:increased expression:respiratory system fluid/secretion
DNA:SNPs: :rs1154404, rs28730619 (human)

RGD

PMID:19395503 PMID:17543375 PMID:19514054 PMID:15919956

RGD:5128891, RGD:5128882, RGD:5128890, RGD:5128892

NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin, C1Q and collagen domain containing

RGD

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine A1 receptor

DNA:SNPs: :1405C>T (human)
protein:increased expression:bronchus

RGD

PMID:19019667 PMID:17959644 PMID:20400685

RGD:4890386, RGD:5129097, RGD:4145444

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

DNA:SNP (human)
mRNA:decreased expression:aorta

RGD

PMID:17293374 PMID:16339780 PMID:19019667 PMID:18310516

RGD:4890380, RGD:4890385, RGD:4890386, RGD:4890366

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor beta 2

susceptibility

ClinVar Annotator: match by term: Beta-2-adrenoreceptor agonist, reduced response to
DNA:SNP: :-1023A>G (human)
DNA:SNPs: :p.R16G, p.Q27E (human)
DNA:SNPs:promoter:multiple (human)
DNA:polymorphism: :p.R16G (human)
DNA:SNP: :p.Q27E (human)

PMID:8383511 PMID:15284533 PMID:16596417 PMID:1655856 PMID:15118671 More...

RGD:5129113, RGD:1331525, RGD:4145081, RGD:4145094, RGD:4145107, RGD:4145108, RGD:4145092, RGD:4145105, RGD:4145061, RGD:4145096

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

advanced glycosylation end product-specific receptor

treatment
onset

CTD Direct Evidence: marker/mechanism
protein:decreased expression:lung (rat)

CTD
RGD

PMID:33075463 PMID:21920897 PMID:23304218 PMID:23304218

RGD:6767554, RGD:7244279, RGD:7244279

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensin II receptor, type 1a

RGD

PMID:17877756 PMID:19080339

RGD:5147452, RGD:5147457

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

mRNA, protein:increased expression:lung

RGD

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

aldehyde dehydrogenase 2 family member

CTD Direct Evidence: marker/mechanism

PMID:9600491 PMID:11506308 PMID:15118671

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

arachidonate 15-lipoxygenase

protein:increased expression:lung

RGD

PMID:19628725 PMID:18692885

RGD:5509605, RGD:5509784

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

arachidonate 5-lipoxygenase

no_association
susceptibility
treatment
severity

DNA:polymorphism:promoter (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:blood, leukocyte
protein:increased expression:lung
DNA:repeat:promoter (human)
DNA:polymorphism:cds:p.E254K (human)

PMID:20128419 PMID:9642160 PMID:12911785 PMID:8879219 PMID:11035107 More...

RGD:4890407, RGD:5147467, RGD:5147465, RGD:5147462, RGD:4890422, RGD:4890408, RGD:734557, RGD:4890415, RGD:4890413, RGD:4890410

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

arachidonate 5-lipoxygenase activating protein

susceptibility
no_association

DNA:SNP: :rs10507391 (human)
mRNA:increased expression:blood, leukocyte
DNA:repeat:promoter:-169(A)21 (human)
DNA:substitution, repeat:promoter:-336G>A, -169(A)19-23 (human)
DNA:polymorphisms:intron:IVS2+12C>A, IVS2+105T>C (human)
protein:increased expression:lung
DNA:polymorphism:promoter (human)
DNA:SNPs (human)

RGD

PMID:20067482 PMID:9642160 PMID:10527888 PMID:12911785 PMID:15784112 More...

RGD:4890405, RGD:5147467, RGD:5147466, RGD:5147465, RGD:5147464, RGD:5147462, RGD:4890422, RGD:4890407, RGD:4890409

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

G

alpha-1-microglobulin/bikunin precursor

protein:increased expression:serum

RGD

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

G

angiogenin

severity

protein:increased expression:sputum

RGD

NCBI chr15:24,312,711...24,323,361

G

annexin A1

RGD

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

amphiregulin

CTD Direct Evidence: marker/mechanism

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

arginase 1

DNA:SNP: :rs2781667 (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung (mouse)
mRNA, protein:increased expression:lung, mononuclear cell (human)

CTD
RGD

PMID:19281908 PMID:19800904 PMID:20124949 PMID:12813022 PMID:12813022

RGD:5129205, RGD:4143187, RGD:4143187

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

arginase 2

severity
susceptibility

DNA:SNP: :rs3742879, rs17249437 (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung (mouse)
DNA:SNPs (human)

CTD
RGD

PMID:19281908 PMID:20124949 PMID:12813022 PMID:16387594

RGD:5129205, RGD:4143187, RGD:5129207

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

BCL2, apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B2

onset

DNA:polymorphism:exon (human)
protein:increased expression:blood, eosinophil

RGD

PMID:11517947 PMID:14727005 PMID:8856156 PMID:19038786

RGD:4890456, RGD:4890454, RGD:4891042, RGD:4891028

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

susceptibility
severity

protein:decreased expression:blood, eosinophil
DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human)
DNA:polymorphisms: :p.V66M, -270C>T (human)
DNA:polymorphisms: :p.V66M (rs6265) (human)
protein:increased expression:plasma

RGD

PMID:12752594 PMID:21723144 PMID:17584309 PMID:19895626 PMID:20874832 More...

RGD:4891122, RGD:8655967, RGD:4891067, RGD:4891117, RGD:4891063, RGD:4891123

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

bone gamma-carboxyglutamate protein

CTD Direct Evidence: marker/mechanism

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

bone morphogenetic protein receptor type 1B

protein:decreased expression:bronchus

RGD

NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368

G

bone morphogenetic protein receptor type 2

protein:decreased expression:bronchus

RGD

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

complement C3

severity

DNA:SNPs: :multiple (human)
protein:increased expression:serum
DNA:SNP: :4896C>T (human)
DNA:SNP:intron:rs11569562 (human)
Interaction with IL4RA
protein:increased expression:respiratory system fluid/secretion

RGD

PMID:16355111 PMID:20589464 PMID:15278436 PMID:18566738 PMID:20402389 More...

RGD:5129505, RGD:5129519, RGD:5129512, RGD:5129501, RGD:5129537, RGD:5129538, RGD:5129681, RGD:5129517

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C3a receptor 1

severity

mRNA:increased expression:lung
protein:increased expression:lung, leukocyte

RGD

PMID:20045013 PMID:17544263 PMID:20802484 PMID:15940127 PMID:15278436

RGD:5129686, RGD:5129560, RGD:5129681, RGD:5129561, RGD:5129512

NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701

G

complement C5

severity

mRNA:decreased expression:lung

RGD

PMID:10973279 PMID:20143644 PMID:20802484 PMID:15278436 PMID:11591795

RGD:5130158, RGD:5129706, RGD:5129681, RGD:5129512, RGD:1600651

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

complement C5a receptor 1

severity

protein:increased expression:lung, leukocyte
protein:increased expression:respiratory tract

RGD

PMID:20802484 PMID:17544263 PMID:15940127 PMID:16511606

RGD:5129681, RGD:5129560, RGD:5129561, RGD:5130166

NCBI chr 1:76,948,622...76,959,826

G

caspase recruitment domain family, member 11

susceptibility

ClinVar Annotator: match by term: Asthma

PMID:18323416 PMID:23027925 PMID:23129749 PMID:25352053 PMID:25741868 More...

NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112

G

coactivator-associated arginine methyltransferase 1

mRNA:decreased expression:lung

RGD

NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689

G

caspase 1

protein:increased expression:serum

RGD

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

catalase

severity

DNA:polymorphism:promoter:-21A>T (human)
CTD Direct Evidence: marker/mechanism
protein:decreased activity:respiratory system fluid/secretion
DNA:polymorphism:promoter:-262C>T (human)
protein:increased expression:erythrocyte

CTD
RGD

PMID:18048809 PMID:19373626 PMID:16622028 PMID:18048809 PMID:19475625

RGD:5130753, RGD:5130867, RGD:5130856, RGD:5130751

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 1

protein:increased expression:respiratory system fluid/secretion

RGD

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 11

susceptibility
treatment
severity

protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :p.A23T (human)
mRNA:increased expression:lung

PMID:16304252 PMID:22932891 PMID:17074272 PMID:9034156 PMID:17845580 More...

RGD:5130930, RGD:7248416, RGD:4145461, RGD:4145451, RGD:4145457, RGD:4145392, RGD:4145387, RGD:4891485

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 17

mRNA:increased expression:lung
protein:increased expression:respiratory system fluid/secretion

RGD

PMID:15993846 PMID:15947487 PMID:20074456 PMID:20237293 PMID:11160256

RGD:2306304, RGD:4145513, RGD:4145487, RGD:4145486, RGD:4145603

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 19

protein:increased expression:bronchus submucosa, mast cell

RGD

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine ligand 2

severity
treatment

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung (mouse)
DNA:haplotype::-2518A>G (human)
protein:increased expression:lung

CTD
RGD

PMID:19373627 PMID:19373627 PMID:12055264 PMID:25441643 PMID:23454776 More...

RGD:4891466, RGD:11528570, RGD:11528569, RGD:8551842, RGD:2307055, RGD:4145509

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

protein:increased expression:respiratory system fluid/secretion
associated with Allergic Rhinitis;protein:increased expression:serum

RGD

PMID:18422729 PMID:22469443

RGD:7483597, RGD:7483618

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 22

protein:increased expression:respiratory system fluid/secretion
mRNA, protein:increased expression:respiratory system mucosa, respiratory system fluid/secretion
mRNA:increased expression:lung

RGD

PMID:18316417 PMID:10384142 PMID:18684970 PMID:15993846

RGD:4891474, RGD:4891475, RGD:4145489, RGD:2306304

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 24

susceptibility

DNA:SNPs: :179T>C, 275C>T (human)
protein:increased expression:respiratory system fluid/secretion
DNA:SNP: :1265A>G (human)
DNA:SNPs: :304C>A, 1272A>G (human)
protein:increased expression:plasma

RGD

PMID:15207712 PMID:17548626 PMID:12952266 PMID:12761043 PMID:18712274 More...

RGD:4891495, RGD:4891484, RGD:4891496, RGD:5130932, RGD:4891483, RGD:4891485, RGD:5130930

NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893

G

C-C motif chemokine ligand 26

treatment

protein:increased expression:plasma
DNA:SNPs: :77C>T, 2497T>G (human)
DNA:SNPs: :77C>T, 716A>G, 1579G>A (human)

RGD

PMID:16304252 PMID:25399816 PMID:25530546 PMID:15207712 PMID:18712274

RGD:5130930, RGD:11087575, RGD:11081163, RGD:4891495, RGD:4891483

NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335

G

C-C motif chemokine ligand 27

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

C-C motif chemokine ligand 28

mRNA:increased expression:lung (mouse)

RGD

NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997

G

C-C motif chemokine ligand 4

RGD

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

susceptibility

protein:increased expression:smooth muscle cell
CTD Direct Evidence: marker/mechanism
DNA:transition:5' utr:-403G>A (human)
protein:increased expression:lung, secretion (mouse)

CTD
RGD

PMID:8534483 PMID:18208670 PMID:20430255 PMID:20092989

RGD:2307112, RGD:4891381, RGD:4891430

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

RGD

PMID:21388664 PMID:19965981

RGD:5130983, RGD:5130979

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine receptor 1

severity

mRNA:increased expression:lung
associated with Respiratory Syncytial Virus Infections

RGD

PMID:15654816 PMID:15593301

RGD:5688158, RGD:5688159

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

susceptibility

DNA:SNP:cds:p.V64I (human)
DNA:haplotype:cds:p.V64I(human)
protein:increased expression:lung, dendritic cell (mouse)

RGD

PMID:17298432 PMID:23454776 PMID:19917684

RGD:4145110, RGD:8551842, RGD:8549811

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 3

protein:increased expression:respiratory system fluid/secretion, neutrophil
DNA:SNP:exon:51T>C (human)

RGD

PMID:18699933 PMID:19017998 PMID:20220260 PMID:16978084 PMID:19657453 More...

RGD:4145633, RGD:4145632, RGD:4145638, RGD:4145646, RGD:4145623, RGD:4145618, RGD:1601020

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

C-C motif chemokine receptor 4

mRNA:increased expression:lung

RGD

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

C-C motif chemokine receptor 5

no_association

DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)
DNA:polymorphism, frameshift mutation: :-59029G>A, p.S185_T195del (rs333) (human)
mRNA:increased expression:lung (mouse)
protein:decreased expression:blood, lymphocyte (human)

RGD

PMID:20220260 PMID:23454776 PMID:16474097 PMID:18094012 PMID:15256090

RGD:4145638, RGD:8551842, RGD:4892093, RGD:4892088, RGD:4892108

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

C-C motif chemokine receptor 6

protein:increased expression:lung, dendritic cell (mouse)

RGD

NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603

G

C-C motif chemokine receptor 7

protein:increased expression:lung, dendritic cell (mouse)

RGD

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

C-C motif chemokine receptor 8

mRNA:increased expression:lung

RGD

NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629

G

C-C motif chemokine receptor 9

mRNA, protein:increased expression:blood, mature NK T cell

RGD

NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969

G

CD14 molecule

severity
no_association
susceptibility

DNA:polymorphism:promoter:c. -260C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:c. -159C>T (human)
DNA:SNPs: :
protein:increased expression:serum|DNA:polymorphism:promoter:c. -159C>T (human)

CTD
RGD

PMID:17607003 PMID:15940135 PMID:15741437 PMID:19096003 PMID:16387800 More...

RGD:4144814, RGD:4144815, RGD:4144228, RGD:4144813, RGD:4144208

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD1d1 molecule

susceptibility

associated with fasciolopsiasis

RGD

NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089

G

CD209c molecule

RGD

NCBI chr12:1,936,233...1,943,841
Ensembl chr12:1,936,396...1,942,040

G

CD209d molecule

NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171

G

CD274 molecule

treatment

associated with Chlamydia pneumonia

RGD

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

Cd28 molecule

RGD

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

CD40 molecule

treatment

RGD

PMID:19220210 PMID:20205594 PMID:20205594 PMID:20941750 PMID:19159017

RGD:5132272, RGD:8547792, RGD:8547792, RGD:4892277, RGD:4144188

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD40 ligand

severity

RGD

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

Cd80 molecule

RGD

PMID:21352203 PMID:21051864 PMID:21440530

RGD:5132620, RGD:5132621, RGD:5132619

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

treatment

protein:increased expression:lung, alveolar macrophage (mouse)
protein:increased expression:blood, B cell (human)
protein:increased expression:lung, dendritic cell (rat)
DNA:snp:exon:p.I179V rs2681417 (human)

RGD

PMID:20941750 PMID:25344652 PMID:9449507 PMID:20668438 PMID:9551945 More...

RGD:4892277, RGD:11354965, RGD:4892555, RGD:4892199, RGD:4892202, RGD:4892280

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cadherin 1

RGD

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin-related family member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:49,641,833...49,702,016
Ensembl chr 6:49,641,813...49,702,017

G

CF transmembrane conductance regulator

susceptibility

DNA:deletion: :F508del(human)

RGD

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

choline O-acetyltransferase

Protein:decreased expression:lung epithelium

RGD

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

chitinase 3 like 1

susceptibility

human gene in mouse model
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 7
DNA:snp:5' utr:g.-131C>G rs4950928 (human)
protein:increased secretion:serum (human)

OMIM
ClinVar
RGD

PMID:18403759 PMID:19414556 PMID:19568425 PMID:18003958

RGD:4892663, RGD:4892630, RGD:4892632

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

chitinase, acidic

no_association

DNA:snps:5' utr, cds:multiple (human)
DNA:snps:multiple (human)
mRNA:increased expression:lung, epithelial cell (human)
mRNA:increased expression:lung (mouse)

RGD

PMID:16179638 PMID:20226308 PMID:19548841 PMID:15192232 PMID:14734765

RGD:4996473, RGD:5024922, RGD:5024921, RGD:4985150, RGD:4990463

NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533

G

CHM like Rab escort protein

RGD

NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862

G

cholinergic receptor, muscarinic 1

RGD

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

DNA:SNP: :rs6962027 (human)

RGD

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

severity

RGD

PMID:20394512 PMID:18348887

RGD:5133437, RGD:5133438

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

component of inhibitor of nuclear factor kappa B kinase complex

RGD

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

chloride channel accessory 1

susceptibility

DNA:SNPs (human)

RGD

PMID:11296262 PMID:17898169 PMID:15318163

RGD:4145661, RGD:4145653, RGD:4145656

NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369

G

claudin 18

CTD Direct Evidence: marker/mechanism

NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351

G

chymase 1

severity
susceptibility
no_association

protein:increased expression:lung epithelium, mast cell (human)
DNA:duplications:3' utr:g.*254-?dupTG, dupGA (human)
DNA:polymorphism:5' utr:g.-1903G>A rs1800875 (human)

RGD

PMID:20813890 PMID:15924217 PMID:15248847

RGD:5128804, RGD:1625396, RGD:1625397

NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233

G

corticotropin releasing hormone receptor 1

DNA:SNP: :RS242941 (human)
DNA:SNPs: :rs1876828, rs242939, rs242941 (human)

RGD

PMID:19663668 PMID:16113459

RGD:5147485, RGD:5147488

NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481

G

corticotropin releasing hormone receptor 2

DNA:SNPs: :multiple (human)

RGD

NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904

G

C-reactive protein

protein:increased expression:serum

RGD

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 2

severity

protein:increased expression:lung
protein:increased expression:sputum

RGD

PMID:20405019 PMID:9717963 PMID:19213775

RGD:5131473, RGD:10449521, RGD:5131476

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 2 receptor subunit beta

RGD

NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157

G

colony stimulating factor 3

protein:increased expression:lung

RGD

PMID:21396376 PMID:20405019

RGD:5133731, RGD:5131473

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cytotoxic T-lymphocyte-associated protein 4

severity
treatment
no_association

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple (human)
DNA:SNP: :rs3087243 (human)
DNA:polymorphism:promoter:-318C>T (human)
DNA:SNPs:promoter, exon:-1147C>T, -318C>T, 49A>G (human)
DNA:polymorphisms:promoter, exon:-318C>T 49A>G (human)

CTD
RGD

PMID:28807506 PMID:15871446 PMID:11726402 PMID:17237396 PMID:15316504 More...

RGD:4891529, RGD:11344922, RGD:4891514, RGD:4891519, RGD:4891526, RGD:4891517, RGD:4891522, RGD:4891510, RGD:4891528, RGD:4891516, RGD:4891527, RGD:4891521

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

catenin alpha 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:23,614,469...25,200,026
Ensembl chr20:23,623,560...25,199,978

G

C-X3-C motif chemokine ligand 1

protein:increased expression:plasma

RGD

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X3-C motif chemokine receptor 1

no_association

DNA:SNPs: :p.V249I, rs2669849 (human)
DNA:polymorphisms: :p.V249I, p.T280M (human)

RGD

PMID:21037587 PMID:17082760 PMID:17505143

RGD:4891882, RGD:4891895, RGD:4891904

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

C-X-C motif chemokine ligand 1

severity

RGD

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

protein:decreased expression:plasma

RGD

PMID:17302903 PMID:16602032 PMID:11994485

RGD:5135439, RGD:5135457, RGD:5135452

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 14

CTD Direct Evidence: marker/mechanism

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 2

mRNA:increased expression:lung

RGD

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

severity

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 6

mRNA:increased expression:bronchus epithelium

RGD

PMID:17234659 PMID:9620668

RGD:5135243, RGD:5135265

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine ligand 9

RGD

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 3

susceptibility
severity

DNA:SNP:intron:IVS1+234G>A (human)
protein:decreased expression:respiratory system fluid/secretion, T cell

RGD

PMID:18094012 PMID:16043121 PMID:16548899 PMID:17641057

RGD:4892088, RGD:5143934, RGD:5143932, RGD:5135484

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

G

cytochrome b-245 alpha chain

susceptibility

DNA:polymorphism: :-930A>G (human)
DNA:SNPs: :-930A>G, 242C>T, 640A>G (human)

RGD

PMID:19459419 PMID:18716406

RGD:4311041, RGD:4772770

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 1, subfamily a, polypeptide 1

mRNA, protein:increased expression, decreased activity:lung

RGD

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily d, polypeptide 4

DNA:polymorphism: :1934G>A (human)

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

mRNA:decreased expression:leukocyte
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:28807506 PMID:20514434 PMID:17081494

RGD:4892076, RGD:4892220

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cysteinyl leukotriene receptor 1

no_association
severity

DNA:SNPs:promoter, exon:multiple (human)
DNA:SNPs:promoter:-634C>T, -475A>C, -336A>G (human)
DNA:SNP: :927T>C (human)
mRNA, protein:increased expression:respiratory system mucosa

RGD

PMID:16771777 PMID:16630147 PMID:16776674 PMID:8087328 PMID:16387808 More...

RGD:4889116, RGD:4784257, RGD:4782072, RGD:4888514, RGD:4843543, RGD:4848936, RGD:4781742, RGD:4781449, RGD:4847129

NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121

G

cysteinyl leukotriene receptor 2

DNA:polymorphism: :601A>G (human)
DNA:polymorphism: :-1220A>C (human)

RGD

PMID:15475736 PMID:15454733

RGD:5144002, RGD:5144003

NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136

G

decorin

RGD

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

defensin beta 1

susceptibility

DNA:SNP: :-1816 T>C (human)
DNA:SNPs:5' utr:g.-52G>A, g.-44C>G, g.-20G>A (human)

RGD

PMID:15696078 PMID:16435024

RGD:4892263, RGD:4892254

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

dynein, axonemal, heavy chain 5

CTD Direct Evidence: marker/mechanism

NCBI chr 2:78,937,788...79,255,551
Ensembl chr 2:78,937,800...79,254,890

G

DNA methyltransferase 1

DNA,mRNA:hypermethylation,decreased expression:promoter,respiratory tract:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23423710 PMID:23196709

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dipeptidyl peptidase like 10

DNA:SNPs (human)
DNA:SNP: :rs10208402 (human)
DNA:SNP:exon (human)
protein:increased expression:bronchus

RGD
GAD

PMID:21103062 PMID:15118671 PMID:19672052 PMID:14566338 PMID:17967935

RGD:4889866, RGD:1331525, RGD:4892275, RGD:4892276, RGD:4892278

NCBI chr13:34,584,420...36,269,292
Ensembl chr13:34,595,868...36,269,292

G

Epstein-Barr virus induced 3

RGD

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

G

endothelin 1

Severe Persistent Allergic Asthma; protein:increased secretion:lung (human)
CTD Direct Evidence: marker/mechanism
DNA:transition:intron:g.4124T>C (human)

CTD
RGD

PMID:16981460 PMID:20588001 PMID:11668616

RGD:4144895, RGD:4144869

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

RGD

PMID:17448648 PMID:18632188

RGD:4892322, RGD:4892288

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

mRNA:increased expression:bronchus, smooth muscle cell
DNA:polymorphism (human)

RGD

PMID:15245576 PMID:17470272 PMID:18632188

RGD:4892324, RGD:4892321, RGD:4892288

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

epidermal growth factor receptor

severity

protein:increased expression:lung epithelium (rat)
protein:increased expression:bronchial epithelium (human)
protein:increased expression:lung epithelium (mouse)

RGD

PMID:19954006 PMID:12580917 PMID:21224214 PMID:21072743

RGD:5131870, RGD:5131468, RGD:5131633, RGD:5131642

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

mRNA:increased expression:bronchoalveolar lavage cell (human)
DNA:snp:5' utr:g.-4071A>G rs7729723 (human)

RGD

PMID:11254538 PMID:18774390 PMID:18507785

RGD:5131985, RGD:5130915, RGD:5131993

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

elongator acetyltransferase complex subunit 1

no_association

RGD

PMID:12774215 PMID:11281413

RGD:5129158, RGD:5129157

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

epoxide hydrolase 1

susceptibility

DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human)

RGD

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

eosinophil peroxidase

severity
disease_progression

protein:increased activity:sputum,nasal,pharyngeal mucosa

RGD

PMID:26645423 PMID:12199967 PMID:20813885

RGD:11574908, RGD:13506892, RGD:13506891

NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952

G

estrogen receptor 2

mRNA:decreased expression:lung (rat)

RGD

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

coagulation factor II, thrombin

protein:increased expression:plasma
associated with Rhinosinusitis, associated with Nasal Polyps;protein:increased expression:nasal mucus

RGD

PMID:21658190 PMID:21711961

RGD:5147753, RGD:5147783

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

F2R like trypsin receptor 1

RGD

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

coagulation factor VII

treatment

RGD

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

G

Fas cell surface death receptor

mRNA:increased expression:eosinophil

RGD

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fc epsilon receptor Ia

severity

Asthma symptoms persistent despite steroids in humans
Fatal asthma subjects

PMID:20937062 PMID:21388666

RGD:5128717, RGD:5128711

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

Fc gamma receptor 2A

protein:increased expression:alveolar macrophage

RGD

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

Fc gamma receptor 2B

RGD

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

Fc gamma receptor 3A

susceptibility

DNA:polymorphism:exon:p.F158V(rs396991)(human)

RGD

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

fibrinogen alpha chain

treatment

RGD

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

FKBP prolyl isomerase 5

ClinVar Annotator: match by term: Asthma

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

forkhead box P3

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:27965764 PMID:29317916 PMID:28944907 PMID:27633092

RGD:38549365, RGD:38548920

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

GATA binding protein 3

RGD

PMID:9949310 PMID:18186587

RGD:5128802, RGD:5128803

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

GC, vitamin D binding protein

protein, mRNA:increased expression:bronchoalveolar lavage fluid:

RGD

PMID:21169467 PMID:21169467

RGD:5509920, RGD:5509920

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glutathione S-transferase alpha 1

susceptibility

DNA:polymorphism:promoter: -69C>T (human)

RGD

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase mu 1

resistance
susceptibility

DNA:deletion: :
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16870661 PMID:18988661 PMID:17651144 PMID:21051083 PMID:11075422

RGD:4142509, RGD:5490962, RGD:4140921

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 3

DNA:polymorphism

RGD

PMID:17550934 PMID:11470996

RGD:5135038, RGD:5135039

NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475

G

glutathione S-transferase, mu 5

DNA:polymorphism

PMID:11470996 PMID:17550934

RGD:5135038 RGD:5135039

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase omega 2

susceptibility

DNA:polymorphism:exon:p. N142D (human)

RGD

NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866

G

glutathione S-transferase pi 1

severity
susceptibility
disease_progression
no_association

DNA:polymorphism:exon:p.I105V (rs1695) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs:exons:p.I105V (rs1695), A114V (rs1138272) (human)
DNA:SNPs:intron,exon:(rs749174), (rs1138272)(human)
DNA:SNPs: :p.I105V, p.A114V (human)
DNA:polymorphism:exon:p.I105V (human)
DNA:SNP: :p.A114V (human)

CTD
RGD

PMID:11994713 PMID:16870661 PMID:18988661 PMID:24117884 PMID:29411558 More...

RGD:4142526, RGD:5490999, RGD:5490991, RGD:5490985, RGD:4140951, RGD:4142519, RGD:4140946, RGD:4140947

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

susceptibility

DNA:deletion: :

RGD

PMID:15300848 PMID:21051083 PMID:11075422

RGD:4142539, RGD:5490962, RGD:4140921

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

hepatitis A virus cellular receptor 1

RGD

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hepatitis A virus cellular receptor 2

RGD

NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137

G

histone deacetylase 2

mRNA:decreased expression:macrophage:

RGD

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

histidine decarboxylase

associated with Rhinitis;DNA:SNP: :p.E644D (rs2073440) (human)

RGD

NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341

G

hypoxia inducible factor 1 subunit alpha

treatment

RGD

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

3-hydroxy-3-methylglutaryl-CoA reductase

RGD

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

severity

CTD Direct Evidence: marker/mechanism
mRNA;protein:increased expression:Leukocytes, Mononuclear

CTD
RGD

PMID:18048809 PMID:20596599 PMID:16196283

RGD:4145403, RGD:4145408

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

histamine N-methyltransferase

no_association
susceptibility

ClinVar Annotator: match by term: Asthma, susceptibility to
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD
RGD

PMID:10752634 PMID:10803682 PMID:16205835 PMID:17651147 PMID:25741868 More...

RGD:5128888, RGD:5128883, RGD:5128885, RGD:5128881, RGD:5128887

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

G

haptoglobin

RGD

PMID:21471098 PMID:21169467

RGD:5144151, RGD:5509920

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hydroxysteroid 11-beta dehydrogenase 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

5-hydroxytryptamine receptor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

intercellular adhesion molecule 1

mRNA:increased expression:aorta (mouse)
CTD Direct Evidence: marker/mechanism
protein:increased secretion:lung (human)
protein:increased expression:lung, serum (rat)

CTD
RGD

PMID:17014439 PMID:25003170 PMID:20400685 PMID:20205697 PMID:20953388

RGD:4145444, RGD:4145509, RGD:4145331

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

treatment
resistance

protein:increased expression:sputum

RGD
GAD

PMID:20817868 PMID:12396623 PMID:15118671 PMID:19542437 PMID:20953328

RGD:4145651, RGD:10755706, RGD:1331525, RGD:5128479, RGD:4145525

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

DNA: SNP: Leu467Pro

RGD

PMID:21737883 PMID:12851715

RGD:6480255, RGD:6480431

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

interferon, lambda 1

exacerbates

associated with common cold;mRNA:decreased expression:sputum (human)
associated with common cold;protein:increased expression: nasal cavity (human)

RGD

PMID:25784275 PMID:22135341

RGD:126848770, RGD:126848775

NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235

G

interferon, lambda 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:83,814,456...83,816,096
Ensembl chr 1:83,814,564...83,816,096

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:83,460,564...83,553,591
Ensembl chr10:83,465,745...83,553,591

G

interleukin 10

treatment
susceptibility

CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :-627C>A (human)
protein:decreased expression:plasma

CTD
RGD

PMID:29317916 PMID:20237464 PMID:21998459 PMID:12938145 PMID:20121766 More...

RGD:4140471, RGD:11046261, RGD:4143221, RGD:4140451, RGD:4140459, RGD:4140421, RGD:5131623

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12A

RGD

PMID:17056578 PMID:17548618

RGD:4438438, RGD:4373570

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

severity
susceptibility

DNA:polymorphisms:introns:
ClinVar Annotator: match by term: Asthma, susceptibility to
DNA:polymorphisms:promoter, 3'utr:
DNA:polymorphism:promoter

PMID:15322986 PMID:15322986 PMID:16210052 PMID:12241719

RGD:1600043, RGD:4145438, RGD:4145428

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

susceptibility
severity
no_association

ISO
IMP
IDA
IEP

ClinVar Annotator: match by term: Asthma, susceptibility to
CTD Direct Evidence: marker/mechanism
associated with Dermatitis, Atopic;DNA, protein:SNP, increased expression:promoter, serum:-1112C>T (human)
DNA:polymorphism: :-1512A>C, -1112C>T, 2044G>A (human)
mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid
protein:increased expression:serum
DNA:polymorphism:cds:p.R130Q (human)
DNA:polymorphisms:promoters,exon4: rs1881457, rs1800925, rs20541 (human)
DNA:polymorphism: :p. R110Q (human)
DNA:SNP: :c. -646A>G (human)
DNA:polymorphism: :c. 1923C>T (human)
protein:increased expression:sputum
DNA:polymorphism:promoter:c. -1055C>T (human)
DNA:polymorphisms: :rs20541, rs1295685(human)
DNA:polymorphism:3'utr:c.4738G>A (human)
DNA:polymorphism: :c.-1055C>T (human)
DNA:polymorphism: :c. 2044G>A (human)

ClinVar
OMIM
CTD
RGD

PMID:10699178 PMID:11588017 PMID:11709756 PMID:12847555 PMID:12928861 More...

RGD:4206706, RGD:8549509, RGD:4892639, RGD:2301686, RGD:4145453, RGD:2307110, RGD:4145508, RGD:4763153, RGD:4145639, RGD:4763761, RGD:4145601, RGD:4145664, RGD:4321828, RGD:4146241, RGD:4145775, RGD:4145777, RGD:4220633, RGD:4145534, RGD:4765128, RGD:4145593, RGD:4145776

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 13 receptor subunit alpha 1

no_association

mRNA:increased expression:bronchus
DNA:polymorphisms:promoter, 3' utr:-281T>G, 1365A>G (human)
DNA:polymorphism: :1398A>G (human)
DNA:polymorphism: :1050C>T (human)

RGD

PMID:20383033 PMID:17392323 PMID:18480254 PMID:17006604 PMID:10686479 More...

RGD:4892646, RGD:4892650, RGD:4892647, RGD:4892639, RGD:4892655, RGD:4892654

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 13 receptor subunit alpha 2

mRNA:increased expression:bronchus
protein:increased expression:serum

RGD

PMID:20383033 PMID:21462799 PMID:17885690

RGD:4892646, RGD:8549521, RGD:4892649

NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381

G

interleukin 15

no_association

DNA:SNPs: :multiple (human)

RGD

PMID:19133918 PMID:16629787 PMID:11160248 PMID:15843549 PMID:15131572

RGD:5000760, RGD:4984421, RGD:4990462, RGD:5000757, RGD:5000758

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 16

no_association
severity

DNA:SNP:promoter:-295T>C (human)
associated with Rhinitis;protein:increased expression:respiratory system fluid/secretion
protein:increased expression:serum

RGD

PMID:10585533 PMID:16387589 PMID:15784111 PMID:16734115 PMID:12872394

RGD:5024937, RGD:5024934, RGD:5024935, RGD:5024928, RGD:5024930

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

G

interleukin 17A

susceptibility

mRNA,protein:increased expression:Leukocytes, Mononuclear, lung, serum
protein:increased expression:sputum
protein:increased expression:alveolar macrophage
DNA:SNP:promoter:rs2275913 (human)

RGD

PMID:18060619 PMID:20351038 PMID:15730730 PMID:18941201 PMID:20437253

RGD:4839043, RGD:4888527, RGD:4889114, RGD:4889152, RGD:4889139

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17 receptor B

associated with Picornaviridae Infections

RGD

NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125

G

interleukin 18

severity
susceptibility
disease_progression

DNA:SNPs:Promoter:c. -607C>A (rs1946518), -137G/C (rs187238) (human)
DNA:SNP:promoter:c.and -137G>C (rs187238)(human)
protein:increased expression:serum
DNA:SNP:promoter: c.-380C>G (rs5744247)(human)
DNA:polymorphism: :c. -105A>C (human)

RGD

PMID:17767553 PMID:16433859 PMID:18826499 PMID:11174201 PMID:20497957 More...

RGD:4889585, RGD:4889923, RGD:4889908, RGD:4889863, RGD:4889898, RGD:4889900, RGD:4889910

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 18 receptor 1

DNA:SNP: :rs3771166 (human)
DNA:SNPs: :multiple (human)

RGD

PMID:19910030 PMID:20860503 PMID:18382474 PMID:11972614 PMID:18774397

RGD:5024945, RGD:5024942, RGD:5024947, RGD:5024948, RGD:5024946

NCBI chr 9:42,727,416...42,760,971
Ensembl chr 9:42,727,869...42,760,715

G

interleukin 19

protein:increased expression:serum

RGD

NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473

G

interleukin 1 alpha

DNA:polymorphisms: :

RGD

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

susceptibility

DNA:polymorphism: :-511C>T (human)
CTD Direct Evidence: marker/mechanism
protein:decreased expression:neutrophil

CTD
RGD

PMID:9176529 PMID:18926055 PMID:19842845 PMID:19684087

RGD:4142864, RGD:4142830, RGD:4142836

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

susceptibility
severity

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs1420101 (human)
DNA:SNPs:intron:rs1420089, rs1861245,rs1946131 (human)
DNA:SNP: :rs10197862 (human)
DNA:SNP: :rs1041973 (human)

CTD
RGD

PMID:19198610 PMID:21150878 PMID:21804549 PMID:24241537 PMID:27472835 More...

RGD:5144235, RGD:5144245, RGD:5144244, RGD:5144243, RGD:5144242, RGD:5144240, RGD:5144239, RGD:5144237

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 1 receptor antagonist

susceptibility
severity

DNA:SNP: :rs2234678 (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple (human)
DNA:SNPs: :rs447713, rs3087271 (human)
protein:increased expression:plasma
DNA, protein:repeat, decreased expression (human)
DNA:polymorphism:intron (human)

CTD
RGD

PMID:9176529 PMID:17107994 PMID:15020290 PMID:16409203 PMID:16724092 More...

RGD:4143208, RGD:4143216, RGD:4143163, RGD:4143209, RGD:4143225, RGD:4143224, RGD:4142864, RGD:4142802

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

susceptibility

DNA:SNP:promoter:rs2069762(human)

RGD

PMID:20926789 PMID:16333313

RGD:4889118, RGD:8663473

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 21

DNA:SNP:exon:5250C>T (human)

RGD

NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996

G

interleukin 22

treatment
severity

mRNA:increased expression:blood, mononuclear cell
protein:increased expression:serum

RGD

PMID:21789181 PMID:21998459 PMID:21535180 PMID:21297073

RGD:5147401, RGD:11046261, RGD:5147409, RGD:5147403

NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186

G

interleukin 23 receptor

RGD

NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021

G

interleukin 25

mRNA, protein:increased expression:lung

RGD

NCBI chr15:28,408,766...28,412,157
Ensembl chr15:28,408,842...28,411,893

G

interleukin 27

susceptibility
treatment

DNA:SNP: :g.-964A>G (human)
protein:increased expression:sputum

RGD

PMID:17318299 PMID:26595888 PMID:17878337 PMID:19542437 PMID:20817868

RGD:5128485, RGD:11076728, RGD:5128491, RGD:5128479, RGD:4145651

NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582

G

interleukin 27 receptor subunit alpha

RGD

NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938

G

interleukin 2 receptor subunit alpha

RGD

PMID:17351063 PMID:20525707 PMID:21377197

RGD:2325990, RGD:5147445, RGD:5147437

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 2 receptor subunit beta

DNA:SNP: :rs2284033 (human)

RGD

PMID:20860503 PMID:18641329

RGD:5024942, RGD:5147447

NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054

G

interleukin 3

susceptibility

DNA:SNP: :rs40401(human)
DNA:polymorphism:cds:+79T>C(S27P)(human)

RGD

PMID:24684517 PMID:15372320

RGD:13506914, RGD:13506916

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 33

treatment
severity

CTD Direct Evidence: marker/mechanism
associated with viral pneumonia;
associated with fungal infectious disease

CTD
RGD

PMID:19198610 PMID:21804549 PMID:24241537 PMID:27472835 PMID:29067999 More...

RGD:39939002, RGD:39938968

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 4

treatment
no_association

DNA:polymorphism (human)
CTD Direct Evidence: marker/mechanism
mRNA, protein:increase expression:leukocyte, serum
protein:increased expression:lung
DNA:SNP: :589C>T (human)
protein:increased expression:respiratory system fluid/secretion
mRNA:increased expression:lung, spleen

CTD
RGD

PMID:18357729 PMID:21103062 PMID:24946644 PMID:24450480 PMID:18211752 More...

RGD:4889866, RGD:10402799, RGD:10402791, RGD:2317290, RGD:5128560, RGD:5128502, RGD:5128500, RGD:5128557

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 receptor

susceptibility
severity
disease_progression

DNA:mutation:cds:p.Q576R (mouse)
OMIM:600807
DNA:SNPs: :multiple
DNA:polymorphism:cds:p.I50V (human)
DNA:SNPs:cds:p. I75V, Q576R (human)
DNA:polymorphism::-1902G/A (human)
protein:increased secretion:plasma|DNA:polymorphism:promoter:c.-3223C>T (human)
DNA:polymorphism:cds:p.Q576R (human)
DNA:SNPs:cds:p.E375A, Q551R (human)
DNA:polymorphism:cds:p. S478P (human)
DNA:polymorphism:cds:p.Q551R (human)

PMID:19770271 PMID:17823973 PMID:18425216 PMID:12133990 PMID:20868478 More...

RGD:4890003, RGD:4890347, RGD:4890346, RGD:4890404, RGD:4890387, RGD:4890406, RGD:4890351, RGD:4890402, RGD:4890349, RGD:4890024, RGD:5128553, RGD:5128514, RGD:4890352, RGD:4890348

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 5

treatment
disease_progression

IDA
ISO
IEP
IMP

CTD Direct Evidence: marker/mechanism
protein:increased expression:lungs, respiratory system fluid/secretion
protein: increased levels: sputum
protein:increased expression:respiratory system fluid/secretion
DNA:polymorphism:promoter:-703C>T (human)

CTD
RGD

PMID:7540862 PMID:23266719 PMID:17074272 PMID:25008888 PMID:11159041 More...

RGD:4145461, RGD:11354973, RGD:5687189, RGD:5687144, RGD:5687140, RGD:4890947, RGD:4890948, RGD:4890963, RGD:4890940, RGD:4890962, RGD:4890938

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 5 receptor subunit alpha

DNA:SNP: :c.25091G>A (human)
DNA:SNPs (human)

RGD

PMID:20513521 PMID:20592918 PMID:17276963 PMID:10848907 PMID:10224351 More...

RGD:5128625, RGD:5128614, RGD:5128617, RGD:5128627, RGD:5128623, RGD:5128626

NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544

G

interleukin 6

CTD Direct Evidence: marker/mechanism
associated with Hypersensitivity;protein:increased expression:sputum
protein:increased expression:lung

CTD
RGD

PMID:29902480 PMID:21115736 PMID:20840469 PMID:20816188 PMID:20658762

RGD:5128630, RGD:4143265, RGD:4143266, RGD:4143271

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:29902480 PMID:17496315 PMID:21115736

RGD:5128662, RGD:5128630

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

interleukin 9

protein:increased expression:respiratory system fluid/secretion
protein:increased expression:sputum, macrophage, cytoplasm

RGD

PMID:12153980 PMID:17446528 PMID:15531759 PMID:15303135 PMID:21356110

RGD:5128700, RGD:5128686, RGD:5128690, RGD:5128691, RGD:5128707

NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895

G

interleukin 9 receptor

RGD

NCBI chr10:15,431,706...15,444,144
Ensembl chr10:15,431,706...15,441,990

G

interleukin-1 receptor-associated kinase 3

susceptibility

ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 5

NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121

G

interferon regulatory factor 1

no_association
susceptibility

DNA:polymorphisms:promoter, cds:-300G>T, 4396A>G, 6355G>A (human)
protein:increased expression:respiratory tract epithelium
DNA:repeat:intron (human)

RGD

PMID:11069564 PMID:10225979 PMID:16961714

RGD:5128726, RGD:5128723, RGD:5128724

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

interferon regulatory factor 3

RGD

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

integrin subunit beta 3

DNA:SNPs: :

RGD

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

integrin subunit beta 6

OMIM:600807

NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671

G

inositol 1,4,5-trisphosphate receptor, type 1

RGD

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

kinase insert domain receptor

associated with Rhinitis,Allergic,Seasonal;protein:increased expression:nasal cavity of mucosa:

RGD

PMID:20921519 PMID:17651148

RGD:5684385, RGD:8551771

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kinesin family member 3a

CTD Direct Evidence: marker/mechanism

NCBI chr10:37,725,930...37,761,183
Ensembl chr10:37,725,970...37,759,191

G

keratin 19

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

leptin

protein:increased expression:plasma

RGD

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 3

treatment

RGD

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

lymphotoxin alpha

susceptibility
no_association

DNA:polymorphisms:promoter
DNA:polymorphism:intron

RGD

PMID:15969671 PMID:18947013 PMID:12530118 PMID:17536219

RGD:4143373, RGD:4143370, RGD:4143254, RGD:4143371

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

leukotriene A4 hydrolase

mRNA:increased expression:lung, cerebral cortex (rat)

RGD

NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600

G

mannose binding lectin 2

susceptibility

associated with Bronchiolitis;DNA:polymorphism:exon:
DNA:SNP:cds:p.G54D(human)

RGD

PMID:22512728 PMID:22674410

RGD:8693709, RGD:12910828

NCBI chr 1:228,016,439...228,024,736

G

MEFV innate immunity regulator, pyrin

susceptibility

DNA:mutations:exons

RGD

NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973

G

macrophage migration inhibitory factor

severity

protein:increased expression:bronchoalveolar lavage fluid
DNA:SNP:promoter:rs755622(human)
DNA:repeats:promoter

RGD

PMID:9637721 PMID:17373669 PMID:19317738 PMID:16186482 PMID:16455830

RGD:4891043, RGD:4891035, RGD:4891059, RGD:4891052, RGD:1641985

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504

G

matrix metallopeptidase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 10

CTD Direct Evidence: marker/mechanism

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 9

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
protein:increased expression:lung
DNA:SNP: : rs2664538(human)
mRNA, protein:increased expression:lung

CTD
RGD

PMID:11742282 PMID:15131573 PMID:21439806 PMID:19361849 PMID:20181264 More...

RGD:5129204, RGD:5129687, RGD:5130859, RGD:2325953, RGD:5129522

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

susceptibility

DNA:polymorphism: :−463G > A (human)
protein:increased expression:serum

RGD

PMID:19544176 PMID:10731862

RGD:5130989, RGD:5130994

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

membrane spanning 4-domains A2

susceptibility

DNA:SNPs:multiple:, rs573790, rs2583476, rs569108
DNA:SNPs: : rs556917, rs502581, rs502419 (human)
DNA:SNP: : -109C>T (human)
Atopy and bronchial hyperresponsiveness, OMIM:147050

RGD

PMID:19218813 PMID:21320344 PMID:19862939 PMID:8817330

RGD:5131151, RGD:5131149, RGD:5131092, RGD:1599903

NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310

G

methylenetetrahydrofolate reductase

DNA:transition:cds:g.677C>T (human)

RGD

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

mucin 1, cell surface associated

protein:increased expression:serum

RGD

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

mucin 2, oligomeric mucus/gel-forming

associated with hypersensitivity

RGD

PMID:11062147 PMID:14594655

RGD:5131178, RGD:7349354

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

mucin 5AC, oligomeric mucus/gel-forming

treatment

mRNA,protein:increased expression:lung
mRNA, protein:increased expression:lung

RGD

PMID:17590487 PMID:21549818 PMID:21780541 PMID:14594655 PMID:17698377

RGD:2324962, RGD:7364729, RGD:7349407, RGD:7349354, RGD:5131204

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

mucin 5B, oligomeric mucus/gel-forming

protein:altered expression:sputum

RGD

PMID:11802783 PMID:11587997

RGD:5131252, RGD:7364763

NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250

G

MYB proto-oncogene, transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

MYD88, innate immune signal transduction adaptor

ameliorates

RGD

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myosin light chain kinase

RGD

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

N-acetyltransferase 2

susceptibility

DNA:polymorphisms: :
Asthma, Aspirin-Induced; DNA:polymorphism: :

RGD

PMID:16924569 PMID:20602614

RGD:5131606, RGD:5131600

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

NFE2 like bZIP transcription factor 2

severity

mRNA:increased expression:bronchoalveolar lavage cell, peripheral blood mononuclear cell (human)

RGD

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nerve growth factor

severity

protein:increased expression:blood, eosinophil
protein:increased expression:lung, serum

RGD

PMID:12752594 PMID:17164945 PMID:17497413 PMID:11737043

RGD:4891122, RGD:4891108, RGD:4891068, RGD:4891123

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

RGD

PMID:16603479 PMID:12540484

RGD:5144070, RGD:5144072

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

nucleotide-binding oligomerization domain containing 1

susceptibility

DNA:SNP: :rs2075817 (human)
DNA:insertion:cds:

RGD

PMID:16918516 PMID:15718249

RGD:5131519, RGD:5131518

NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404

G

nucleotide-binding oligomerization domain containing 2

susceptibility

DNA:polymorphisms:intron, exon/3'UTR (rs1077861, rs3135500) (human)

RGD

PMID:16008671 PMID:21051079

RGD:5131477, RGD:5508757

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

nitric oxide synthase 1

susceptibility

DNA:repeats:exon
DNA:repeats:intron
DNA:repeats: :

RGD

PMID:10833424 PMID:14767694 PMID:10673365 PMID:20609134

RGD:5132860, RGD:5132615, RGD:5132869, RGD:5132863

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

disease_progression
severity
no_association

protein:increased expression:lung, bronchoalveolar lavage fluid
CTD Direct Evidence: marker/mechanism
protein:increased expression, increased activity:lung (rat)
DNA:repeats:promoter
associated with Rhinitis, Allergic, Seasonal; protein:increased expression:nasal mucosa
DNA:SNP:exon:p.S608L (human)
DNA:repeats:promoter, introns (human)
mRNA:increased expression:monocyte
DNA:repeat:promoter

CTD
RGD

PMID:19800904 PMID:17161822 PMID:21847581 PMID:18714530 PMID:18254476 More...

RGD:4891927, RGD:5509073, RGD:4891508, RGD:4891910, RGD:4891925, RGD:4891924, RGD:4891419, RGD:4891953, RGD:4891957, RGD:4891480

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

susceptibility

DNA:snps, repeat, haplotype:promoter, introns, exons:multiple (human)
DNA:polymorphisms:promoter:c. -786C>T, -691C>T (human)
DNA:repeats:intron

RGD

PMID:18486767 PMID:16837812 PMID:16081038

RGD:4892053, RGD:4892058, RGD:4892062

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

neuropeptide S receptor 1

susceptibility

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 2

OMIM
CTD
ClinVar
RGD

PMID:15073379 PMID:15710598 PMID:15764725 PMID:16926187 PMID:17702965 More...

RGD:4891923, RGD:4891922, RGD:4891921

NCBI chr 8:22,606,946...22,831,558
Ensembl chr 8:22,606,946...22,831,558

G

neuropeptide Y

CTD Direct Evidence: marker/mechanism

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

NAD(P)H quinone dehydrogenase 1

susceptibility

DNA:SNP:exon:c. 609C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:exon:c.609C>T (human)

CTD
RGD

PMID:20049212 PMID:19027876 PMID:19591959

RGD:5135006, RGD:5135005

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 1

treatment
susceptibility
severity

DNA:polymorphism:intron
protein:increased expression, decreased activity:leukocyte, mononuclear

RGD

PMID:18396779 PMID:20727335 PMID:21113676 PMID:18799869 PMID:15295049

RGD:4892328, RGD:7174728, RGD:4892568, RGD:4892594, RGD:4892609

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neurotrophin 3

protein:increased expression:lung, serum

RGD

PMID:11737043 PMID:17497413

RGD:4891123, RGD:4891068

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophin 4

protein:increased expression:lung, serum

RGD

NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243

G

neurotrophic receptor tyrosine kinase 1

mRNA:increased expression:lung:

RGD

PMID:20934630 PMID:16708804

RGD:5684766, RGD:5684772

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

ORMDL sphingolipid biosynthesis regulator 3

CTD Direct Evidence: marker/mechanism

PMID:21150878 PMID:25256354

NCBI chr10:83,590,052...83,596,035
Ensembl chr10:83,590,071...83,598,620

G

purinergic receptor P2Y12

RGD

PMID:22010907 PMID:19822647

RGD:6480532, RGD:6480533

NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361

G

poly (ADP-ribose) polymerase 1

treatment

protein:increased activation:lung, blood, mononuclear cell
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18261157 PMID:12594058 PMID:26205779 PMID:26205779

RGD:5683910, RGD:11073727, RGD:11073727

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

programmed cell death 1

treatment

associated with Chlamydia pneumonia

RGD

NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937

G

phosphodiesterase 4B

CTD Direct Evidence: marker/mechanism

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

phosphodiesterase 4D

CTD Direct Evidence: marker/mechanism

PMID:19426955 PMID:21611147

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

G

platelet derived growth factor subunit B

protein: increased expression

RGD

PMID:21216974 PMID:21216974

RGD:6483071, RGD:6483071

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

placental growth factor

RGD

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

RGD

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

RGD

NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785

G

phospholipase A2 group 4A

RGD

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

phospholipase A2 group VII

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:10733466 PMID:10733466

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

G

plasminogen activator, urokinase

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21912604 PMID:18519237

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

protein phosphatase 2 catalytic subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

perforin 1

RGD

PMID:22250087 PMID:21426642

RGD:6482815, RGD:6482818

NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701

G

proteoglycan 2, pro eosinophil major basic protein

severity
disease_progression
no_association

mRNA:increased expression:eosinophil:
associated with cough;protein:increased expression:sputum:
associated with viral infection;mRNA:increased expression:sputum:

RGD

PMID:16982448 PMID:22022864 PMID:24450586 PMID:11067904

RGD:13506941, RGD:13506944, RGD:13506943, RGD:13506942

NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101

G

protein arginine methyltransferase 1

mRNA:increased expression:lung

RGD

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

protein arginine methyltransferase 2

mRNA:increased expression:lung, spleen

RGD

NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643

G

protein arginine methyltransferase 3

mRNA:increased expression:lung

RGD

NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435

G

protein arginine methyltransferase 5

mRNA:increased expression:lung, spleen

RGD

NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296

G

protein C, inactivator of coagulation factors Va and VIIIa

treatment

RGD

NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133

G

phosphatase and tensin homolog

CTD Direct Evidence: therapeutic

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin D2 receptor

susceptibility

NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679

G

prostaglandin D2 receptor 2

Aspirin exacerbated asthma
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:27103662 PMID:19796209 PMID:19392992 PMID:18757520

RGD:5135020, RGD:5135019, RGD:5135018

NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213

G

prostaglandin E receptor 3

treatment

RGD

NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434

G

prostaglandin-endoperoxide synthase 2

susceptibility
severity

mRNA:increased expression:lung
DNA:SNP: :8473T>C (human)
mRNA, protein:increased expression:lung:
DNA:SNP: :rs689465 (human)

RGD

PMID:19878559 PMID:15316498 PMID:17573729 PMID:18097056 PMID:18489027 More...

RGD:5135514, RGD:5143931, RGD:5143923, RGD:5135534, RGD:5135526, RGD:5135522, RGD:5135515

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAD50 double strand break repair protein

CTD Direct Evidence: marker/mechanism

NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396

G

ras homolog family member A

RGD

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ribonuclease A family member 3

CTD Direct Evidence: marker/mechanism

PMID:8874658 PMID:12153692 PMID:12587966

NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790

G

RT1 class II, locus B

susceptibility

DNA:polymorphisms: :

RGD

G

RT1 class II, locus Ba

DNA:polymorphisms (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism (human)

CTD
RGD

PMID:10792356 PMID:12890388 PMID:10051703 PMID:11802952 PMID:19052351

RGD:5147799, RGD:1331670, RGD:5147831, RGD:5147617

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

susceptibility
disease_progression
no_association

Alternaria sensitive asthma
DNA:polymorphisms: :
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms (human)

CTD
RGD

PMID:10792356 PMID:20298583 PMID:20159242 PMID:20214848 PMID:23331206 More...

RGD:4144113, RGD:13506913, RGD:4144181, RGD:13506906, RGD:5147831, RGD:5147799, RGD:5147617

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class II, locus Da

susceptibility

DNA:polymorphisms: :

RGD

NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455

G

RT1 class II, locus Db1

susceptibility
no_association
severity

DNA:polymorphisms: :
CTD Direct Evidence: marker/mechanism
DNA:polymorphism (human)

CTD
RGD

PMID:16792590 PMID:19528258 PMID:20159242 PMID:23331206 PMID:10051703 More...

RGD:4144196, RGD:13506913, RGD:13506906, RGD:1331670, RGD:5147663, RGD:5147607, RGD:4144181

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

RT1 class II, locus Ha

susceptibility

DNA:polymorphism: :

RGD

NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244

G

RT1 class II, locus Hb, pseudogene 1

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:polymorphisms: :

PMID:16792590 PMID:17956852 PMID:21814517

NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618

G

RT1 class Ib, locus M3, gene 1

susceptibility

CTD Direct Evidence: marker/mechanism

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

RUNX family transcription factor 1

DNA:SNPs: :multiple

RGD

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

RUNX family transcription factor 3

OMIM:600807

NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156

G

secretoglobin family 1A member 1

susceptibility

mRNA,protein:decreased expression:bronchial alveolar lavage fluid, lung:
ClinVar Annotator: match by term: Asthma, susceptibility to
associated with allergic rhinitis; DNA:SNP:exon:38G>A (human)
protein:decreased expression:serum

PMID:9550363 PMID:9643286 PMID:12100044 PMID:12921604 PMID:21255142 More...

RGD:5144052, RGD:5144226, RGD:5144148

NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610

G

secretoglobin, family 3A, member 2

susceptibility
severity
no_association

DNA:SNP:promoter:-112G>A (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Asthma, susceptibility to
mRNA,protein:decreased expression:;lung
protein:increased expression:sputum

CTD
OMIM
ClinVar
RGD

PMID:11813133 PMID:11813133 PMID:15531759 PMID:16456148 PMID:17218572 More...

RGD:5144229, RGD:5128690, RGD:5144233, RGD:5144232, RGD:5144231, RGD:5144230

NCBI chr18:35,932,840...35,935,762
Ensembl chr18:35,932,840...35,935,762

G

selectin L

RGD

PMID:21437035 PMID:21515793

RGD:5685685, RGD:5685696

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

serpin family A member 1

Fisher rats, shown to exhibit hyperactive airway responses at 14 days of age, had higher transcript and protein levels of Serpina1 than same age Brown Norway rats.

RGD

NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339

G

serpin family E member 1

susceptibility
no_association
severity

protein:increased activity, increased expression:plasma, lung
DNA:polymorphism:promoter:rs1799768 (human)
protein:increased expression:plasma

RGD

PMID:18594148 PMID:19063817 PMID:19604112 PMID:19703828

RGD:4144836, RGD:4144832, RGD:4144833, RGD:4144831

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

surfactant protein A1

protein:decreased expression:lung, Clara cell, pneumocyte
mRNA, protein:increased expression:lung

RGD

PMID:15816355 PMID:16629790 PMID:18802356 PMID:18926058

RGD:4143398, RGD:4143462, RGD:4143516, RGD:4143289

NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685

G

surfactant protein B

protein:increased expression:lung
mRNA, protein:decreased expression:lung
protein:decreased expression:lung, Clara cell

RGD

PMID:16629790 PMID:11472974 PMID:18926058 PMID:15816355

RGD:4143462, RGD:4143465, RGD:4143289, RGD:4143398

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

surfactant protein C

susceptibility

mRNA, protein:decreased expression:lung
protein:increased expression:lung
DNA:polymorphism: :p.A53T (human)

RGD

PMID:11472974 PMID:16629790 PMID:19910179

RGD:4143465, RGD:4143462, RGD:4144063

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

surfactant protein D

protein:increased expression:lung
associated with Bronchitis;protein:increased expression:lung
mRNA, protein:increased expression:lung

RGD

PMID:16629790 PMID:11472974 PMID:18266831 PMID:16839409 PMID:18802356

RGD:4143462, RGD:4143465, RGD:4143517, RGD:4143508, RGD:4143516

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

solute carrier family 11 member 1

RGD

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

G

solute carrier family 18 member A3

RGD

NCBI chr16:7,713,630...7,716,491

G

solute carrier family 22 member 1

RGD

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 5 member 7

mRNA:decreased expression:lung

RGD

NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258

G

solute carrier family 6 member 4

susceptibility

DNA:repeat:intron (human)

RGD

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

superoxide dismutase 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

RGD

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

small proline rich protein 2B

CTD Direct Evidence: marker/mechanism

NCBI chr 2:177,852,824...177,853,096
Ensembl chr 2:177,852,824...177,853,096

G

signal transducer and activator of transcription 4

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:28807506 PMID:18211752

NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 6

treatment

RGD

PMID:19087723 PMID:16083555

RGD:7244151, RGD:7244153

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

tachykinin, precursor 1

protein:increased expression:lung

RGD

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

tachykinin receptor 1

protein:increased expression:lung
mRNA:increased expression:lung
mRNA,protein:increased expression:lung

RGD

PMID:17392578 PMID:8240667 PMID:16409782

RGD:2304339, RGD:5147645, RGD:5147475

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

tachykinin receptor 2

DNA:SNP:cds:p.G231E (human)

RGD

PMID:20175803 PMID:19880429

RGD:5147640, RGD:5147641

NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446

G

transporter 1, ATP binding cassette subfamily B member

susceptibility

DNA:polymorphism: :

RGD

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

T-box transcription factor 21

CTD Direct Evidence: marker/mechanism
OMIM:600807

NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831

G

thromboxane A2 receptor

susceptibility
severity

ClinVar Annotator: match by term: Asthma
DNA:polymorphism:cds:924T>C(human)

PMID:2955539 PMID:7929844 PMID:8428006 PMID:8613548 PMID:15118671 More...

RGD:1331525, RGD:11059535, RGD:11059534

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

G

transforming growth factor, beta 1

onset
no_association

DNA:SNP: :-509C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs:promoter, exon:multiple (human)
DNA:SNP:cds:915G>C (human)
mRNA:increased expression:lung
protein:increased expression:serum
DNA:polymorphisms: :multiple (human)
DNA:polymorphism: :-509C>T (human)

CTD
RGD

PMID:16365456 PMID:19138248 PMID:17673695 PMID:18366906 PMID:19096005 More...

RGD:4145295, RGD:4145280, RGD:4145143, RGD:4145132, RGD:4145142, RGD:4145113, RGD:4145139, RGD:4145144, RGD:4143443, RGD:4145299, RGD:4145297

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

thrombomodulin

RGD

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

TIMP metallopeptidase inhibitor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

toll-like receptor 1

susceptibility

DNA:SNP (human)

RGD

NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125

G

toll-like receptor 10

susceptibility

DNA:SNP (human)

RGD

NCBI chr14:43,400,843...43,414,056
Ensembl chr14:43,406,217...43,413,917

G

toll-like receptor 2

susceptibility
severity

DNA:SNP: :596T>C (human)
DNA:polymorphism:cds:p.R753Q(human)
DNA:SNP: :rs3804100 (human)
DNA:SNP: :rs7656411 (human)
DNA:SNP: :rs4696480 (human)

RGD

PMID:19096003 PMID:22402138 PMID:19148143 PMID:18202345 PMID:20815312 More...

RGD:4144228, RGD:7800732, RGD:2312679, RGD:4145343, RGD:4145352, RGD:4144171, RGD:4145334

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 3

no_association

Asthma, Virus-Induced; mRNA:increased expression:sputum (human)
DNA:snp:cds:p.L412F (human)

RGD

PMID:21129050 PMID:17434873 PMID:14987294 PMID:17610940 PMID:21364926

RGD:5129226, RGD:5129478, RGD:5129493, RGD:5129475, RGD:5128500

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

toll-like receptor 4

susceptibility
no_association
severity

DNA:Polymorphism:cds:p.D299G (human)
DNA:SNPs::
protein:decreased expression:leukocytes, mononuclear
DNA:SNPs: :rs10983755, rs1927914 (human)
DNA:polymorphisms:cds:c.896A>G, 1196C>T (human)

RGD

PMID:15356557 PMID:20628601 PMID:20685742 PMID:19067129 PMID:19330007 More...

RGD:4144817, RGD:4144176, RGD:4144171, RGD:4144190, RGD:4144141, RGD:4144188, RGD:4144198

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 6

susceptibility

DNA:SNP (human)
DNA:SNP: :p.S249P (human)

RGD

PMID:18547625 PMID:15266299

RGD:4889528, RGD:4889538

NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685

G

toll-like receptor 9

no_association
susceptibility
severity

DNA:SNP:promoter:g.-1237T>C rs5743836 (human)
DNA:snp:promoter:g.-1237T>C rs5743836 (human)
protein:increased expression:peripheral blood mononuclear cell (human)

RGD

PMID:21324137 PMID:18312481 PMID:20016192 PMID:20072849

RGD:5130712, RGD:4144208, RGD:5129104, RGD:4889523

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

G

tenascin C

CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple (human)
protein:increased expression:bronchus basement membrane
DNA:SNP:exon:p.L1677I (human)

CTD
RGD

PMID:16115819 PMID:17125141 PMID:18305139 PMID:9310019 PMID:16115819

RGD:4889565, RGD:4889589, RGD:4889572, RGD:4889569

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

susceptibility
no_association

DNA:polymorphism:promoter: c. -308A>G (human)
ClinVar Annotator: match by term: Asthma, susceptibility to
CTD Direct Evidence: marker/mechanism
associated with obesity; DNA:polymorphism:promoter
DNA:polymorphisms:: rs1799964, rs1799724 (human)
DNA:polymorphisms: :
associated with nasal polys; protein:increased expression:nose
DNA:polymorphism:promoter:c.-863C > A (human)

ClinVar
OMIM
CTD
RGD

PMID:8056188 PMID:9818939 PMID:10450718 PMID:11261930 PMID:11506397 More...

RGD:4143443, RGD:4143238, RGD:4145508, RGD:4143254, RGD:4143240, RGD:4142802, RGD:4143369, RGD:4143372

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

protein:increased expression:lung (mouse)

RGD

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNFAIP3 interacting protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:39,037,048...39,084,328
Ensembl chr10:39,037,058...39,077,625

G

transient receptor potential cation channel, subfamily A, member 1

severity

CTD Direct Evidence: marker/mechanism
ovalbumin sensitization

CTD
RGD

PMID:19458046 PMID:31969645

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily A, member 1;CRISPR/Cas9 induced mutant 1, Gne

severity

ovalbumin sensitization

RGD

G

thymic stromal lymphopoietin

CTD Direct Evidence: marker/mechanism

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

urocortin

associated with Hypersensitivity;mRNA, protein:increased expression:lung

RGD

NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950

G

urotensin 2

RGD

NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237

G

vitamin D receptor

no_association

DNA:SNP: :rs7975232 (human)
DNA:SNPs (human)
DNA:SNPs: :multiple (human)
DNA:SNP (human)

RGD

PMID:19622139 PMID:20124605 PMID:15282200 PMID:21103062

RGD:4889868, RGD:4889867, RGD:4889854, RGD:4889866

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor A

protein:increased expression:sputum
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:11907124 PMID:15201500 PMID:19263519 PMID:19178538

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vasoactive intestinal peptide

RGD

PMID:21419198 PMID:16782752

RGD:5685381, RGD:5685620

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216