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ONTOLOGY REPORT - ANNOTATIONS


Term:pheochromocytoma
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Accession:DOID:0050771 term browser browse the term
Definition:A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Synonyms:exact_synonym: phaeochromocytoma;   pheochromocytomas
 related_synonym: pheochromocytoma, susceptibility to
 primary_id: MESH:D010673
 alt_id: OMIM:171300
 xref: GARD:7385
For additional species annotation, visit the Alliance of Genome Resources.


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pheochromocytoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cfap126 cilia and flagella associated protein 126 JBrowse link 13 89,480,058 89,495,949 RGD:8554872
G Chga chromogranin A JBrowse link 6 126,434,226 126,445,569 RGD:6906907
RGD:11554173
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:11554173
G Dbh dopamine beta-hydroxylase JBrowse link 3 5,709,236 5,731,895 RGD:11554173
G Ddc dopa decarboxylase JBrowse link 14 91,905,919 91,996,816 RGD:11554173
G Dmbt1 deleted in malignant brain tumors 1 JBrowse link 1
1
201,620,642
203,149,414
201,689,905
203,228,705
RGD:1599780
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:7240710
RGD:11554173
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 JBrowse link X 21,696,796 21,699,241 RGD:13792787
G Kif1b kinesin family member 1B JBrowse link 5 165,994,803 166,133,497 RGD:7240710
RGD:8554872
G L1cam L1 cell adhesion molecule JBrowse link X 156,901,244 156,928,064 RGD:11570409
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:11554173
G Maob monoamine oxidase B JBrowse link X 6,430,694 6,533,520 RGD:11554173
G Max MYC associated factor X JBrowse link 6 99,984,260 100,011,460 RGD:7240710
RGD:8554872
RGD:11554173
G Mpz myelin protein zero JBrowse link 13 89,524,204 89,530,070 RGD:8554872
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:11554173
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:2324930
RGD:8554872
RGD:11554173
RGD:7240710
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:8554872
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 JBrowse link 1 226,543,671 226,572,414 RGD:8554872
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:1624151
RGD:8554872
RGD:7240710
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:8554872
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:7240710
RGD:8554872
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:11554173
G Tmem127 transmembrane protein 127 JBrowse link 3 119,677,575 119,690,371 RGD:7240710
RGD:8554872
RGD:11554173
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:1580371
RGD:8554872
RGD:11554173
RGD:7240710
Carney Triad term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:8554872
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:8554872
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:8554872
Carney-Stratakis syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alg9 ALG9, alpha-1,2-mannosyltransferase JBrowse link 8 55,202,140 55,265,478 RGD:8554872
G Btg4 BTG anti-proliferation factor 4 JBrowse link 8 55,408,917 55,508,100 RGD:8554872
G Colca2 colorectal cancer associated 2 JBrowse link 8 55,674,561 55,682,811 RGD:8554872
G Cryab crystallin, alpha B JBrowse link 8 55,178,543 55,182,546 RGD:8554872
G Dixdc1 DIX domain containing 1 JBrowse link 8 55,091,232 55,164,636 RGD:8554872
G Dlat dihydrolipoamide S-acetyltransferase JBrowse link 8 55,062,549 55,087,832 RGD:8554872
G Fdxacb1 ferredoxin-fold anticodon binding domain containing 1 JBrowse link 8 55,196,758 55,201,610 RGD:8554872
G Hoatz HOATZ cilia and flagella associated protein JBrowse link 8 55,471,705 55,490,973 RGD:8554872
G Hspb2 heat shock protein family B (small) member 2 JBrowse link 8 55,176,648 55,178,227 RGD:8554872
G Layn layilin JBrowse link 8 55,447,203 55,469,420 RGD:8554872
G LOC689959 hypothetical protein LOC689959 JBrowse link 8 55,164,736 55,174,613 RGD:8554872
G Mir34b microRNA 34b JBrowse link 8 55,492,542 55,492,625 RGD:8554872
G Mir34c microRNA 34c JBrowse link 8 55,492,024 55,492,100 RGD:8554872
G Nkapd1 NKAP domain containing 1 JBrowse link 8 55,039,731 55,050,259 RGD:8554872
G Pih1d2 PIH1 domain containing 2 JBrowse link 8 55,050,284 55,060,289 RGD:8554872
G Pou2af1 POU class 2 homeobox associating factor 1 JBrowse link 8 55,603,968 55,631,448 RGD:8554872
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta JBrowse link 8 55,279,278 55,311,768 RGD:8554872
G RGD1564937 similar to RIKEN cDNA 1110032A03 JBrowse link 8 55,169,413 55,194,692 RGD:8554872
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:7240710
RGD:8554872
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:7240710
RGD:8554872
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:7240710
RGD:8554872
G Sik2 salt-inducible kinase 2 JBrowse link 8 55,309,005 55,408,608 RGD:8554872
G Timm8b translocase of inner mitochondrial membrane 8 homolog B JBrowse link 8 55,037,750 55,039,130 RGD:8554872
Carotid Body Tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:8554872
Extra-Adrenal Paraganglioma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:8554872
Glomus Jugulare Tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:8554872
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:1581416
Glomus Tympanicum Tumor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:8547978
Glomus Vagale Tumors term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Glmn glomulin, FKBP associated protein JBrowse link 14 3,204,390 3,247,703 RGD:8554872
RGD:7240710
Hereditary Paraganglioma-Pheochromocytoma Syndromes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Max MYC associated factor X JBrowse link 6 99,984,260 100,011,460 RGD:8554872
G Mpz myelin protein zero JBrowse link 13 89,524,204 89,530,070 RGD:8554872
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:8554872
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 JBrowse link 1 226,543,671 226,572,414 RGD:8554872
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:8554872
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:8554872
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:8554872
G Tmem127 transmembrane protein 127 JBrowse link 3 119,677,575 119,690,371 RGD:8554872
paraganglioma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bap1 Brca1 associated protein 1 JBrowse link 16 7,336,685 7,345,511 RGD:11554173
G Mpz myelin protein zero JBrowse link 13 89,524,204 89,530,070 RGD:8554872
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:13592920
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 JBrowse link 1 226,543,671 226,572,414 RGD:13592920
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:1624151
RGD:8554872
RGD:11554173
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:1599507
RGD:8554872
RGD:13592920
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:1302858
RGD:8554872
RGD:11554173
G Sstr2 somatostatin receptor 2 JBrowse link 10 102,136,283 102,143,449 RGD:11554173
Paragangliomas 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:7240710
RGD:8554872
Paragangliomas 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 JBrowse link 1 226,543,671 226,572,414 RGD:7240710
RGD:8554872
Paragangliomas 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpz myelin protein zero JBrowse link 13 89,524,204 89,530,070 RGD:8554872
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:8554872
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:7240710
RGD:8554872
Paragangliomas 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Padi2 peptidyl arginine deiminase 2 JBrowse link 5 159,428,479 159,471,113 RGD:8554872
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:7240710
RGD:8554872
Paragangliomas 5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:7240710
RGD:8554872
G Zmynd11 zinc finger, MYND-type containing 11 JBrowse link 17 63,825,616 63,914,740 RGD:8554872
Paragangliomas 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc25a11 solute carrier family 25 member 11 JBrowse link 10 57,265,903 57,268,018 RGD:7240710
RGD:8554872
Paragangliomas 7 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dlst dihydrolipoamide S-succinyltransferase JBrowse link 6 108,936,534 108,961,322 RGD:7240710
RGD:8554872
Paragangliomas with Sensorineural Hearing Loss term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:8554872

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Term Annotations click to browse term
  disease 15984
    disease of cellular proliferation 5886
      benign neoplasm 940
        organ system benign neoplasm 442
          endocrine organ benign neoplasm 137
            pheochromocytoma 54
              Neurofibromatosis-Pheochromocytoma-Duodenal Carcinoid Syndrome 0
              Pheochromocytoma Islet Cell Tumor Syndrome 0
              malignant pheochromocytoma + 0
              paraganglioma + 38
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.