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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:oral squamous cell carcinoma
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Accession:DOID:0050866 term browser browse the term
Definition:An oral cavity cancer that has_material_basis_in squamous cells. (DO)
Synonyms:exact_synonym: OSCC;   mouth squamous cell carcinoma
 xref: EFO:0000199;   GARD:7263;   NCI:C132823


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oral squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase severity ISO DNA:mutations RGD PMID:16676365 RGD:126925209 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Ada adenosine deaminase disease_progression ISO RGD PMID:27221867 RGD:152995268 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 disease_progression ISO RGD PMID:26464646 RGD:11526681 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295 		JBrowse link
G Angpt1 angiopoietin 1 ISO protein:decreased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 ISO protein:increased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Arid2 AT-rich interaction domain 2 disease_progression ISO RGD PMID:31918270 RGD:150340710 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512 		JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B severity ISO protein:increased expression:oral mucosa (human) RGD PMID:26138391 RGD:11046268 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747 		JBrowse link
G Atm ATM serine/threonine kinase disease_progression ISO protein:increased expression:mucosa of oral region (human) RGD PMID:29928356 PMID:18288488 RGD:150340604, RGD:150340709 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 ISO RGD PMID:26984774 RGD:14700648 NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:69,834,463...69,872,278 		JBrowse link
G Axin1 axin 1 disease_progression ISO protein:decreased expression:oral epithelium (human)
mRNA:increased expression:oral epithelium (human)		 RGD PMID:17143481 PMID:21393552 RGD:150530474, RGD:150530486 NCBI chr10:15,163,684...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axin2 axin 2 susceptibility
disease_progression
ameliorates		 ISO DNA:SNP:intron: C>T (rs3923087)(human) RGD PMID:21393552 PMID:33046030 PMID:33046030 RGD:150530486, RGD:151356656, RGD:151356656 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding ISO protein:increased expression:saliva
protein:decreased expression:saliva		 RGD PMID:29199150 PMID:33564003 RGD:153350131, RGD:153350144 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091 		JBrowse link
G Barhl2 BarH-like homeobox 2 ISO protein:decreased expression:mouth mucosa RGD PMID:27542258 RGD:14390167 NCBI chr14:3,340,465...3,345,362
Ensembl chr14:3,340,465...3,345,353 		JBrowse link
G Bcl2l1 Bcl2-like 1 ISO mRNA, protein:increased expression:mouth (human) RGD PMID:34111459 RGD:153344573 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 treatment ISO Human cells in mouse model RGD PMID:27602964 RGD:151665310 NCBI chr 4:178,833,085...178,838,685
Ensembl chr 4:178,834,271...178,838,468 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO protein:increased expression:oral cavity (human) RGD PMID:20967871 RGD:152999012 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 disease_progression
ameliorates		 ISO protein:increased expression:oral cavity (human)
protein:decreased expression:oral cavity (human)
mRNA:increased expression:oral cavity (human)		 RGD PMID:23852810 PMID:21952624 PMID:29286141 PMID:20967871 RGD:152998980, RGD:152998987, RGD:152999009, RGD:152999012 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 ISO protein:increased expression:oral cavity (human) RGD PMID:20967871 RGD:152999012 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Brinp2 BMP/retinoic acid inducible neural specific 2 ISO DNA:amplication:oral epithelium RGD PMID:21334929 RGD:14398483 NCBI chr13:70,431,006...70,532,766
Ensembl chr13:70,431,010...70,531,810 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 disease_progression ISO RGD PMID:24706327 RGD:14398491 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979 		JBrowse link
G Btk Bruton tyrosine kinase treatment ISO mRNA:increased expression:oral epithelium (human) RGD PMID:33640903 RGD:151347851 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Calr calreticulin exacerbates ISO protein:increased expression:oral epithelium (human)
protein:increased expression:mouth (human)		 RGD PMID:23375593 PMID:28599487 RGD:150521688, RGD:150520158 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 ISO RGD PMID:30205384 RGD:18337270 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600 		JBrowse link
G Car12 carbonic anhydrase 12 disease_progression ISO RGD PMID:22172588 RGD:153352330 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Cbx2 chromobox 2 disease_progression ISO RGD PMID:24885002 RGD:9586732 NCBI chr10:104,278,517...104,287,384
Ensembl chr10:104,278,549...104,287,383 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 susceptibility
disease_progression		 ISO
IEP		 DNA:polymorphism,haplotype::2518A>G(human)
associated with social isolation;protein:increased expression:tongue (rat)		 RGD PMID:21883707 PMID:33411841 RGD:8661694, RGD:152998999 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 susceptibility ISO DNA:polymorphism,haplotype:cds:p.V64I(human) RGD PMID:21883707 RGD:8661694 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cdc73 cell division cycle 73 ISO mRNA:altered expression: tongue, oral cavity (human) RGD PMID:24257751 RGD:150537040 NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656 		JBrowse link
G Cdh1 cadherin 1 disease_progression ISO RGD PMID:26464646 RGD:11526681 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A susceptibility
disease_progression
no_association		 ISO DNA:polymorphism:exon:149A>G(human)
DNA:polymorphism: :98C>A(human)		 RGD PMID:10873097 PMID:10873097 PMID:15817070 PMID:18251939 RGD:8662371, RGD:8662371, RGD:8662374, RGD:8662395 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cers1 ceramide synthase 1 exacerbates ISO RGD PMID:33753723 RGD:156431057 NCBI chr16:19,097,309...19,112,519
Ensembl chr16:19,104,466...19,112,519 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B disease_progression ISO protein:increased expression:mouth mucosa: RGD PMID:22882088 RGD:9587477 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070 		JBrowse link
G Clptm1l CLPTM1-like susceptibility ISO DNA:SNP: :rs402710(human) RGD PMID:28025427 RGD:150530487 NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530 		JBrowse link
G Ctnnd1 catenin delta 1 disease_progression ISO RGD PMID:26464646 RGD:11526681 NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO RGD PMID:22660220 RGD:14700952 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 susceptibility ISO DNA:SNP:exon: (rs2296241) (human) RGD PMID:22612324 RGD:151665337 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO RGD PMID:22954124 RGD:14700880 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Daxx death-domain associated protein ameliorates ISO human cell line in a mouse model RGD PMID:26205068 RGD:152025200 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO mRNA, protein:increased expression:mouth (human) RGD PMID:31253192 RGD:151347620 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 severity ISO RGD PMID:29945346 RGD:150429700 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta disease_progression ISO RGD PMID:24625449 PMID:24625449 RGD:9589120, RGD:9589120 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dock6 dedicator of cytokinesis 6 disease_progression ISO RGD PMID:34742001 RGD:155791563 NCBI chr 8:20,342,089...20,394,660
Ensembl chr 8:20,342,089...20,394,552 		JBrowse link
G Efnb2 ephrin B2 ISO protein:increased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:11673832 RGD:126781761 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:11673832 RGD:126781761 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:14595263 RGD:126781770 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit susceptibility ISO DNA:SNPs, haplotypes: :multiple
associated with oral mucosa leukoplakia		 RGD PMID:24122997 PMID:26807327 PMID:21697275 RGD:126779588, RGD:126779606, RGD:126781699 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Fat1 FAT atypical cadherin 1 onset ISO protein:increased expression:tongue (mouse)
DNA:mutations:multiple		 RGD PMID:30624777 PMID:28435450 RGD:151347668, RGD:151347687 NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO associated with human papillomavirus;DNA:missense mutation:cds: p.S249C (human) RGD PMID:30563911 RGD:38500239 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 severity ISO DNA:SNP:exon 9: p.G388R (human) RGD PMID:20127014 RGD:150520164 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 ISO mRNA:decreased expression:oral epithelium (human) RGD PMID:32048621 RGD:149735374 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO mRNA, protein:increased expression:mouth (human) RGD PMID:34111459 RGD:153344573 NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase IEP RGD PMID:27375172 RGD:13792673 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gpx1 glutathione peroxidase 1 exacerbates ISO protein:increased expression:oral cavity (human) RGD PMID:28653098 RGD:152995473 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx4 glutathione peroxidase 4 disease_progression ISO protein:increased expression:oral cavity (human) RGD PMID:28653098 RGD:152995473 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta susceptibility ISO DNA:SNP:intron: (rs9879992) (human) RGD PMID:21393552 RGD:150530486 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 severity ISO DNA:deletion: : (human) RGD PMID:22213390 PMID:14662415 RGD:12792245, RGD:14700962 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO mRNA,protein:decreased expression:mucosa: RGD PMID:16982972 RGD:10755432 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone disease_progression ISO protein:increased expression:mucosa of oral region (human) RGD PMID:29928356 RGD:150340604 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO protein:increased expression:tongue (mouse) RGD PMID:30624777 RGD:151347668 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hp haptoglobin ISO protein:increased expression:saliva RGD PMID:29199150 RGD:153350131 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Il10 interleukin 10 susceptibility ISO DNA:SNP:promoter:-592A>C (human) RGD PMID:28157558 RGD:14975130 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO RGD PMID:19065664 RGD:8549498 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Il1b interleukin 1 beta disease_progression IEP associated with social isolation;protein:increased expression:tongue (rat) RGD PMID:33411841 RGD:152998999 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:10389944 RGD:8662949 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 disease_progression ISO RGD PMID:24625449 RGD:9589120 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA, protein:increased expression:mouth (human) RGD PMID:34111459 RGD:153344573 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO associated with papillomavirus infectious disease;protein:increased expression:oral cavity (human) RGD PMID:28155253 RGD:151347666 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kmt2d lysine methyltransferase 2D severity ISO RGD PMID:31660637 RGD:150521713 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Mcph1 microcephalin 1 ISO mRNA:protein:decreased expression:oral cavity, tissue (human) RGD PMID:23472065 RGD:9589036 NCBI chr16:71,021,855...71,224,067
Ensembl chr16:71,024,588...71,224,122 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression, altered expression:mouth mucosa: RGD PMID:20662906 RGD:8548617 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mir155 microRNA 155 disease_progression ISO RGD PMID:30194167 PMID:29909906 PMID:28413645 RGD:21079420, RGD:21079468, RGD:24922225 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir187 microRNA 187 ISO RNA:increased expression:plasma RGD PMID:27542258 RGD:14390167 NCBI chr18:15,731,194...15,731,297
Ensembl chr18:15,731,194...15,731,297 		JBrowse link
G Mir20a microRNA 20a ISO RGD PMID:26781875 RGD:26884343 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir221 microRNA 221 exacerbates ISO RGD PMID:21226887 RGD:151708999 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir222 microRNA 222 disease_progression
exacerbates		 ISO RGD PMID:31841247 PMID:21226887 RGD:151708741, RGD:151708999 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir31 microRNA 31 treatment ISO RGD PMID:20233326 RGD:153297767 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:missense mutation:cds:677C>T (human) RGD PMID:16365753 RGD:10449416 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 ISO protein:increased expression:oral cavity (human) RGD PMID:20967871 RGD:152999012 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Notch1 notch receptor 1 ISO protein:increased expression:tongue (mouse) RGD PMID:30624777 RGD:151347668 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:decreased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plau plasminogen activator, urokinase severity ISO protein:increased expression:oral mucosa (rat) RGD PMID:15878520 RGD:8547730 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plcg1 phospholipase C, gamma 1 disease_progression
ameliorates		 ISO protein:decreased expression:oral cavity (human) RGD PMID:26464646 PMID:25085076 RGD:11526681, RGD:151356936 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Prdx2 peroxiredoxin 2 ISO protein:increased expression:saliva RGD PMID:29199150 RGD:153350131 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Pten phosphatase and tensin homolog disease_progression ISO protein:increased expression:oral epithelium (human) RGD PMID:33109573 RGD:127285606 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO mRNA,protein:decreased expression:mouth mucosa (human) RGD PMID:30532780 RGD:151347832 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 treatment ISO RGD PMID:21176871 RGD:152600900 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563 		JBrowse link
G Rad21 RAD21 cohesin complex component exacerbates ISO mRNA:decreased expression:oral cavity (human) RGD PMID:16416296 RGD:150520028 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mouth (human) RGD PMID:34111459 RGD:153344573 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpine1 serpin family E member 1 severity
disease_progression		 ISO protein:increased expression:oral mucosa (rat) RGD PMID:15878520 PMID:24999729 RGD:8547730, RGD:13208508 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO protein:increased expression:mucosa of oral region (human) RGD PMID:24743017 RGD:151665336 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 severity ISO RGD PMID:23801167 RGD:151361213 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Tert telomerase reverse transcriptase susceptibility ISO DNA:SNPs: :rs2736100,rs2736098(human) RGD PMID:28025427 RGD:150530487 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 ISO protein:decreased expression:oral epithelium (human) RGD PMID:24122999 RGD:150429611 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
G Tnf tumor necrosis factor disease_progression IEP associated with social isolation;protein:increased expression:tongue (rat) RGD PMID:33411841 RGD:152998999 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 ISO DNA:missense mutations: :multiple
protein:increased expression:mouth (human)		 RGD PMID:27283772 PMID:34111459 RGD:14995497, RGD:153344573 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ttr transthyretin ISO protein:increased expression:saliva (human) RGD PMID:23784731 RGD:151664609 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wnt11 Wnt family member 11 susceptibility ISO DNA:SNP:exon: A>G (rs1533767) (human) RGD PMID:21393552 RGD:150530486 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21086
    Stomatognathic Diseases 1260
      mouth disease 935
        Mouth Neoplasms 269
          oral cavity cancer 145
            oral squamous cell carcinoma 100
Path 2
Term Annotations click to browse term
  disease 21086
    Pathological Conditions, Signs and Symptoms 13268
      Signs and Symptoms 10704
        Neurologic Manifestations 9942
          sensory system disease 6847
            mouth disease 935
              Mouth Neoplasms 269
                oral cavity cancer 145
                  oral squamous cell carcinoma 100
paths to the root