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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:fatty liver disease
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Accession:DOID:9452 term browser browse the term
Definition:A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis. (DO)
Synonyms:exact_synonym: Liver Steatosis;   Steatohepatitis;   Steatosis of Liver;   fatty change of liver;   fatty liver;   hepatic lipidosis;   hepatosteatosis;   liver steatoses;   steatohepatitides;   visceral steatoses;   visceral steatosis
 primary_id: MESH:D005234
 xref: ICD10CM:K70.0;   ICD9CM:571.0
For additional species annotation, visit the Alliance of Genome Resources.

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fatty liver disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 treatment IEP
ISO		 associated with adult growth hormone deficiency RGD PMID:15995177, PMID:26362727, PMID:30130150 RGD:1598534, RGD:21408552, RGD:18936993 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 IEP RGD PMID:16139386 RGD:1598602 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 IEP mRNA, protein:increased expression:liver RGD PMID:17640958 RGD:2301064 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha IDA RGD PMID:16485039 RGD:1625727 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acacb acetyl-CoA carboxylase beta IDA RGD PMID:16485039 RGD:1625727 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing IEP
ISO		 associated with hepatitis C;protein:increased expression:serum
protein:increased expression:plasma		 RGD PMID:17006986, PMID:20714777, PMID:16115302 RGD:1599139, RGD:5686883, RGD:5686674 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adipor2 adiponectin receptor 2 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:30225267, PMID:19076162 RGD:21406435, RGD:2307264 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Adk adenosine kinase ISS OMIM:228100 MouseDO NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888 		JBrowse link
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:11718682 RGD:1559320 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring ISO RGD PMID:17332477 RGD:14349048 NCBI chr 9:94,228,960...94,232,001
Ensembl chr 9:94,228,960...94,232,001 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated ISO associated with obesity RGD PMID:16197789 RGD:1601177 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Angptl4 angiopoietin-like 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28842503, PMID:15837923 RGD:1625354 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079 		JBrowse link
G Apoa1 apolipoprotein A1 treatment IEP RGD PMID:30231880 RGD:25671436 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apob apolipoprotein B IEP
ISO		 mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism		 CTD PMID:12048068 PMID:17303181, PMID:17203948 RGD:2325770 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Apoe apolipoprotein E IMP RGD PMID:29459263 RGD:13703129 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Atf4 activating transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27664470 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321 		JBrowse link
G Atp7b ATPase copper transporting beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17303181 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Ca3 carbonic anhydrase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Cat catalase IEP
ISO		 protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism		 CTD PMID:10860543, PMID:21452373 RGD:5130871 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29684222, PMID:22983634 RGD:8548844 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:liver RGD PMID:28011329, PMID:28011329 RGD:14995306, RGD:14995306 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Cd36 CD36 molecule ISO RGD PMID:19788606 RGD:6893500 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24469900 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Cndp2 carnosine dipeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr18:81,521,966...81,539,065
Ensembl chr18:81,521,968...81,539,065 		JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:15787813 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 IEP protein:increased expression:liver (rat) RGD PMID:20347174 RGD:4144089 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:14614508 RGD:734818 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Ctsb cathepsin B IEP mRNA, protein:increased expression, increased activity:liver, cytosol (rat) RGD PMID:18452148 RGD:2315513 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO mRNA,protein:increased expression:liver,serum RGD PMID:25048951 RGD:27095890 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cycs cytochrome c, somatic ISO CTD Direct Evidence: marker/mechanism CTD PMID:10860543 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11929713 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27036855 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 ISO mRNA:increased expression:liver (mouse) RGD PMID:31175967 RGD:25671414 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IEP
ISO		 protein:increased expression:liver
CTD Direct Evidence: marker/mechanism		 CTD PMID:18952117, PMID:19404342, PMID:14606109 RGD:4892244, RGD:1626302 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23391614 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27664470 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 treatment IMP RGD PMID:17526931 RGD:10400884 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:14608355 RGD:734934 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265 		JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008134 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G F2r coagulation factor II (thrombin) receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008134 PMID:21907177 PMID:22841818 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340 		JBrowse link
G Fabp1 fatty acid binding protein 1 ISO Western diet-induced hepatic steatosis RGD PMID:17058218 RGD:1626440 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fgf21 fibroblast growth factor 21 severity ISO CTD Direct Evidence: therapeutic CTD PMID:24184811, PMID:32195457 RGD:25330354 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 severity ISO RGD PMID:32195457 RGD:25330354 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fis1 fission, mitochondrial 1 IEP protein:increased expression:liver (rat) RGD PMID:24663492 RGD:12453042 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308 		JBrowse link
G Foxa1 forkhead box A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24469900 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 IEP mRNA:increased expression:liver (rat) RGD PMID:29534506 RGD:14695544 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Gck glucokinase IDA
ISO		 associated with Hyperglycemia RGD PMID:22925001, PMID:22925001 RGD:7488945, RGD:7488945 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 disease_progression ISO RGD PMID:19670414 RGD:14747016 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 8:122,957,570...122,987,236
Ensembl chr 8:122,954,948...122,987,191 		JBrowse link
G Gpt glutamic--pyruvic transaminase ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum		 CTD PMID:19481104, PMID:30185098 RGD:14975167 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 ISO mRNA:increased expression:liver RGD PMID:15122758 RGD:14975241 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10860543 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx4 glutathione peroxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26042203 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO DNA:point mutations: ;1132C>T,1528G>C;LCHAD deficiency,OMIM:609015 RGD PMID:7846063 RGD:1599882 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17116638 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995 		JBrowse link
G Has3 hyaluronan synthase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27042213 NCBI chr19:39,063,298...39,077,745
Ensembl chr19:39,063,998...39,077,722 		JBrowse link
G Hfe homeostatic iron regulator no_association ISO Non-alcoholic steatohepatitis (NASH)
non-alcoholic fatty liver disease		 RGD PMID:12105842, PMID:11473047 RGD:1601460, RGD:1601452 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985 		JBrowse link
G Hhex hematopoietically expressed homeobox ISO CTD Direct Evidence: marker/mechanism CTD PMID:24469900 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649 		JBrowse link
G Hm13 histocompatibility minor 13 ISO associated with hepatitis RGD PMID:27142248 RGD:40924634 NCBI chr 3:148,150,695...148,189,623
Ensembl chr 3:148,150,698...148,189,623 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:liver: RGD PMID:23647685 RGD:11354957 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISS OMIM:228100 MouseDO NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748 		JBrowse link
G Il10 interleukin 10 IEP associated with Diabetes Mellitus RGD PMID:18267346 RGD:2308948 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 IMP RGD PMID:18802068 RGD:4145478 NCBI chr  X:118,443,955...118,514,716
Ensembl chr  X:118,443,823...118,513,061 		JBrowse link
G Il18 interleukin 18 IDA RGD PMID:19084941 RGD:4889416 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta IEP protein:increased expression:serum RGD PMID:17436085 RGD:1626661 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 ISO
IAGP		 associated with Diabetes Mellitus; protein:increased expression:extracellular space (mouse)
associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:liver, extracellular space (rat)		 RGD PMID:19205029, PMID:19076162 RGD:2307258, RGD:2307264 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ins2 insulin 2 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 CTD PMID:9048448, PMID:18713300 RGD:2311137 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Insig1 insulin induced gene 1 severity ISO
IEP		 associated with Obesity
associated with Obesity;mRNA:increased expression:liver		 RGD PMID:15096598, PMID:15096598 RGD:2308857, RGD:2308857 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Insig2 insulin induced gene 2 severity ISO associated with Obesity RGD PMID:15096598 RGD:2308857 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458 		JBrowse link
G Insr insulin receptor treatment IEP
IMP		 associated with obesity;human gene in mouse model
protein:decreased phosphorylation: liver (rat)		 RGD PMID:25160038, PMID:30642871, PMID:22546076 RGD:14700926, RGD:14701028, RGD:14700935 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:22275361 RGD:6483019 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 ISO RGD PMID:22367278 RGD:6893372 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Ldlr low density lipoprotein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25554529 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lep leptin severity IEP
ISO		 associated with morbid obesity;protein:decreased exprssion:serum (human)
CTD Direct Evidence: marker/mechanism		 CTD PMID:12661780 PMID:19716478 PMID:23839791 PMID:24525044 PMID:25554529 PMID:27071101 PMID:27712037, PMID:28281237 RGD:21201250 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25367288 PMID:29743445 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Lgals3 galectin 3 ISS OMIM:228100 MouseDO NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537 		JBrowse link
G Lrp6 LDL receptor related protein 6 ISS OMIM:228100 MouseDO NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO RGD PMID:21540183 RGD:9585751 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mat1a methionine adenosyltransferase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12060674 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133 		JBrowse link
G Mc4r melanocortin 4 receptor ISS OMIM:228100 MouseDO NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725 		JBrowse link
G Mfn2 mitofusin 2 IEP protein:decreased expression:liver (rat) RGD PMID:24663492 RGD:12453042 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145 		JBrowse link
G Mir10b microRNA 10b ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 3:61,647,978...61,648,086
Ensembl chr 3:61,647,978...61,648,086 		JBrowse link
G Mir125a microRNA 125a ISO RGD PMID:31988048 RGD:21403676 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911 		JBrowse link
G Mir134 microRNA 134 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 6:133,884,547...133,884,619
Ensembl chr 6:133,884,531...133,884,633 		JBrowse link
G Mir139 microRNA 139 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612 		JBrowse link
G Mir148b microRNA 148b ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 7:144,912,038...144,912,134
Ensembl chr 7:144,912,038...144,912,134 		JBrowse link
G Mir150 microRNA 150 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058 		JBrowse link
G Mir154 microRNA 154 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 6:133,888,586...133,888,669
Ensembl chr 6:133,888,586...133,888,669 		JBrowse link
G Mir17 microRNA 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr15:100,179,879...100,179,962
Ensembl chr15:100,179,879...100,179,962 		JBrowse link
G Mir183 microRNA 183 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 4:57,463,569...57,463,678
Ensembl chr 4:57,463,569...57,463,678 		JBrowse link
G Mir219a1 microRNA 219a-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr20:3,816,158...3,816,267
Ensembl chr20:3,816,158...3,816,267 		JBrowse link
G Mir22 microRNA 22 severity ISO RGD PMID:32195457, PMID:32195457 RGD:25330354, RGD:25330354 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686 		JBrowse link
G Mir224 microRNA 224 IEP associated with Hepatitis C, Chronic;miRNA:increased expression:liver (human) RGD PMID:25386083 RGD:18182925 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835 		JBrowse link
G Mir320a microRNA 320a ISO CTD Direct Evidence: marker/mechanism CTD PMID:30125006 NCBI chr15:52,134,276...52,134,357
Ensembl chr15:52,134,276...52,134,357 		JBrowse link
G Mir34a microRNA 34a ISO CTD Direct Evidence: marker/mechanism CTD PMID:23834033 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592 		JBrowse link
G Mir410 microRNA 410 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 6:133,893,997...133,894,072
Ensembl chr 6:133,893,993...133,894,073 		JBrowse link
G Mir449c microRNA 449c ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr 2:44,896,066...44,896,164
Ensembl chr 2:44,896,066...44,896,164 		JBrowse link
G Mir503 microRNA 503 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr  X:158,148,476...158,148,546
Ensembl chr  X:158,148,476...158,148,546 		JBrowse link
G Mir542 microRNA 542 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22363424 NCBI chr  X:158,152,146...158,152,224
Ensembl chr  X:158,152,146...158,152,224 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO associated with Hepatitis C, Chronic; DNA:transition:cds:g.677C>T (human) RGD PMID:15834927 RGD:1580580 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
G Mttp microsomal triglyceride transfer protein ISO associated with Hepatitis C;mRNA:decreased expression:liver
CTD Direct Evidence: marker/mechanism		 CTD PMID:17303181, PMID:16697730 RGD:1625483 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO CTD Direct Evidence: therapeutic CTD PMID:24210820 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Neil1 nei-like DNA glycosylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16446448 PMID:21285402 NCBI chr 8:61,817,258...61,824,023
Ensembl chr 8:61,817,258...61,823,102 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28555106, PMID:22367278 RGD:6893372 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IDA RGD PMID:21643627 RGD:5135028 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IEP protein:increased activity:liver RGD PMID:17721935 RGD:5133249 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27664470 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27664470 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23651738 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 treatment
severity		 ISO CTD Direct Evidence: marker/mechanism
knockout eliminates treatment effectiveness		 CTD PMID:29142166, PMID:12971955, PMID:23104131 RGD:15045573, RGD:14696795 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25182422 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nrep neuronal regeneration related protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IEP
ISO		 protein:increased expression:liver (rat)
ClinVar Annotator: match by term: Liver steatosis		 ClinVar PMID:19303950 PMID:20157015 PMID:22857269 PMID:25741868 PMID:26467025 PMID:27890673 PMID:28492532, PMID:24663492 RGD:12453042 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803 		JBrowse link
G Otc ornithine transcarbamylase IEP protein:increased expression:serum (rat) RGD PMID:18823438 RGD:4144061 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069 		JBrowse link
G Pex5 peroxisomal biogenesis factor 5 ISO RGD PMID:21756965 RGD:25440484 NCBI chr 4:156,983,914...157,009,675
Ensembl chr 4:156,983,915...157,009,674
Ensembl chr 4:156,983,915...157,009,674 		JBrowse link
G Plau plasminogen activator, urokinase ISS OMIM:228100 MouseDO NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Plin2 perilipin 2 ISO associated with Obesity
CTD Direct Evidence: marker/mechanism		 CTD PMID:16439473, PMID:17484887 RGD:1625752 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 severity ISO CTD Direct Evidence: marker/mechanism
associated with Hepatitis B, Chronic;DNA:SNP: :rs738409 (p.I148M) (human)
associated with Wilson disease;DNA:SNP: :rs738409 (p.I148M) (human)
associated with Hepatitis C, Chronic;DNA:SNP: :rs738409 (p.I148M) (human)		 CTD PMID:25678388, PMID:25284145, PMID:25678388, PMID:21319195, PMID:23564580 RGD:14981590, RGD:11055420, RGD:14981585, RGD:14981583 NCBI chr 7:125,034,760...125,056,165
Ensembl chr 7:125,034,764...125,055,976 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:167377 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26945512 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO
IEP		 associated with Diabetes Mellitus (CTD:0000249); in high fat-fed foz/foz obese/diabetic mice
associated with Hepatitis C, Chronic;mRNA:decreased expression:liver (human)
CTD Direct Evidence: therapeutic		 CTD PMID:19124612, PMID:21929649, PMID:16393287 RGD:5509939, RGD:15042851 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:23851158 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IEP RGD PMID:15112352 RGD:1580685 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha treatment IDA
IEP
ISO		 protein:decreased methylation:liver (rat) RGD PMID:23274094, PMID:22521344, PMID:23174781 RGD:7241844, RGD:7242179, RGD:7242012 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO RGD PMID:19162361 RGD:6484544 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404 		JBrowse link
G Prkcd protein kinase C, delta ISO RGD PMID:17596878 RGD:1642523 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Psma5 proteasome 20S subunit alpha 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714 		JBrowse link
G Pten phosphatase and tensin homolog IEP
ISO		 protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism		 CTD PMID:27022031, PMID:18166358, PMID:15199412 RGD:2292522, RGD:1302555 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP mRNA,protein:increased expression:liver RGD PMID:21643627 RGD:5135028 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptma prothymosin alpha ISO CTD Direct Evidence: therapeutic CTD PMID:15885234 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IDA RGD PMID:21643627 RGD:5135028 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:26769846 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741 		JBrowse link
G Scd stearoyl-CoA desaturase ISO CTD Direct Evidence: therapeutic CTD PMID:21661758 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Serpina6 serpin family A member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247 		JBrowse link
G Serpine1 serpin family E member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18641190 PMID:29684222 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO associated with Obesity RGD PMID:17596878 RGD:1642523 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066 		JBrowse link
G Sirt1 sirtuin 1 ISO associated with Obesity
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD PMID:21321189 PMID:23834033 PMID:24184811 PMID:24210820 PMID:24442997, PMID:21540183 RGD:9585751 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Sirt6 sirtuin 6 ISO CTD Direct Evidence: therapeutic CTD PMID:28536482 NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063 		JBrowse link
G Sirt7 sirtuin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24210820 NCBI chr10:109,796,046...109,802,821
Ensembl chr10:109,796,020...109,802,739 		JBrowse link
G Slc13a5 solute carrier family 13 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26303333 NCBI chr10:58,806,581...58,835,549
Ensembl chr10:58,810,058...58,834,538 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slc27a4 solute carrier family 27 member 4 IEP mRNA, protein:increased expression RGD PMID:16248953 RGD:1625640 NCBI chr 3:8,363,937...8,376,858
Ensembl chr 3:8,363,937...8,376,858 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12048068 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 IEP RGD PMID:16139386 RGD:1598602 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO associated with Obesity RGD PMID:15240880 RGD:1625677 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO associated with Obesity RGD PMID:15240880 RGD:1625677 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Sod1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27349771 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10860543 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24469900 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO RGD PMID:16799967 RGD:25671424 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Sts steroid sulfatase ISO CTD Direct Evidence: therapeutic CTD PMID:24497646 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750 		JBrowse link
G Suox sulfite oxidase IEP protein:decreased expression:liver RGD PMID:15144217 RGD:1600114 NCBI chr 7:3,098,228...3,102,179
Ensembl chr 7:3,098,245...3,102,142 		JBrowse link
G Tf transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008134 PMID:21907177 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333 		JBrowse link
G Tlr4 toll-like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18641190 PMID:27022031 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23348005 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Txn1 thioredoxin 1 IEP RGD PMID:18578693 RGD:2306156 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752 		JBrowse link
G Ucp2 uncoupling protein 2 IEP
ISO		 mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism		 CTD PMID:10860543, PMID:21114362 RGD:7204423 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:30905785, PMID:30905785 RGD:14402029, RGD:14402029 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Xbp1 X-box binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097666 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
Alcoholic Fatty Liver term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:plasma RGD PMID:16115302 RGD:5686674 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adipor2 adiponectin receptor 2 treatment IEP
ISO		 RGD PMID:26115886, PMID:18755807, PMID:27220557, PMID:22013387 RGD:25330099, RGD:25824943, RGD:25824939, RGD:25440493 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member severity
treatment
susceptibility		 IDA
ISO		 human transgene in mouse model
protein:altered processing:liver (mouse)
DNA:missense mutation:cds:p.E504K (human)		 RGD PMID:17058263, PMID:25457208, PMID:29156373, PMID:29063269 RGD:1599041, RGD:15036811, RGD:15036805, RGD:14696776 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment ISO RGD PMID:25557254 RGD:14995489 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 treatment ISO RGD PMID:25557254 RGD:14995489
G Ccr5 C-C motif chemokine receptor 5 disease_progression ISO RGD PMID:27859576 RGD:14401742 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614 		JBrowse link
G Cd36 CD36 molecule ISO RGD PMID:24280415 RGD:11041117 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Crp C-reactive protein IEP protein:increased expression:serum: RGD PMID:21806828 RGD:9491781 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Ctsb cathepsin B IEP protein:increased activity:liver, cytosol (rat) RGD PMID:17850215 RGD:2315516 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26428356, PMID:25583360, PMID:24064383 RGD:14700884, RGD:14700870 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO RGD PMID:22905112 RGD:9588654 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Hamp hepcidin antimicrobial peptide IEP mRNA:decreased expression:liver RGD PMID:19253830 RGD:11041633 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Ldlr low density lipoprotein receptor IEP protein:decreased expression: liver (rat) RGD PMID:20028367 RGD:21410185 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Mir155 microRNA 155 ISO RGD PMID:26867493 RGD:25671474 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase IEP RGD PMID:17156888 RGD:1642369 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18703563 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Serpine1 serpin family E member 1 IEP mRNA:increased expression:liver (rat) RGD PMID:25561792 RGD:11075083 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Serpinf1 serpin family F member 1 IEP protein:decreased expression:liver RGD PMID:18996124 RGD:2312349 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287 		JBrowse link
G Sod1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19951287 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 IEP RGD PMID:11477087 RGD:1625694 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 IEP RGD PMID:18296740 RGD:7207884 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Tlr4 toll-like receptor 4 severity ISO RGD PMID:29884546, PMID:21463341 RGD:14697697, RGD:14700554 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor susceptibility
treatment		 ISO
IEP		 DNA:SNP:promoter:-238G>A (human) RGD PMID:9214463, PMID:20143470 RGD:14995434, RGD:38508901 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Congenital Visceral Steatosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adk adenosine kinase ISO RGD PMID:11997462 RGD:1300259 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888 		JBrowse link
non-alcoholic fatty liver term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:serum: RGD PMID:27639593 RGD:14995335 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO protein:increased expression:serum: RGD PMID:23730648 RGD:14747013 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068 		JBrowse link
G Gpt glutamic--pyruvic transaminase ISO protein:increased expression:liver,serum RGD PMID:18710424 RGD:14975250 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 ISO protein:increased expression:liver,serum RGD PMID:18710424 RGD:14975250 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 severity
susceptibility		 ISO RGD PMID:29861476, PMID:31064654 RGD:14985251, RGD:14985252 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 severity ISO cholic acid fed FXR-/- mouse RGD PMID:12971955 RGD:15045573 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
non-alcoholic fatty liver disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP mRNA:increased expression:liver (rat) RGD PMID:22112382 RGD:11040992 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B IEP mRNA:increased expression:liver (rat) RGD PMID:22112382 RGD:11040992 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20040336 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 severity ISO CTD Direct Evidence: marker/mechanism
DNA:SNPs:exon:p.Glu1188Val(rs17222723),p.Tyr1515Cys(rs8187710)(human)		 CTD PMID:29341352, PMID:18926681 RGD:14700775 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 IEP protein:increased expression:liver RGD PMID:22112382 RGD:11040992 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 disease_progression IEP mRNA:increased expression:liver (rat) RGD PMID:23117815, PMID:25263431 RGD:15045604, RGD:15045610 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 disease_progression IEP mRNA:decreased expression:liver (rat)
mRNA:increased expression:liver (rat)		 RGD PMID:23117815, PMID:25263431 RGD:15045604, RGD:15045610 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain treatment IEP RGD PMID:23076603 RGD:10047124 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain treatment IEP RGD PMID:22569299, PMID:23076603 RGD:10047121, RGD:10047124 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526 		JBrowse link
G Ace angiotensin I converting enzyme ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Aco1 aconitase 1 IDA protein:increased activity:liver RGD PMID:23805238 RGD:11541090 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218 		JBrowse link
G Actb actin, beta IDA protein:increased carbonylation:liver RGD PMID:25282656 RGD:11541097 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841 		JBrowse link
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 IEP mRNA, protein:increased expression, increased activity:liver, plasma (rat) RGD PMID:19652891 RGD:2315953 NCBI chr 3:5,519,921...5,558,390
Ensembl chr 3:5,519,990...5,558,166 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:29718361 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing susceptibility
treatment
disease_progression		 IEP
ISO		 protein:decreased expression:serum
DNA:SNPs:5'utr, :-11377C>G, +45T>G (rs266729, rs2241766) (human)
associated with type 2 diabetes mellitus;DNA:SNP:5' utr:-11377C>G (rs266729) (human)
DNA:hypermethylation
CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:liver
associated with Obesity, Morbid;
associated with obesity;protein:decreased expression:serum:		 CTD PMID:20415685, PMID:22152320, PMID:22269154, PMID:26042596, PMID:27860427, PMID:19606393, PMID:18713296, PMID:15239085, PMID:21255792 RGD:5685373, RGD:14401719, RGD:11076260, RGD:14401717, RGD:5686841, RGD:5686810, RGD:5686660, RGD:5686355 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adipor2 adiponectin receptor 2 susceptibility
treatment
severity		 ISO
IEP		 DNA:missense mutation:cds: (human)
mRNA:increased expression:liver (human)
mRNA:increased expression:liver (rat)
mRNA, protein:decreased expression:serum, liver (mouse)		 RGD PMID:25345946, PMID:25536648, PMID:19422483, PMID:26770322, PMID:17006986, PMID:29569260 RGD:24922200, RGD:25824941, RGD:25440492, RGD:25330097, RGD:1599139, RGD:24922201 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Adrb3 adrenoceptor beta 3 ISO DNA:missense mutation:cds:p.W64R (rs4994) (human) RGD PMID:15318095 RGD:5684892 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632 		JBrowse link
G Ahcy adenosylhomocysteinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29127188 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082 		JBrowse link
G Ahr aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29416063 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29718361 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29718361 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 ISS OMIM:613282 | OMIM:613387 MouseDO NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member treatment
susceptibility		 ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds: (rs671) (human)		 CTD PMID:29718361, PMID:25392542, PMID:27214654, PMID:31026768 RGD:15042863, RGD:11536476, RGD:15036808 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29718361 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO RGD PMID:20967760 RGD:5509622 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161 		JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO RGD PMID:26420354 RGD:25671437 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoe apolipoprotein E IDA RGD PMID:21184788 RGD:6904141 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha IDA RGD PMID:25222487 RGD:13703054 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:25666834 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749 		JBrowse link
G B3gat1 beta-1,3-glucuronyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24211274 NCBI chr 8:27,777,024...27,804,368
Ensembl chr 8:27,777,179...27,804,515 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29718361 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 severity IEP
ISO		 protein:increased expression:plasma RGD PMID:25813056, PMID:24927058 RGD:14995922, RGD:14995928 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 disease_progression
treatment		 IEP
IMP		 RGD PMID:27639593, PMID:27639593 RGD:14995335, RGD:14995335 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 susceptibility ISO DNA:polymorphism: :190A>G(human) RGD PMID:26591766 RGD:14995492
G Cd14 CD14 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:20353583 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153 		JBrowse link
G Cd36 CD36 molecule ISO mRNA:increased expression:liver RGD PMID:21216282, PMID:24280415 RGD:6893543, RGD:11041117 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b IEP mRNA:increased expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244 		JBrowse link
G Col1a1 collagen type I alpha 1 chain treatment ISO
IDA		 RGD PMID:23703580, PMID:17241878 RGD:8552713, RGD:2308807 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A treatment ISO CTD Direct Evidence: marker/mechanism CTD PMID:29289645, PMID:31211621 RGD:14747028 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Csf2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 treatment ISO RGD PMID:28824718 RGD:27095887 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15706422 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27565560 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 ISO protein:decreased expression:liver (mouse) RGD PMID:29710028 RGD:25671411 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD PMID:26428356, PMID:26703967, PMID:28458161, PMID:25317811 RGD:11573192, RGD:14700881, RGD:14700871 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 IEP mRNA:decreased expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 treatment IEP
ISO		 RGD PMID:24166662, PMID:17618857 RGD:10400900, RGD:10401056 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 treatment ISO RGD PMID:31961704 RGD:21408561 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29289645 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit IEP RGD PMID:24351808 RGD:9588320 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011 		JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:22841818 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23127599 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fgf21 fibroblast growth factor 21 severity ISO CTD Direct Evidence: therapeutic CTD PMID:26797127 PMID:29289645, PMID:32195457 RGD:25330354 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 severity ISO RGD PMID:32195457 RGD:25330354 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Folr2 folate receptor beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:30794826 NCBI chr 1:166,915,045...166,933,377
Ensembl chr 1:166,915,045...166,919,302 		JBrowse link
G Foxo1 forkhead box O1 treatment IMP associated with Diabetes Mellitus, Experimental RGD PMID:30186875 RGD:14401598 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 treatment ISO associated with type 2 diabetes mellitus RGD PMID:30100243, PMID:27840945 RGD:14695535, RGD:14695545 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment IEP RGD PMID:20211032 RGD:10449177 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gnmt glycine N-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:31086990 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627 		JBrowse link
G Gpt glutamic--pyruvic transaminase severity ISO protein:increased activity:plasma RGD PMID:24768200, PMID:22922605 RGD:14975160, RGD:14975251 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 ISO protein:increased activity:plasma RGD PMID:22922605 RGD:14975251 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071 		JBrowse link
G Gpx1 glutathione peroxidase 1 treatment ISO RGD PMID:24597775 RGD:11352823 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsr glutathione-disulfide reductase treatment IEP RGD PMID:24622831 RGD:10401873 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23643483 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23643483 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23643483 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23643483 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha IEP protein:decreased expression:liver RGD PMID:24782632 RGD:14694831 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175 		JBrowse link
G Hamp hepcidin antimicrobial peptide IEP associated with iron overload;protein:increased expression:serum (human)
mRNA:increased expression:liver (human)		 RGD PMID:29871592, PMID:28051796 RGD:15042878, RGD:15042880 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation:cds:p.C282Y (human) RGD PMID:9453491 RGD:8694420 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase disease_progression IEP mRNA:decreased expression:liver
mRNA:altered expression:liver (rat)
mRNA:decreased expression:liver (rat)		 RGD PMID:19913842, PMID:25263431, PMID:23117815 RGD:5508690, RGD:15045610, RGD:15045604 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hp haptoglobin IEP
ISO		 protein:increased expression:serum
protein:decreased expression:serum		 RGD PMID:21806828, PMID:21806828 RGD:9491781, RGD:9491781 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804 		JBrowse link
G Ide insulin degrading enzyme IEP RGD PMID:26576191 RGD:13792804 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495 		JBrowse link
G Igf1 insulin-like growth factor 1 susceptibility IEP associated with Fetal Growth Retardation;mRNA:increased expression:liver (rat) RGD PMID:24275070 RGD:12904726 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor susceptibility IEP associated with Fetal Growth Retardation;mRNA:increased expression:liver (rat) RGD PMID:24275070 RGD:12904726 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:21115542 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748 		JBrowse link
G Il10 interleukin 10 severity ISO associated with morbid obesity RGD PMID:25894568 RGD:14975151 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:18802068 RGD:4145478 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il18 interleukin 18 treatment
severity		 IEP
ISO		 protein:increased expression:plasma RGD PMID:24006666, PMID:28660148, PMID:20422882 RGD:8655964, RGD:14696674, RGD:14696664 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta no_association ISO DNA:SNPs:CDS:rs1143634 (human)
DNA:SNPs:CDS:rs16944 (human)		 RGD PMID:27730688, PMID:27730688 RGD:14975293, RGD:14975293 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rn interleukin 1 receptor antagonist severity ISO associated with morbid obesity, protein:increased expression:serum (human) RGD PMID:22027586 RGD:14401582 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il3 interleukin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973 		JBrowse link
G Il4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 ISO mRNA,protein:increased expression:liver,plasma
DNA:SNPs:promoter:rs10499563, rs1800795 (human)		 RGD PMID:18510618, PMID:27730688 RGD:7829808, RGD:14975293 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Insr insulin receptor susceptibility
treatment		 IMP
ISO
IEP		 DNA:deletion:cds:codon 306 in exon 4 (mouse)
DNA:deletion:cds: (codon 306, exon 4) (mouse)		 RGD PMID:28468951, PMID:28468951, PMID:29325294 RGD:14700929, RGD:14700929, RGD:14700932 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Irs1 insulin receptor substrate 1 IEP RGD PMID:20846698 RGD:6483014 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Irs2 insulin receptor substrate 2 IEP RGD PMID:20846698 RGD:6483014 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684 		JBrowse link
G Jak2 Janus kinase 2 IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD PMID:28100771, PMID:18782535 RGD:6483030 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Klb klotho beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:29289645 NCBI chr14:44,529,523...44,614,093 JBrowse link
G Krt18 keratin 18 disease_progression ISO
IEP		 protein:increased expression:serum (human)
associated with Metabolic Syndrome; protein:increased expression:liver, serum (rat)
protein:increased degradation:serum (rat)		 RGD PMID:30839434, PMID:29989845, PMID:30149902, PMID:30089409 RGD:18337481, RGD:26884460, RGD:18337497, RGD:18337482 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131 		JBrowse link
G Lama1 laminin subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123 		JBrowse link
G Ldlr low density lipoprotein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20938947 PMID:23127599 PMID:23285030 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lep leptin ISO
IEP		 associated with Type 2 Diabetes Mellitus;protein:increased expression:plasma
associated with type 2 diabetes mellitus;protein:increased expression:serum (human)
associated with Hepatitis C, Chronic;proteinLincreased expression:serum (human)
CTD Direct Evidence: marker/mechanism		 CTD PMID:24211274, PMID:18713300, PMID:30052309, PMID:20476641 RGD:2311137, RGD:25330349, RGD:25330346 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lepr leptin receptor susceptibility ISO
ISS		 DNA:intron:c.2673+1118C>T (rs6700896) (human)
DNA:SNP:cds:p.Q223R(human)
OMIM:613282 | OMIM:613387		 MouseDO PMID:22215535, PMID:27257426 RGD:14696694, RGD:21079462 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Lif LIF, interleukin 6 family cytokine ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642 		JBrowse link
G Lpl lipoprotein lipase treatment IDA
IEP		 RGD PMID:30214514, PMID:27978932 RGD:13793398, RGD:13794377 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 treatment IEP associated with Diabetes Mellitus, Type 2; RGD PMID:24404139 RGD:13506784 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase disease_progression ISO RGD PMID:24845607 RGD:14694829 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
G Mfn2 mitofusin 2 treatment IEP RGD PMID:26401075 RGD:13204743 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145 		JBrowse link
G Mir155 microRNA 155 ISO miRNA:decreased expression:blood, liver RGD PMID:27856635, PMID:27832630 RGD:21079446, RGD:25671479 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667 		JBrowse link
G Mir200b microRNA 200b severity ISO induced by nutritional deficiency. RGD PMID:22561871, PMID:20548288 RGD:14928332, RGD:14974031 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238 		JBrowse link
G Mir20a microRNA 20a IEP associated with type 2 diabetes mellitus RGD PMID:30030064 RGD:25823148 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418 		JBrowse link
G Mir22 microRNA 22 severity
treatment		 ISO RGD PMID:32195457, PMID:32195457 RGD:25330354, RGD:25330354 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686 		JBrowse link
G Mir34a microRNA 34a ISO miRNA:increased expression:plasma RGD PMID:27077736 RGD:11533145 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase severity
susceptibility		 ISO DNA:SNP: :1298A > C (human)
DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human)		 RGD PMID:24488901, PMID:17563923 RGD:14696706, RGD:14696748 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
G Mttp microsomal triglyceride transfer protein ISO RGD PMID:15094225 RGD:1581245 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 treatment IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD PMID:25294219, PMID:23592516 RGD:10412712 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISS OMIM:613282 | OMIM:613387 MouseDO NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO mRNA, protein:increased expression:liver (mouse) RGD PMID:21948338 RGD:5509578 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD PMID:29289645, PMID:28932253 RGD:13434914 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 IEP mRNA:decreased expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 treatment
disease_progression
susceptibility		 ISO
IEP		 CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (rat)
mRNA:decreased expression:liver (rat)
DNA:deletion:cds:exon 9 (mouse)		 CTD PMID:29142166 PMID:32062620, PMID:29743187, PMID:30257410, PMID:25263431, PMID:23117815, PMID:23700488 RGD:14696797, RGD:15090799, RGD:15045610, RGD:15045604, RGD:14701033 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29515023 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29289645 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29416063 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 ISS OMIM:613282 | OMIM:613387 MouseDO NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase treatment IEP RGD PMID:29031784 RGD:13831310 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530 		JBrowse link
G Pla2g7 phospholipase A2 group VII ISO protein:increased expression:serum RGD PMID:22112193 RGD:6482771 NCBI chr 9:19,935,754...19,978,013
Ensembl chr 9:19,935,768...19,978,013 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: NAFLD1
ClinVar Annotator: match by term: Susceptibility to Nonalcoholic Fatty Liver Disease
DNA:SNPs: :rs738407, rs738409, and rs2896019 (human)
associated with obesity;DNA:SNP: :rs738409 (p.I148M) (human)
ClinVar Annotator: match by term: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1		 CTD
ClinVar		 PMID:18820647 PMID:21381068 PMID:22992668 PMID:24033266 PMID:24531328 PMID:24917523 PMID:25290313 PMID:26200108 PMID:27180240 PMID:27288299 PMID:28073161 PMID:28090653 PMID:28492532 PMID:28744905 PMID:29158695, PMID:24831885, PMID:24477042, PMID:26740948 RGD:14981596, RGD:14981593, RGD:13463463 NCBI chr 7:125,034,760...125,056,165
Ensembl chr 7:125,034,764...125,055,976 		JBrowse link
G Pon2 paraoxonase 2 treatment IEP RGD PMID:22536512 RGD:8661257 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha treatment ISO CTD Direct Evidence: marker/mechanism CTD PMID:23603006, PMID:31211621 RGD:14747028 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16574099 PMID:29289645 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha susceptibility IDA
ISO		 associated with Obesity; DNA:missense mutation:cds:p.G482S rs8192678 (human) RGD PMID:21373642, PMID:23269818 RGD:6484527, RGD:7241847 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prf1 perforin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24211274 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:29341352 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860 		JBrowse link
G Prkca protein kinase C, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:29341352 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkcd protein kinase C, delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:29341352 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Prkce protein kinase C, epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:29341352 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Pten phosphatase and tensin homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:26023714 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 treatment ISO RGD PMID:26723251 RGD:11086779 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rag2 recombination activating 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24211274 NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 disease_progression ISO
IEP		 mRNA:decreased expression:liver
mRNA, protein:decreased expression:liver,serum		 RGD PMID:23507574, PMID:23507574, PMID:23507574 RGD:15036822, RGD:15036822, RGD:15036822 NCBI chr 4:78,205,809...78,208,956
Ensembl chr 4:78,205,812...78,208,767 		JBrowse link
G Rdx radixin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29341352 NCBI chr 8:56,570,728...56,612,851
Ensembl chr 8:56,585,396...56,610,612 		JBrowse link
G Retn resistin IEP protein:increased expression:serum RGD PMID:20560816 RGD:7207249 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249 		JBrowse link
G Samm50 SAMM50 sorting and assembly machinery component ISO DNA:SNPs: : RGD PMID:26740948 RGD:13463463 NCBI chr 7:125,058,966...125,082,506
Ensembl chr 7:125,058,897...125,082,505 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23127599 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Serpinb2 serpin family B member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010 		JBrowse link
G Serpine1 serpin family E member 1 ISO protein:increased expression:blood: RGD PMID:25091195 RGD:13208545 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sidt2 SID1 transmembrane family, member 2 ISS OMIM:613282 | OMIM:613387 MouseDO NCBI chr 8:50,230,335...50,246,979
Ensembl chr 8:50,230,339...50,246,656 		JBrowse link
G Sirt1 sirtuin 1 treatment
severity		 IEP
ISO		 CTD Direct Evidence: therapeutic
associated with Obesity, Morbid;mRNA:decreased expression:visceral abdominal adipose tissue
protein:decreased expression:liver		 CTD PMID:26026874, PMID:17498258, PMID:20033348, PMID:22902550 RGD:9585663, RGD:9586021, RGD:9585746 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Sirt2 sirtuin 2 treatment IDA associated with Obesity RGD PMID:22327056 RGD:9586049 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952 		JBrowse link
G Sirt3 sirtuin 3 treatment IDA associated with Obesity RGD PMID:22327056 RGD:9586049 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Sirt4 sirtuin 4 IEP RGD PMID:20651844 RGD:9586052 NCBI chr12:46,862,358...46,876,593
Ensembl chr12:46,868,416...46,876,592 		JBrowse link
G Sirt6 sirtuin 6 treatment IEP RGD PMID:21373642 RGD:6484527 NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063 		JBrowse link
G Sod2 superoxide dismutase 2 treatment ISO RGD PMID:15094225, PMID:24597775 RGD:1581245, RGD:11352823 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23603006 PMID:24633463 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IDA RGD PMID:18782535 RGD:6483030 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Stc2 stanniocalcin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097666 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295 		JBrowse link
G Tff3 trefoil factor 3 treatment ISO mRNA,protein:decreased expression:liver: RGD PMID:31211621, PMID:31211621 RGD:14747028, RGD:14747028 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481 		JBrowse link
G Tfrc transferrin receptor IEP protein:increased expression:liver RGD PMID:23805238 RGD:11541090 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21664615 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 treatment
severity		 IEP
ISO		 mRNA:increased expression:liver: RGD PMID:23301938, PMID:25413054, PMID:22253482 RGD:7777122, RGD:14700658, RGD:14700656 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA:increased expression:liver (human, mouse) RGD PMID:28687713 RGD:18337289 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171 		JBrowse link
G Tm6sf2 transmembrane 6 superfamily member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24531328 NCBI chr16:21,092,483...21,099,695
Ensembl chr16:21,092,308...21,099,878 		JBrowse link
G Tnf tumor necrosis factor treatment
severity		 IEP
ISO		 protein:increased expression:serum, liver (rat)
associated with morbid obesity		 RGD PMID:25219124, PMID:19034968, PMID:25894568 RGD:10450574, RGD:14995482, RGD:14975151 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:20353583 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
G Trib3 tribbles pseudokinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29289645 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Ucp2 uncoupling protein 2 treatment IDA
ISO
IEP		 mRNA:increased expression:liver
mRNA, protein:increased expression:liver		 RGD PMID:21359922, PMID:18308829, PMID:18543254 RGD:7175312, RGD:7204435, RGD:7204434 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Vdr vitamin D receptor treatment ISO mRNA,protein:increased expression:hepatocyte: RGD PMID:27245430, PMID:27245430, PMID:27245430 RGD:14401753, RGD:14401753, RGD:14401753 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vldlr very low density lipoprotein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29289645 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205 		JBrowse link
G Xbp1 X-box binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24097666 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
non-alcoholic steatohepatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 treatment ISO RGD PMID:29505790 RGD:19165131 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Acer3 alkaline ceramidase 3 treatment
disease_progression		 ISO mRNA:increased expression:liver RGD PMID:31949129, PMID:31949129, PMID:31949129 RGD:35673324, RGD:35673324, RGD:35673324 NCBI chr 1:163,160,987...163,263,621
Ensembl chr 1:163,160,979...163,263,606 		JBrowse link
G Adipor2 adiponectin receptor 2 susceptibility
treatment		 IEP
ISO		 mRNA:decreased expression:liver (rat)
associated with obesity
associated with obesity;protein:decreased expression:liver (mouse)		 RGD PMID:20606728, PMID:30131158, PMID:20965162, PMID:18666257, PMID:19763702 RGD:21076282, RGD:25824942, RGD:25440494, RGD:25330095, RGD:25330094 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO
IEP		 human gene in mouse model
mRNA, protein: increased expression:liver, serum (rat)		 RGD PMID:24793484, PMID:30187493 RGD:21408551, RGD:25671434 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 susceptibility ISO
IEP		 RNA:increased expression:liver:
mRNA:increased expression:liver (rat)		 RGD PMID:24429361, PMID:20606728, PMID:30369082 RGD:14975280, RGD:21076282, RGD:14995462 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:serum: RGD PMID:27639593 RGD:14995335 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Cldn1 claudin 1 IEP mRNA:increased expression:distal colon (rat) RGD PMID:31189495 RGD:26884351 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 severity ISO mRNA,protein:increased expression:liver,serum RGD PMID:25048951, PMID:25048951 RGD:27095890, RGD:27095890 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 ISO mRNA:increased expression:liver (human) RGD PMID:28774887 RGD:15045601 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 treatment ISO
IEP		 mRNA:increased expression:liver (human)
mRNA, protein:altered expression:liver (rat) treatment with INT-767		 RGD PMID:28774887, PMID:30038487 RGD:15045601, RGD:15092090 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 treatment IEP mRNA, protein:altered expression:liver (rat) treatment with INT-767 RGD PMID:30038487 RGD:15092090 NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594 		JBrowse link
G Il10 interleukin 10 ISO DNA:SNP:promoter:-1082A>G (rs1800896) (human) RGD PMID:28852433 RGD:14975143 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il6 interleukin 6 ISO DNA:SNP:promoter:-174���G/C (human) RGD PMID:28852433 RGD:14975143 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Irf5 interferon regulatory factor 5 ISO mRNA:increased expression:liver RGD PMID:27942586 RGD:40924562 NCBI chr 4:56,804,477...56,816,271
Ensembl chr 4:56,805,132...56,820,543 		JBrowse link
G Krt18 keratin 18 severity ISO
IEP		 protein:increased degradation:plasma (human)
protein:altered degradation:liver, serum (rat)
protein:increased expression:serum (human)
associated with morbid obesity;protein:increased degradation: plasma(human)
protein:increased degradation:serum (human)		 RGD PMID:19585618, PMID:24071521, PMID:21993925, PMID:18995215, PMID:19333204, PMID:24630506 RGD:18337489, RGD:27226810, RGD:18337499, RGD:18337495, RGD:18337493, RGD:18337490 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131 		JBrowse link
G Lepr leptin receptor susceptibility ISO DNA:SNPs: :rs1137100,rs1137101(human) RGD PMID:23278404 RGD:14696696 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Mc4r melanocortin 4 receptor ISS MouseDO NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725 		JBrowse link
G Mir21 microRNA 21 ameliorates ISO RNA:increased expression:liver RGD PMID:26338827, PMID:26338827 RGD:41404659, RGD:41404659 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301 		JBrowse link
G Mir221 microRNA 221 treatment ISO RGD PMID:30316865 RGD:18337274 NCBI chr  X:3,684,480...3,684,588
Ensembl chr  X:3,684,480...3,684,588 		JBrowse link
G Mir223 microRNA 223 treatment ISO RNA:increased expression:liver: RGD PMID:31585800, PMID:30964207, PMID:30964207 RGD:21408547, RGD:21408549, RGD:21408549 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 treatment IEP RGD PMID:25385666 RGD:21201312 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 treatment IEP mRNA, protein:altered expression:liver (rat) treatment with INT-767 RGD PMID:30038487 RGD:15092090 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nox4 NADPH oxidase 4 susceptibility IEP mRNA:increased expression:liver (rat) RGD PMID:20606728 RGD:21076282 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 treatment ISO
IEP		 mRNA:increased expression:liver (human)
mRNA, protein:altered expression:liver (rat) treatment with INT-767		 RGD PMID:28774887, PMID:30038487 RGD:15045601, RGD:15092090 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 treatment IEP mRNA, protein:altered expression:liver (rat) treatment with INT-767 RGD PMID:30038487 RGD:15092090 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO human gene in a mouse model
protein:increased expression:serum (human)		 RGD PMID:28365916, PMID:26121037 RGD:27226700, RGD:27226705 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287 		JBrowse link
G Smad4 SMAD family member 4 ISO protein:increased expression:liver: RGD PMID:29696816, PMID:29696816 RGD:18937002, RGD:18937002 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199 		JBrowse link
G Sod1 superoxide dismutase 1 susceptibility IEP mRNA:decreased expression:liver (rat) RGD PMID:20606728 RGD:21076282 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 susceptibility IEP
ISO		 mRNA:decreased expression:liver (rat) RGD PMID:20606728, PMID:24649902 RGD:21076282, RGD:26923960 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 treatment IEP mRNA, protein:altered expression:liver (rat) treatment with INT-767 RGD PMID:30038487 RGD:15092090 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:29482933 RGD:15090806 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061 		JBrowse link
G Tlr9 toll-like receptor 9 disease_progression ISO mRNA, protein:increased expression:serum, liver (mouse) RGD PMID:24650018 RGD:18337469 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171 		JBrowse link
G Tnf tumor necrosis factor susceptibility IEP mRNA:increased expression:liver (rat) RGD PMID:20606728 RGD:21076282 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Txnip thioredoxin interacting protein ISO RGD PMID:29482933 RGD:15090806 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
Reye syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin treatment IEP RGD PMID:25162205 RGD:14694843 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Txnip thioredoxin interacting protein ISS MouseDO NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16909
    disease of anatomical entity 16281
      endocrine system disease 5713
        liver disease 2423
          fatty liver disease 291
            Acute Fatty Liver of Pregnancy 0
            Alcoholic Fatty Liver 23
            Congenital Visceral Steatosis 1
            Lipoatrophy with Diabetes, Hepatic Steatosis, Cardiomyopathy, and Leukomelanodermic Papules 0
            Reye syndrome 2
            non-alcoholic fatty liver disease + 186
Path 2
Term Annotations click to browse term
  disease 16909
    Developmental Disease 10557
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 8872
        genetic disease 8389
          inherited metabolic disorder 2355
            lipid metabolism disorder 925
              lipid storage disease 518
                fatty liver disease 291
                  Acute Fatty Liver of Pregnancy 0
                  Alcoholic Fatty Liver 23
                  Congenital Visceral Steatosis 1
                  Lipoatrophy with Diabetes, Hepatic Steatosis, Cardiomyopathy, and Leukomelanodermic Papules 0
                  Reye syndrome 2
                  non-alcoholic fatty liver disease + 186
paths to the root