RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: fatty liver disease
Accession: DOID:9452
browse the term
Definition: A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis. (DO)
Synonyms: exact_synonym: Liver Steatosis; Steatohepatitis; Steatosis of Liver; fatty change of liver; fatty liver; hepatic lipidosis; hepatosteatosis; liver steatoses; steatohepatitides; visceral steatoses; visceral steatosis
primary_id: MESH:D005234
xref: ICD10CM:K70.0 ; ICD9CM:571.0
For additional species annotation, visit the
Alliance of Genome Resources .
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Abca1
ATP binding cassette subfamily A member 1
treatment
IEP ISO
associated with adult growth hormone deficiency
RGD
PMID:15995177 , PMID:26362727 , PMID:30130150
RGD:1598534 , RGD:21408552 , RGD:18936993
NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
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Abcc2
ATP binding cassette subfamily C member 2
IEP
RGD
PMID:16139386
RGD:1598602
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcc3
ATP binding cassette subfamily C member 3
IEP
mRNA, protein:increased expression:liver
RGD
PMID:17640958
RGD:2301064
NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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Acaca
acetyl-CoA carboxylase alpha
IDA
RGD
PMID:16485039
RGD:1625727
NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
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Acacb
acetyl-CoA carboxylase beta
IDA
RGD
PMID:16485039
RGD:1625727
NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
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Adipoq
adiponectin, C1Q and collagen domain containing
IEP ISO
associated with hepatitis C;protein:increased expression:serum protein:increased expression:plasma
RGD
PMID:17006986 , PMID:20714777 , PMID:16115302
RGD:1599139 , RGD:5686883 , RGD:5686674
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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Adipor2
adiponectin receptor 2
treatment
IEP
associated with Diabetes Mellitus, Experimental
RGD
PMID:30225267 , PMID:19076162
RGD:21406435 , RGD:2307264
NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
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Adk
adenosine kinase
ISS
OMIM:228100
MouseDO
NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
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Adrb2
adrenoceptor beta 2
ISO
RGD
PMID:11718682
RGD:1559320
NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
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Akp3
alkaline phosphatase 3, intestine, not Mn requiring
ISO
RGD
PMID:17332477
RGD:14349048
NCBI chr 9:94,228,960...94,232,001
Ensembl chr 9:94,228,960...94,232,001
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Alpl
alkaline phosphatase, biomineralization associated
ISO
associated with obesity
RGD
PMID:16197789
RGD:1601177
NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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Angptl4
angiopoietin-like 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28842503 , PMID:15837923
RGD:1625354
NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
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Apoa1
apolipoprotein A1
treatment
IEP
RGD
PMID:30231880
RGD:25671436
NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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Apob
apolipoprotein B
IEP ISO
mRNA:increased expression:liver CTD Direct Evidence: marker/mechanism
CTD
PMID:12048068 PMID:17303181 , PMID:17203948
RGD:2325770
NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
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Apoe
apolipoprotein E
IMP
RGD
PMID:29459263
RGD:13703129
NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
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Atf4
activating transcription factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27664470
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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Atp5if1
ATP synthase inhibitory factor subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
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Atp7b
ATPase copper transporting beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17303181
NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
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Birc3
baculoviral IAP repeat-containing 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
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Ca3
carbonic anhydrase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
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Cat
catalase
IEP ISO
protein:decreased expression:liver CTD Direct Evidence: marker/mechanism
CTD
PMID:10860543 , PMID:21452373
RGD:5130871
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29684222 , PMID:22983634
RGD:8548844
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccl5
C-C motif chemokine ligand 5
ISO
mRNA:increased expression:liver
RGD
PMID:28011329 , PMID:28011329
RGD:14995306 , RGD:14995306
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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Cd36
CD36 molecule
ISO
RGD
PMID:19788606
RGD:6893500
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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Cebpb
CCAAT/enhancer binding protein beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24469900
NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
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Cndp2
carnosine dipeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr18:81,521,966...81,539,065
Ensembl chr18:81,521,968...81,539,065
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Col3a1
collagen type III alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15787813
NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
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Cps1
carbamoyl-phosphate synthase 1
IEP
protein:increased expression:liver (rat)
RGD
PMID:20347174
RGD:4144089
NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
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Creb1
cAMP responsive element binding protein 1
ISO
RGD
PMID:14614508
RGD:734818
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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Ctsb
cathepsin B
IEP
mRNA, protein:increased expression, increased activity:liver, cytosol (rat)
RGD
PMID:18452148
RGD:2315513
NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
mRNA,protein:increased expression:liver,serum
RGD
PMID:25048951
RGD:27095890
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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Cycs
cytochrome c, somatic
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10860543
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11929713
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27036855
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
ISO
mRNA:increased expression:liver (mouse)
RGD
PMID:31175967
RGD:25671414
NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
IEP ISO
protein:increased expression:liver CTD Direct Evidence: marker/mechanism
CTD
PMID:18952117 , PMID:19404342 , PMID:14606109
RGD:4892244 , RGD:1626302
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Cyp7b1
cytochrome P450 family 7 subfamily B member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23391614
NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
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Ddit3
DNA-damage inducible transcript 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27664470
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Dgat2
diacylglycerol O-acyltransferase 2
treatment
IMP
RGD
PMID:17526931
RGD:10400884
NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
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Dhrs7
dehydrogenase/reductase 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
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Epas1
endothelial PAS domain protein 1
ISO
RGD
PMID:14608355
RGD:734934
NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
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F2
coagulation factor II
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20008134
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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F2r
coagulation factor II (thrombin) receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20008134 PMID:21907177 PMID:22841818
NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
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Fabp1
fatty acid binding protein 1
ISO
Western diet-induced hepatic steatosis
RGD
PMID:17058218
RGD:1626440
NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
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Fgf21
fibroblast growth factor 21
severity
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24184811 , PMID:32195457
RGD:25330354
NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
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Fgfr1
Fibroblast growth factor receptor 1
severity
ISO
RGD
PMID:32195457
RGD:25330354
NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
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Fis1
fission, mitochondrial 1
IEP
protein:increased expression:liver (rat)
RGD
PMID:24663492
RGD:12453042
NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
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Foxa1
forkhead box A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24469900
NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
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G6pc1
glucose-6-phosphatase catalytic subunit 1
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:29534506
RGD:14695544
NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
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Gck
glucokinase
IDA ISO
associated with Hyperglycemia
RGD
PMID:22925001 , PMID:22925001
RGD:7488945 , RGD:7488945
NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
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Ggt1
gamma-glutamyltransferase 1
disease_progression
ISO
RGD
PMID:19670414
RGD:14747016
NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
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Gpd1l
glycerol-3-phosphate dehydrogenase 1-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 8:122,957,570...122,987,236
Ensembl chr 8:122,954,948...122,987,191
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Gpt
glutamic--pyruvic transaminase
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum
CTD
PMID:19481104 , PMID:30185098
RGD:14975167
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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Gpt2
glutamic--pyruvic transaminase 2
ISO
mRNA:increased expression:liver
RGD
PMID:15122758
RGD:14975241
NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071
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Gpx1
glutathione peroxidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10860543
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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Gpx4
glutathione peroxidase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26042203
NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
ISO
DNA:point mutations: ;1132C>T,1528G>C;LCHAD deficiency,OMIM:609015
RGD
PMID:7846063
RGD:1599882
NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
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Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17116638
NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
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Has3
hyaluronan synthase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27042213
NCBI chr19:39,063,298...39,077,745
Ensembl chr19:39,063,998...39,077,722
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Hfe
homeostatic iron regulator
no_association
ISO
Non-alcoholic steatohepatitis (NASH) non-alcoholic fatty liver disease
RGD
PMID:12105842 , PMID:11473047
RGD:1601460 , RGD:1601452
NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
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Hhex
hematopoietically expressed homeobox
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24469900
NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
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Hm13
histocompatibility minor 13
ISO
associated with hepatitis
RGD
PMID:27142248
RGD:40924634
NCBI chr 3:148,150,695...148,189,623
Ensembl chr 3:148,150,698...148,189,623
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Hspa5
heat shock protein family A (Hsp70) member 5
IEP
associated with Diabetes Mellitus, Experimental;mRNA:increased expression:liver:
RGD
PMID:23647685
RGD:11354957
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ISS
OMIM:228100
MouseDO
NCBI chr X:156,254,187...156,280,046
Ensembl chr X:156,257,173...156,270,748
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Il10
interleukin 10
IEP
associated with Diabetes Mellitus
RGD
PMID:18267346
RGD:2308948
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il13ra2
interleukin 13 receptor subunit alpha 2
IMP
RGD
PMID:18802068
RGD:4145478
NCBI chr X:118,443,955...118,514,716
Ensembl chr X:118,443,823...118,513,061
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Il18
interleukin 18
IDA
RGD
PMID:19084941
RGD:4889416
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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Il1b
interleukin 1 beta
IEP
protein:increased expression:serum
RGD
PMID:17436085
RGD:1626661
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il6
interleukin 6
ISO IAGP
associated with Diabetes Mellitus; protein:increased expression:extracellular space (mouse) associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:liver, extracellular space (rat)
RGD
PMID:19205029 , PMID:19076162
RGD:2307258 , RGD:2307264
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Ins2
insulin 2
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma CTD Direct Evidence: marker/mechanism
CTD
PMID:9048448 , PMID:18713300
RGD:2311137
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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Insig1
insulin induced gene 1
severity
ISO IEP
associated with Obesity associated with Obesity;mRNA:increased expression:liver
RGD
PMID:15096598 , PMID:15096598
RGD:2308857 , RGD:2308857
NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
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Insig2
insulin induced gene 2
severity
ISO
associated with Obesity
RGD
PMID:15096598
RGD:2308857
NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
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Insr
insulin receptor
treatment
IEP IMP
associated with obesity;human gene in mouse model protein:decreased phosphorylation: liver (rat)
RGD
PMID:25160038 , PMID:30642871 , PMID:22546076
RGD:14700926 , RGD:14701028 , RGD:14700935
NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
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Jak2
Janus kinase 2
ISO
RGD
PMID:22275361
RGD:6483019
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
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Keap1
Kelch-like ECH-associated protein 1
ISO
RGD
PMID:22367278
RGD:6893372
NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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Ldlr
low density lipoprotein receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25554529
NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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Lep
leptin
severity
IEP ISO
associated with morbid obesity;protein:decreased exprssion:serum (human) CTD Direct Evidence: marker/mechanism
CTD
PMID:12661780 PMID:19716478 PMID:23839791 PMID:24525044 PMID:25554529 PMID:27071101 PMID:27712037 , PMID:28281237
RGD:21201250
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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Lepr
leptin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25367288 PMID:29743445
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Lgals3
galectin 3
ISS
OMIM:228100
MouseDO
NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
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Lrp6
LDL receptor related protein 6
ISS
OMIM:228100
MouseDO
NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
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Mapk8
mitogen-activated protein kinase 8
ISO
RGD
PMID:21540183
RGD:9585751
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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Mat1a
methionine adenosyltransferase 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12060674
NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
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Mc4r
melanocortin 4 receptor
ISS
OMIM:228100
MouseDO
NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
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Mfn2
mitofusin 2
IEP
protein:decreased expression:liver (rat)
RGD
PMID:24663492
RGD:12453042
NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
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Mir10b
microRNA 10b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 3:61,647,978...61,648,086
Ensembl chr 3:61,647,978...61,648,086
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Mir125a
microRNA 125a
ISO
RGD
PMID:31988048
RGD:21403676
NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
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Mir134
microRNA 134
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 6:133,884,547...133,884,619
Ensembl chr 6:133,884,531...133,884,633
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Mir139
microRNA 139
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612
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Mir148b
microRNA 148b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 7:144,912,038...144,912,134
Ensembl chr 7:144,912,038...144,912,134
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Mir150
microRNA 150
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
G
Mir154
microRNA 154
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 6:133,888,586...133,888,669
Ensembl chr 6:133,888,586...133,888,669
G
Mir17
microRNA 17
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr15:100,179,879...100,179,962
Ensembl chr15:100,179,879...100,179,962
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Mir183
microRNA 183
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 4:57,463,569...57,463,678
Ensembl chr 4:57,463,569...57,463,678
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Mir219a1
microRNA 219a-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr20:3,816,158...3,816,267
Ensembl chr20:3,816,158...3,816,267
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Mir22
microRNA 22
severity
ISO
RGD
PMID:32195457 , PMID:32195457
RGD:25330354 , RGD:25330354
NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
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Mir224
microRNA 224
IEP
associated with Hepatitis C, Chronic;miRNA:increased expression:liver (human)
RGD
PMID:25386083
RGD:18182925
NCBI chr X:152,223,754...152,223,835
Ensembl chr X:152,223,754...152,223,835
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Mir320a
microRNA 320a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30125006
NCBI chr15:52,134,276...52,134,357
Ensembl chr15:52,134,276...52,134,357
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Mir34a
microRNA 34a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23834033
NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
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Mir410
microRNA 410
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 6:133,893,997...133,894,072
Ensembl chr 6:133,893,993...133,894,073
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Mir449c
microRNA 449c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 2:44,896,066...44,896,164
Ensembl chr 2:44,896,066...44,896,164
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Mir503
microRNA 503
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr X:158,148,476...158,148,546
Ensembl chr X:158,148,476...158,148,546
G
Mir542
microRNA 542
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr X:158,152,146...158,152,224
Ensembl chr X:158,152,146...158,152,224
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Mthfr
methylenetetrahydrofolate reductase
ISO
associated with Hepatitis C, Chronic; DNA:transition:cds:g.677C>T (human)
RGD
PMID:15834927
RGD:1580580
NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
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Mttp
microsomal triglyceride transfer protein
ISO
associated with Hepatitis C;mRNA:decreased expression:liver CTD Direct Evidence: marker/mechanism
CTD
PMID:17303181 , PMID:16697730
RGD:1625483
NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
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Myc
MYC proto-oncogene, bHLH transcription factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24210820
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Neil1
nei-like DNA glycosylase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16446448 PMID:21285402
NCBI chr 8:61,817,258...61,824,023
Ensembl chr 8:61,817,258...61,823,102
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Nfe2l2
nuclear factor, erythroid 2-like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28555106 , PMID:22367278
RGD:6893372
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Nfkb1
nuclear factor kappa B subunit 1
IDA
RGD
PMID:21643627
RGD:5135028
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nqo1
NAD(P)H quinone dehydrogenase 1
IEP
protein:increased activity:liver
RGD
PMID:17721935
RGD:5133249
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27664470
NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27664470
NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23651738
NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
treatment severity
ISO
CTD Direct Evidence: marker/mechanism knockout eliminates treatment effectiveness
CTD
PMID:29142166 , PMID:12971955 , PMID:23104131
RGD:15045573 , RGD:14696795
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25182422
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Nrep
neuronal regeneration related protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
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Opa1
OPA1, mitochondrial dynamin like GTPase
IEP ISO
protein:increased expression:liver (rat) ClinVar Annotator: match by term: Liver steatosis
ClinVar
PMID:19303950 PMID:20157015 PMID:22857269 PMID:25741868 PMID:26467025 PMID:27890673 PMID:28492532 , PMID:24663492
RGD:12453042
NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
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Otc
ornithine transcarbamylase
IEP
protein:increased expression:serum (rat)
RGD
PMID:18823438
RGD:4144061
NCBI chr X:13,524,804...13,601,074
Ensembl chr X:13,524,607...13,601,069
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Pex5
peroxisomal biogenesis factor 5
ISO
RGD
PMID:21756965
RGD:25440484
NCBI chr 4:156,983,914...157,009,675
Ensembl chr 4:156,983,915...157,009,674 Ensembl chr 4:156,983,915...157,009,674
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Plau
plasminogen activator, urokinase
ISS
OMIM:228100
MouseDO
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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Plin2
perilipin 2
ISO
associated with Obesity CTD Direct Evidence: marker/mechanism
CTD
PMID:16439473 , PMID:17484887
RGD:1625752
NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
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Pnpla3
patatin-like phospholipase domain containing 3
severity
ISO
CTD Direct Evidence: marker/mechanism associated with Hepatitis B, Chronic;DNA:SNP: :rs738409 (p.I148M) (human) associated with Wilson disease;DNA:SNP: :rs738409 (p.I148M) (human) associated with Hepatitis C, Chronic;DNA:SNP: :rs738409 (p.I148M) (human)
CTD
PMID:25678388 , PMID:25284145 , PMID:25678388 , PMID:21319195 , PMID:23564580
RGD:14981590 , RGD:11055420 , RGD:14981585 , RGD:14981583
NCBI chr 7:125,034,760...125,056,165
Ensembl chr 7:125,034,764...125,055,976
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Pomc
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:167377
NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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Pon1
paraoxonase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26945512
NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
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Ppara
peroxisome proliferator activated receptor alpha
ISO IEP
associated with Diabetes Mellitus (CTD:0000249); in high fat-fed foz/foz obese/diabetic mice associated with Hepatitis C, Chronic;mRNA:decreased expression:liver (human) CTD Direct Evidence: therapeutic
CTD
PMID:19124612 , PMID:21929649 , PMID:16393287
RGD:5509939 , RGD:15042851
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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Ppard
peroxisome proliferator-activated receptor delta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23851158
NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
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Pparg
peroxisome proliferator-activated receptor gamma
IEP
RGD
PMID:15112352
RGD:1580685
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Ppargc1a
PPARG coactivator 1 alpha
treatment
IDA IEP ISO
protein:decreased methylation:liver (rat)
RGD
PMID:23274094 , PMID:22521344 , PMID:23174781
RGD:7241844 , RGD:7242179 , RGD:7242012
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
ISO
RGD
PMID:19162361
RGD:6484544
NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
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Prkcd
protein kinase C, delta
ISO
RGD
PMID:17596878
RGD:1642523
NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
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Psma5
proteasome 20S subunit alpha 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714
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Pten
phosphatase and tensin homolog
IEP ISO
protein:decreased expression:liver CTD Direct Evidence: marker/mechanism
CTD
PMID:27022031 , PMID:18166358 , PMID:15199412
RGD:2292522 , RGD:1302555
NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
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Ptgs2
prostaglandin-endoperoxide synthase 2
IMP
mRNA,protein:increased expression:liver
RGD
PMID:21643627
RGD:5135028
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Ptma
prothymosin alpha
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15885234
NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
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Rela
RELA proto-oncogene, NF-kB subunit
IDA
RGD
PMID:21643627
RGD:5135028
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Ripk3
receptor-interacting serine-threonine kinase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26769846
NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
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Scd
stearoyl-CoA desaturase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21661758
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
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Serpina6
serpin family A member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
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Serpine1
serpin family E member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18641190 PMID:29684222
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Shc1
SHC adaptor protein 1
ISO
associated with Obesity
RGD
PMID:17596878
RGD:1642523
NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
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Sirt1
sirtuin 1
ISO
associated with Obesity CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:21321189 PMID:23834033 PMID:24184811 PMID:24210820 PMID:24442997 , PMID:21540183
RGD:9585751
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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Sirt6
sirtuin 6
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:28536482
NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063
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Sirt7
sirtuin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24210820
NCBI chr10:109,796,046...109,802,821
Ensembl chr10:109,796,020...109,802,739
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Slc13a5
solute carrier family 13 member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26303333
NCBI chr10:58,806,581...58,835,549
Ensembl chr10:58,810,058...58,834,538
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Slc22a8
solute carrier family 22 member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
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Slc27a4
solute carrier family 27 member 4
IEP
mRNA, protein:increased expression
RGD
PMID:16248953
RGD:1625640
NCBI chr 3:8,363,937...8,376,858
Ensembl chr 3:8,363,937...8,376,858
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Slc2a2
solute carrier family 2 member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12048068
NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
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Slco1a4
solute carrier organic anion transporter family, member 1a4
IEP
RGD
PMID:16139386
RGD:1598602
NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
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Socs1
suppressor of cytokine signaling 1
ISO
associated with Obesity
RGD
PMID:15240880
RGD:1625677
NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
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Socs3
suppressor of cytokine signaling 3
ISO
associated with Obesity
RGD
PMID:15240880
RGD:1625677
NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
G
Sod1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27349771
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10860543
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Srebf1
sterol regulatory element binding transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24469900
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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Stat4
signal transducer and activator of transcription 4
ISO
RGD
PMID:16799967
RGD:25671424
NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
G
Sts
steroid sulfatase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24497646
NCBI chr X:45,420,418...45,428,748
Ensembl chr X:45,420,596...45,428,750
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Suox
sulfite oxidase
IEP
protein:decreased expression:liver
RGD
PMID:15144217
RGD:1600114
NCBI chr 7:3,098,228...3,102,179
Ensembl chr 7:3,098,245...3,102,142
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Tf
transferrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20008134 PMID:21907177
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
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Tlr4
toll-like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18641190 PMID:27022031
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23348005
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Txn1
thioredoxin 1
IEP
RGD
PMID:18578693
RGD:2306156
NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
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Ucp2
uncoupling protein 2
IEP ISO
mRNA:increased expression:liver CTD Direct Evidence: marker/mechanism
CTD
PMID:10860543 , PMID:21114362
RGD:7204423
NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
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Vdr
vitamin D receptor
ISO
RGD
PMID:30905785 , PMID:30905785
RGD:14402029 , RGD:14402029
NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
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Xbp1
X-box binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24097666
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
protein:increased expression:plasma
RGD
PMID:16115302
RGD:5686674
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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Adipor2
adiponectin receptor 2
treatment
IEP ISO
RGD
PMID:26115886 , PMID:18755807 , PMID:27220557 , PMID:22013387
RGD:25330099 , RGD:25824943 , RGD:25824939 , RGD:25440493
NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
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Aldh2
aldehyde dehydrogenase 2 family member
severity treatment susceptibility
IDA ISO
human transgene in mouse model protein:altered processing:liver (mouse) DNA:missense mutation:cds:p.E504K (human)
RGD
PMID:17058263 , PMID:25457208 , PMID:29156373 , PMID:29063269
RGD:1599041 , RGD:15036811 , RGD:15036805 , RGD:14696776
NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
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Ccl2
C-C motif chemokine ligand 2
treatment
ISO
RGD
PMID:25557254
RGD:14995489
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccr2
C-C motif chemokine receptor 2
treatment
ISO
RGD
PMID:25557254
RGD:14995489
G
Ccr5
C-C motif chemokine receptor 5
disease_progression
ISO
RGD
PMID:27859576
RGD:14401742
NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
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Cd36
CD36 molecule
ISO
RGD
PMID:24280415
RGD:11041117
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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Crp
C-reactive protein
IEP
protein:increased expression:serum:
RGD
PMID:21806828
RGD:9491781
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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Ctsb
cathepsin B
IEP
protein:increased activity:liver, cytosol (rat)
RGD
PMID:17850215
RGD:2315516
NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26428356 , PMID:25583360 , PMID:24064383
RGD:14700884 , RGD:14700870
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Dnmt1
DNA methyltransferase 1
ISO
RGD
PMID:22905112
RGD:9588654
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
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Hamp
hepcidin antimicrobial peptide
IEP
mRNA:decreased expression:liver
RGD
PMID:19253830
RGD:11041633
NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
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Ldlr
low density lipoprotein receptor
IEP
protein:decreased expression: liver (rat)
RGD
PMID:20028367
RGD:21410185
NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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Mir155
microRNA 155
ISO
RGD
PMID:26867493
RGD:25671474
NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
G
Pemt
phosphatidylethanolamine N-methyltransferase
IEP
RGD
PMID:17156888
RGD:1642369
NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
G
Ppara
peroxisome proliferator activated receptor alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18703563
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
G
Serpine1
serpin family E member 1
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:25561792
RGD:11075083
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Serpinf1
serpin family F member 1
IEP
protein:decreased expression:liver
RGD
PMID:18996124
RGD:2312349
NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
G
Sod1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19951287
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
G
Sod2
superoxide dismutase 2
IEP
RGD
PMID:11477087
RGD:1625694
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
G
Stat4
signal transducer and activator of transcription 4
IEP
RGD
PMID:18296740
RGD:7207884
NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
G
Tlr4
toll-like receptor 4
severity
ISO
RGD
PMID:29884546 , PMID:21463341
RGD:14697697 , RGD:14700554
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
G
Tnf
tumor necrosis factor
susceptibility treatment
ISO IEP
DNA:SNP:promoter:-238G>A (human)
RGD
PMID:9214463 , PMID:20143470
RGD:14995434 , RGD:38508901
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
G
Adk
adenosine kinase
ISO
RGD
PMID:11997462
RGD:1300259
NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
G
Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased expression:serum:
RGD
PMID:27639593
RGD:14995335
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
G
Ggt1
gamma-glutamyltransferase 1
ISO
protein:increased expression:serum:
RGD
PMID:23730648
RGD:14747013
NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
G
Gpt
glutamic--pyruvic transaminase
ISO
protein:increased expression:liver,serum
RGD
PMID:18710424
RGD:14975250
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
G
Gpt2
glutamic--pyruvic transaminase 2
ISO
protein:increased expression:liver,serum
RGD
PMID:18710424
RGD:14975250
NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
severity susceptibility
ISO
RGD
PMID:29861476 , PMID:31064654
RGD:14985251 , RGD:14985252
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
severity
ISO
cholic acid fed FXR-/- mouse
RGD
PMID:12971955
RGD:15045573
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
G
Abcb1a
ATP binding cassette subfamily B member 1A
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:22112382
RGD:11040992
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
G
Abcb1b
ATP-binding cassette, subfamily B (MDR/TAP), member 1B
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:22112382
RGD:11040992
NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
G
Abcb4
ATP binding cassette subfamily B member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20040336
NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
G
Abcc2
ATP binding cassette subfamily C member 2
severity
ISO
CTD Direct Evidence: marker/mechanism DNA:SNPs:exon:p.Glu1188Val(rs17222723),p.Tyr1515Cys(rs8187710)(human)
CTD
PMID:29341352 , PMID:18926681
RGD:14700775
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
G
Abcc3
ATP binding cassette subfamily C member 3
IEP
protein:increased expression:liver
RGD
PMID:22112382
RGD:11040992
NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
G
Abcg5
ATP binding cassette subfamily G member 5
disease_progression
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:23117815 , PMID:25263431
RGD:15045604 , RGD:15045610
NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
G
Abcg8
ATP binding cassette subfamily G member 8
disease_progression
IEP
mRNA:decreased expression:liver (rat) mRNA:increased expression:liver (rat)
RGD
PMID:23117815 , PMID:25263431
RGD:15045604 , RGD:15045610
NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
G
Acadm
acyl-CoA dehydrogenase medium chain
treatment
IEP
RGD
PMID:23076603
RGD:10047124
NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
G
Acadvl
acyl-CoA dehydrogenase, very long chain
treatment
IEP
RGD
PMID:22569299 , PMID:23076603
RGD:10047121 , RGD:10047124
NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
G
Ace
angiotensin I converting enzyme
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
G
Aco1
aconitase 1
IDA
protein:increased activity:liver
RGD
PMID:23805238
RGD:11541090
NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
G
Actb
actin, beta
IDA
protein:increased carbonylation:liver
RGD
PMID:25282656
RGD:11541097
NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
G
Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
IEP
mRNA, protein:increased expression, increased activity:liver, plasma (rat)
RGD
PMID:19652891
RGD:2315953
NCBI chr 3:5,519,921...5,558,390
Ensembl chr 3:5,519,990...5,558,166
G
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29718361
NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
G
Adipoq
adiponectin, C1Q and collagen domain containing
susceptibility treatment disease_progression
IEP ISO
protein:decreased expression:serum DNA:SNPs:5'utr, :-11377C>G, +45T>G (rs266729, rs2241766) (human) associated with type 2 diabetes mellitus;DNA:SNP:5' utr:-11377C>G (rs266729) (human) DNA:hypermethylation CTD Direct Evidence: marker/mechanism mRNA, protein:decreased expression:liver associated with Obesity, Morbid; associated with obesity;protein:decreased expression:serum:
CTD
PMID:20415685 , PMID:22152320 , PMID:22269154 , PMID:26042596 , PMID:27860427 , PMID:19606393 , PMID:18713296 , PMID:15239085 , PMID:21255792
RGD:5685373 , RGD:14401719 , RGD:11076260 , RGD:14401717 , RGD:5686841 , RGD:5686810 , RGD:5686660 , RGD:5686355
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
G
Adipor2
adiponectin receptor 2
susceptibility treatment severity
ISO IEP
DNA:missense mutation:cds: (human) mRNA:increased expression:liver (human) mRNA:increased expression:liver (rat) mRNA, protein:decreased expression:serum, liver (mouse)
RGD
PMID:25345946 , PMID:25536648 , PMID:19422483 , PMID:26770322 , PMID:17006986 , PMID:29569260
RGD:24922200 , RGD:25824941 , RGD:25440492 , RGD:25330097 , RGD:1599139 , RGD:24922201
NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
G
Adrb3
adrenoceptor beta 3
ISO
DNA:missense mutation:cds:p.W64R (rs4994) (human)
RGD
PMID:15318095
RGD:5684892
NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
G
Ahcy
adenosylhomocysteinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29127188
NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
G
Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29416063
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29718361
NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
G
Aldh1b1
aldehyde dehydrogenase 1 family, member B1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29718361
NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
G
Aldh1l2
aldehyde dehydrogenase 1 family, member L2
ISS
OMIM:613282 | OMIM:613387
MouseDO
NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
G
Aldh2
aldehyde dehydrogenase 2 family member
treatment susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:missense mutation:cds: (rs671) (human)
CTD
PMID:29718361 , PMID:25392542 , PMID:27214654 , PMID:31026768
RGD:15042863 , RGD:11536476 , RGD:15036808
NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
G
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29718361
NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733
G
Alox15
arachidonate 15-lipoxygenase
ISO
RGD
PMID:20967760
RGD:5509622
NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
G
Apoa1
apolipoprotein A1
treatment
ISO
RGD
PMID:26420354
RGD:25671437
NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
G
Apoe
apolipoprotein E
IDA
RGD
PMID:21184788
RGD:6904141
NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
G
Atp5f1a
ATP synthase F1 subunit alpha
IDA
RGD
PMID:25222487
RGD:13703054
NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
G
Atp5f1b
ATP synthase F1 subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25666834
NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
G
B3gat1
beta-1,3-glucuronyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24211274
NCBI chr 8:27,777,024...27,804,368
Ensembl chr 8:27,777,179...27,804,515
G
Cat
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29718361
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
G
Ccl2
C-C motif chemokine ligand 2
severity
IEP ISO
protein:increased expression:plasma
RGD
PMID:25813056 , PMID:24927058
RGD:14995922 , RGD:14995928
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
G
Ccl5
C-C motif chemokine ligand 5
disease_progression treatment
IEP IMP
RGD
PMID:27639593 , PMID:27639593
RGD:14995335 , RGD:14995335
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
G
Ccr2
C-C motif chemokine receptor 2
susceptibility
ISO
DNA:polymorphism: :190A>G(human)
RGD
PMID:26591766
RGD:14995492
G
Cd14
CD14 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20353583
NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
G
Cd36
CD36 molecule
ISO
mRNA:increased expression:liver
RGD
PMID:21216282 , PMID:24280415
RGD:6893543 , RGD:11041117
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
G
Cideb
cell death-inducing DFFA-like effector b
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:25263431
RGD:15045610
NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
G
Col1a1
collagen type I alpha 1 chain
treatment
ISO IDA
RGD
PMID:23703580 , PMID:17241878
RGD:8552713 , RGD:2308807
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
G
Cpt1a
carnitine palmitoyltransferase 1A
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29289645 , PMID:31211621
RGD:14747028
NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
G
Csf2
colony stimulating factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
G
Cxcl10
C-X-C motif chemokine ligand 10
treatment
ISO
RGD
PMID:28824718
RGD:27095887
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15706422
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27565560
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
G
Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
ISO
protein:decreased expression:liver (mouse)
RGD
PMID:29710028
RGD:25671411
NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD
PMID:26428356 , PMID:26703967 , PMID:28458161 , PMID:25317811
RGD:11573192 , RGD:14700881 , RGD:14700871
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
IEP
mRNA:decreased expression:liver (rat)
RGD
PMID:25263431
RGD:15045610
NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
G
Dgat2
diacylglycerol O-acyltransferase 2
treatment
IEP ISO
RGD
PMID:24166662 , PMID:17618857
RGD:10400900 , RGD:10401056
NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
G
Ech1
enoyl-CoA hydratase 1
treatment
ISO
RGD
PMID:31961704
RGD:21408561
NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
G
Eif2ak1
eukaryotic translation initiation factor 2 alpha kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29289645
NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
G
Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
IEP
RGD
PMID:24351808
RGD:9588320
NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
G
F2
coagulation factor II
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22841818
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
G
Fas
Fas cell surface death receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23127599
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
G
Fgf21
fibroblast growth factor 21
severity
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26797127 PMID:29289645 , PMID:32195457
RGD:25330354
NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
G
Fgfr1
Fibroblast growth factor receptor 1
severity
ISO
RGD
PMID:32195457
RGD:25330354
NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
G
Folr2
folate receptor beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30794826
NCBI chr 1:166,915,045...166,933,377
Ensembl chr 1:166,915,045...166,919,302
G
Foxo1
forkhead box O1
treatment
IMP
associated with Diabetes Mellitus, Experimental
RGD
PMID:30186875
RGD:14401598
NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
treatment
ISO
associated with type 2 diabetes mellitus
RGD
PMID:30100243 , PMID:27840945
RGD:14695535 , RGD:14695545
NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
G
G6pd
glucose-6-phosphate dehydrogenase
treatment
IEP
RGD
PMID:20211032
RGD:10449177
NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
G
Gnmt
glycine N-methyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31086990
NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
G
Gpt
glutamic--pyruvic transaminase
severity
ISO
protein:increased activity:plasma
RGD
PMID:24768200 , PMID:22922605
RGD:14975160 , RGD:14975251
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
G
Gpt2
glutamic--pyruvic transaminase 2
ISO
protein:increased activity:plasma
RGD
PMID:22922605
RGD:14975251
NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071
G
Gpx1
glutathione peroxidase 1
treatment
ISO
RGD
PMID:24597775
RGD:11352823
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
G
Gsr
glutathione-disulfide reductase
treatment
IEP
RGD
PMID:24622831
RGD:10401873
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
G
Gsta1
glutathione S-transferase alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23643483
NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
G
Gstm1
glutathione S-transferase mu 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23643483
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
G
Gstp1
glutathione S-transferase pi 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23643483
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
G
Gstt1
glutathione S-transferase theta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23643483
NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
IEP
protein:decreased expression:liver
RGD
PMID:24782632
RGD:14694831
NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
G
Hamp
hepcidin antimicrobial peptide
IEP
associated with iron overload;protein:increased expression:serum (human) mRNA:increased expression:liver (human)
RGD
PMID:29871592 , PMID:28051796
RGD:15042878 , RGD:15042880
NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
G
Hfe
homeostatic iron regulator
ISO
DNA:missense mutation:cds:p.C282Y (human)
RGD
PMID:9453491
RGD:8694420
NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
disease_progression
IEP
mRNA:decreased expression:liver mRNA:altered expression:liver (rat) mRNA:decreased expression:liver (rat)
RGD
PMID:19913842 , PMID:25263431 , PMID:23117815
RGD:5508690 , RGD:15045610 , RGD:15045604
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
G
Hp
haptoglobin
IEP ISO
protein:increased expression:serum protein:decreased expression:serum
RGD
PMID:21806828 , PMID:21806828
RGD:9491781 , RGD:9491781
NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
G
Ide
insulin degrading enzyme
IEP
RGD
PMID:26576191
RGD:13792804
NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
G
Igf1
insulin-like growth factor 1
susceptibility
IEP
associated with Fetal Growth Retardation;mRNA:increased expression:liver (rat)
RGD
PMID:24275070
RGD:12904726
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
G
Igf1r
insulin-like growth factor 1 receptor
susceptibility
IEP
associated with Fetal Growth Retardation;mRNA:increased expression:liver (rat)
RGD
PMID:24275070
RGD:12904726
NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21115542
NCBI chr X:156,254,187...156,280,046
Ensembl chr X:156,257,173...156,270,748
G
Il10
interleukin 10
severity
ISO
associated with morbid obesity
RGD
PMID:25894568
RGD:14975151
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
G
Il13
interleukin 13
ISO
protein:increased expression:serum
RGD
PMID:18802068
RGD:4145478
NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
G
Il18
interleukin 18
treatment severity
IEP ISO
protein:increased expression:plasma
RGD
PMID:24006666 , PMID:28660148 , PMID:20422882
RGD:8655964 , RGD:14696674 , RGD:14696664
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
G
Il1a
interleukin 1 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
G
Il1b
interleukin 1 beta
no_association
ISO
DNA:SNPs:CDS:rs1143634 (human) DNA:SNPs:CDS:rs16944 (human)
RGD
PMID:27730688 , PMID:27730688
RGD:14975293 , RGD:14975293
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1rn
interleukin 1 receptor antagonist
severity
ISO
associated with morbid obesity, protein:increased expression:serum (human)
RGD
PMID:22027586
RGD:14401582
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
G
Il3
interleukin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
G
Il4
interleukin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
G
Il6
interleukin 6
ISO
mRNA,protein:increased expression:liver,plasma DNA:SNPs:promoter:rs10499563, rs1800795 (human)
RGD
PMID:18510618 , PMID:27730688
RGD:7829808 , RGD:14975293
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Insr
insulin receptor
susceptibility treatment
IMP ISO IEP
DNA:deletion:cds:codon 306 in exon 4 (mouse) DNA:deletion:cds: (codon 306, exon 4) (mouse)
RGD
PMID:28468951 , PMID:28468951 , PMID:29325294
RGD:14700929 , RGD:14700929 , RGD:14700932
NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
G
Irs1
insulin receptor substrate 1
IEP
RGD
PMID:20846698
RGD:6483014
NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
G
Irs2
insulin receptor substrate 2
IEP
RGD
PMID:20846698
RGD:6483014
NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
G
Jak2
Janus kinase 2
IDA ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28100771 , PMID:18782535
RGD:6483030
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
G
Klb
klotho beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29289645
NCBI chr14:44,529,523...44,614,093
G
Krt18
keratin 18
disease_progression
ISO IEP
protein:increased expression:serum (human) associated with Metabolic Syndrome; protein:increased expression:liver, serum (rat) protein:increased degradation:serum (rat)
RGD
PMID:30839434 , PMID:29989845 , PMID:30149902 , PMID:30089409
RGD:18337481 , RGD:26884460 , RGD:18337497 , RGD:18337482
NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
G
Lama1
laminin subunit alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123
G
Ldlr
low density lipoprotein receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20938947 PMID:23127599 PMID:23285030
NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
G
Lep
leptin
ISO IEP
associated with Type 2 Diabetes Mellitus;protein:increased expression:plasma associated with type 2 diabetes mellitus;protein:increased expression:serum (human) associated with Hepatitis C, Chronic;proteinLincreased expression:serum (human) CTD Direct Evidence: marker/mechanism
CTD
PMID:24211274 , PMID:18713300 , PMID:30052309 , PMID:20476641
RGD:2311137 , RGD:25330349 , RGD:25330346
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
G
Lepr
leptin receptor
susceptibility
ISO ISS
DNA:intron:c.2673+1118C>T (rs6700896) (human) DNA:SNP:cds:p.Q223R(human) OMIM:613282 | OMIM:613387
MouseDO
PMID:22215535 , PMID:27257426
RGD:14696694 , RGD:21079462
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
G
Lif
LIF, interleukin 6 family cytokine
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
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Lpl
lipoprotein lipase
treatment
IDA IEP
RGD
PMID:30214514 , PMID:27978932
RGD:13793398 , RGD:13794377
NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
G
Mapk8
mitogen-activated protein kinase 8
treatment
IEP
associated with Diabetes Mellitus, Type 2;
RGD
PMID:24404139
RGD:13506784
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
G
Met
MET proto-oncogene, receptor tyrosine kinase
disease_progression
ISO
RGD
PMID:24845607
RGD:14694829
NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
G
Mfn2
mitofusin 2
treatment
IEP
RGD
PMID:26401075
RGD:13204743
NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
G
Mir155
microRNA 155
ISO
miRNA:decreased expression:blood, liver
RGD
PMID:27856635 , PMID:27832630
RGD:21079446 , RGD:25671479
NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
G
Mir200b
microRNA 200b
severity
ISO
induced by nutritional deficiency.
RGD
PMID:22561871 , PMID:20548288
RGD:14928332 , RGD:14974031
NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238
G
Mir20a
microRNA 20a
IEP
associated with type 2 diabetes mellitus
RGD
PMID:30030064
RGD:25823148
NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
G
Mir22
microRNA 22
severity treatment
ISO
RGD
PMID:32195457 , PMID:32195457
RGD:25330354 , RGD:25330354
NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
G
Mir34a
microRNA 34a
ISO
miRNA:increased expression:plasma
RGD
PMID:27077736
RGD:11533145
NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
G
Mmp1
matrix metallopeptidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
G
Mthfr
methylenetetrahydrofolate reductase
severity susceptibility
ISO
DNA:SNP: :1298A > C (human) DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human)
RGD
PMID:24488901 , PMID:17563923
RGD:14696706 , RGD:14696748
NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
G
Mttp
microsomal triglyceride transfer protein
ISO
RGD
PMID:15094225
RGD:1581245
NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
G
Nfe2l2
nuclear factor, erythroid 2-like 2
treatment
IDA ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25294219 , PMID:23592516
RGD:10412712
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Nlrp3
NLR family, pyrin domain containing 3
ISS
OMIM:613282 | OMIM:613387
MouseDO
NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
G
Nos2
nitric oxide synthase 2
ISO
mRNA, protein:increased expression:liver (mouse)
RGD
PMID:21948338
RGD:5509578
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29289645 , PMID:28932253
RGD:13434914
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Nr1h3
nuclear receptor subfamily 1, group H, member 3
IEP
mRNA:decreased expression:liver (rat)
RGD
PMID:25263431
RGD:15045610
NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
treatment disease_progression susceptibility
ISO IEP
CTD Direct Evidence: marker/mechanism mRNA:increased expression:liver (rat) mRNA:decreased expression:liver (rat) DNA:deletion:cds:exon 9 (mouse)
CTD
PMID:29142166 PMID:32062620 , PMID:29743187 , PMID:30257410 , PMID:25263431 , PMID:23117815 , PMID:23700488
RGD:14696797 , RGD:15090799 , RGD:15045610 , RGD:15045604 , RGD:14701033
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
G
Nr5a2
nuclear receptor subfamily 5, group A, member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29515023
NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
G
Pdk4
pyruvate dehydrogenase kinase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29289645
NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
G
Pemt
phosphatidylethanolamine N-methyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29416063
NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
G
Pgrmc1
progesterone receptor membrane component 1
ISS
OMIM:613282 | OMIM:613387
MouseDO
NCBI chr X:123,205,869...123,213,880
Ensembl chr X:123,205,869...123,213,882
G
Phyh
phytanoyl-CoA 2-hydroxylase
treatment
IEP
RGD
PMID:29031784
RGD:13831310
NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
G
Pla2g7
phospholipase A2 group VII
ISO
protein:increased expression:serum
RGD
PMID:22112193
RGD:6482771
NCBI chr 9:19,935,754...19,978,013
Ensembl chr 9:19,935,768...19,978,013
G
Pnpla3
patatin-like phospholipase domain containing 3
susceptibility
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: NAFLD1 ClinVar Annotator: match by term: Susceptibility to Nonalcoholic Fatty Liver Disease DNA:SNPs: :rs738407, rs738409, and rs2896019 (human) associated with obesity;DNA:SNP: :rs738409 (p.I148M) (human) ClinVar Annotator: match by term: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
CTD ClinVar
PMID:18820647 PMID:21381068 PMID:22992668 PMID:24033266 PMID:24531328 PMID:24917523 PMID:25290313 PMID:26200108 PMID:27180240 PMID:27288299 PMID:28073161 PMID:28090653 PMID:28492532 PMID:28744905 PMID:29158695 , PMID:24831885 , PMID:24477042 , PMID:26740948
RGD:14981596 , RGD:14981593 , RGD:13463463
NCBI chr 7:125,034,760...125,056,165
Ensembl chr 7:125,034,764...125,055,976
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Pon2
paraoxonase 2
treatment
IEP
RGD
PMID:22536512
RGD:8661257
NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
G
Ppara
peroxisome proliferator activated receptor alpha
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23603006 , PMID:31211621
RGD:14747028
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
G
Ppard
peroxisome proliferator-activated receptor delta
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:16574099 PMID:29289645
NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
G
Ppargc1a
PPARG coactivator 1 alpha
susceptibility
IDA ISO
associated with Obesity; DNA:missense mutation:cds:p.G482S rs8192678 (human)
RGD
PMID:21373642 , PMID:23269818
RGD:6484527 , RGD:7241847
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
G
Prf1
perforin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24211274
NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
G
Prkaca
protein kinase cAMP-activated catalytic subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29341352
NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
G
Prkca
protein kinase C, alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29341352
NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
G
Prkcd
protein kinase C, delta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29341352
NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
G
Prkce
protein kinase C, epsilon
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29341352
NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
G
Pten
phosphatase and tensin homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26023714
NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
G
Ptgs2
prostaglandin-endoperoxide synthase 2
treatment
ISO
RGD
PMID:26723251
RGD:11086779
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Rag2
recombination activating 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24211274
NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134
G
Rarres2
retinoic acid receptor responder 2
disease_progression
ISO IEP
mRNA:decreased expression:liver mRNA, protein:decreased expression:liver,serum
RGD
PMID:23507574 , PMID:23507574 , PMID:23507574
RGD:15036822 , RGD:15036822 , RGD:15036822
NCBI chr 4:78,205,809...78,208,956
Ensembl chr 4:78,205,812...78,208,767
G
Rdx
radixin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29341352
NCBI chr 8:56,570,728...56,612,851
Ensembl chr 8:56,585,396...56,610,612
G
Retn
resistin
IEP
protein:increased expression:serum
RGD
PMID:20560816
RGD:7207249
NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
G
Samm50
SAMM50 sorting and assembly machinery component
ISO
DNA:SNPs: :
RGD
PMID:26740948
RGD:13463463
NCBI chr 7:125,058,966...125,082,506
Ensembl chr 7:125,058,897...125,082,505
G
Scarb1
scavenger receptor class B, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23127599
NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
G
Serpinb2
serpin family B member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
G
Serpine1
serpin family E member 1
ISO
protein:increased expression:blood:
RGD
PMID:25091195
RGD:13208545
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Sidt2
SID1 transmembrane family, member 2
ISS
OMIM:613282 | OMIM:613387
MouseDO
NCBI chr 8:50,230,335...50,246,979
Ensembl chr 8:50,230,339...50,246,656
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Sirt1
sirtuin 1
treatment severity
IEP ISO
CTD Direct Evidence: therapeutic associated with Obesity, Morbid;mRNA:decreased expression:visceral abdominal adipose tissue protein:decreased expression:liver
CTD
PMID:26026874 , PMID:17498258 , PMID:20033348 , PMID:22902550
RGD:9585663 , RGD:9586021 , RGD:9585746
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
G
Sirt2
sirtuin 2
treatment
IDA
associated with Obesity
RGD
PMID:22327056
RGD:9586049
NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
G
Sirt3
sirtuin 3
treatment
IDA
associated with Obesity
RGD
PMID:22327056
RGD:9586049
NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
G
Sirt4
sirtuin 4
IEP
RGD
PMID:20651844
RGD:9586052
NCBI chr12:46,862,358...46,876,593
Ensembl chr12:46,868,416...46,876,592
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Sirt6
sirtuin 6
treatment
IEP
RGD
PMID:21373642
RGD:6484527
NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063
G
Sod2
superoxide dismutase 2
treatment
ISO
RGD
PMID:15094225 , PMID:24597775
RGD:1581245 , RGD:11352823
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
G
Srebf1
sterol regulatory element binding transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23603006 PMID:24633463
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
G
Stat3
signal transducer and activator of transcription 3
IDA
RGD
PMID:18782535
RGD:6483030
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
G
Stc2
stanniocalcin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24097666
NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
G
Tff3
trefoil factor 3
treatment
ISO
mRNA,protein:decreased expression:liver:
RGD
PMID:31211621 , PMID:31211621
RGD:14747028 , RGD:14747028
NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
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Tfrc
transferrin receptor
IEP
protein:increased expression:liver
RGD
PMID:23805238
RGD:11541090
NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
G
Tgfb1
transforming growth factor, beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21664615
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
G
Tlr4
toll-like receptor 4
treatment severity
IEP ISO
mRNA:increased expression:liver:
RGD
PMID:23301938 , PMID:25413054 , PMID:22253482
RGD:7777122 , RGD:14700658 , RGD:14700656
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
G
Tlr9
toll-like receptor 9
ISO
mRNA:increased expression:liver (human, mouse)
RGD
PMID:28687713
RGD:18337289
NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
G
Tm6sf2
transmembrane 6 superfamily member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24531328
NCBI chr16:21,092,483...21,099,695
Ensembl chr16:21,092,308...21,099,878
G
Tnf
tumor necrosis factor
treatment severity
IEP ISO
protein:increased expression:serum, liver (rat) associated with morbid obesity
RGD
PMID:25219124 , PMID:19034968 , PMID:25894568
RGD:10450574 , RGD:14995482 , RGD:14975151
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20353583
NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
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Trib3
tribbles pseudokinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29289645
NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
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Ucp2
uncoupling protein 2
treatment
IDA ISO IEP
mRNA:increased expression:liver mRNA, protein:increased expression:liver
RGD
PMID:21359922 , PMID:18308829 , PMID:18543254
RGD:7175312 , RGD:7204435 , RGD:7204434
NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
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Vdr
vitamin D receptor
treatment
ISO
mRNA,protein:increased expression:hepatocyte:
RGD
PMID:27245430 , PMID:27245430 , PMID:27245430
RGD:14401753 , RGD:14401753 , RGD:14401753
NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
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Vldlr
very low density lipoprotein receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29289645
NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
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Xbp1
X-box binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24097666
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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Abca1
ATP binding cassette subfamily A member 1
treatment
ISO
RGD
PMID:29505790
RGD:19165131
NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
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Acer3
alkaline ceramidase 3
treatment disease_progression
ISO
mRNA:increased expression:liver
RGD
PMID:31949129 , PMID:31949129 , PMID:31949129
RGD:35673324 , RGD:35673324 , RGD:35673324
NCBI chr 1:163,160,987...163,263,621
Ensembl chr 1:163,160,979...163,263,606
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Adipor2
adiponectin receptor 2
susceptibility treatment
IEP ISO
mRNA:decreased expression:liver (rat) associated with obesity associated with obesity;protein:decreased expression:liver (mouse)
RGD
PMID:20606728 , PMID:30131158 , PMID:20965162 , PMID:18666257 , PMID:19763702
RGD:21076282 , RGD:25824942 , RGD:25440494 , RGD:25330095 , RGD:25330094
NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
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Apoa1
apolipoprotein A1
treatment
ISO IEP
human gene in mouse model mRNA, protein: increased expression:liver, serum (rat)
RGD
PMID:24793484 , PMID:30187493
RGD:21408551 , RGD:25671434
NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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Ccl2
C-C motif chemokine ligand 2
susceptibility
ISO IEP
RNA:increased expression:liver: mRNA:increased expression:liver (rat)
RGD
PMID:24429361 , PMID:20606728 , PMID:30369082
RGD:14975280 , RGD:21076282 , RGD:14995462
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased expression:serum:
RGD
PMID:27639593
RGD:14995335
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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Cldn1
claudin 1
IEP
mRNA:increased expression:distal colon (rat)
RGD
PMID:31189495
RGD:26884351
NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
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Cxcl10
C-X-C motif chemokine ligand 10
severity
ISO
mRNA,protein:increased expression:liver,serum
RGD
PMID:25048951 , PMID:25048951
RGD:27095890 , RGD:27095890
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
ISO
mRNA:increased expression:liver (human)
RGD
PMID:28774887
RGD:15045601
NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
treatment
ISO IEP
mRNA:increased expression:liver (human) mRNA, protein:altered expression:liver (rat) treatment with INT-767
RGD
PMID:28774887 , PMID:30038487
RGD:15045601 , RGD:15092090
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
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Gpbar1
G protein-coupled bile acid receptor 1
treatment
IEP
mRNA, protein:altered expression:liver (rat) treatment with INT-767
RGD
PMID:30038487
RGD:15092090
NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594
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Il10
interleukin 10
ISO
DNA:SNP:promoter:-1082A>G (rs1800896) (human)
RGD
PMID:28852433
RGD:14975143
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il6
interleukin 6
ISO
DNA:SNP:promoter:-174���G/C (human)
RGD
PMID:28852433
RGD:14975143
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Irf5
interferon regulatory factor 5
ISO
mRNA:increased expression:liver
RGD
PMID:27942586
RGD:40924562
NCBI chr 4:56,804,477...56,816,271
Ensembl chr 4:56,805,132...56,820,543
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Krt18
keratin 18
severity
ISO IEP
protein:increased degradation:plasma (human) protein:altered degradation:liver, serum (rat) protein:increased expression:serum (human) associated with morbid obesity;protein:increased degradation: plasma(human) protein:increased degradation:serum (human)
RGD
PMID:19585618 , PMID:24071521 , PMID:21993925 , PMID:18995215 , PMID:19333204 , PMID:24630506
RGD:18337489 , RGD:27226810 , RGD:18337499 , RGD:18337495 , RGD:18337493 , RGD:18337490
NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
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Lepr
leptin receptor
susceptibility
ISO
DNA:SNPs: :rs1137100,rs1137101(human)
RGD
PMID:23278404
RGD:14696696
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Mc4r
melanocortin 4 receptor
ISS
MouseDO
NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
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Mir21
microRNA 21
ameliorates
ISO
RNA:increased expression:liver
RGD
PMID:26338827 , PMID:26338827
RGD:41404659 , RGD:41404659
NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
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Mir221
microRNA 221
treatment
ISO
RGD
PMID:30316865
RGD:18337274
NCBI chr X:3,684,480...3,684,588
Ensembl chr X:3,684,480...3,684,588
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Mir223
microRNA 223
treatment
ISO
RNA:increased expression:liver:
RGD
PMID:31585800 , PMID:30964207 , PMID:30964207
RGD:21408547 , RGD:21408549 , RGD:21408549
NCBI chr X:65,367,812...65,367,921
Ensembl chr X:65,367,812...65,367,921
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Nfe2l2
nuclear factor, erythroid 2-like 2
treatment
IEP
RGD
PMID:25385666
RGD:21201312
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Nfkb1
nuclear factor kappa B subunit 1
treatment
IEP
mRNA, protein:altered expression:liver (rat) treatment with INT-767
RGD
PMID:30038487
RGD:15092090
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nox4
NADPH oxidase 4
susceptibility
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:20606728
RGD:21076282
NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
treatment
ISO IEP
mRNA:increased expression:liver (human) mRNA, protein:altered expression:liver (rat) treatment with INT-767
RGD
PMID:28774887 , PMID:30038487
RGD:15045601 , RGD:15092090
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Pck1
phosphoenolpyruvate carboxykinase 1
treatment
IEP
mRNA, protein:altered expression:liver (rat) treatment with INT-767
RGD
PMID:30038487
RGD:15092090
NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
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Serpinf1
serpin family F member 1
treatment
ISO
human gene in a mouse model protein:increased expression:serum (human)
RGD
PMID:28365916 , PMID:26121037
RGD:27226700 , RGD:27226705
NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
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Smad4
SMAD family member 4
ISO
protein:increased expression:liver:
RGD
PMID:29696816 , PMID:29696816
RGD:18937002 , RGD:18937002
NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
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Sod1
superoxide dismutase 1
susceptibility
IEP
mRNA:decreased expression:liver (rat)
RGD
PMID:20606728
RGD:21076282
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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Sod2
superoxide dismutase 2
susceptibility
IEP ISO
mRNA:decreased expression:liver (rat)
RGD
PMID:20606728 , PMID:24649902
RGD:21076282 , RGD:26923960
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Srebf1
sterol regulatory element binding transcription factor 1
treatment
IEP
mRNA, protein:altered expression:liver (rat) treatment with INT-767
RGD
PMID:30038487
RGD:15092090
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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Tlr2
toll-like receptor 2
ISO
RGD
PMID:29482933
RGD:15090806
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
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Tlr9
toll-like receptor 9
disease_progression
ISO
mRNA, protein:increased expression:serum, liver (mouse)
RGD
PMID:24650018
RGD:18337469
NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
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Tnf
tumor necrosis factor
susceptibility
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:20606728
RGD:21076282
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Txnip
thioredoxin interacting protein
ISO
RGD
PMID:29482933
RGD:15090806
NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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Alb
albumin
treatment
IEP
RGD
PMID:25162205
RGD:14694843
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Txnip
thioredoxin interacting protein
ISS
MouseDO
NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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