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ONTOLOGY REPORT - ANNOTATIONS


Term:hyperthyroidism
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Accession:DOID:7998 term browser browse the term
Definition:Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
Synonyms:exact_synonym: Hyperthyroids;   hyperthyroid;   overactive thyroid;   primary hyperthyroidism
 primary_id: MESH:D006980
 alt_id: RDO:0005704
 xref: NCI:C3123;   ORDO:99819
For additional species annotation, visit the Alliance of Genome Resources.


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hyperthyroidism term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1599133
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:2306952
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:2306952
G Anxa5 annexin A5 JBrowse link 2 123,162,477 123,194,730 RGD:2306952
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1599158
G Apoa2 apolipoprotein A2 JBrowse link 13 89,596,872 89,598,805 RGD:1599158
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:1599190
G Aqp1 aquaporin 1 JBrowse link 4 85,551,503 85,563,683 RGD:11554173
G Bdh1 3-hydroxybutyrate dehydrogenase 1 JBrowse link 11 72,577,547 72,619,435 RGD:4105460
G Cab39 calcium binding protein 39 JBrowse link 9 92,834,327 92,895,778 RGD:10059691
G Cartpt CART prepropeptide JBrowse link 2 30,125,249 30,127,408 RGD:11554173
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:9068475
RGD:11554173
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:8547761
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:2314689
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:2315547
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:9068475
RGD:11554173
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:10401891
RGD:11554173
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10755742
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:2311524
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:7364857
RGD:11049472
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 12 19,306,615 19,313,877 RGD:2317698
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:6893690
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 JBrowse link 10 86,683,875 86,690,815 RGD:10448989
G Pcsk1 proprotein convertase subtilisin/kexin type 1 JBrowse link 2 91,450,162 91,497,091 RGD:2308889
RGD:1601276
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11554173
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:10059691
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:7421571
G Serpina7 serpin family A member 7 JBrowse link X 110,226,565 110,232,202 RGD:1600139
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:8547758
G Slc34a1 solute carrier family 34 member 1 JBrowse link 17 9,747,766 9,762,739 RGD:7243131
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:625494
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:8655984
RGD:11554173
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:11554173
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:10059691
G Tshr thyroid stimulating hormone receptor JBrowse link 6 115,170,290 115,306,871 RGD:11554173
G Ucp3 uncoupling protein 3 JBrowse link 1 165,482,912 165,495,895 RGD:2313535
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:1600445
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480446
Graves Ophthalmopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:9071200
RGD:9086875
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8549459
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:7421511
RGD:7421521
RGD:7421523
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:8158124
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:7794734
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:8548854
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:7364859
RGD:7365083
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655878
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:7794734
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:7387296
RGD:8549808
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:8662939
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:7421521
RGD:8549554
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:5686901
G Kif1a kinesin family member 1A JBrowse link 9 100,171,851 100,253,626 RGD:12911230
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:8552818
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:11554173
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:7829763
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:11554173
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:8547756
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:7365073
RGD:12904066
RGD:7794734
G Tshr thyroid stimulating hormone receptor JBrowse link 6 115,170,290 115,306,871 RGD:8548662
RGD:8548673
Graves' disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:5686818
RGD:5686857
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:8548467
G Arid5b AT-rich interaction domain 5B JBrowse link 20 21,713,900 21,881,193 RGD:11554173
G B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 JBrowse link 14 107,592,336 107,617,189 RGD:11554173
G Btnl2 butyrophilin-like 2 JBrowse link 20 4,140,184 4,156,365 RGD:9685042
G C4a complement C4A JBrowse link 20 2,651,599 2,678,183 RGD:5688264
G C4b complement C4B (Chido blood group) JBrowse link 20 4,302,344 4,316,752 RGD:5688264
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:9068908
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:8547766
RGD:8547778
RGD:8547769
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:8547747
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:2302000
RGD:11554173
RGD:11352245
RGD:7421517
RGD:7421515
RGD:7421507
RGD:7421505
RGD:1300388
RGD:2302001
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:5147671
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:9588624
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:8693348
RGD:10045850
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:8662820
G Fkbp1b FKBP prolyl isomerase 1B JBrowse link 6 29,975,863 29,987,252 RGD:1580387
G Gc GC, vitamin D binding protein JBrowse link 14 20,267,023 20,302,577 RGD:5509883
RGD:11554173
RGD:7240710
RGD:5509886
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:8547807
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:8158121
RGD:8547702
RGD:8158124
G Ifih1 interferon induced with helicase C domain 1 JBrowse link 3 48,557,696 48,604,097 RGD:11554173
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:8142372
RGD:8157604
RGD:8157599
RGD:8142393
RGD:8142373
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:8548837
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:5686433
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:7364858
RGD:7365074
RGD:7365026
RGD:7364862
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:7829719
RGD:8549544
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:9068423
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655878
RGD:8655916
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7401177
RGD:7401207
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:8662947
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:8549554
RGD:8549564
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:5686901
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:7829719
RGD:7829750
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:7829750
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:8693341
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:8548778
RGD:8548790
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:7387246
G Ogg1 8-oxoguanine DNA glycosylase JBrowse link 4 145,282,828 145,289,367 RGD:8657376
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:6484538
RGD:11554173
RGD:7829763
RGD:7829738
G Rnaset2 ribonuclease T2 JBrowse link 1 53,174,879 53,192,048 RGD:11554173
G RT1-Ba RT1 class II, locus Ba JBrowse link 20 4,066,133 4,070,726 RGD:8547558
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:7421572
RGD:7483568
G RT1-CE13 RT1 class I, locus CE13 RGD:7365094
RGD:7365110
RGD:7365118
RGD:7365112
RGD:7365098
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:7365065
RGD:7365089
RGD:7365073
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:8547709
RGD:8547756
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:7207875
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:7244137
G Tg thyroglobulin JBrowse link 7 107,467,260 107,652,897 RGD:8548606
RGD:8548645
RGD:8548644
RGD:8548643
RGD:8548630
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:7365073
RGD:7394807
RGD:7394790
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:8547807
G Tshr thyroid stimulating hormone receptor JBrowse link 6 115,170,290 115,306,871 RGD:8548654
RGD:11554173
RGD:7240710
RGD:8548669
RGD:8548665
RGD:8548664
RGD:8548663
RGD:8548661
RGD:8548657
RGD:8548656
RGD:8548655
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:1331525
RGD:8158053
RGD:8157632
RGD:8157628
RGD:8157624
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:7483621
Hyperfunctioning Thyroid Adenoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tshr thyroid stimulating hormone receptor JBrowse link 6 115,170,290 115,306,871 RGD:8554872
Hyperthyroidism, Familial Gestational term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tshr thyroid stimulating hormone receptor JBrowse link 6 115,170,290 115,306,871 RGD:7240710
RGD:8554872
Nonautoimmune Hyperthyroidism term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cep128 centrosomal protein 128 JBrowse link 6 114,759,474 115,158,004 RGD:8554872
G Tshr thyroid stimulating hormone receptor JBrowse link 6 115,170,290 115,306,871 RGD:8548658
RGD:8554872
RGD:7240710
selective pituitary thyroid hormone resistance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:7240710
RGD:8554872
Thyrotoxic Periodic Paralysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:8554872
RGD:11554173
RGD:7240710
G RT1-CE13 RT1 class I, locus CE13 RGD:8655904
thyrotoxicosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:2311054
G Mt-cyb mitochondrially encoded cytochrome b JBrowse link MT 14,136 15,278 RGD:2298979
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:11554173
G Tshr thyroid stimulating hormone receptor JBrowse link 6 115,170,290 115,306,871 RGD:11554173

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Term Annotations click to browse term
  disease 15502
    disease of anatomical entity 14856
      endocrine system disease 4819
        thyroid gland disease 309
          hyperthyroidism 92
            Graves' disease + 59
            Hyperthyroidism, Familial Gestational 1
            Isolated Thyrotropin Deficiency 0
            Nonautoimmune Hyperthyroidism 2
            Plummer's disease 0
            selective pituitary thyroid hormone resistance 1
            thyrotoxicosis + 6
            toxic diffuse goiter 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.