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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Kidney Reperfusion Injury
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Accession:DOID:9006223 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the kidney, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: Kidney Ischemia-Reperfusion Injury;   Renal Ischemia-Reperfusion Injury;   Renal Reperfusion Injury
For additional species annotation, visit the Alliance of Genome Resources.



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Kidney Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IMP RGD PMID:21680852 RGD:6893484 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 IEP mRNA:decreased expression:kidney RGD PMID:20528771 RGD:9685432 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 treatment IEP RGD PMID:22015440 RGD:13703100 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adam2 ADAM metallopeptidase domain 2 IEP RGD PMID:11967014 RGD:10047130 NCBI chr15:40,242,783...40,284,025
Ensembl chr15:40,242,783...40,283,952
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 IEP RGD PMID:18272597 RGD:9684850 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:21412771 RGD:8695946 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adm adrenomedullin treatment IEP
ISO
protein:increased expression:serum: RGD PMID:20538296 PMID:20538296 RGD:7364948, RGD:7364948 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO RGD PMID:31089212 RGD:27226686 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO RGD PMID:22022451 RGD:7241603 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Anxa1 annexin A1 treatment IDA RGD PMID:20953576 RGD:7421585 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa5 annexin A5 ISO RGD PMID:21918686 RGD:7242028 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 treatment IEP RGD PMID:26362957 RGD:13703110 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO RGD PMID:18535924 RGD:7241574 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Atm ATM serine/threonine kinase IEP protein:increased expression:kidney RGD PMID:22768306 RGD:10053607 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:23151253 RGD:10054101 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:18221257 PMID:29285062 RGD:2293026, RGD:13792599 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:18725957 RGD:7241559 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Becn1 beclin 1 treatment IEP RGD PMID:26412257 RGD:11561958 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bnip3 BCL2 interacting protein 3 IEP mRNA, protein:increased expression:kidney RGD PMID:23698117 RGD:11561968 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G C3 complement C3 treatment IEP RGD PMID:19691975 RGD:7411689 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Calca calcitonin-related polypeptide alpha IMP RGD PMID:19194162 RGD:7204479 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:23151253 RGD:10054101 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 IEP RGD PMID:17596683 RGD:5684536 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 treatment ISO RGD PMID:22160777 RGD:7247742 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment ISO
IDA
mRNA, protein:increased expression:kidney, lung, serum RGD PMID:20396927 PMID:18650485 RGD:4891433, RGD:11526113 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd14 CD14 molecule ISO mRNA,protein:increased expression:kidney RGD PMID:10966493 RGD:7204444 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd40 CD40 molecule treatment IMP RGD PMID:25993320 RGD:11251055 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cfb complement factor B ISO RGD PMID:16467447 PMID:12538716 RGD:7242709, RGD:7242734 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfh complement factor H treatment IEP
ISO
protein:decreased expression:serum: RGD PMID:20538296 PMID:20538296 RGD:7364948, RGD:7364948 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Ciita class II, major histocompatibility complex, transactivator ISO RGD PMID:14569092 RGD:7242896 NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
JBrowse link
G Csf1 colony stimulating factor 1 ISO mRNA:increased expression:kidney RGD PMID:23143303 PMID:19196448 RGD:7257565, RGD:7257570 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO RGD PMID:23143303 RGD:7257565 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO RGD PMID:22189844 PMID:9407517 RGD:7204675, RGD:7204727 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO RGD PMID:20038794 RGD:7257679 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 IEP protein:increased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 treatment IMP RGD PMID:23552495 RGD:7244372 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Daxx death-domain associated protein ISO protein:increased expression:kidney: RGD PMID:18480747 PMID:18480747 RGD:9587836, RGD:9587836 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO protein:increased expression:kidney (mouse) RGD PMID:31383731 RGD:151347540 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
JBrowse link
G Dhfr dihydrofolate reductase IEP mRNA,protein:decreased expression:kidney: RGD PMID:18408363 RGD:11040540 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Drd3 dopamine receptor D3 treatment IDA RGD PMID:25989500 RGD:13506961 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IEP mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr19:52,867,914...52,907,169
Ensembl chr19:52,869,486...52,907,777
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 IEP mRNA, protein:decreased expression:kidney RGD PMID:19349364 RGD:11252083 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:16980042 RGD:10450580 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Eng endoglin IEP
ISO
mRNA, protein:increased expression:kidney (rat) RGD PMID:16751653 PMID:16751653 RGD:7248779, RGD:7248779 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Ep300 E1A binding protein p300 IEP protein:altered localization:kidney (rat) RGD PMID:23936185 RGD:7257563 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:19961832 PMID:25581532 RGD:10401077, RGD:11041698 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G F3 coagulation factor III, tissue factor IEP protein:decreased expression:lung RGD PMID:25883098 RGD:11341735 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fas Fas cell surface death receptor treatment IEP RGD PMID:29285062 RGD:13792599 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand treatment IEP RGD PMID:29285062 RGD:13792599 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fcgr1a Fc gamma receptor 1A treatment ISO RGD PMID:22402584 RGD:9685699 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994
JBrowse link
G Fga fibrinogen alpha chain IEP mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain treatment IEP
ISO
mRNA, protein:increased expression:kidney RGD PMID:21685370 PMID:21685370 RGD:7175292, RGD:7175292 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain IEP mRNA,protein:increased expression:kidney RGD PMID:21685370 RGD:7175292 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fn1 fibronectin 1 IEP RGD PMID:11352844 RGD:7205629 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:19095962 RGD:7242184 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gfer growth factor, augmenter of liver regeneration treatment IEP
ISO
protein:increased expression:kidney: RGD PMID:20332418 PMID:20332418 RGD:9685723, RGD:9685723 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869
JBrowse link
G Glo1 glyoxalase 1 IMP RGD PMID:19211689 RGD:7242566 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gsr glutathione-disulfide reductase treatment IEP RGD PMID:24630969 RGD:10401866 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G H2ax H2A.X variant histone treatment IEP RGD PMID:23726287 RGD:8693706 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Has1 hyaluronan synthase 1 IEP RGD PMID:22529164 RGD:9588636 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
JBrowse link
G Has2 hyaluronan synthase 2 IEP RGD PMID:22529164 RGD:9588636 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 IEP
ISO
protein:increased expression:urine: RGD PMID:23552495 PMID:23019274 PMID:23085062 RGD:7244372, RGD:7245495, RGD:7245489 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment
severity
IDA
IMP
RGD PMID:17519789 PMID:22432008 RGD:1626334, RGD:9068883 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 treatment IMP RGD PMID:21291499 RGD:10755580 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsf1 heat shock transcription factor 1 IEP protein:increased expression:kidney (rat) RGD PMID:23102208 RGD:10402775 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IEP RGD PMID:7569112 RGD:7242788 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hyal1 hyaluronidase 1 IEP RGD PMID:22529164 RGD:9588636 NCBI chr 8:108,250,654...108,254,526
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Hyal2 hyaluronidase 2 IEP RGD PMID:22529164 RGD:9588636 NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850
JBrowse link
G Ifng interferon gamma treatment ISO RGD PMID:28355607 RGD:14975115 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP mRNA: increased expression: kidney: 3 and 5 days post ischemia RGD PMID:10990448 RGD:7242905 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment IMP RGD PMID:19546526 RGD:7495779 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 treatment IDA
ISO
RGD PMID:24079335 PMID:28664613 RGD:7364864, RGD:14975137 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 treatment IMP RGD PMID:22089199 RGD:8655971 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta IDA RGD PMID:20030532 RGD:7175501 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein
mouse model treated with human protein
RGD PMID:18363573 PMID:9555664 PMID:16849996 RGD:6907101, RGD:6909149, RGD:6907359 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Itgb2 integrin subunit beta 2 ISO
IMP
Associated with renal transplant patients RGD PMID:20504838 PMID:11007822 RGD:6907049, RGD:6907073 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 IEP protein:decreased expression:kidney RGD PMID:21250976 RGD:7297045 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Kl Klotho treatment IEP
ISO
mRNA,protein:decreased expression:renal tubule: RGD PMID:16204278 PMID:16204278 RGD:10403064, RGD:10403064 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Lcn2 lipocalin 2 IEP
ISO
protein:increased expression:urine:
mRNA,protein:increased expression:kidney,urine
mRNA,protein:increased expression:kidney:
RGD PMID:23364806 PMID:27800610 PMID:20181666 PMID:23085062 RGD:7245469, RGD:126790572, RGD:126779563, RGD:7245489 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lep leptin resistance IDA RGD PMID:22969992 RGD:6909133 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lgals3 galectin 3 IEP mRNA:increased expression:kidney RGD PMID:10980121 RGD:9685228 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment ISO
IEP
RGD PMID:20075199 PMID:26412257 RGD:11561916, RGD:11561958 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment IMP RGD PMID:23952292 RGD:10412647 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mc1r melanocortin 1 receptor IEP protein:decreased expression:kidney outer medulla RGD PMID:18790174 RGD:5687322 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
JBrowse link
G Mir381 microRNA 381 IEP RNA:decreased expression:kidney RGD PMID:29073721 RGD:13825150 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Mpo myeloperoxidase IEP
ISO
protein:increased activity:kidney RGD PMID:22950848 PMID:18055546 RGD:6909167, RGD:7174699 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Muc1 mucin 1, cell surface associated treatment IDA RGD PMID:22019164 RGD:7245959 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEP mRNA:increased expression:kidney (rat) RGD PMID:17220792 RGD:7207777 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 IEP
ISO
RGD PMID:24096033 PMID:22160772 RGD:13801197, RGD:13801199 NCBI chr 1:243,408,659...243,413,701
Ensembl chr 1:243,408,619...243,413,817
JBrowse link
G Nes nestin IEP RGD PMID:24503548 RGD:11570523 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:29291552 RGD:13504682 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:20471588 RGD:7247717 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:21545725 RGD:11035217 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 severity ISO mRNA:increased expression:kidney RGD PMID:22343121 PMID:22343121 RGD:14700869, RGD:14700869 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase IEP RGD PMID:12531391 RGD:2317150 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Pax2 paired box 2 IEP mRNA, protein:increased expression:kidney RGD PMID:12444203 RGD:727468 NCBI chr 1:243,616,509...243,697,454
Ensembl chr 1:243,616,606...243,695,321
JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP mRNA,protein:increased expression:tubule, S3 segment: RGD PMID:10550325 RGD:8554477 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP mRNA:increased expression:kidney RGD PMID:10550325 RGD:8554477 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IMP
IEP
mRNA:increased expression:kidney RGD PMID:12819032 PMID:10550325 RGD:1580850, RGD:8554477 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel IEP protein:increased expression:kidney (rat) RGD PMID:12454224 RGD:1580868 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha treatment IDA RGD PMID:24918615 RGD:10059636 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rnls renalase, FAD-dependent amine oxidase ISO mRNA,protein:decreased expression:kidney,plasma: RGD PMID:23393318 PMID:23393318 RGD:7327166, RGD:7327166 NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823
JBrowse link
G Serpina1 serpin family A member 1 treatment ISO RGD PMID:28235038 RGD:14695051 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Serpinc1 serpin family C member 1 severity IMP RGD PMID:26108065 PMID:26108065 RGD:11354006, RGD:11354006 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpinc1em2Mcwi serpin family C member 1; ZFN induced mutant 2, Medical College of Wisconsin IMP RGD PMID:26108065 RGD:11354006
G Shh sonic hedgehog signaling molecule ISO mRNA, protein:increased expression:kidney RGD PMID:24744439 RGD:12859042 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Sirt1 sirtuin 1 treatment IEP RGD PMID:22324445 RGD:9495930 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc22a1 solute carrier family 22 member 1 IEP RGD PMID:21835768 RGD:7243877 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 IEP RGD PMID:21835768 RGD:7243877 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc34a1 solute carrier family 34 member 1 IEP protein:decreased expression:renal proximal tubule, brush border membrane (rat) RGD PMID:15775707 RGD:2311304 NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP RGD PMID:12819032 RGD:1580850 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat6 signal transducer and activator of transcription 6 severity ISO RGD PMID:12709397 RGD:7244143 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Tfpi tissue factor pathway inhibitor ISO RGD PMID:11796005 RGD:11062062 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tlr2 toll-like receptor 2 treatment
severity
IDA
ISO
RGD PMID:23239000 PMID:11801667 PMID:20130923 PMID:22750071 PMID:23023072 RGD:7207892, RGD:7241087, RGD:7240552, RGD:7207896, RGD:7207894 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 treatment IDA
ISO
RGD PMID:23239000 PMID:11801667 PMID:20130923 RGD:7207892, RGD:7241087, RGD:7240552 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:serum RGD PMID:19925291 RGD:2315112 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO mRNA:increased expression:lung RGD PMID:22728466 RGD:7245543 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP protein:increased expression:kidney RGD PMID:20164827 RGD:7240507 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vwf von Willebrand factor IEP protein:increased expression:serum: RGD PMID:12684225 RGD:11080744 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Xdh xanthine dehydrogenase treatment IMP associated with Diabetes Mellitus, Type 2 RGD PMID:22995295 PMID:20616412 RGD:7247637, RGD:7247695 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 IEP RGD PMID:20176611 RGD:11541086 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Alb albumin disease_progression ISO RGD PMID:24370342 RGD:11035281 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO RGD PMID:17298994 RGD:7241819 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccn2 cellular communication network factor 2 disease_progression IEP mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Clu clusterin treatment IEP RGD PMID:22494435 RGD:9068431 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:22845765 RGD:7241226 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp7 matrix metallopeptidase 7 treatment IDA RGD PMID:18209025 RGD:9685339 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Pdgfa platelet derived growth factor subunit A IEP RGD PMID:11889420 RGD:11080974 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP mRNA:increased expression:kidney: RGD PMID:15785371 PMID:11889420 RGD:10449491, RGD:11080974 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP RGD PMID:11889420 RGD:11080974 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEP RGD PMID:11889420 RGD:11080974 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Serpine1 serpin family E member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600, RGD:13208601 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18156
    disease of anatomical entity 17531
      cardiovascular system disease 4842
        vascular disease 3616
          Reperfusion Injury 729
            Kidney Reperfusion Injury 133
              Chronic Allograft Nephropathy 14
Path 2
Term Annotations click to browse term
  disease 18156
    disease of anatomical entity 17531
      Urogenital Diseases 4703
        urinary system disease 2393
          kidney disease 2163
            kidney failure 509
              acute kidney failure 293
                Kidney Reperfusion Injury 133
                  Chronic Allograft Nephropathy 14
paths to the root