RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: periodontitis
Accession: DOID:824
browse the term
Definition: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Synonyms: exact_synonym: Pericementitides; Pericementitis; Periodontitides; chronic pericementitis
primary_id: MESH:D010518
alt_id: RDO:0006318
xref: ICD10CM:K05.3 ; NCI:C34918
For additional species annotation, visit the
Alliance of Genome Resources .
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Adrb1
adrenoceptor beta 1
IMP ISO ISS
MouseDO RGD
PMID:18275933 PMID:21958237
RGD:5129135 , RGD:7241545
NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
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Ager
advanced glycosylation end product-specific receptor
ISO IEP
protein:increased expression:periodontium (rat)
RGD
PMID:22795565 PMID:22924807
RGD:6784499 , RGD:7245487
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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App
amyloid beta precursor protein
ISO
mRNA:increased expression:gingiva
RGD
PMID:28285126
RGD:13801025
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Ccl2
C-C motif chemokine ligand 2
IEP
protein:increased expression:gingiva
RGD
PMID:17876613
RGD:2306992
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccr1
C-C motif chemokine receptor 1
ISO
RGD
PMID:20053385
RGD:5688142
NCBI chr 8:123,556,286...123,561,841
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Cd14
CD14 molecule
IEP
protein:increased expression:monocyte, neutrophil:
RGD
PMID:17565820
RGD:7191232
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd274
CD274 molecule
IEP
protein:increased expression:periodontium
RGD
PMID:32346701
RGD:40886271
NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd40lg
CD40 ligand
ISO
protein:increased expression:serum (human)
RGD
PMID:22523383
RGD:11352302
NCBI chr X:135,127,119...135,138,302
Ensembl chr X:135,126,969...135,138,306
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Cldn1
claudin 1
IEP
mRNA,protein:decreased expression:epithelium:
RGD
PMID:22092031
RGD:11344891
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20011938
NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
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Cxcl12
C-X-C motif chemokine ligand 12
ISO
RGD
PMID:18454663
RGD:2306575
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcl2
C-X-C motif chemokine ligand 2
IEP
protein:increased expression:gingival epithelium
RGD
PMID:20096665
RGD:5135002
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
ISO ISS
MouseDO RGD
PMID:15491310
RGD:14700983
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Elane
elastase, neutrophil expressed
susceptibility
ISO ISS
associated with Severe Congenital Neutropenia;DNA:mutations: :
MouseDO RGD
PMID:21796505
RGD:10450515
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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Fmod
fibromodulin
ISO
protein:increased expression:gingiva
RGD
PMID:15196146
RGD:2315079
NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
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Fpr1
formyl peptide receptor 1
ISO
ClinVar Annotator: match by term: Periodontitis
ClinVar
PMID:28492532
NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
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Ggt1
gamma-glutamyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12747453
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Gnrh1
gonadotropin releasing hormone 1
ISO ISS
DNA:snp:exon:c.59C>G (human)
MouseDO RGD
PMID:15490304
RGD:9685136
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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Gstm1
glutathione S-transferase mu 1
ISO ISS
MouseDO RGD
PMID:15491310
RGD:14700983
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Hmgb1
high mobility group box 1
IEP
protein:increased expression:gingiva
RGD
PMID:24692854
RGD:10402172
NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
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Ifngr1
interferon gamma receptor 1
ISO
RGD
PMID:20655098
RGD:6480271
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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Il10
interleukin 10
treatment
IEP ISO
associated with type 2 diabetes mellitus
RGD
PMID:23843954 PMID:30405072 PMID:27795360
RGD:7364998 , RGD:14975259 , RGD:14975132
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1a
interleukin 1 alpha
ISO
mRNA:increased expression:gingiva
RGD
PMID:22795294
RGD:6906881
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
treatment
ISO IEP
mRNA:increased expression:gingiva associated with Severe Congenital Neutropenia;protein:increased expression:gingival crevicular fluid mRNA:increased expression:gingiva, stroma (rat)
RGD
PMID:22795294 PMID:21796505 PMID:27795360 PMID:24586097 PMID:23167849
RGD:6906881 , RGD:10450515 , RGD:14975132 , RGD:10450598 , RGD:7175547
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
susceptibility
ISO ISS
mRNA:increased expression:gingiva associated with Kidney Failure, Chronic;DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)
MouseDO RGD
PMID:22795294 PMID:22795294
RGD:6906881 , RGD:6906881
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il33
interleukin 33
severity
ISO
associated with Gram-Negative Bacterial Infections;mRNA:increased expression:gingvia
RGD
PMID:25808546 PMID:25808546
RGD:39938855 , RGD:39938855
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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Il6
interleukin 6
susceptibility treatment
ISO ISS
chronic periodontitis
MouseDO RGD
PMID:17209781 PMID:27795360
RGD:1601588 , RGD:14975132
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jak1
Janus kinase 1
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:26825585 PMID:23333931
RGD:18936995 , RGD:18936997
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Lbp
lipopolysaccharide binding protein
IEP
associated with Diabetes Mellitus, Type 2;mRNA:increased expression:gingiva
RGD
PMID:23730973
RGD:9685198
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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Met
MET proto-oncogene, receptor tyrosine kinase
IEP
mRNA, protein:increased expression:gingival pocket (rat)
RGD
PMID:16827730
RGD:2317520
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mme
membrane metallo-endopeptidase
ISO
mRNA:increased expression:gingiva
RGD
PMID:28285126
RGD:13801025
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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Mmp1
matrix metallopeptidase 1
ISO
protein:increased expression, increased activity:gingiva, gingival crevicular fluid (human)
RGD
PMID:11876270
RGD:7207044
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp13
matrix metallopeptidase 13
IEP
RGD
PMID:19393988
RGD:10043174
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Mmp2
matrix metallopeptidase 2
IEP
protein:increased expression: periodontal ligament
RGD
PMID:16845949
RGD:2325939
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3
matrix metallopeptidase 3
IEP
protein:increased expression:serum
RGD
PMID:19961752
RGD:2325862
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22808498 PMID:24640096
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nampt
nicotinamide phosphoribosyltransferase
IEP
associated with type 2 diabetes mellitus;mRNA:increased expression:adipose tissue:
RGD
PMID:26456152
RGD:13781894
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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Ntrk1
neurotrophic receptor tyrosine kinase 1
IEP
protein:increased expression:neuron
RGD
PMID:20200421
RGD:5684768
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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Parp1
poly (ADP-ribose) polymerase 1
ISO
RGD
PMID:14630900
RGD:10413909
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pdcd1
programmed cell death 1
IEP
protein:increased expression:periodontium
RGD
PMID:32346701
RGD:40886271
NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
protein:increased expression:gingiva, blood vessels (mouse)
RGD
PMID:21979132
RGD:6771178
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Postn
periostin
IEP
protein:decreased expression:mandible:
RGD
PMID:24212842
RGD:10041024
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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Ppara
peroxisome proliferator activated receptor alpha
IDA
possible therapeutic target
RGD
PMID:21253492
RGD:5509938
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ripk3
receptor-interacting serine-threonine kinase 3
treatment
ISO
associated with Gram-Negative Bacterial Infections
RGD
PMID:31758083
RGD:127229920
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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Stat1
signal transducer and activator of transcription 1
treatment
ISO
RGD
PMID:26825585
RGD:18936995
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
treatment
ISO
RGD
PMID:26825585
RGD:18936995
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tlr4
toll-like receptor 4
ISO
ClinVar Annotator: match by term: Pericementitis
ClinVar
PMID:10835634 PMID:12124407 PMID:15547160 PMID:15829498 PMID:16879199 PMID:17704786 PMID:26079505 PMID:26174031 More...
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
treatment
IEP
RGD
PMID:24586097
RGD:10450598
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trem1
triggering receptor expressed on myeloid cells 1
IEP
mRNA,protein:increased expression:periodontium
RGD
PMID:29972971
RGD:127284858
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Vcam1
vascular cell adhesion molecule 1
IEP
associated with obesity;protein:increased expression:aorta:
RGD
PMID:20065945
RGD:7240508
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vdr
vitamin D receptor
ISO
GAD
PMID:15118671
RGD:1331525
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vip
vasoactive intestinal peptide
IDA
RGD
PMID:19792856
RGD:5685624
NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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Brinp3
BMP/retinoic acid inducible neural specific 3
ISO
mRNA:increased expression:saliva
RGD
PMID:20383335
RGD:14398489
NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770
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Ccl2
C-C motif chemokine ligand 2
susceptibility
ISO ISS
DNA:polymorphism,haplotype::2518A>G(human) OMIM:170650 | OMIM:608526
MouseDO RGD
PMID:21264360
RGD:8661707
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccr2
C-C motif chemokine receptor 2
susceptibility
ISO ISS
DNA:polymorphism,haplotype:cds:p.V64I(human) OMIM:170650 | OMIM:608526
MouseDO RGD
PMID:21264360
RGD:8661707
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Col1a1
collagen type I alpha 1 chain
ISO ISS
DNA:SNP OMIM:170650 | OMIM:608526
MouseDO RGD
PMID:15081423
RGD:5688299
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Crp
C-reactive protein
ISO
protein:increased expression:serum:
RGD
PMID:16013223
RGD:9491835
NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
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Ctsc
cathepsin C
ISO
ClinVar Annotator: match by term: Aggressive Periodontitis | ClinVar Annotator: match by term: Periodontitis, aggressive 1
OMIM ClinVar
PMID:10581027 PMID:10662808 PMID:14974080 PMID:23311634 PMID:24033266 PMID:24936511 PMID:25741868 PMID:28492532 More...
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Gstm1
glutathione S-transferase mu 1
ISO ISS
OMIM:170650 | OMIM:608526
MouseDO RGD
PMID:17524385
RGD:14700939
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Gstt1
glutathione S-transferase theta 1
ISO ISS
OMIM:170650 | OMIM:608526
MouseDO RGD
PMID:17524385
RGD:14700939
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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Il10
interleukin 10
ISO ISS
DNA:SNP:promoter:-592C>A (rs1800872) (human) OMIM:170650 | OMIM:608526 protien:decreased expression:plasma
MouseDO RGD
PMID:28662328 PMID:28868949
RGD:14975139 , RGD:14975264
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1r2
interleukin 1 receptor type 2
ISO ISS
associated with Periodontitis; OMIM:170650 | OMIM:608526 DNA:SNPs,haplotype: :rs3819370, rs3218974,rs3218977(human)
MouseDO RGD
PMID:18315432 PMID:24818754
RGD:8662884 , RGD:8662885
NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
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Il2
interleukin 2
ISO
RGD
PMID:21730256
RGD:5147873
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il6
interleukin 6
ISO ISS
DNA:SNP:promoter:-174G>C (human) OMIM:170650 | OMIM:608526
MouseDO RGD
PMID:28662328
RGD:14975139
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Postn
periostin
ISS
OMIM:170650 | OMIM:608526
MouseDO
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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Ppia
peptidylprolyl isomerase A
ISO
protein:increased expression:gingiva (human)
RGD
PMID:27176139
RGD:150429628
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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Brinp3
BMP/retinoic acid inducible neural specific 3
susceptibility
ISO
DNA:SNP: :rs1935881(human)
RGD
PMID:25887438
RGD:14398485
NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770
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Ccl2
C-C motif chemokine ligand 2
ISO
RGD
PMID:20059422
RGD:8661721
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl7
C-C motif chemokine ligand 7
disease_progression
ISO
protein:increased expression:gingival crevicular fluid, gingvia
RGD
PMID:20151806
RGD:6483776
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccr2
C-C motif chemokine receptor 2
ISO
RGD
PMID:20059422
RGD:8661721
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Cxcl12
C-X-C motif chemokine ligand 12
ISO
mRNA:increased expression:gingival tissues (human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20731768 PMID:21382035
RGD:6480655
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcr4
C-X-C motif chemokine receptor 4
ISO
mRNA:increased expression:gingival tissues (human)
RGD
PMID:21382035
RGD:6480655
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Dsc1
desmocollin 1
ISO
mRNA:decreased expression:gingival tissues (human)
RGD
PMID:21382035
RGD:6480655
NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494
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Dsg1
desmoglein 1
ISO
mRNA:decreased expression:gingival tissues (human)
RGD
PMID:21382035
RGD:6480655
NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443
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Esr1
estrogen receptor 1
no_association
ISO
DNA:polymorphism
RGD
PMID:15324358 PMID:15324358
RGD:10045837 , RGD:10045837
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Gstm1
glutathione S-transferase mu 1
ISO
RGD
PMID:17524385
RGD:14700939
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Il10
interleukin 10
ISO
DNA:SNPs, haplotype:promoter:-592C>A, -819 C>T, -1082G>A (human)
RGD
PMID:31055876
RGD:14975127
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1rl1
interleukin 1 receptor-like 1
ISO
mRNA:increased expression:gingiva
RGD
PMID:25808546
RGD:39938855
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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Il33
interleukin 33
ISO
mRNA,protein:increased expression:gingiva
RGD
PMID:25808546
RGD:39938855
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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Itgb2
integrin subunit beta 2
ISO
mRNA:increased expression:gingival tissues (human)
RGD
PMID:21382035
RGD:6480655
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Mir155
microRNA 155
treatment
ISO
RGD
PMID:29517812
RGD:21403685
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Mmp1
matrix metallopeptidase 1
severity no_association
ISO
mRNA:increased expression:gingiva (human) DNA:insertion:promoter:g.-1607insG (human)
RGD
PMID:22401717 PMID:12622858 PMID:15312099
RGD:7206856 , RGD:7207045 , RGD:7207046
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp2
matrix metallopeptidase 2
treatment
ISO IDA
mRNA:increased expression:gingival tissues (human) associated with Atherosclerosis
RGD
PMID:21382035 PMID:24820783
RGD:6480655 , RGD:13207324
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
treatment
IDA
associated with Atherosclerosis
RGD
PMID:24820783
RGD:13207324
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nes
nestin
ISO
mRNA:decreased expression:gingival tissues (human)
RGD
PMID:21382035
RGD:6480655
NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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Rac2
Rac family small GTPase 2
ISO
mRNA:increased expression:gingival tissues (human)
RGD
PMID:21382035
RGD:6480655
NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
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Ripk3
receptor-interacting serine-threonine kinase 3
ISO
protein:increased expression,'increased phosphorylation:gingiva (human)
RGD
PMID:30814594
RGD:127229937
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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Tlr2
toll-like receptor 2
severity
ISO
protein:increased expression:gingiva:
RGD
PMID:21848608
RGD:7794852
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr3
toll-like receptor 3
severity
ISO
protein:increased expression:gingiva:
RGD
PMID:21848608
RGD:7794852
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
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Tlr4
toll-like receptor 4
severity
ISO
protein:increased expression:gingiva:
RGD
PMID:21848608
RGD:7794852
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr9
toll-like receptor 9
severity
ISO
protein:increased expression:gingiva:
RGD
PMID:21848608
RGD:7794852
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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Tnfsf11
TNF superfamily member 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20731768
NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
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Vdr
vitamin D receptor
susceptibility
ISO
DNA:SNP:exon:rs731236(human)
RGD
PMID:14572874
RGD:14402032
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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C1r
complement C1r
ISO
ClinVar Annotator: match by term: Ehlers-Danlos syndrome, periodontal type 1
OMIM ClinVar
PMID:890102 PMID:2260589 PMID:12776252 PMID:22739343 PMID:25741868 PMID:27663155 PMID:27745832 PMID:33268848 More...
NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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C1s
complement C1s
ISO
ClinVar Annotator: match by term: Ehlers-Danlos syndrome, periodontal type 1
ClinVar
PMID:27745832
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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C1r
complement C1r
ISO
ClinVar Annotator: match by term: Ehlers-Danlos syndrome, periodontal type 2
ClinVar
PMID:890102 PMID:2260589 PMID:12776252 PMID:22739343 PMID:27663155 PMID:27745832 More...
NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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C1s
complement C1s
ISO
ClinVar Annotator: match by term: Ehlers-Danlos syndrome, periodontal type 2
OMIM ClinVar
PMID:25741868 PMID:27745832 PMID:28492532
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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Ccl7
C-C motif chemokine ligand 7
ISO
protein:increased expression:periodontal ligament
RGD
PMID:20646081
RGD:6483772
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccr2
C-C motif chemokine receptor 2
ISO
mRNA:increased expression:gingiva:
RGD
PMID:16101967
RGD:8661719
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Ccr3
C-C motif chemokine receptor 3
ISO
RGD
PMID:11683586
RGD:6893426
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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Ccl2
C-C motif chemokine ligand 2
IEP
RGD
PMID:24631631
RGD:8661717
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl7
C-C motif chemokine ligand 7
disease_progression
ISO
protein:increased expression:periodontal ligament
RGD
PMID:20646081
RGD:6483772
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccr2
C-C motif chemokine receptor 2
IEP
RGD
PMID:24631631
RGD:8661717
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Ciita
class II, major histocompatibility complex, transactivator
IDA
RGD
PMID:20478458
RGD:7242892
NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
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Cxcr2
C-X-C motif chemokine receptor 2
IEP
RGD
PMID:22341067
RGD:7257692
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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Fgf2
fibroblast growth factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16631837
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Il17a
interleukin 17A
IEP
protein:increased expression:Periapical Tissue
RGD
PMID:19166776
RGD:4832829
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Tnfrsf11b
TNF receptor superfamily member 11B
treatment
IEP
Lactobacillus acidophilus
RGD
PMID:32436602
RGD:42721981
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
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Elane
elastase, neutrophil expressed
IEP
protein:increased expression:neutrophil:
RGD
PMID:19913217
RGD:10450566
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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