Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Alzheimer's disease
go back to main search page
Accession:DOID:10652 term browser browse the term
Definition:A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Synonyms:exact_synonym: AD;   Alzheimer Disease;   Alzheimer Disease, Susceptibility To;   Alzheimer Sclerosis;   Alzheimer Syndrome;   Alzheimer Type Dementia;   Alzheimer Type Dementia (ATD);   Alzheimer Type Senile Dementia;   Alzheimer dementia (AD);   Alzheimers dementia;   Early Onset Alzheimer Disease;   Familial Alzheimer Disease (FAD);   Focal Onset Alzheimer's Disease;   Late Onset Alzheimer Disease;   Presenile Alzheimer Dementia;   SDAT;   acute confusional senile dementia;   presenile dementia;   primary senile degenerative dementia;   senile dementia
 narrow_synonym: ALZHEIMER DISEASE, EARLY-ONSET, WITH CEREBRAL AMYLOID ANGIOPATHY;   ALZHEIMER DISEASE, PROTECTION AGAINST;   EARLY-ONSET FAMILIAL ALZHEIMER DISEASE;   presenile and senile dementia
 related_synonym: Alzheimer Disease, Early-Onset, Susceptibility To;   Alzheimer Disease, Late-Onset, Susceptibility To;   Alzheimer disease, association with;   alpha-2-macroglobulin polymorphism;   familial Alzheimer disease;   transferrin variant C1/C2
 primary_id: MESH:D000544
 alt_id: OMIM:502500
 xref: GARD:10254;   ICD9CM:331.0;   NCI:C2866
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
Alzheimer's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin no_association
onset
ISO ClinVar Annotator: match by term: ALPHA-2-MACROGLOBULIN POLYMORPHISM
ClinVar Annotator: match by term: Alzheimer disease, susceptibility to
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms: :multiple
DNA:deletion, polymorphisms, haplotypes: :multiple
DNA:polymorphism: :p.I1000V (human)
DNA:insertion/deletion, substitution
DNA:deletion:splice junction:
ClinVar
CTD
RGD
PMID:1370808 PMID:1717945 PMID:9697696 PMID:9811940 PMID:15023809 More... RGD:1300322, RGD:10046016, RGD:10046016, RGD:10046015, RGD:10046014, RGD:10046012, RGD:1302534 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abat 4-aminobutyrate aminotransferase ISO RGD PMID:1627256 RGD:10046060 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 ISO RGD PMID:15024730 RGD:1300323 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, early onset
CTD
ClinVar
PMID:21460840 PMID:25741868 PMID:25807283 PMID:26141617 PMID:27066581 More... NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A ISO RGD PMID:25991605 RGD:13801010 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO RGD PMID:25991605 RGD:13801010 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abi3 ABI family, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28714976 NCBI chr10:80,769,819...80,780,816
Ensembl chr10:80,769,822...80,780,816
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO protein:increased expression:brain: RGD PMID:19700222 RGD:8693570 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain ISO protein:decreased expression:brain RGD PMID:25260493 RGD:10047114 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
JBrowse link
G Ace angiotensin I converting enzyme IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:9916793 PMID:10643899 PMID:14872014 PMID:17192785 PMID:30820047 More... RGD:2325232, RGD:1331525 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ache acetylcholinesterase ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:22944069 PMID:23047022 PMID:16581404 RGD:5509844 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 IEP
ISO
protein:decreased expression:cerebral cortex, hippocampus
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:30820047 PMID:23296102 PMID:24792732 RGD:13703032, RGD:13703037 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 onset IEP
ISO
protein:decreased expression:cerebral cortex, hippocampus
DNA:missense mutation: :p.R215I (rs142946965) (human)
RGD PMID:24792732 PMID:29988083 RGD:13703037, RGD:13782143 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adam2 ADAM metallopeptidase domain 2 ISO protein:increased expression:brain RGD PMID:10686596 RGD:10047127 NCBI chr15:40,242,783...40,284,025
Ensembl chr15:40,242,783...40,283,952
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 IEP protein:decreased expression:hippocampus RGD PMID:24792732 RGD:13703037 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 ISO ClinVar Annotator: match by term: Alzheimer's disease
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:16369530 PMID:16921174 PMID:24691562 PMID:30820047 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:plasma
protein:increased expression:cerebrospinal fluid, plasma
RGD PMID:22213409 PMID:20727007 RGD:5686377, RGD:5686881 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adnp activity-dependent neuroprotector homeobox ISO RGD PMID:18199809 PMID:17720885 RGD:2312791, RGD:2312792 NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312
JBrowse link
G Adra1a adrenoceptor alpha 1A susceptibility ISO RGD PMID:114750 RGD:5688374 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adrb3 adrenoceptor beta 3 ISO DNA:missense mutation:cds:p.W64R (human) RGD PMID:17440948 RGD:2311642 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO
IDA
IEP
protein:increased expression:brain (human)
mRNA:increased expression:hippocampus, cerebral cortex (mouse)
protein:increased expression:hippocampus (rat)
RGD PMID:8751438 PMID:21593432 PMID:23164356 PMID:23396166 PMID:23396166 More... RGD:1300365, RGD:7245965, RGD:7244287, RGD:7244266, RGD:7244266, RGD:6784502 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen ISO protein:increased expression:cerebrospinal fluid RGD PMID:21297254 RGD:5129180 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment ISO protein:decreased expression:substantia nigra: RGD PMID:21929736 PMID:8666063 RGD:10047395, RGD:10047397 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Aif1 allograft inflammatory factor 1 ISO mRNA:increased expression:frontal cortex (human)
protein:altered expression:hippocampus (mouse)
RGD PMID:16340083 PMID:19084047 RGD:2313045, RGD:2313023 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 ISO protein:increased expression:cortex,nucleus:
protein:increased expression:basal forebrain,amygdala:
RGD PMID:24915960 PMID:22536549 RGD:10053592, RGD:10053593 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akap5 A-kinase anchoring protein 5 ISO protein:increased expression:cell soma, dendritic arbor (human) RGD PMID:10460255 RGD:2313287 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 ISO protein:increased expression:superior, middle temporal gyrus; RGD PMID:11597610 RGD:14349051 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO protein:increased tyrosine phosphorylation:cerebral cortex RGD PMID:18023354 RGD:5509085 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member onset ISO RGD PMID:15126281 RGD:1599042 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO protein:increased expression:brain RGD PMID:20570249 PMID:15111312 RGD:5509595, RGD:5509620 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Ambra1 autophagy and beclin 1 regulator 1 ISO RGD PMID:23910655 RGD:14390071 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221
JBrowse link
G Amfr autocrine motility factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22313999 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
JBrowse link
G Ang angiogenin severity ISO protein:decreased expression:serum RGD PMID:22449478 RGD:6892705 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Anxa5 annexin A5 ISO protein:increased expression:brain, plasma
protein:increased expression: plasma
RGD PMID:20648654 PMID:20648654 RGD:7242030, RGD:7242030 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Aoc3 amine oxidase, copper containing 3 severity ISO protein:increased expression:plasma RGD PMID:17393059 RGD:2313919 NCBI chr10:86,272,757...86,280,702 JBrowse link
G Apbb1 amyloid beta precursor protein binding family B member 1 susceptibility
no_association
ISO DNA:mutations::multiple
mRNA:altered expression:brain:
DNA:deletion:intron:
DNA:polymorphism:intron:
RGD PMID:9799084 PMID:10723070 PMID:12727304 PMID:11099823 RGD:2301212, RGD:10054036, RGD:10054031, RGD:10054028 NCBI chr 1:159,896,889...159,920,505
Ensembl chr 1:159,896,880...159,920,627
JBrowse link
G Apbb2 amyloid beta precursor protein binding family B member 2 onset ISO DNA:SNPs: :rs13133980,rs17443013(human) RGD PMID:15714520 RGD:9684954 NCBI chr14:41,557,918...41,878,622 JBrowse link
G Apc APC regulator of WNT signaling pathway ISO protein:increased expression:astrocyte RGD PMID:11547943 RGD:6484525 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit treatment ISO RGD PMID:28588301 PMID:29926633 RGD:13703122, RGD:13703123 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
JBrowse link
G Aplp2 amyloid beta precursor like protein 2 IDA RGD PMID:8086458 RGD:734582 NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
JBrowse link
G Apoa1 apolipoprotein A1 resistance ISO DNA: : :transgenic model RGD PMID:20847045 PMID:19863188 RGD:5508212, RGD:5508218 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa4 apolipoprotein A4 no_association ISO DNA:missense mutation:cds:p.Q360H (human)
DNA:snp, haplotype:cds:p.S147N (rs5104) (human)
RGD PMID:21356380 PMID:10559562 PMID:9272683 PMID:16013913 RGD:5685638, RGD:5685682, RGD:5685681, RGD:5685661 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoc1 apolipoprotein C1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:29107063 PMID:30319691 PMID:11825674 RGD:1578472 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
JBrowse link
G Apod apolipoprotein D ISO protein:increased expression:cerebrospinal fluid, hippocampus RGD PMID:9751198 RGD:2311209 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Apoe apolipoprotein E susceptibility
treatment
no_association
ISO
IEP
ClinVar Annotator: match by term: Late onset Alzheimer disease
DNA:SNP: :APOEe4(human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:-491A>T,-427T>C(human)
protein:increased expression:hippocampus, synapse (rat)
protein:increased expression:parietal cortex, synapse (human)
DNA:missense mutations, haplotype:cds:p.C112R, (rs7412) (human)
ClinVar
CTD
RGD
PMID:2987927 PMID:3922972 PMID:7263700 PMID:8346443 PMID:8618665 More... RGD:1331525, RGD:10427727, RGD:12904712, RGD:7771594, RGD:6903910, RGD:6903910, RGD:6903233 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein susceptibility
treatment
ISO
IDA
IEP
ClinVar Annotator: match by term: Alzheimer disease
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease
human transgene in rat model
ClinVar Annotator: match by term: Alzheimer's disease
associated with hypertension
ClinVar Annotator: match by OMIM:104300
DNA:mutation:p.D678N (human)
protein:increased expression:cerebral spinal fluid fluid,brain:
protein:decreased expression:cerebrospinal fluid:
ClinVar Annotator: match by term: Alzheimer disease, protection against
ClinVar
CTD
RGD
PMID:1303239 PMID:1303275 PMID:1307241 PMID:1415269 PMID:1497677 More... RGD:1599199, RGD:2290385, RGD:13782183, RGD:13782049, RGD:13782047, RGD:13782044, RGD:10054280, RGD:1302530, RGD:10054258, RGD:10054257 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp4 aquaporin 4 ISO RGD PMID:21107133 RGD:5148012 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18503570 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Ass1 argininosuccinate synthase 1 ISO protein:increased expression:brain, glial cell (human) RGD PMID:11556547 RGD:4139898 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atf2 activating transcription factor 2 ISO RGD PMID:9138733 PMID:15878807 RGD:10047399, RGD:10047400 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atm ATM serine/threonine kinase disease_progression ISO RGD PMID:23861893 RGD:10047419 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha treatment
onset
ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:increased modification:inferior parietal cortex (human)
CTD
RGD
PMID:19374891 PMID:25561935 PMID:19374891 RGD:13703056, RGD:13703046 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta ISO RGD PMID:28474567 RGD:13792588 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
JBrowse link
G Atp5mg ATP synthase membrane subunit g ISO RGD PMID:28474567 RGD:13792588 NCBI chr 8:45,226,750...45,233,582
Ensembl chr 8:45,225,686...45,233,559
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP treatment ISO RGD PMID:30266287 PMID:30266287 RGD:14696823, RGD:14696823 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
JBrowse link
G Atp6v0e1 ATPase H+ transporting V0 subunit e1 ISO RGD PMID:23211594 RGD:10401913 NCBI chr10:16,479,656...16,502,732
Ensembl chr10:16,479,567...16,524,434
JBrowse link
G Atp7a ATPase copper transporting alpha IEP mRNA:decreased expression:pituitary gland, vascular plexus (rat) RGD PMID:20027333 RGD:8657017 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atr ATR serine/threonine kinase ISO RGD PMID:23861893 RGD:10047419 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Bace1 beta-secretase 1 susceptibility
treatment
ISO
IEP
CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:12824768 PMID:16407166 PMID:12824768 PMID:28763060 PMID:29038004 RGD:1358439, RGD:1358439, RGD:13782083, RGD:13782077 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bace2 beta-secretase 2 susceptibility ISO mRNA,protein:increased expression:gyrus:
DNA:SNP,haplotype:exon:
RGD PMID:22074738 PMID:16023140 RGD:13782172, RGD:13782180 NCBI chr11:36,707,473...36,789,550
Ensembl chr11:36,707,458...36,789,546
JBrowse link
G Bad BCL2-associated agonist of cell death treatment ISO protein:increased expression:temporal cortex, membrane RGD PMID:15339646 PMID:9507158 RGD:10053639, RGD:10053642 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 ISO protein:decreased expression:cerebral cortex, postsynaptic density (human) RGD PMID:23537733 RGD:11576299 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134
JBrowse link
G Bak1 BCL2-antagonist/killer 1 ISO protein:increased expression:temporal cortex, membrane RGD PMID:9507158 RGD:10053642 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Barhl1 BarH-like homeobox 1 ISO protein:decreased expression:brain RGD PMID:28956815 RGD:14390165 NCBI chr 3:12,241,327...12,248,649
Ensembl chr 3:12,241,327...12,248,649
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18077176 PMID:17639989 PMID:29587274 PMID:29777699 PMID:21585051 More... RGD:2293073, RGD:13782188, RGD:13782186, RGD:10054049, RGD:10054047, RGD:10054039 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcan brevican ISO protein:altered modification:brain RGD PMID:20180882 RGD:14392785 NCBI chr 2:173,454,479...173,467,717
Ensembl chr 2:173,454,482...173,467,460
JBrowse link
G Bche butyrylcholinesterase severity ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:23022600 PMID:22012848 PMID:16973370 RGD:5687327, RGD:5688056 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP
ISO
IDA
CTD Direct Evidence: marker/mechanism
protein:increased expression:temporal cortex, membrane
CTD
RGD
PMID:18077176 PMID:17639989 PMID:29587274 PMID:29777699 PMID:26897372 More... RGD:2293073, RGD:13782188, RGD:13782186, RGD:11522767, RGD:10054049, RGD:10054047, RGD:10053642 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 ISO protein:increased expression:temporal cortex, membrane RGD PMID:9507158 RGD:10053642 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l2 Bcl2-like 2 treatment ISO
IEP
protein:increased expression:hippocampus, cortex RGD PMID:15147516 PMID:20460763 RGD:14394419, RGD:14394421 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bdnf brain-derived neurotrophic factor treatment
no_association
onset
IMP
ISO
IEP
CTD Direct Evidence: marker/mechanism
DNA:polymorphisms: :196G>A (p.V66M), 270C>T (human)
DNA:polymorphisms, haplotypes: :196G>A (p.V66M), 270C>T, 11757G>C (human)
DNA:polymorphism: :p.V66M (human)
protein:decreased expression:parietal cortex
DNA:SNP:CDS:rs1048218 (human)
CTD
RGD
PMID:17344400 PMID:20646587 PMID:24877042 PMID:16565926 PMID:23215636 More... RGD:4891131, RGD:10059402, RGD:10059346, RGD:10059345, RGD:10059343, RGD:10058980, RGD:5508228, RGD:1331525 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 ISO protein:decreased expression:gray matter RGD PMID:18497889 PMID:20863706 RGD:6483101, RGD:6483102 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bin1 bridging integrator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460841 PMID:33589840 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO RGD PMID:19463786 RGD:10414082 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bptf bromodomain PHD finger transcription factor ISO protein:increased expression:microglia: RGD PMID:9792236 RGD:9586059 NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769
JBrowse link
G Brip1 BRCA1 interacting helicase 1 ISO associated with Down Syndrome;protein:increased ubiquitination:frontal cortex (human) RGD PMID:25391381 RGD:11252150 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
JBrowse link
G Btg3 BTG anti-proliferation factor 3 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
JBrowse link
G C1qb complement C1q B chain ISO mRNA:increased expression:microglial cell RGD PMID:1362796 RGD:1599518 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G C2 complement C2 ISO DNA:SNP, haplotype: :p.E318D (rs9332739) (human) RGD PMID:22300950 RGD:7401250 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G C3 complement C3 ISO DNA:SNP: :rs22300199 (human) RGD PMID:22300950 RGD:7401250 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C5ar1 complement C5a receptor 1 ISO protein:decreased expression:brain RGD PMID:12759460 RGD:5130177 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO protein:decreased expression:brain RGD PMID:23403102 RGD:13782264 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Calm1 calmodulin 1 ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:cerebellar cortex:
CTD
RGD
PMID:11470324 PMID:11470324 RGD:13792493 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calml5 calmodulin-like 5 ISO protein:altered expression:neuron,glia RGD PMID:11470324 RGD:13792493 NCBI chr17:66,394,433...66,395,390 JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO RGD PMID:15621017 RGD:13681926 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Capn1 calpain 1 onset ISO protein:increased activity:brain: RGD PMID:8622780 PMID:11231011 RGD:13792495, RGD:13792663 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capn2 calpain 2 ISO protein:increased expression:cytosol RGD PMID:9654354 RGD:13792661 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp1 caspase 1 ISO RGD PMID:12633148 RGD:13782269 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 treatment IEP RGD PMID:29126976 RGD:13782165 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp2 caspase 2 ISO RGD PMID:12633148 RGD:13782269 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18077176 PMID:10319819 PMID:29642617 PMID:12633148 PMID:29587274 More... RGD:734692, RGD:13782291, RGD:13782269, RGD:13782188, RGD:13782186 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 ISO RGD PMID:12633148 RGD:13782269 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 ISO DNA:SNPs, haplotype RGD PMID:26621834 PMID:12633148 RGD:11344490, RGD:13782269 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 treatment ISO
IEP
RGD PMID:16772874 PMID:29642617 PMID:12633148 RGD:13782268, RGD:13782291, RGD:13782269 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 treatment IEP
ISO
RGD PMID:29777699 PMID:12633148 RGD:13782186, RGD:13782269 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cass4 Cas scaffold protein family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30320580 PMID:33589840 NCBI chr 3:161,162,520...161,202,523
Ensembl chr 3:161,163,436...161,202,186
JBrowse link
G Cast calpastatin ISO protein:decreased expression:brain RGD PMID:20595388 PMID:19020018 RGD:5509799, RGD:5509809 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
JBrowse link
G Cav1 caveolin 1 ISS OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907 MouseDO NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccdc6 coiled-coil domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr20:18,432,177...18,528,186
Ensembl chr20:18,433,695...18,528,658
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:cerebrum, blood vessels (human) RGD PMID:18440671 RGD:4890025 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccng1 cyclin G1 ISO protein:increased expression:brain, neuron RGD PMID:12214116 RGD:2316025 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 severity ISO RGD PMID:14595653 RGD:5688166 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO
IMP
protein:increased expression:brain, microglia (human) RGD PMID:9665462 PMID:15979806 RGD:4890447, RGD:4890446 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd2ap CD2-associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460840 PMID:21460841 PMID:30320580 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199
JBrowse link
G Cd33 CD33 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460840 PMID:21460841 NCBI chr 1:93,935,418...93,940,452
Ensembl chr 1:93,930,971...93,950,149
JBrowse link
G Cd36 CD36 molecule ISO RGD PMID:16563568 RGD:6893531 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:21414686 RGD:5490302 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:frontal cortex, astrocyte RGD PMID:11755016 PMID:11755016 RGD:8547803, RGD:8547803 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:10817927 RGD:5688277 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdk5 cyclin-dependent kinase 5 treatment IEP
ISO
DNA:SNP:intron:g.149800G>C (human) RGD PMID:28269780 PMID:28085018 PMID:15917097 RGD:13508590, RGD:13792587, RGD:13782365 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 ISO DNA:SNP:3' UTR:rs735555 (human) RGD PMID:28578378 PMID:19154537 PMID:24725413 RGD:13782362, RGD:13782364, RGD:13782363 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cdk7 cyclin-dependent kinase 7 ISO protein:increased expression:neuron: RGD PMID:11124424 RGD:10059352 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha ISO protein:decreased expression:forebrain, hindbrain (mouse)
mRNA:increased expression:hippocampus (human)
RGD PMID:21492414 PMID:14769913 RGD:10401190, RGD:10401224 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta treatment ISO mRNA:increased expression:hippocampus CA1 (human) RGD PMID:12391607 PMID:23911420 RGD:10401229, RGD:10401268 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cftr CF transmembrane conductance regulator ISO protein:decreased expression:hypothalamus RGD PMID:14757935 RGD:11566025 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chat choline O-acetyltransferase IEP
ISO
DNA:polymorphism:CDS:4G>A (human) RGD PMID:16834974 PMID:12401548 RGD:1600851, RGD:1358495 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chodl chondrolectin ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:17,654,137...17,676,450
Ensembl chr11:17,654,206...17,676,441
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO RGD PMID:15465084 RGD:1358509 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18071042 PMID:15465084 RGD:1358509 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17192785 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cib1 calcium and integrin binding 1 IEP protein:decreased expression:brain (human) RGD PMID:15885068 RGD:10401854 NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Clock clock circadian regulator susceptibility ISO DNA:snp:intron:c.982+247G>C (rs1554483) (human)
DNA:snp:3' utr:c.3111T>C (human)
DNA:snp:intron:c.560-1279C>G (rs4580704) (human)
RGD PMID:23781009 PMID:23912676 PMID:23357097 RGD:10401861, RGD:10401872, RGD:10401862 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
JBrowse link
G Clu clusterin ISO ClinVar Annotator: match by term: Alzheimer's disease
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
RGD
PMID:19734902 PMID:19734903 PMID:21460841 PMID:28492532 PMID:29476165 More... RGD:8903235 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase ISO RGD PMID:21918687 RGD:6483333 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C ISO RGD PMID:28474567 RGD:13792588 NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
JBrowse link
G Crebbp CREB binding protein treatment ISO protein:increased phosphorylation:hippocampus: RGD PMID:21149712 PMID:17760871 RGD:10059608, RGD:10059609 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crh corticotropin releasing hormone ISO protein:decreased expression:cerebral cortex (human)
CTD Direct Evidence: therapeutic
CTD
RGD
PMID:7477348 PMID:7477348 RGD:5508831 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crp C-reactive protein ISO RGD PMID:22202667 RGD:6904208 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:30279455 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:10514399 RGD:10395229 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
JBrowse link
G Csnk1d casein kinase 1, delta severity ISO protein:increased expression:CA1 field of hippocampus:
mRNA,protein:increased expression:brain:
RGD PMID:10514399 PMID:10814741 RGD:10395229, RGD:10395230 NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614
JBrowse link
G Csnk1e casein kinase 1, epsilon ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:10514399 RGD:10395229 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
JBrowse link
G Cst3 cystatin C susceptibility ISO protein:decreased expression:serum (human)
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
RGD
PMID:17192785 PMID:18026100 PMID:18824671 PMID:15907478 RGD:2314333, RGD:1358533 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Ctnnb1 catenin beta 1 treatment ISO
IEP
protein:increased expression:neuron,cytoplasm:
protein:decreased expression:hippocampus
protein:decreased expression:nucleus:
RGD PMID:15781969 PMID:12610652 PMID:11226152 RGD:10395258, RGD:10395276, RGD:1302533 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsd cathepsin D ISO RGD PMID:11304834 RGD:1358532 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctss cathepsin S ISO RGD PMID:7717452 RGD:5686914 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:16,982,752...17,030,078
Ensembl chr11:16,982,860...17,030,046
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 ISO mRNA:altered expression:cerebellum, hippocampus (human)
DNA:polymorphism
RGD PMID:18180323 PMID:16882736 RGD:4889108, RGD:1600861 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7574463 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19286353 PMID:12232784 RGD:1358575 NCBI chr 6:127,243,315...127,274,765
Ensembl chr 6:127,243,315...127,274,760
JBrowse link
G Cyyr1 cysteine and tyrosine rich 1 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:24,557,620...24,664,007
Ensembl chr11:24,515,316...24,663,961
JBrowse link
G Dbn1 drebrin 1 disease_progression ISO protein:decreased expression:hippocampal formation:
mRNA:decreased expression:parietal cortex, temporal cortex, hippocampus:
protein:decreased expression:hippocampus,neuronal spine:
RGD PMID:8838578 PMID:18338803 PMID:17912741 RGD:10395286, RGD:10398821, RGD:10398820 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23042211 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 ISO RGD PMID:24156266 RGD:13792688 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase susceptibility ISO DNA:polymorphisms: : RGD PMID:10227647 RGD:1358587 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Dnm1 dynamin 1 ISO
IEP
protein:decreased expression:hippocampus,entorhinal cortex:
mRNA,protein:decreased expression:hippocampus, temporal cortex
denntate gyrus, hippocampus, entorhinal cortex
RGD PMID:20847448 PMID:20847448 PMID:20847448 RGD:13506238, RGD:13506238, RGD:13506238 NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538
JBrowse link
G Dnm1l dynamin 1-like ISO protein:decreased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19374891 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Drd1 dopamine receptor D1 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 ISO protein:decreased expression:blood, lymphocyte RGD PMID:11087905 RGD:5686416 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd4 dopamine receptor D4 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Drd5 dopamine receptor D5 ISO protein:increased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chr14:72,489,347...72,490,774
Ensembl chr14:72,489,347...72,490,774
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 ISO protein:increased expression:brain RGD PMID:9402150 RGD:13207349 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
JBrowse link
G E2f1 E2F transcription factor 1 ISO protein:increased expression:cerebral cortex,cytoplasm: RGD PMID:11939591 RGD:10401093 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Ece1 endothelin converting enzyme 1 ISO RGD PMID:15340356 RGD:1580902 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 ISO protein:increased expression:CA1field of hippocampus: RGD PMID:8750861 RGD:10401216 NCBI chr 3:168,265,893...168,275,071 JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO protein:hyperphosphorylation:brain: RGD PMID:1331687 RGD:10401652 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase ISO RGD PMID:16098202 RGD:10401651 NCBI chr 1:175,393,119...175,454,452
Ensembl chr 1:175,393,154...175,455,164
JBrowse link
G Egf epidermal growth factor ISO protein:decreased expression:platelet RGD PMID:21875409 RGD:10059680 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor treatment ISO RGD PMID:23019586 RGD:10059684 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 treatment ISO protein:increased expression:temporal cortex, hippocampus (human) RGD PMID:21489990 PMID:23642031 PMID:21969301 RGD:5131647, RGD:10395279, RGD:10395277 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 ISO protein:increased threonine phosphorylation:hippocampus RGD PMID:24315369 PMID:15567511 RGD:10395344, RGD:10395348 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha severity ISO CTD Direct Evidence: marker/mechanism
protein:increased phosphorylation:hippocampus
CTD
RGD
PMID:17406652 PMID:16691116 PMID:24315369 PMID:16954686 RGD:10395316, RGD:10395344, RGD:10395343 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Elk1 ETS transcription factor ELK1 ISO RGD PMID:20126313 RGD:7488914 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased S-glutathionylation, decreased activity:inferior parietal cortex
CTD
RGD
PMID:19374891 PMID:17387692 RGD:13792613 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Ep300 E1A binding protein p300 ISO mRNA:increased expression:temporal cortex (human) RGD PMID:23585551 RGD:7327146 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epha1 Eph receptor A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460840 PMID:21460841 NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846
JBrowse link
G Epha4 Eph receptor A4 ISO protein:decreased expression:hippocampus RGD PMID:19542617 PMID:19542617 RGD:6218956, RGD:6218956 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Ephb2 Eph receptor B2 ameliorates ISO RGD PMID:21113149 RGD:12859080 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Ephx1 epoxide hydrolase 1 ISO protein:increased expression:hippocampus RGD PMID:16630050 RGD:5688388 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22004348 PMID:23813967 RGD:10395389, RGD:10400882 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epor erythropoietin receptor ISO protein:increased expression:brain, astrocyte RGD PMID:17483696 RGD:10395387 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit ISO protein:increased expression:brain RGD PMID:9714461 RGD:5688738 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO protein:increased expression:brain RGD PMID:9714461 RGD:5688738 NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329
JBrowse link
G Esr1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:17192785 PMID:10558867 RGD:1358612 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 susceptibility ISO DNA:SNPs:3' utr: (rs4986938), (rs1255953) (human)
DNA:snps:introns:IVS3-1880C>T, IVS4+1231C>T (rs1271573, rs1256043) (human)
protein:decreased expression:choroid plexus
mRNA:increased expression:cerebral cortex
RGD PMID:17132983 PMID:15944651 PMID:15082146 PMID:15916731 RGD:5508768, RGD:8693346, RGD:5508784, RGD:5508772 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:8333868 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fabp3 fatty acid binding protein 3 ISO protein:decreased expression:cerebral cortex (human) RGD PMID:15068254 RGD:1578460 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fadd Fas associated via death domain ISO RGD PMID:16085017 RGD:13782385 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor ISO DNA:snp:promoter:g.-670G>A (human)
protein:increased expression:brain, plaque (human)
RGD PMID:11129341 PMID:12742739 RGD:1358615, RGD:8663481 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fgf1 fibroblast growth factor 1 ISO RGD PMID:20079650 RGD:5509878 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:9748519 RGD:10402073 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fis1 fission, mitochondrial 1 ISO protein:increased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Foxo3 forkhead box O3 ISO protein:increased expression:lymphoblast,nucleus:
protein:increased expression:hippocampal neuron (mouse)
mRNA:increased expression:brain:
protein:altered expression:cortical neuron,nucleus:
RGD PMID:23153928 PMID:28157684 PMID:23585551 PMID:23661003 RGD:10402185, RGD:11061905, RGD:7327146, RGD:10402187 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 ISO RGD PMID:19760337 RGD:13801191 NCBI chr 8:45,679,054...45,705,958
Ensembl chr 8:45,678,885...45,705,958
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO protein:decreased expression:cerebral cortex, soluble fraction (human) RGD PMID:14999081 PMID:15708437 RGD:1358600, RGD:1358602 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase onset
susceptibility
ISO
IDA
DNA:snps:5' utr, intron: (rs3741916, rs1060621) (human)
protein:decreased activity:cerebral cortex, cerebellum
protein:decreased activity:cerebral cortex, hippocampus
protein:increased S-glutathionylation, decreased activity:inferior parietal cortex
DNA:SNPs, haplotypes: :rs740850, rs1060620 (human)
DNA:SNP:5' utr:rs3741916 (human)
RGD PMID:15507493 PMID:17324518 PMID:17324518 PMID:17387692 PMID:18340469 More... RGD:1358618, RGD:13792614, RGD:13792614, RGD:13792613, RGD:13792612, RGD:13792611, RGD:13792604 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic onset ISO DNA:snps:promoter, intron: (rs4806173, rs12984928) (human)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:17192785 PMID:15507493 RGD:1358618 NCBI chr 1:85,979,096...85,994,153
Ensembl chr 1:85,979,098...85,993,640
JBrowse link
G Gcg glucagon ISO RGD PMID:23035082 RGD:10402366 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO mRNA, protein:alternate form, decreased expression:brain RGD PMID:22081608 RGD:5688777 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Ghrh growth hormone releasing hormone treatment ISO RGD PMID:23211425 RGD:10401233 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889
JBrowse link
G Glud1 glutamate dehydrogenase 1 ISO protein:increased expression:brain
protein:increased expression, decreased oxidation:brain
RGD PMID:16341942 PMID:16298240 RGD:6484555, RGD:6484556 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Glul glutamate-ammonia ligase ISO protein:increased oxidation:brain (human)
protein:increased expression:cerebrospinal fluid:significant increase in active protein vs normal patients and controls with other neurological disorders (human)
RGD PMID:12160938 PMID:1361232 RGD:2301427, RGD:2301429 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gnas GNAS complex locus ISO RGD PMID:8012802 RGD:10401266 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Grid2ip Grid2 interacting protein ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar PMID:25741868 NCBI chr12:11,166,567...11,203,765
Ensembl chr12:11,167,874...11,203,676
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO RGD PMID:24156266 RGD:13792688 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:24156266 RGD:13792688 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B no_association ISO DNA:SNPs:promoter, exon, 3' utr:-200T>G (rs1019385), 2664C>T (rs1806201), 5072G>T (rs890) (human)
DNA:SNPs:promoter:-200T>G (rs1019385), -1447T>C, -1497G>A (rs12368476) (human)
DNA:SNP:promoter:-421C>A (rs3764028) (human)
DNA:SNP: :2664C>T (rs1806201) (human)
DNA:SNP, haplotype: :rs1806201 (human)
RGD PMID:24156266 PMID:18303265 PMID:18983893 PMID:18983893 PMID:24292895 More... RGD:13792688, RGD:13792714, RGD:13792713, RGD:13792713, RGD:13792709, RGD:13792709 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO DNA: deletion: exons 7,8: heterozygote RGD PMID:18522748 RGD:5688375 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Grn granulin precursor severity
onset
ISO DNA:SNP:3'UTR:rs5848(human)
ClinVar Annotator: match by term: Alzheimer's disease
DNA:SNPs: :rs5848, rs850713, rs4792939 (human)
DNA:mutations: :
mRNA, protein:increased expression:microglia, neuron:
DNA:deletion:exon:c.154delA(human)
ClinVar
RGD
PMID:30279455 PMID:20197700 PMID:19016491 PMID:18565828 PMID:19557827 More... RGD:5509600, RGD:10401636, RGD:5509616, RGD:5509606, RGD:5509601 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha treatment ISO RGD PMID:18410522 PMID:22623685 RGD:10401797, RGD:10401801 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO
IDA
DNA:SNP:promoter:rs334558 (human)
CTD Direct Evidence: marker/mechanism
protein:decreased phosphorylation:hippocampus:
DNA:altered methylation:CpG island:
CTD
RGD
PMID:17409235 PMID:22944069 PMID:11226152 PMID:29257340 PMID:27893738 More... RGD:1302533, RGD:13792777, RGD:13792736, RGD:13782364, RGD:10401801, RGD:10045670, RGD:10045669, RGD:10045668 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase treatment ISO
IEP
protein:decreased expression:blood
mRNA:increased expression:hippocampus
RGD PMID:17721818 PMID:21376020 PMID:19374888 PMID:10096042 RGD:10401827, RGD:10401857, RGD:10401849, RGD:10401847 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase ISO RGD PMID:15693022 RGD:5508441 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gstm3 glutathione S-transferase mu 3 ISO RGD PMID:15621212 RGD:5688745 NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 ISO DNA:SNP:cds: rs7483 (human) RGD PMID:18423940 RGD:5688729 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gsto1 glutathione S-transferase omega 1 onset
susceptibility
no_association
ISO DNA:polymorphism:exon:p. A140D (rs4925) (human) RGD PMID:14570706 PMID:20818931 PMID:15917099 RGD:1358651, RGD:5490521, RGD:5490514 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Gsto2 glutathione S-transferase omega 2 onset
no_association
ISO DDNA:polymorphism: : -183 A>G (rs2297235)(human)
DNA:polymorphism:promoter: -183 A>G (rs2297235)(human)
RGD PMID:14570706 PMID:15917099 RGD:1358651, RGD:5490514 NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866
JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility
onset
ISO mRNA:decreased expression:cerebral cortex
DNA:polymorphisms
DNA:polymorphism:exon:
RGD PMID:15805147 PMID:23211594 PMID:24584466 PMID:17911365 RGD:5490123, RGD:10401913, RGD:10401912, RGD:5490271 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 susceptibility
onset
ISO DNA:deletion: : RGD PMID:10215103 PMID:17911365 RGD:5490213, RGD:5490271 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 ISO RGD PMID:15571982 RGD:10401946 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO protein:decreased expression:brain RGD PMID:25260493 RGD:10047114 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta ISO RGD PMID:11430884 RGD:1600786 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 IEP RGD PMID:21428213 RGD:10450508 NCBI chr10:15,337,265...15,338,121 JBrowse link
G Hdac2 histone deacetylase 2 ISO protein:increased expression:hippocampus: RGD PMID:22388814 RGD:9590324 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hfe homeostatic iron regulator ISO with Tf C2 variant;DNA:missense mutation:cds:p.C282Y (human)
ClinVar Annotator: match by term: Alzheimer's disease
ClinVar Annotator: match by term: Alzheimer disease
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
RGD
PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... RGD:1358657 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO mRNA, protein:increased expression:cerebral cortex, microvessel (human)
protein:increased expression:brain, microvessel (mouse)
RGD PMID:16627934 PMID:21904637 RGD:9068875, RGD:9068888 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 ISO RGD PMID:23905994 RGD:10402058 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:17724290 RGD:5508460 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 ISO protein:increased expression:hippocampus, temporal cortex (human)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:11144356 PMID:7778849 RGD:1358658 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO protein:decreased expression:entorhinal cortex (human) RGD PMID:22628224 RGD:9999191 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 ISO protein:decreased expression:entorhinal cortex (human) RGD PMID:22628224 RGD:9999191 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO protein:increased expression:brain, neuron (human) RGD PMID:10661494 RGD:10412306 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 treatment ISO protein:increased expression:brain (human)
protein:increased expression:hippocampus, neuron, mitochondria
RGD PMID:9338779 PMID:11869808 PMID:21307267 RGD:1358426, RGD:632866, RGD:13792781 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 ISO mRNA:altered expression:cerebellum, hippocampus (human) RGD PMID:18180323 RGD:4889108 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ISO mRNA:altered expression:cerebellum, hippocampus (human) RGD PMID:18180323 RGD:4889108 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ISO mRNA:altered expression:cerebellum, hippocampus (human) RGD PMID:18180323 RGD:4889108 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Hsf1 heat shock transcription factor 1 ISO
IEP
protein:altered localization:promoter (mouse)
protein:decreased expression:cerebellum (rat)
RGD PMID:24849358 PMID:23665061 RGD:10402385, RGD:10402771 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO protein:decreased expression:serum (human) RGD PMID:23948885 RGD:10413860 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO DNA:polymorphism: :-110A>C(human) RGD PMID:15832029 RGD:10402403
G Hspa1b heat shock protein family A (Hsp70) member 1B disease_progression ISO DNA:polymorphism: : RGD PMID:12967056 RGD:10402401 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:17050040 PMID:17050040 RGD:10402560, RGD:10402560 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IEP mRNA,protein:increased expression:brainstem, astrocyte: RGD PMID:25772164 RGD:10402580 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IDA
ISO
protein:increased modification:brain
protein:increased expression:mitochondrion:
protein:increased expression:cytosol, mitochondrion:
RGD PMID:15802185 PMID:22753410 PMID:22753410 RGD:1624243, RGD:10402831, RGD:10402831 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO RGD PMID:20508993 RGD:5683632 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 susceptibility ISO DNA:silent mutation:cds: 267C>T (human) RGD PMID:10624811 RGD:1358662 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
JBrowse link
G Htra2 HtrA serine peptidase 2 ISO protein:increased activity:frontal cortex (human) RGD PMID:21163861 RGD:5688722 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO DNA:missense mutation:cds:p.K469E (human) RGD PMID:12498973 RGD:1358664 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ide insulin degrading enzyme treatment ISO
IEP
IDA
protein:decreased expression:cerebrospinal fluid
associated with Insulin Resistance
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:17192785 PMID:12634421 PMID:28157092 PMID:28164769 PMID:29948724 More... RGD:737718, RGD:13792829, RGD:13792824, RGD:13792800, RGD:13792798, RGD:13792793, RGD:13792792, RGD:13792790 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Igf1 insulin-like growth factor 1 treatment
onset
susceptibility
ISO protein:decreased expression:hippocampus:
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum:
DNA:polymorphism:intron: rs972936(human)
protein:altered expression:plasma,cerebral spinal fluid:
CTD
RGD
PMID:15750215 PMID:23740209 PMID:10399774 PMID:24054991 PMID:23089282 More... RGD:10045852, RGD:10402576, RGD:10045860, RGD:10045854, RGD:10045853, RGD:10045853 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor treatment
severity
ISO
IEP
IMP
DNA: haploinsufficiency:: full knockout dies at birth
CTD Direct Evidence: marker/mechanism
protein:increased expression: cerebral cortex:
protein:increased expression:temporal cortex:
CTD
RGD
PMID:15750215 PMID:20409077 PMID:23562514 PMID:18479783 PMID:18479783 More... RGD:5686420, RGD:12904921, RGD:10045894, RGD:10045894, RGD:10045879, RGD:10045879, RGD:10045878 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2 insulin-like growth factor 2 treatment IEP
ISO
mRNA:decreased expression:brain
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:15750215 PMID:16627931 PMID:24685003 PMID:21040071 PMID:24887203 RGD:5509963, RGD:10402559, RGD:10402558, RGD:10045934 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igf2r insulin-like growth factor 2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15750215 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 ISO protein:decreased expression:temporal cortex: RGD PMID:18479783 RGD:10045894 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 treatment ISO protein:increased expression:serum
mRNA:decreased expression:hippocampus
RGD PMID:23473966 PMID:10399774 PMID:24964199 RGD:10402570, RGD:10402576, RGD:10402572 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment IEP protein:increased expression:hippocampus: RGD PMID:24380241 RGD:10045941 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 susceptibility
treatment
ISO DNA:SNPs,haplotype: -1082G>A, -819T>C, -592C>A (human) RGD PMID:14746878 PMID:21803105 RGD:1358665, RGD:7364841 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha susceptibility
disease_progression
no_association
ISO protein:increased expression:microglial cell, cortical layer:
DNA:SNP:5'UTR:rs1800587(human)
RGD PMID:10716257 PMID:9775393 PMID:11402127 PMID:19158434 RGD:1358667, RGD:10046059, RGD:10045947, RGD:10045945 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta onset
no_association
treatment
ISO
IEP
IDA
protein:increased expression:plasma
DNA:SNP: :rs1143634 (human)
DNA:SNP:promoter:-31T>C (human)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:18675847 PMID:16600299 PMID:20413850 PMID:18830724 PMID:18830724 More... RGD:1626633, RGD:13793381, RGD:13792820, RGD:13792820, RGD:13792819, RGD:11522340, RGD:13792818, RGD:13792817, RGD:13792816, RGD:7204700 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 severity ISO protein:increased secretion:mononuclear cell: RGD PMID:8915041 PMID:8586980 RGD:10047080, RGD:10047081 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 ISO protein:decreased expression:plasma RGD PMID:17934472 PMID:18769539 RGD:5686815, RGD:5686817 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il33 interleukin 33 ISS OMIM:608907 MouseDO NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 ISO DNA:polymorphisms:promoter RGD PMID:20213229 RGD:10402788 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 treatment IDA RGD PMID:27088818 RGD:11062148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor no_association ISO protein:increased expression:cerebrospinal fluid, plasma
DNA:SNPs:promoter:-208G>A (rs4845617) (human)
DNA:SNPs:promoter, exon:-530G>T, 48867A/>C (p.D358A, rs8192284) (human)
RGD PMID:12664314 PMID:20197062 PMID:20197062 RGD:10402808, RGD:10402810, RGD:10402810 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer ISO protein:decreased expression:cerebrospinal fluid RGD PMID:10095017 RGD:10402847 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Il7 interleukin 7 ISO RGD PMID:22571981 RGD:10402933 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO CTD Direct Evidence: marker/mechanism CTD PMID:30320580 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Ins1 insulin 1 IEP mRNA:decreased expression:hippocampus RGD PMID:17448147 RGD:2298713 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Ins2 insulin 2 IEP
ISO
mRNA:decreased expression:cerebral cortex
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:9443474 PMID:15750215 PMID:17448147 RGD:2298713 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insr insulin receptor treatment ISO
IEP
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:brain
protein:altered localization:brain, neuron
CTD
RGD
PMID:24055495 PMID:23011726 PMID:16627931 PMID:18479783 RGD:10403036, RGD:5509963, RGD:10045894 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Iqck IQ motif containing K ISO CTD Direct Evidence: marker/mechanism CTD PMID:30820047 NCBI chr 1:173,199,308...173,316,990
Ensembl chr 1:173,199,316...173,316,984
JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO DNA:SNPs: :rs2656070, rs13180(human) RGD PMID:16914832 RGD:6893299 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
JBrowse link
G Irs1 insulin receptor substrate 1 treatment
severity
ISO
IEP
protein:increased expression, increased serine phosphorylation, increased tyrosine phosphorylation:hippocampus CA1
protein:decreased expression:hippocampus:
DNA:SNP:cds:rs1801278(human)
protein:altered expression:temporal cortex:
protein:increased serine phosphorylation:hippocampus
RGD PMID:22476197 PMID:23011726 PMID:22527777 PMID:23660953 PMID:24589556 More... RGD:6482860, RGD:10403036, RGD:10045939, RGD:10045935, RGD:10045932, RGD:10045894, RGD:6482861 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irs2 insulin receptor substrate 2 severity ISO mRNA:decreased expression:hippocampus:
protein:decreased expression:temporal cortex:
RGD PMID:19487308 PMID:24887203 PMID:18479783 RGD:10045878, RGD:10045934, RGD:10045894 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 ISO protein:decreased expression:temporal cortex, frontal cortex (human) RGD PMID:8819138 RGD:6482821 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Jak2 Janus kinase 2 treatment ISO RGD PMID:18813209 RGD:10403051 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jam2 junctional adhesion molecule 2 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063
JBrowse link
G Kcnc1 potassium voltage-gated channel subfamily C member 1 ISO mRNA, protein:decreased expression:neocortex (mouse) RGD PMID:21912965 RGD:9686062 NCBI chr 1:96,902,953...96,944,744
Ensembl chr 1:96,902,953...96,944,744
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 ISO mRNA:decreased expression:neocortex (mouse)
mRNA, protein:increased expression: frontal cortex
RGD PMID:21912965 PMID:15485486 RGD:9686062, RGD:10411900 NCBI chr 2:195,063,967...195,099,233
Ensembl chr 2:195,071,769...195,099,233
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 onset ISO DNA:SNP: :rs16934131 (human) RGD PMID:21480501 RGD:10412025 NCBI chr15:302,078...1,001,198
Ensembl chr15:302,214...1,001,198
JBrowse link
G Kl Klotho treatment ISO mRNA,protein:decreased expression:cerebral choroid,serum: RGD PMID:23973442 RGD:10403049 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Klc1 kinesin light chain 1 susceptibility ISO DNA:SNPs: :rs8007903, rs3212079 (human)
DNA:SNP:intron:56836G>C (human)
RGD PMID:19911314 PMID:15364413 RGD:5683908, RGD:5684007 NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031
JBrowse link
G Klk6 kallikrein related-peptidase 6 ISO RGD PMID:12480753 PMID:12074831 RGD:1358604, RGD:1358599 NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121
JBrowse link
G Klrg1 killer cell lectin like receptor G1 ISO ClinVar Annotator: match by term: Alzheimer disease, susceptibility to
ClinVar Annotator: match by term: ALPHA-2-MACROGLOBULIN POLYMORPHISM
ClinVar PMID:1370808 PMID:1717945 PMID:9697696 PMID:9811940 PMID:15023809 More... NCBI chr 4:155,455,465...155,467,301
Ensembl chr 4:155,455,495...155,467,424
JBrowse link
G L1cam L1 cell adhesion molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16298234 RGD:6483456 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857
JBrowse link
G Ldlr low density lipoprotein receptor no_association ISO DNA:SNPs:exon:rs5925, rs5927, rs5930 (human)
DNA:SNPs:exon (human)
DNA:SNPs:exon:rs5925, rs5930, rs11669576 (human)
DNA:SNPs: :rs5925, rs2738444, rs11669576 (human)
RGD PMID:21755005 PMID:15585340 PMID:16378661 PMID:15689450 PMID:16741934 More... RGD:5490231, RGD:5490244, RGD:5490243, RGD:5490242, RGD:5490241, RGD:5490239 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lep leptin treatment IDA
ISO
associated with Obesity
CTD Direct Evidence: therapeutic
compared to cortisol;protein:altered expression:plasma (human)
CTD
RGD
PMID:20157255 PMID:25296496 PMID:9755363 RGD:10053617, RGD:10053632 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lipc lipase C, hepatic type no_association ISO DNA:SNPs: :rs6074, rs6083, rs6084 (human)
DNA:SNPs: :rs6084 (human)
RGD PMID:17175070 PMID:17175070 RGD:1600644, RGD:1600644 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lipi lipase I ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:14,189,323...14,228,992
Ensembl chr11:14,189,323...14,228,985
JBrowse link
G Lpl lipoprotein lipase no_association
severity
ISO DNA:point mutations: :p.N291S, p.S447X (human)
DNA:polymorphism:intron
DNA:SNPs: :rs268, rs328 (human)
DNA:SNPs: :multiple
DNA, mRNA:SNP, decreased expression: :rs285 (human)
RGD PMID:24004859 PMID:10206232 PMID:12133567 PMID:15331147 PMID:16013913 More... RGD:13793392, RGD:13799353, RGD:13793397, RGD:13793396, RGD:5685661, RGD:13793395, RGD:13793393 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp1 LDL receptor related protein 1 treatment ISO
IEP
ISS
DNA:SNP:exon 3:C>T (human)
OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907
MouseDO
RGD
PMID:9635959 PMID:19150622 PMID:29115637 RGD:1358747, RGD:13800553, RGD:13799352 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Lrp8 LDL receptor related protein 8 no_association ISO DNA:polymorphism:exon:2622T>C (human)
DNA:polymorphisms: :multiple
RGD PMID:12399018 PMID:20208369 RGD:6483064, RGD:6483065 NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 onset ISO RGD PMID:11425005 RGD:1358749 NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414
JBrowse link
G Maoa monoamine oxidase A ISO RGD PMID:1627256 RGD:10046060 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:7816197 PMID:21075085 PMID:1627256 RGD:10046060 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map2 microtubule-associated protein 2 IDA RGD PMID:22083255 RGD:6483322 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment
onset
ISO mRNA:increased expression: CA2 field of hippocampus, pyramidal neuron RGD PMID:28079060 PMID:24334724 RGD:13800563, RGD:13800868 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk14 mitogen activated protein kinase 14 treatment IEP
ISO
mRNA:increased expression:frontal lobe cortex, hippocampus CA2 (rat) RGD PMID:20529587 PMID:17784957 RGD:10047076, RGD:10047104 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO RGD PMID:28079060 RGD:13800563 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 disease_progression ISO protein:increased expression:brain,CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO protein:increased expression:brain,CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau treatment
onset
no_association
ISO
IDA
protein:increased expression:CSF (human)
ClinVar Annotator: match by term: Alzheimer's disease
CTD Direct Evidence: marker/mechanism
protein:hyperphosphorylation:brain:
DNA:mutation:cds:p.R406W(human)
DNA:SNP, haplotypes:promoter:rs242557 (human)
DNA:SNPs, haplotypes:promoter:rs242557 (human)
ClinVar
CTD
RGD
PMID:12852432 PMID:14517953 PMID:15750215 PMID:20157255 PMID:21715663 More... RGD:1302530, RGD:127284889, RGD:13800908, RGD:13800904, RGD:13782165, RGD:10412709, RGD:10412704, RGD:10412701, RGD:8158105, RGD:8158097 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO protein:decreased expression:cerebrospinal fluid (human)
DNA:haplotype:promoter:
RGD PMID:9631454 PMID:23348713 RGD:4889155, RGD:12910848 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mcm2 minichromosome maintenance complex component 2 ISO RGD PMID:19946466 PMID:17070803 RGD:10412048, RGD:10412050 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Mdm4 MDM4 regulator of p53 disease_progression ISO RGD PMID:23861893 RGD:10047419 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226
JBrowse link
G Mfn1 mitofusin 1 ISO protein:decreased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mfn2 mitofusin 2 ISO
IEP
protein:decreased expression:hippocampus (human)
protein:increased expression:hippocampus (rat)
RGD PMID:19605646 PMID:28302704 RGD:7800727, RGD:12910737 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir100 microRNA 100 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304
JBrowse link
G Mir124-3 microRNA 124-3 ISO CTD Direct Evidence: therapeutic CTD PMID:28867212 NCBI chr 3:168,014,952...168,015,038
Ensembl chr 3:168,014,952...168,015,038
JBrowse link
G Mir125b2 microRNA 125b-2 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir146a microRNA 146a ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099153 PMID:25992776 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir155 microRNA 155 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir296 microRNA 296 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915
JBrowse link
G Mir375 microRNA 375 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mir708 microRNA 708 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr 1:150,599,876...150,599,963
Ensembl chr 1:150,599,876...150,599,963
JBrowse link
G Mir99a microRNA 99a ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
JBrowse link
G Mirlet7c1 microRNA let-7c-1 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
JBrowse link
G Mme membrane metallo-endopeptidase treatment
no_association
severity
onset
ISS
ISO
IEP
OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907
associated with Endotoxemia
DNA:SNPs, repeat:multiple:multiple
DNA:SNPs:introns:rs1836915, rs6776185, rs6801319 (human)
DNA:SNPs, haplotypes:promoter, introns:-204G>C, IVS17-294C>T, IVS22+36C>A (human)
DNA:SNPs, repeats, deletion:promoter:multiple
DNA:repeats
DNA:SNPs:5' utr, 3' utr:rs3736187, rs989692, rs701109 (human)
DNA:SNPs: :multiple
DNA:SNP: :rs6797911 (human)
DNA:SNP:3' utr:rs6665 (human)
MouseDO
RGD
PMID:25416980 PMID:25884928 PMID:20141738 PMID:17928142 PMID:17928142 More... RGD:13801033, RGD:13801034, RGD:13801024, RGD:13801023, RGD:13801023, RGD:13801022, RGD:13801021, RGD:13801020, RGD:1600813, RGD:13801019, RGD:13801012, RGD:13801011, RGD:13801011, RGD:13801010, RGD:13801009 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:decreased expression:platelet RGD PMID:21875409 RGD:10059680 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:plasma (human) RGD PMID:17697439 RGD:7207052 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, susceptibility to
CTD
ClinVar
PMID:11087769 PMID:12915675 PMID:15023809 PMID:17304047 PMID:25741868 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO protein:decreased expression:cerebral cortex (human) RGD PMID:15337312 RGD:2317734 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Mrpl39 mitochondrial ribosomal protein L39 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:23,779,655...23,795,146
Ensembl chr11:23,779,662...23,795,125
JBrowse link
G Ms4a4a membrane spanning 4-domains A4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460841 NCBI chr 1:208,060,507...208,085,121
Ensembl chr 1:208,046,971...208,085,119
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO mRNA:decreased expression:frontal cortex, Brodmann area 9 (human)
ClinVar Annotator: match by term: Alzheimer's disease
ClinVar
RGD
PMID:7624338 PMID:15972314 PMID:15075441 RGD:5490287 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 no_association ISO DNA:mutation::m.5460G>A (human) RGD PMID:1352971 PMID:1370613 RGD:5507833, RGD:5507834 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 ISO mRNA:decreased expression:brain RGD PMID:10447460 RGD:5508713 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
JBrowse link
G Mt1 metallothionein 1 ISO RGD PMID:22766972 RGD:10412319 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A ISO
IEP
mRNA:decreased expression:cerebral cortex (rat) RGD PMID:22766972 PMID:16914836 RGD:10412319, RGD:10412320 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mt3 metallothionein 3 ISO mRNA:decreased expression:brain
mRNA:increased expression:brain
RGD PMID:1464312 PMID:10595827 PMID:16444595 PMID:19619132 RGD:6480485, RGD:9685805, RGD:6480619, RGD:6480534 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17192785 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 ISO RGD PMID:14557245 RGD:2302388 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
JBrowse link
G Napb NSF attachment protein beta ISO protein:decreased expression:temporal cortex RGD PMID:11244216 RGD:10412652 NCBI chr 3:136,132,248...136,179,225
Ensembl chr 3:136,133,428...136,179,345
JBrowse link
G Nbn nibrin ISO RGD PMID:15337312 RGD:2317734 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Ncam1 neural cell adhesion molecule 1 IEP RGD PMID:31028587 RGD:40925918 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ncam2 neural cell adhesion molecule 2 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:20,104,974...20,592,168
Ensembl chr11:20,104,925...20,591,984
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO protein:altered localization RGD PMID:10873554 RGD:2314452 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nck2 NCK adaptor protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
JBrowse link
G Ncstn nicastrin no_association
onset
ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation, SNPs:exon, intron, 3' utr:multiple
DNA:missense mutation: :417N>Y (human)
DNA:SNPs, haplotype:introns:multiple
protein:increased modification:brain
DNA:SNP:promoter:-436C>T (human)
DNA:SNPs:promoter:-796T>G, -1216C>A (human)
DNA:SNP:promoter:-922G>T (rs10752637) (human)
CTD
RGD
PMID:17192785 PMID:14642438 PMID:23595812 PMID:11992262 PMID:11992262 More... RGD:13801188, RGD:13801187, RGD:13801052, RGD:13801052, RGD:13801051, RGD:13801050, RGD:13801050, RGD:13801049, RGD:13801048 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 ISO RGD PMID:28474567 RGD:13792588 NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 ISO RGD PMID:19760337 RGD:13801191 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 ISO mRNA:increased expression:blood RGD PMID:26943237 RGD:11572212 NCBI chr 7:113,866,382...113,870,239
Ensembl chr 7:113,866,382...113,870,239
JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 ISO RGD PMID:28474567 RGD:13792588 NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:60,129,154...60,139,446
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:14570706 RGD:1358651 NCBI chr 1:243,408,659...243,413,701
Ensembl chr 1:243,408,619...243,413,817
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 onset ISO RGD PMID:28242297 RGD:13824970 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 ISO DNA:SNP: :rs6859 (human)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:29107063 PMID:30319691 PMID:30320580 PMID:22159054 RGD:6484658 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
JBrowse link
G Nefl neurofilament light chain ISO protein:increased expression:CSF (human) RGD PMID:29368621 PMID:29391125 RGD:127284889, RGD:127285384 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain ISO protein:decreased glycosylation:cerebral cortex RGD PMID:17687114 RGD:9743945 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 onset
treatment
ISO
IEP
DNA:snps, haplotype:5' utr, intron:multiple (human)
protein:increased expression:brain, nucleus
RGD PMID:20064547 PMID:19805328 PMID:22913737 PMID:23771816 RGD:6893326, RGD:10412689, RGD:10412685, RGD:10412683 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngb neuroglobin treatment IEP RGD PMID:23428737 RGD:9743955 NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830
JBrowse link
G Ngf nerve growth factor IEP RGD PMID:21368378 RGD:5144128 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor treatment
no_association
ISO
IEP
protein:altered localization:brain
protein:altered expression:urine
protein:decreased expression:basal nucleus of telencephalon, neuron
DNA:SNPs, haplotypes: :multiple
DNA:SNP:CDS:rs2072446 (human)
RGD PMID:19334058 PMID:2557638 PMID:23545424 PMID:19070649 PMID:8215963 More... RGD:5508225, RGD:10414073, RGD:10413895, RGD:10413894, RGD:10413893, RGD:10413892, RGD:10413891, RGD:5508228 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nog noggin ISO RGD PMID:19463786 RGD:10414082 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Nos1 nitric oxide synthase 1 susceptibility
no_association
ISO DNA:repeat:promoter
DNA:repeat:exon
DNA:SNP:exon:-84G>A (human)
RGD PMID:21098972 PMID:12384247 PMID:10964481 PMID:17418914 PMID:17418914 RGD:13824974, RGD:13824978, RGD:13824976, RGD:13824975, RGD:13824975 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 IDA
ISO
RGD PMID:21163295 PMID:12384247 PMID:16908860 RGD:4891161, RGD:13824978, RGD:5508721 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 onset ISO human gene in rat model
ClinVar Annotator: match by term: Alzheimer disease
ClinVar Annotator: match by term: Alzheimer disease, late-onset, susceptibility to
CTD Direct Evidence: marker/mechanism
DNA:snp:cds:p.E298D (human)
ClinVar
CTD
RGD
PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More... RGD:2292144, RGD:13824978, RGD:1358752 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Npy neuropeptide Y treatment IEP
ISO
CTD Direct Evidence: marker/mechanism
protein:decreased expression:plasma
CTD
RGD
PMID:11709213 PMID:22266216 PMID:8592643 RGD:10431479, RGD:10432246 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nrg1 neuregulin 1 disease_progression ISO RGD PMID:12528817 PMID:29295823 RGD:10449002, RGD:41404730 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nrgn neurogranin ISO RGD PMID:9329454 RGD:9835394 NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Ntf3 neurotrophin 3 ISO DNA:missense mutation:cds:p.G63E (human) RGD PMID:9502217 RGD:1358754 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Ntn1 netrin 1 treatment ISO RGD PMID:30066400 RGD:13782183 NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 disease_progression ISO early onset sporadic AD; DNA:SNP:CDS:rs6336 (human)
mRNA:decreased expression:brain
RGD PMID:18780967 PMID:21397006 RGD:5508228, RGD:5684531 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 treatment ISO
IEP
sporadic AD; DNA:SNP:intron:rs2289656 (human) RGD PMID:18780967 PMID:24877042 PMID:21900882 RGD:5508228, RGD:10059402, RGD:5684548 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nudt1 nudix hydrolase 1 ISO protein:decreased expression:hippocampus RGD PMID:21538080 RGD:10449033 NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO protein:decreased expression:brain RGD PMID:19605646 RGD:7800727 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO protein:altered localization RGD PMID:18347024 RGD:2299169 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 susceptibility ISO protein:increased activity:brain:
DNA:haplotypes:cds:rs1136410,rs1805404 (human)
DNA:haplotypes: :
RGD PMID:22051244 PMID:21616968 PMID:20486200 PMID:17290104 RGD:5510011, RGD:10413888, RGD:10413887, RGD:10413885 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO mRNA,protein:increased expression:brain: RGD PMID:9701251 RGD:9835364 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pcdh11x protocadherin 11 X-linked ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer's disease
CTD
ClinVar
PMID:19136949 PMID:29476165 NCBI chr  X:86,058,348...86,751,078
Ensembl chr  X:86,058,394...86,747,036
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 disease_progression ISO DNA:SNPs
DNA:SNP: :rs8192708(human)
RGD PMID:17440948 PMID:20574532 RGD:2311642, RGD:10427727 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 ISO mRNA:increased expression:cerebral cortex: RGD PMID:8736634 RGD:10448277 NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor ISO RGD PMID:14746899 RGD:1642360 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566
JBrowse link
G Pde2a phosphodiesterase 2A treatment ISO RGD PMID:22771768 RGD:10449025 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO protein:increased expression:plasma: RGD PMID:22279551 RGD:10449445 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 onset ISO mRNA:decreased expression:hippocampus RGD PMID:15941609 PMID:11853019 PMID:7770119 PMID:10210891 RGD:2302869, RGD:2302863, RGD:2302735, RGD:2302864 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25390692 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682
JBrowse link
G Phactr2 phosphatase and actin regulator 2 ISO mRNA: splice variants RGD PMID:20590401 RGD:6483097 NCBI chr 1:7,591,254...7,860,431
Ensembl chr 1:7,597,927...7,860,289
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19734902 PMID:21460841 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO RGD PMID:20025958 RGD:6482689 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 onset ISO DNA:polymorphism: :p.M326I (human) RGD PMID:12185156 RGD:1625215 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISS OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907 MouseDO NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Plau plasminogen activator, urokinase no_association ISO ClinVar Annotator: match by term: Alzheimer disease, late-onset, susceptibility to
CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple
mRNA:increased expression:brain
ClinVar
CTD
RGD
PMID:12898287 PMID:15615772 PMID:15616835 PMID:16341549 PMID:28492532 More... RGD:6483793, RGD:6484115, RGD:6483807, RGD:6483794 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plcb1 phospholipase C beta 1 ISS
ISO
OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907 MouseDO
RGD
PMID:8534418 RGD:13825140 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcd1 phospholipase C, delta 1 ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar
RGD
PMID:25741868 PMID:8534418 RGD:13825140 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO RGD PMID:8534418 RGD:13825140 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Plcg2 phospholipase C, gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28714976 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase onset ISO DNA:snps:5' utr:g.-390G>A, g.-184G>A rs876493 (human) RGD PMID:11378842 RGD:5130171 NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556
JBrowse link
G Pon1 paraoxonase 1 ISO DNA:polymorphisms:multiple SNPs (human) RGD PMID:16319130 RGD:5509926 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon2 paraoxonase 2 ISO DNA:missense mutation:cds:p.C311S (human)
DNA:SNPs:multiple
RGD PMID:11803456 PMID:16319130 RGD:1580219, RGD:5509926 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Pon3 paraoxonase 3 ISO DNA:polymorphisms:multiple SNPs (human) RGD PMID:16319130 RGD:5509926 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Poted POTE ankyrin domain family member D ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr17:57,942,124...57,975,149
Ensembl chr17:57,942,162...57,975,654
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha no_association ISO DNA:SNP:CDS:rs1800206, p.L162V (human)
No association found for any polymorphisms of PPARA, including rs1800206 (human)
RGD PMID:12938026 PMID:17850927 RGD:5561899, RGD:5561928 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma no_association
susceptibility
ISO DNA:SNPs: :multiple (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:cds:p.P12A(human)
CTD
RGD
PMID:15993441 PMID:16407166 PMID:30328325 PMID:18573313 PMID:17440948 RGD:2301852, RGD:2311642 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha disease_progression ISO
IDA
mRNA, protein:decreased expression:hippocampal formation (human) RGD PMID:22540007 PMID:22510382 PMID:19273754 RGD:6484260, RGD:7242180, RGD:7242017 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B severity ISO protein:decreased expression:cerebral cortex (mouse)
protein:decreased expression:brain, synaptosome (human)
RGD PMID:23764848 PMID:23764848 RGD:10043802, RGD:10043802 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta ISO DNA:repeat RGD PMID:21029765 RGD:5686295 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha disease_progression ISO DNA:SNP: :rs1868402 (human) RGD PMID:23727081 PMID:21223993 RGD:13830878, RGD:13830879 NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907
JBrowse link
G Prkcb protein kinase C, beta ISO RGD PMID:8534418 RGD:13825140 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase treatment ISO protein:increased expression:vessel,astrocyte: RGD PMID:24105468 PMID:19716418 RGD:10412735, RGD:10412736 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Prnp prion protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, early-onset, susceptibility to
CTD
ClinVar
PMID:1353341 PMID:1677164 PMID:1682813 PMID:1684089 PMID:1971924 More... NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Psen1 presenilin 1 ISO DNA:missense mutations:cds:multiple (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease
ClinVar Annotator: match by term: Alzheimer's disease
ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease
CTD
ClinVar
RGD
PMID:7596406 PMID:8773614 PMID:9384602 PMID:9851443 PMID:9851450 More... RGD:1302519, RGD:13782044 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 severity ISO DNA:missense mutation:cds:p.N141I (human)
ClinVar Annotator: match by term: Alzheimer disease
ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer's disease
DNA:missense mutations:cds:p.N141I, p.M239V (human)
ClinVar
RGD
CTD
PMID:9050898 PMID:9384602 PMID:10976645 PMID:11723295 PMID:12925374 More... RGD:9743900, RGD:9743900, RGD:1302522 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:22044482 RGD:6483525 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IMP
ISO
protein:increased expression:cerebral cortex RGD PMID:21701788 PMID:10560656 PMID:20157512 RGD:5688147, RGD:5688249, RGD:5688156 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO
mRNA:decreased expression:neocortex, hippocampus RGD PMID:21701788 PMID:8892355 PMID:9740394 RGD:5688147, RGD:5688254, RGD:5688252 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 severity ISO protein:increased expression:prefrontal cortex (human)
protein:increased expression:dentate gyrus (mouse)
RGD PMID:20427654 PMID:16237174 PMID:20956308 RGD:9835008, RGD:10044037, RGD:9835007 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
JBrowse link
G Pyy peptide YY ISO CTD Direct Evidence: marker/mechanism CTD PMID:11709213 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815
JBrowse link
G Rbm11 RNA binding motif protein 11 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:14,234,851...14,244,846
Ensembl chr11:14,234,890...14,244,090
JBrowse link
G Rcan1 regulator of calcineurin 1 ISO RGD PMID:11483593 RGD:1580889 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Reg1a regenerating family member 1 alpha ISO mRNA:increased expression:brain (human) RGD PMID:2394826 RGD:9850119 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570
JBrowse link
G Reln reelin ISO protein:increased expression:cerebrospinal fluid (human)
protein: increased expression: brain
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:20610758 PMID:12645087 PMID:20025970 RGD:729771, RGD:13207521 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G RGD1563888 similar to DNA segment, Chr 16, ERATO Doi 472, expressed ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:17,229,129...17,262,307
Ensembl chr11:17,229,138...17,262,483
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO RGD PMID:21473952 RGD:5147563 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Runx1 RUNX family transcription factor 1 ISO associated with Down Syndrome RGD PMID:20946940 RGD:6482829 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G S100b S100 calcium binding protein B severity ISO
IEP
protein:decreased expression:cerebrospinal fluid RGD PMID:21080947 PMID:19705461 PMID:20105309 PMID:20953641 RGD:5508775, RGD:5508798, RGD:5508787, RGD:5508780 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:14,484,523...14,534,900
Ensembl chr11:14,483,893...14,534,900
JBrowse link
G Sell selectin L severity ISO protein:decreased expression:plasma RGD PMID:21484243 RGD:5685677 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Selp selectin P severity ISO protein:decreased expression:plasma RGD PMID:21484243 RGD:5685677 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Serpine2 serpin family E member 2 ISO RGD PMID:2813392 RGD:2317937 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Serpinf1 serpin family F member 1 IDA
ISO
protein:increased expression:cerebrospinal fluid, serum (human) RGD PMID:17073149 PMID:28320113 RGD:2312353, RGD:27226702 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
JBrowse link
G Shc1 SHC adaptor protein 1 ISO protein:increased phosphorylation:neuron RGD PMID:15837797 RGD:1643185 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Sirt1 sirtuin 1 treatment ISO protein:increased expression:forebrain (mouse) RGD PMID:17581637 PMID:16751189 RGD:2290573, RGD:10047116 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt3 sirtuin 3 ISO mRNA:increased expression:brain RGD PMID:23139766 RGD:9586045 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Slc18a3 solute carrier family 18 member A3 ISO mRNA, protein:decreased expression:frontal association cortex
mRNA:decreased expression:cerebral cortex
RGD PMID:21743130 PMID:21333939 RGD:5686430, RGD:5686673 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Slc25a4 solute carrier family 25 member 4 ISO RGD PMID:21958963 RGD:9681463 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO RGD PMID:8179300 RGD:2313620 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a3 solute carrier family 2 member 3 ISO RGD PMID:8179300 RGD:2313620 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24055495 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc30a4 solute carrier family 30 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16580781 NCBI chr 3:109,753,270...109,775,306
Ensembl chr 3:109,753,273...109,775,306
JBrowse link
G Slc30a6 solute carrier family 30 member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16580781 NCBI chr 6:21,020,931...21,050,785
Ensembl chr 6:21,020,931...21,050,785
JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO protein:altered expression:synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Slc8a2 solute carrier family 8 member A2 ISO protein:altered expression:synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072
JBrowse link
G Slc8a3 solute carrier family 8 member A3 ISO protein:altered expression:parietal cortex, synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508
JBrowse link
G Snap91 synaptosome associated protein 91 ISO protein:decreased expression:dentate gyrus molecular layer,hippocampus,entorhinal, tempocampal corteces:
denntate gyrus, hippocampus, entorhinal cortex
RGD PMID:20847448 PMID:20847448 RGD:13506238, RGD:13506238 NCBI chr 8:87,738,056...87,852,690
Ensembl chr 8:87,738,824...87,852,367
JBrowse link
G Snca synuclein alpha ISO human gene in a mouse model
protein:increased expression:cerebrospinal fluid
RGD PMID:11572944 PMID:18577885 RGD:1302528, RGD:6478792 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sncb synuclein, beta ISO mRNA:decreased expression:brain RGD PMID:11578596 RGD:6480194 NCBI chr17:9,846,802...9,855,013
Ensembl chr17:9,846,802...9,855,012
JBrowse link
G Sncg synuclein, gamma ISO protein:increased expression:cerebrospinal fluid RGD PMID:18577885 RGD:6478792 NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
JBrowse link
G Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 ISO protein:increased expression:cerebral cortex (human) RGD PMID:24023061 RGD:10448959 NCBI chr 1:95,856,039...95,876,434
Ensembl chr 1:95,856,036...95,876,392
JBrowse link
G Snrpa small nuclear ribonucleoprotein polypeptide A ISO protein:increased expression:cerebral cortex (human) RGD PMID:24023061 RGD:10448959 NCBI chr 1:82,481,770...82,490,540
Ensembl chr 1:82,481,770...82,490,538
JBrowse link
G Sod1 superoxide dismutase 1 ISO
IEP
mRNA:altered expression:hippocampus, hypothalamus (rat)
protein:decreased expression:frontal lobe (human)
RGD PMID:22072713 PMID:20027333 PMID:22072713 RGD:8655610, RGD:8657017, RGD:8655610 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19374891 PMID:16369462 RGD:1579972 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sorl1 sortilin related receptor 1 ISO RGD PMID:15313836 RGD:1581303 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Spint1 serine peptidase inhibitor, Kunitz type 1 ISO protein:decreased expression:parietal cortex (human) RGD PMID:9743567 RGD:1581317 NCBI chr 3:106,231,082...106,244,121
Ensembl chr 3:106,231,444...106,244,119
JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr14:94,226,312...94,248,162
Ensembl chr14:94,148,837...94,249,162
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO protein:decreased tyrosine phosphorylation:dentate gyrus
protein:decreased tyrosine phosphorylation:dentate gyrus, CA1 field of hippocampus
RGD PMID:18813209 PMID:18813209 RGD:10403051, RGD:10403051 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stox1 storkhead box 1 severity ISO protein:increased expression:CA4 field of hippocampus (human) RGD PMID:20110611 RGD:11554028 NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939
JBrowse link
G Syp synaptophysin ISO
IEP
protein:decreased expression:dentate gyrus molecular layer,hippocampus,entorhinal, tempocampal corteces:
mRNA,protein:decreased expression:hippocampus, temporal cortex
denntate gyrus, hippocampus, entorhinal cortex
RGD PMID:20847448 PMID:20847448 PMID:20847448 RGD:13506238, RGD:13506238, RGD:13506238 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO DNA:SNP: :(rs241448)(human) RGD PMID:16595160 RGD:6482265 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
JBrowse link
G Tardbp TAR DNA binding protein ISO protein:increased expression, phosphorylation:motor cortex
protein:increased expression:brain
RGD PMID:21376022 PMID:21070634 RGD:5687139, RGD:5687178 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Tbp TATA box binding protein ISO protein:increased expression:hippocampus, entorhinal cortex (human) RGD PMID:15193429 RGD:5684338 NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase treatment ISO RGD PMID:27190010 RGD:13601984 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tf transferrin ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Transferrin variant c1/c2
CTD
ClinVar
PMID:9272172 PMID:15060098 PMID:17192785 PMID:20029940 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfam transcription factor A, mitochondrial susceptibility ISO DNA:SNP: :rs1937 (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:intron:IVS4+113A>G (rs2306604) (human)
CTD
RGD
PMID:17192785 PMID:21799244 PMID:17537576 RGD:6767575, RGD:6771185 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Thbd thrombomodulin ISO RGD PMID:15760641 RGD:5685018 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO RGD PMID:12614934 RGD:1580169 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:16157451 RGD:1580680 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 ISO protein:decreased expression:brain cortex (human) RGD PMID:18652896 RGD:2317276 NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753
JBrowse link
G Tmprss15 transmembrane serine protease 15 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:17,677,741...17,802,255
Ensembl chr11:17,677,741...17,802,255
JBrowse link
G Tnf tumor necrosis factor no_association
onset
susceptibility
ISO DNA:polymorphism:promoter:multiple(human)
DNA:polymorphism:promoter:-308G>A(human)
protein:decreased expression:brain:
DNA:haploltype:promoter:-863A>C,-308G>A(human)
protein:increased secretion:serum:
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, protection against
CTD
ClinVar
RGD
PMID:10400991 PMID:16908746 PMID:17192785 PMID:12962917 PMID:18834925 More... RGD:1580320, RGD:13825257, RGD:13825256, RGD:13825255, RGD:13825253, RGD:13825250, RGD:13825248, RGD:13825248 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A no_association ISO protein:increased expression:brain:
protein:increased expression:cerebrospinal fluid:
RGD PMID:20110607 PMID:21978728 PMID:17724122 PMID:17267158 RGD:13825249, RGD:13825268, RGD:13825267, RGD:13825266 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:decreased expression:brain:
protein:increased expression:cerebrospinal fluid:
RGD PMID:20110607 PMID:21978728 RGD:13825249, RGD:13825268 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27023435 PMID:29107063 PMID:30319691 PMID:30320580 NCBI chr 1:79,358,781...79,370,976
Ensembl chr 1:79,358,786...79,370,915
JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:17581637 RGD:2290573 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:15182943 RGD:1580467 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Tpi1 triosephosphate isomerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19374891 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Tpp1 tripeptidyl peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10320038 NCBI chr 1:160,097,984...160,104,108
Ensembl chr 1:160,096,833...160,104,129
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24663666 PMID:28714976 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:16341938 RGD:1580518 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tspan14 tetraspanin 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr16:16,784,242...16,841,368
Ensembl chr16:16,783,234...16,841,400
JBrowse link
G Ttr transthyretin ISO RGD PMID:16552785 RGD:1580525 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 ISO RGD PMID:14722078 RGD:1580538 NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590
JBrowse link
G Ucp1 uncoupling protein 1 ISO protein:decreased expression:plasma (human) RGD PMID:24498895 RGD:10045648 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 ISO DNA:hypermethylation:promoter:
protein:decreased expression:temporal cortex
RGD PMID:26943237 PMID:11130185 RGD:11572212, RGD:13831335 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
JBrowse link
G Usp25 ubiquitin specific peptidase 25 ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348
JBrowse link
G Vcp valosin-containing protein ISO ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:30279455 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:15732116 PMID:15732116 RGD:1580571 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin ISO protein:increased expression:brain RGD PMID:19728994 PMID:19728994 RGD:6480519, RGD:6480519 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vldlr very low density lipoprotein receptor ISO DNA:repeat RGD PMID:7550352 RGD:737739 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Vps13c vacuolar protein sorting 13 homolog C ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar PMID:25741868 NCBI chr 8:68,478,366...68,651,893
Ensembl chr 8:68,478,395...68,651,895
JBrowse link
G Vsnl1 visinin-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25806004 NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
JBrowse link
G Wt1 WT1 transcription factor ISO RGD PMID:12914969 RGD:1580623 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link
G Wwox WW domain-containing oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30820047 NCBI chr19:42,432,141...43,360,278 JBrowse link
G Xrn1 5'-3' exoribonuclease 1 susceptibility ISO DNA:snp:intron:c.1883+365T>C (rs1351965) (human) RGD PMID:22984654 RGD:11528589 NCBI chr 8:96,527,871...96,637,385
Ensembl chr 8:96,528,195...96,632,739
JBrowse link
Alzheimer's disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Alzheimer disease, type 1
ClinVar Annotator: match by term: APP POLYMORPHISM
ClinVar
OMIM
PMID:1303239 PMID:1303275 PMID:1415269 PMID:1520398 PMID:1634237 More... NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Hfe homeostatic iron regulator ISO OMIM NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
G Mpo myeloperoxidase ISO OMIM NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos3 nitric oxide synthase 3 ISO OMIM NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Plau plasminogen activator, urokinase ISO OMIM NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
Alzheimer's disease 18 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 susceptibility ISO ClinVar Annotator: match by term: Alzheimer disease 18
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:19608551 PMID:24055016 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
Alzheimer's disease 19 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pld3 phospholipase D family, member 3 ISO ClinVar Annotator: match by term: ALZHEIMER DISEASE 19, LATE-ONSET ClinVar PMID:24336208 PMID:25832408 PMID:25832410 PMID:25832411 NCBI chr 1:82,821,863...82,844,280
Ensembl chr 1:82,821,875...82,844,072
JBrowse link
Alzheimer's disease 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO ClinVar Annotator: match by term: Late onset familial Alzheimer disease OMIM
ClinVar
PMID:2987927 PMID:3922972 PMID:7263700 PMID:8346443 PMID:8618665 More... NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
Alzheimer's disease 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO OMIM NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Kif5c kinesin family member 5C ISO protein:decreased expression:cerebellum (human) RGD PMID:24569455 RGD:12859086 NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO ClinVar Annotator: match by term: Early onset Alzheimer disease with behavioral disturbance ClinVar PMID:18412265 PMID:18688798 PMID:18716801 PMID:18781329 PMID:19699188 More... NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease, type 3
ClinVar Annotator: match by term: ALZHEIMER DISEASE, FAMILIAL, 3
ClinVar Annotator: match by term: Early onset Alzheimer disease with behavioral disturbance
OMIM
ClinVar
PMID:1985297 PMID:2025423 PMID:2793034 PMID:7550356 PMID:7581374 More... NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
Alzheimer's disease 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, type 4
ClinVar Annotator: match by term: Alzheimer disease familial type 4
CTD
ClinVar
PMID:2987927 PMID:3922972 PMID:7263700 PMID:8346443 PMID:8618665 More... NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Psen1 presenilin 1 ISO ClinVar Annotator: match by synonym: ALZHEIMER DISEASE, FAMILIAL, 4
ClinVar Annotator: match by term: Alzheimer disease, type 4
ClinVar PMID:8910898 PMID:9189043 PMID:9804121 PMID:15205973 PMID:27777022 More... NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 ISO ClinVar Annotator: match by term: Alzheimer disease, type 4
ClinVar Annotator: match by term: Alzheimer disease familial type 4
ClinVar Annotator: match by OMIM:606889
OMIM
ClinVar
PMID:7550356 PMID:7638622 PMID:7651536 PMID:8661049 PMID:8939861 More... NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
Alzheimer's disease 9 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 susceptibility ISO ClinVar Annotator: match by term: ALZHEIMER DISEASE 9, LATE-ONSET
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:25741868 PMID:25807283 PMID:26141617 PMID:27066581 PMID:28492532 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
Alzheimer's Disease, Familial, 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: ALZHEIMER DISEASE, FAMILIAL, 1 ClinVar PMID:1303239 PMID:1303275 PMID:8499923 PMID:9754958 PMID:9848098 More... NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease familial 3, with spastic paraparesis ClinVar PMID:24121961 PMID:25741868 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Psen1 presenilin 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with spastic paraparesis and apraxia
CTD
ClinVar
PMID:11920851 PMID:15534188 PMID:25741868 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Unusual Plaques term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease, familial, with spastic paraparesis and unusual plaques
ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with spastic paraparesis and unusual plaques
ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with unusual plaques
ClinVar PMID:7550356 PMID:8755489 PMID:9172170 PMID:9546792 PMID:10720282 More... NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 ISO ClinVar Annotator: match by term: POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY 2
ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2
ClinVar
OMIM
PMID:6681564 PMID:12080485 PMID:12754369 PMID:12925681 PMID:15883308 More... NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
Presenile and Senile Dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:2987927 PMID:3922972 PMID:7263700 PMID:8346443 PMID:8618665 More... NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:1303239 PMID:1303275 PMID:1679289 PMID:2111584 PMID:8499923 More... NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
G Il1b interleukin 1 beta IDA RGD PMID:23126199 RGD:7193138 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    Diseases of the Aged 1292
      dementia 712
        Alzheimer's disease 491
          Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy 1
          Alzheimer's Disease, Familial Early-Onset, with Coexisting Amyloid and Prion Pathology 0
          Alzheimer's disease 1 + 5
          Alzheimer's disease 10 0
          Alzheimer's disease 11 0
          Alzheimer's disease 12 0
          Alzheimer's disease 13 0
          Alzheimer's disease 14 0
          Alzheimer's disease 15 0
          Alzheimer's disease 16 0
          Alzheimer's disease 17 0
          Alzheimer's disease 18 1
          Alzheimer's disease 19 1
          Alzheimer's disease 2 1
          Alzheimer's disease 3 + 4
          Alzheimer's disease 4 3
          Alzheimer's disease 5 0
          Alzheimer's disease 6 0
          Alzheimer's disease 7 0
          Alzheimer's disease 8 0
          Alzheimer's disease 9 1
          Lewy Body Variant of Alzheimer's Disease 0
          Presenile and Senile Dementia + 5
Path 2
Term Annotations click to browse term
  disease 17289
    disease of anatomical entity 16625
      nervous system disease 12154
        central nervous system disease 10420
          brain disease 9782
            disease of mental health 7070
              cognitive disorder 1952
                dementia 712
                  Alzheimer's disease 491
                    Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy 1
                    Alzheimer's Disease, Familial Early-Onset, with Coexisting Amyloid and Prion Pathology 0
                    Alzheimer's disease 1 + 5
                    Alzheimer's disease 10 0
                    Alzheimer's disease 11 0
                    Alzheimer's disease 12 0
                    Alzheimer's disease 13 0
                    Alzheimer's disease 14 0
                    Alzheimer's disease 15 0
                    Alzheimer's disease 16 0
                    Alzheimer's disease 17 0
                    Alzheimer's disease 18 1
                    Alzheimer's disease 19 1
                    Alzheimer's disease 2 1
                    Alzheimer's disease 3 + 4
                    Alzheimer's disease 4 3
                    Alzheimer's disease 5 0
                    Alzheimer's disease 6 0
                    Alzheimer's disease 7 0
                    Alzheimer's disease 8 0
                    Alzheimer's disease 9 1
                    Lewy Body Variant of Alzheimer's Disease 0
                    Presenile and Senile Dementia + 5
paths to the root