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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Ulcer
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Accession:DOID:9005175 term browser browse the term
Definition:A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
Synonyms:exact_synonym: Ulcers
 xref: MESH:D014456;   MONDO:0043839


show annotations for term's descendants           Sort by:
Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr5 C-C motif chemokine receptor 5 ISO associated with Herpes Genitalis RGD PMID:18008231 RGD:8551830 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20668000 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO protein:increased expression, alternative forms:mucosa of stomach RGD PMID:21600881 RGD:8655658 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 susceptibility ISO associated with sickle cell anemia; RGD PMID:23590899 RGD:10450838 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO protein:increased expression:esophagus (rat) RGD PMID:12368217 RGD:632996 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Itgb3 integrin beta 3 susceptibility ISO associated with Behcet Syndrome; DNA:polymorphism: : RGD PMID:21813062 RGD:8693342 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) ISO RGD PMID:12452868 RGD:1582583 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:12452868 RGD:1582583 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO associated with Melanoma RGD PMID:15750195 RGD:8693676 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Ppif peptidylprolyl isomerase F (cyclophilin F) ISO CTD Direct Evidence: marker/mechanism CTD PMID:20668000 NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892 		JBrowse link
Buruli ulcer disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 susceptibility ISO ClinVar Annotator: match by term: Buruli ulcer, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM		 PMID:16395392 NCBI chr 1:74,414,318...74,429,974
Ensembl chr 1:74,414,354...74,425,221 		JBrowse link
chronic ulcer of skin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 ISO RGD PMID:19638336 RGD:2315843 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Scleroderma, Systemic;protein:increased expression:blood RGD PMID:8099861 RGD:8547587 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Itgb2 integrin beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9653089 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Lama3 laminin, alpha 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12915477 NCBI chr18:12,466,806...12,716,070
Ensembl chr18:12,466,876...12,716,070 		JBrowse link
G Mmp9 matrix metallopeptidase 9 susceptibility ISO associated with Scleroderma, Systemic in males;DNA:SNP:promoter:-1562C>T (rs3918242) (human) RGD PMID:21455563 RGD:8547865 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:24244623 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Pdgfa platelet derived growth factor, alpha ISO RGD PMID:16383039 RGD:2292163 NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125 		JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide ISO RGD PMID:16383039 RGD:2292163 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876 		JBrowse link
G Pepd peptidase D ISO CTD Direct Evidence: marker/mechanism CTD PMID:16470701 NCBI chr 7:34,611,832...34,744,131
Ensembl chr 7:34,611,804...34,744,133 		JBrowse link
G Plcb3 phospholipase C, beta 3 IMP RGD PMID:10669417 RGD:737745 NCBI chr19:6,931,081...6,951,738
Ensembl chr19:6,929,693...6,953,838 		JBrowse link
corneal ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 ISO associated with Arthritis,Rheumatoid;mRNA:increased expression:keratocyte: RGD PMID:12714388 RGD:7829721 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric ISO associated with Hypersensitivity;mRNA:decreased expression:eye RGD PMID:16251127 RGD:7364739 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:24244623 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19553628 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Tnf tumor necrosis factor ISO associated with Arthritis,Rheumatoid;mRNA:increased expression:keratocyte: RGD PMID:12714388 RGD:7829721 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
decubitus ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 ISO RGD PMID:23740668 RGD:8655548 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO mRNA, protein:increased expression:deep dorsal muscles (rat) RGD PMID:20223667 RGD:8694460 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Il10 interleukin 10 ISO mRNA:increased expression:skin RGD PMID:26177082 RGD:11049489 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Kdr kinase insert domain protein receptor ISO protein:increased expression:skin: RGD PMID:12692851 RGD:8551845 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:skin: RGD PMID:12692851 PMID:23740668 RGD:8551845, RGD:8655548 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Diabetic Foot term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:20836881 RGD:5686889 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood RGD PMID:21941211 RGD:6767555 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Crp C-reactive protein, pentraxin-related disease_progression ISO protein:increased expression:blood: RGD PMID:22712631 RGD:6906887 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Gja1 gap junction protein, alpha 1 ISO protein:increased expression:dermis RGD PMID:22455314 RGD:7207269 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G H19 H19, imprinted maternally expressed transcript ameliorates ISO
IMP		 RNA:increased expression:foot (human) RGD PMID:33174326 PMID:33174326 RGD:156451663, RGD:156451663 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,133,957 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO mRNA,protein:decreased expression:blood serum, foot (human) RGD PMID:34293021 RGD:155260332 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hspa1b heat shock protein 1B severity ISO DNA:polymorphism: :1538G>A (human) RGD PMID:19731315 RGD:8662463 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:fibroblast of dermis,stratum basale of epidermis: RGD PMID:10727985 RGD:8549356 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il15 interleukin 15 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell RGD PMID:17014667 RGD:2313575 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Itgam integrin alpha M ISO protein:increased expression:pes (human) RGD PMID:37087778 RGD:329853756 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 ISO protein:increased expression:serum: RGD PMID:19997692 RGD:8694068 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Mir17 microRNA 17 ISO RGD PMID:36333728 RGD:329349308 NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186 		JBrowse link
G Mir210 microRNA 210 ISO miRNA:increased expression:blood serum, foot (human) RGD PMID:34293021 RGD:155260332 NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406 		JBrowse link
G Mmp9 matrix metallopeptidase 9 severity ISO RGD PMID:22688339 RGD:8547813 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Notch1 notch 1 ISO protein:increased expression:skin, epidermis: RGD PMID:30886104 RGD:155646129 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Plat plasminogen activator, tissue ISO RGD PMID:17275886 RGD:2311669 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Ptx3 pentraxin related gene ISO protein:decreased expression:plasma (human) RGD PMID:30767386 RGD:38501100 NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226 		JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human); RGD PMID:23936790 RGD:7777174 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
duodenal ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22387998 NCBI chr 2:26,732,508...26,754,973
Ensembl chr 2:26,732,515...26,754,991 		JBrowse link
G Aco1 aconitase 1 ISO protein:increased activity:duodenal mucosa RGD PMID:19342511 RGD:11541091 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator ISO RGD PMID:15905414 RGD:1599596 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Egr1 early growth response 1 IMP RGD PMID:24385009 RGD:8694318 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Il27 interleukin 27 ISO associated with Helicobacter Infections;protein:increased expression:blood serum (human) RGD PMID:31702083 RGD:126790551 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:12481160 PMID:17045617 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18451993 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Psca prostate stem cell antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:22387998 NCBI chr15:74,586,688...74,588,914
Ensembl chr15:74,586,688...74,588,918 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12481160 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 ISO mRNA, protein:increased expression:duodenal mucosa RGD PMID:19342511 RGD:11541091 NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:24385009 RGD:8694318 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tfrc transferrin receptor ISO protein:increased expression:duodenal mucosa RGD PMID:19342511 RGD:11541091 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: therapeutic CTD PMID:12868675 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Candidiasis;protein:decreased expression:Duodenum: RGD PMID:18622701 RGD:7483560 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Foot Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 ISO associated with Diabetes Mellitus RGD PMID:19509015 RGD:2311355 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
gastric ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO protein:decreased activity:stomach: RGD PMID:20029210 RGD:152998951 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Adm adrenomedullin ISO CTD Direct Evidence: therapeutic CTD PMID:9845272 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027 		JBrowse link
G Agt angiotensinogen treatment ISO RGD PMID:24231511 RGD:11039418 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Angpt1 angiopoietin 1 ISO protein:increased expression:stomach RGD PMID:12768384 RGD:1601496 NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373 		JBrowse link
G Angpt2 angiopoietin 2 ISO protein:increased expression:stomach (rat) RGD PMID:12768384 RGD:1601496 NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment ISO RGD PMID:24378970 RGD:10053695 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO RGD PMID:24378970 RGD:10053695 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 treatment ISO RGD PMID:24378970 RGD:10053695 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:29339218 RGD:13792597 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase ISO protein:increased expression:stomach
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:1887894 PMID:17895592 RGD:5130860 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cblif cobalamin binding intrinsic factor ISO associated with Polycythemia; mRNA:decreased expression:gastric mucosa: RGD PMID:26485402 RGD:11049581 NCBI chr19:11,724,907...11,740,811
Ensembl chr19:11,724,918...11,740,811 		JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9872509 PMID:10422768 PMID:10458643 PMID:11025360 PMID:11787760 More... NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator treatment ISO RGD PMID:23596793 RGD:11567229 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Col18a1 collagen, type XVIII, alpha 1 ISO Protein:decreased expression:serum RGD PMID:11353854 RGD:1600910 NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382 		JBrowse link
G Egf epidermal growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:9324159 PMID:9479624 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:20723003 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G F13a1 coagulation factor XIII, A1 subunit ISO RGD PMID:11435721 RGD:708325 NCBI chr13:37,051,150...37,234,220
Ensembl chr13:37,051,152...37,234,220 		JBrowse link
G Fas Fas cell surface death receptor treatment ISO RGD PMID:29339218 RGD:13792597 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand treatment ISO RGD PMID:29339218 RGD:13792597 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fgf2 fibroblast growth factor 2 treatment ISO RGD PMID:9127818 RGD:8655642 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fos FBJ osteosarcoma oncogene treatment ISO RGD PMID:37637418 PMID:24496494 RGD:405650590, RGD:405650591 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Foxo4 forkhead box O4 ISO mRNA,protein:increased expression:gastric mucosa: RGD PMID:22735908 RGD:10402364 NCBI chr  X:100,297,855...100,304,479
Ensembl chr  X:100,298,134...100,304,479 		JBrowse link
G Ghrl ghrelin ISO CTD Direct Evidence: therapeutic CTD PMID:15177919 PMID:16259727 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841 		JBrowse link
G Hrh3 histamine receptor H3 ISO RGD PMID:15680274 RGD:1626428 NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281 		JBrowse link
G Iapp islet amyloid polypeptide ISO CTD Direct Evidence: therapeutic CTD PMID:9286623 NCBI chr 6:142,244,151...142,249,546
Ensembl chr 6:142,244,149...142,249,687 		JBrowse link
G Idua iduronidase, alpha-L ISO RGD PMID:3713687 RGD:12910841 NCBI chr 5:108,808,197...108,833,312
Ensembl chr 5:108,808,197...108,832,423 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:11376495 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 treatment IMP RGD PMID:23874957 RGD:39458037 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Il25 interleukin 25 treatment ISO RGD PMID:26054198 RGD:40902976 NCBI chr14:55,170,152...55,173,294
Ensembl chr14:55,170,152...55,173,294 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: therapeutic CTD PMID:10422768 PMID:11025360 PMID:11787760 PMID:15024038 PMID:16015682 More... NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO RGD PMID:25518106 RGD:13800896 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO RGD PMID:25518106 RGD:13800896 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mmp13 matrix metallopeptidase 13 ISO mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:stomach secretion
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17603938 PMID:17603938 RGD:1642033 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric treatment ISO mRNA, protein:decreased expression:stomach RGD PMID:11956390 PMID:16240224 RGD:2324968, RGD:7364759 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Muc6 mucin 6, gastric treatment ISO RGD PMID:16240224 RGD:7364759 NCBI chr 7:141,212,404...141,241,659
Ensembl chr 7:141,213,373...141,241,641 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:12481160 PMID:15138204 PMID:19066340 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19066340 PMID:29095895 RGD:13446410 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16357062 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Oxt oxytocin ISO RGD PMID:11764003 RGD:2304192 NCBI chr 2:130,416,432...130,418,974
Ensembl chr 2:130,418,093...130,418,974 		JBrowse link
G Oxtr oxytocin receptor ISO RGD PMID:11764003 RGD:2304192 NCBI chr 6:112,450,646...112,467,800
Ensembl chr 6:112,450,644...112,466,904 		JBrowse link
G Ptger1 prostaglandin E receptor 1 (subtype EP1) treatment ISO
IMP		 RGD PMID:10807413 PMID:10807413 RGD:10043357, RGD:10043357 NCBI chr 8:84,393,171...84,399,385
Ensembl chr 8:84,393,307...84,399,382 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10594344 PMID:19066340 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IAGP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9024292 PMID:10594344 PMID:11376495 PMID:12481160 PMID:19066340 More... RGD:2300260, RGD:2300260 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Sst somatostatin ISO RGD PMID:17990461 RGD:2303186 NCBI chr16:23,708,327...23,710,041
Ensembl chr16:23,708,323...23,709,708 		JBrowse link
G Tek TEK receptor tyrosine kinase ISO protein:increased expression:stomach RGD PMID:12768384 RGD:1601496 NCBI chr 4:94,627,322...94,763,213
Ensembl chr 4:94,627,526...94,763,213 		JBrowse link
G Tff1 trefoil factor 1 ISO mRNA, protein:increased expression:stomach mucosa RGD PMID:11350545 RGD:2292012 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 ISO mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15138204 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11353854 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vgf VGF nerve growth factor inducible ISO CTD Direct Evidence: therapeutic CTD PMID:20805684 NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205 		JBrowse link
Leg Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr2 fibroblast growth factor receptor 2 ISO associated with chronic venous insufficiency;DNA:SNP:3' utr: (human) RGD PMID:15854058 RGD:155663562 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
Oral Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16391412 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO associated with Behcet Syndrome;protein:increased expression:muccal mucosa: RGD PMID:20580281 RGD:12910477 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: therapeutic CTD PMID:16391412 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO associated with Lupus Erythematosus, Systemic;DNA:SNP:intron:c.274-23582A>C (rs7574865) (human) RGD PMID:21719445 RGD:5147916 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
PAPA syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700017B05Rik RIKEN cDNA 1700017B05 gene ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,159,605...57,169,882
Ensembl chr 9:57,160,400...57,169,895 		JBrowse link
G Arid3b AT-rich interaction domain 3B ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,697,636...57,744,130
Ensembl chr 9:57,697,636...57,744,076 		JBrowse link
G Ccdc33 coiled-coil domain containing 33 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,935,956...58,026,111
Ensembl chr 9:57,935,960...58,026,106 		JBrowse link
G Cimap1c ciliary microtubule associated protein 1C ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:56,755,940...56,779,199
Ensembl chr 9:56,755,943...56,771,963 		JBrowse link
G Clk3 CDC-like kinase 3 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,657,904...57,672,397
Ensembl chr 9:57,657,907...57,673,143 		JBrowse link
G Commd4 COMM domain containing 4 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,062,319...57,065,633
Ensembl chr 9:57,062,319...57,065,615 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,423,012...57,439,710
Ensembl chr 9:57,428,557...57,439,709 		JBrowse link
G Cplx3 complexin 3 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,507,275...57,513,564
Ensembl chr 9:57,507,275...57,513,564 		JBrowse link
G Csk c-src tyrosine kinase ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,533,929...57,560,758
Ensembl chr 9:57,533,929...57,560,914 		JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Edc3 enhancer of mRNA decapping 3 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,615,823...57,659,782
Ensembl chr 9:57,615,823...57,659,782 		JBrowse link
G Etfa electron transferring flavoprotein, alpha polypeptide ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:55,361,720...55,419,528
Ensembl chr 9:55,361,792...55,419,527 		JBrowse link
G Fam219b family with sequence similarity 219, member B ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,443,648...57,450,471
Ensembl chr 9:57,444,811...57,450,467 		JBrowse link
G Fbxo22 F-box protein 22 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:55,116,219...55,131,717
Ensembl chr 9:55,116,209...55,131,717 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Imp3 IMP3, U3 small nucleolar ribonucleoprotein ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:56,844,784...56,845,682
Ensembl chr 9:56,844,759...56,845,682 		JBrowse link
G Isl2 insulin related protein 2 (islet 2) ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:55,445,961...55,454,951
Ensembl chr 9:55,445,956...55,453,464 		JBrowse link
G Islr immunoglobulin superfamily containing leucine-rich repeat ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:58,063,547...58,066,563
Ensembl chr 9:58,063,551...58,111,589 		JBrowse link
G Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:58,103,580...58,113,563
Ensembl chr 9:58,103,580...58,111,602 		JBrowse link
G Lman1l lectin, mannose-binding 1 like ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,514,080...57,528,057
Ensembl chr 9:57,514,368...57,528,057 		JBrowse link
G Loxl1 lysyl oxidase-like 1 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:58,195,006...58,220,495
Ensembl chr 9:58,195,021...58,220,469 		JBrowse link
G Man2c1 mannosidase, alpha, class 2C, member 1 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,037,953...57,049,497
Ensembl chr 9:57,037,974...57,050,006 		JBrowse link
G Mpi mannose phosphate isomerase ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,448,744...57,460,095
Ensembl chr 9:57,451,539...57,460,046 		JBrowse link
G Neil1 nei endonuclease VIII-like 1 (E. coli) ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589 		JBrowse link
G Nrg4 neuregulin 4 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:55,127,506...55,190,937
Ensembl chr 9:55,127,506...55,234,128 		JBrowse link
G Pml promyelocytic leukemia ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069 		JBrowse link
G Ppcdc phosphopantothenoylcysteine decarboxylase ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,292,378...57,347,440
Ensembl chr 9:57,292,378...57,347,407 		JBrowse link
G Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 ISO ClinVar Annotator: match by term: Familial recurrent arthritis | ClinVar Annotator: match by term: Pyogenic arthritis, pyoderma gangrenosum and acne | ClinVar Annotator: match by term: Pyogenic arthritis, pyoderma gangrenosum, and severe cystic acne
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:9262226 PMID:9536098 PMID:11971877 PMID:14595024 PMID:15580218 More... NCBI chr 9:55,985,729...56,036,174
Ensembl chr 9:55,997,246...56,036,172 		JBrowse link
G Ptpn9 protein tyrosine phosphatase, non-receptor type 9 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:56,902,252...56,970,092
Ensembl chr 9:56,902,207...56,970,091 		JBrowse link
G Rcn2 reticulocalbin 2 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:55,949,129...55,966,367
Ensembl chr 9:55,949,129...55,969,166 		JBrowse link
G Rpp25 ribonuclease P/MRP 25 subunit ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,411,385...57,412,730
Ensembl chr 9:57,411,309...57,412,731 		JBrowse link
G Scamp2 secretory carrier membrane protein 2 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,468,227...57,496,081
Ensembl chr 9:57,468,226...57,496,078 		JBrowse link
G Scamp5 secretory carrier membrane protein 5 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,348,610...57,375,343
Ensembl chr 9:57,348,610...57,375,343 		JBrowse link
G Scaper S phase cyclin A-associated protein in the ER ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:55,457,163...55,845,505
Ensembl chr 9:55,457,163...55,845,403 		JBrowse link
G Sema7a sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,846,879...57,870,148
Ensembl chr 9:57,847,395...57,870,148 		JBrowse link
G Sin3a transcriptional regulator, SIN3A (yeast) ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:56,979,271...57,035,652
Ensembl chr 9:56,979,324...57,035,650 		JBrowse link
G Snupn snurportin 1 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:56,855,158...56,893,545
Ensembl chr 9:56,858,162...56,890,490 		JBrowse link
G Snx33 sorting nexin 33 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:56,824,472...56,835,726
Ensembl chr 9:56,824,477...56,835,655 		JBrowse link
G Stoml1 stomatin-like 1 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:58,160,443...58,169,807
Ensembl chr 9:58,160,447...58,169,803 		JBrowse link
G Stra6 stimulated by retinoic acid gene 6 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,971,076...58,061,287
Ensembl chr 9:57,971,071...58,061,279 		JBrowse link
G Tmem266 transmembrane protein 266 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:55,234,194...55,345,629
Ensembl chr 9:55,234,197...55,345,629 		JBrowse link
G Ube2q2 ubiquitin-conjugating enzyme E2Q family member 2 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:55,056,602...55,114,813
Ensembl chr 9:55,056,138...55,114,813 		JBrowse link
G Ubl7 ubiquitin-like 7 (bone marrow stromal cell-derived) ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,818,280...57,837,624
Ensembl chr 9:57,818,262...57,837,251 		JBrowse link
G Ulk3 unc-51-like kinase 3 ISO ClinVar Annotator: match by term: Familial recurrent arthritis ClinVar PMID:28492532 NCBI chr 9:57,496,423...57,503,516
Ensembl chr 9:57,496,735...57,503,516 		JBrowse link
peptic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO associated with Asthma;mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cldn3 claudin 3 ISO protein:altered expression:epithelial cell, esophagus: RGD PMID:21373849 RGD:11344880 NCBI chr 5:135,015,068...135,016,330
Ensembl chr 5:135,015,068...135,016,326 		JBrowse link
G Cldn4 claudin 4 ISO protein:altered localization:esophagus epithelium, cytoplasm RGD PMID:16143882 RGD:2317602 NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18193101 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Egfr epidermal growth factor receptor ISO mRNA, protein:increased expression:esophagus, basal cell RGD PMID:11966524 RGD:10395244 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G F11r F11 receptor treatment ISO RGD PMID:19478094 RGD:7488941 NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171 		JBrowse link
G Il13 interleukin 13 ISO associated with asthma; mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid RGD PMID:18222984 RGD:2307110 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il5 interleukin 5 ISO associated with asthma; mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression: esophagus RGD PMID:28757556 RGD:25824949 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Mir29a microRNA 29a ISO RGD PMID:28757556 RGD:25824949 NCBI chr 6:31,039,595...31,039,682
Ensembl chr 6:31,039,595...31,039,682 		JBrowse link
G Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) ISO protein:decreased expression:esophageal epithelium (rat) RGD PMID:23942904 RGD:9854630 NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738 		JBrowse link
G Ptges prostaglandin E synthase ISO protein:increased expression:esophagus RGD PMID:16210398 RGD:2300085 NCBI chr 2:30,779,483...30,793,309
Ensembl chr 2:30,779,483...30,819,875 		JBrowse link
G Tjp1 tight junction protein 1 ISO RGD PMID:19653339 RGD:2325133 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:15942680 RGD:1580209 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor susceptibility ISO DNA:SNPs,haplotype:exon:rs1989969,rs2238135 (human) RGD PMID:25910066 RGD:11055189 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
peptic ulcer disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:19827302 RGD:2314640 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 treatment
susceptibility		 ISO DNA:polymorphisms:exons:
DNA:SNP: :CYP2C19*17(human)		 RGD PMID:9867757 PMID:23267857 RGD:124713408, RGD:124713412 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16384872 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Gast gastrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10700044 NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822 		JBrowse link
G Gsr glutathione reductase treatment ISO RGD PMID:24480520 RGD:10401900 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO associated with Helicobacter Infections;DNA:polymorphisms:cds:HLA-DRB1*07, HLA-DRB1*17 (human) RGD PMID:20405713 RGD:5147609 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G Hmox1 heme oxygenase 1 ISO RGD PMID:20610858 RGD:4145283 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) treatment ISO RGD PMID:23884819 RGD:11667098 NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19448967 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il27 interleukin 27 ISO associated with Helicobacter infections;protein:increased expression:blood serum (human) RGD PMID:21791025 RGD:126790506 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113 		JBrowse link
G Il33 interleukin 33 susceptibility ISO associated with Helicobacter Infections;DNA:SNP: : rs1929992(human) RGD PMID:31491552 RGD:39938849 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
pyoderma gangrenosum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mefv Mediterranean fever ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr16:3,524,838...3,536,073
Ensembl chr16:3,525,082...3,535,961 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:skin RGD PMID:21658319 RGD:8657060 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:skin RGD PMID:21658319 RGD:8657060 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr 9:55,985,729...56,036,174
Ensembl chr 9:55,997,246...56,036,172 		JBrowse link
Varicose Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 (alpha) no_association ISO RGD PMID:16153823 RGD:1626508 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) ISO DNA:polymorphism:intron:(CA) dinucleotide repeat (human)
DNA:SNPs:promoter, exon		 RGD PMID:16153823 PMID:18070128 RGD:1626508, RGD:8553061 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Hfe homeostatic iron regulator susceptibility
onset		 ISO associated with Chronic Venous Disease;DNA:missense mutation:cds:p.C282Y (human)
associated with Chronic Venous Disease;DNA:missense mutation:cds:p.H63D (human)		 RGD PMID:16102632 PMID:16678024 RGD:1582685, RGD:8694379 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
G Lepr leptin receptor ISO mRNA:decreased expression:skin RGD PMID:22773832 RGD:10412021 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 ISO protein:decreased expression:serum: RGD PMID:19997692 RGD:8694068 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Mir21a microRNA 21a ISO miRNA:increased expression:skin: RGD PMID:22773832 RGD:10412021 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
Zollinger-Ellison syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin ISO protein:decreased expression:serum RGD PMID:908508 RGD:2325683 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Egf epidermal growth factor ISO protein:increased expression:saliva RGD PMID:10811321 RGD:2317668 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Igf1r insulin-like growth factor I receptor ISO mRNA and protein: increased expression::poor prognosis for high expression RGD PMID:15867218 RGD:7242847 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16234
    Pathological Conditions, Signs and Symptoms 12645
      Pathologic Processes 7995
        Ulcer 183
          Oral Ulcer 4
          Umbilical Cord Ulceration and Intestinal Atresia 0
          chronic ulcer of skin + 89
          corneal ulcer + 5
          peptic ulcer disease + 89
paths to the root