Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pdgfa (platelet derived growth factor, alpha) Mus musculus
Analyze
Symbol: Pdgfa
Name: platelet derived growth factor, alpha
Description: Predicted to have several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including animal organ development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Localizes to extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in malignant glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; glioma pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: PDGF A-chain; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A
Orthologs:
Homo sapiens (human) : PDGFA (platelet derived growth factor subunit A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdgfa (platelet derived growth factor subunit A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfa (platelet derived growth factor subunit A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFA (platelet derived growth factor subunit A)
Canis lupus familiaris (dog) : PDGFA (platelet derived growth factor subunit A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfa (platelet derived growth factor subunit A)
Sus scrofa (pig) : PDGFA (platelet derived growth factor subunit A)
Chlorocebus sabaeus (African green monkey) : PDGFA (platelet derived growth factor subunit A)
Heterocephalus glaber (naked mole-rat) : Pdgfa (platelet derived growth factor subunit A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl5138,976,014 - 138,997,370 (-)EnsemblGRCm38mm10GRCm38
GRCm385138,976,014 - 139,000,792 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375139,452,925 - 139,470,907 (-)NCBIGRCm37mm9NCBIm37
MGSCv365139,230,613 - 139,248,595 (-)NCBImm8
Celera5136,032,139 - 136,049,986 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pdgfa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11067
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.