RGD Reference Report - Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis. - Rat Genome Database

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Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis.

Authors: Uemura, Risa  Murakami, Yoshiki  Hashimoto, Atsushi  Sawada, Akinari  Otani, Koji  Taira, Koichi  Hosomi, Shuhei  Nagami, Yasuaki  Tanaka, Fumio  Kamata, Noriko  Yamagami, Hirokazu  Tanigawa, Tetsuya  Watanabe, Toshio  Taguchi, Y-H  Fujiwara, Yasuhiro 
Citation: Uemura R, etal., Int J Mol Sci. 2017 Jul 25;18(8). pii: ijms18081611. doi: 10.3390/ijms18081611.
RGD ID: 25824949
Pubmed: (View Article at PubMed) PMID:28757556
DOI: Full-text: DOI:10.3390/ijms18081611

Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disease. However, the role of exosomal microRNAs (miRNAs) and esophageal miRNAs in GERD has not been studied. A rat model of acid reflux esophagitis was used to establish a novel diagnosis marker for GERD and examine dynamics of miRNA expression in GERD. Rats were sacrificed 3 (acute phase), 7 (sub-acute phase) and 21 days (chronic phase) after induction of esophagitis. Exosomes were extracted from serum, and the expression patterns of serum miRNAs were analyzed. Four upregulated miRNAs (miR-29a-3p, 128-3p, 223-3p and 3473) were identified by microarray analysis. The expression levels of exosomal miR-29a-3p were significantly higher in the chronic phase of reflux esophagitis compared with controls, and increased expression of miR-29a-3p was specific to chronic reflux esophagitis. Esophageal miR-223-3p expression was higher compared with controls, and gradually decreased from acute to chronic phase in esophagitis. In conclusion, exosomal miR-29a-3p and esophageal miR-223-3p might play roles in GERD.

Annotation

Disease Annotations    
peptic esophagitis  (IEP,ISO)

Gene Ontology Annotations    

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Mir223  (microRNA 223)
Mir29a  (microRNA 29a)

Genes (Mus musculus)
Mir223  (microRNA 223)
Mir29a  (microRNA 29a)

Genes (Homo sapiens)
MIR223  (microRNA 223)
MIR29A  (microRNA 29a)


Additional Information