Mir29a (microRNA 29a) - Rat Genome Database

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Gene: Mir29a (microRNA 29a) Mus musculus
Analyze
Symbol: Mir29a
Name: microRNA 29a
RGD ID: 1607664
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; and long-term synaptic potentiation. Part of RISC complex. Is expressed in brain; eye posterior segment; heart; and lung. Orthologous to human MIR29A (microRNA 29a).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: Mir; mir-29a; Mirn29a; mmu-mir-; mmu-mir-29a
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39631,039,595 - 31,039,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl631,039,595 - 31,039,682 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38631,062,660 - 31,062,747 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl631,062,660 - 31,062,747 (-)Ensemblmm10GRCm38
MGSCv37631,012,660 - 31,012,747 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera631,048,423 - 31,048,510 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.55NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (IDA)
epigenetic regulation of gene expression  (ISO)
long-term synaptic potentiation  (IEP)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of circulating fibrinogen levels  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (IDA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
positive regulation of wound healing  (ISO)
sensory perception of sound  (IEP)
tissue remodeling  (IGI)
vasodilation  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Assessment of Cell-Free Long Non-Coding RNA-H19 and miRNA-29a, miRNA-29b Expression and Severity of Diabetes. Alfaifi M, etal., Diabetes Metab Syndr Obes. 2020 Oct 14;13:3727-3737. doi: 10.2147/DMSO.S273586. eCollection 2020.
2. LncRNA H19 Drives Proliferation of Cardiac Fibroblasts and Collagen Production via Suppression of the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β Axis. Guo F, etal., Mol Cells. 2022 Mar 31;45(3):122-133. doi: 10.14348/molcells.2021.0066.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway. Sun Q, etal., Aging (Albany NY). 2020 Jun 16;12(12):11446-11465. doi: 10.18632/aging.103230. Epub 2020 Jun 16.
6. Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis. Uemura R, etal., Int J Mol Sci. 2017 Jul 25;18(8). pii: ijms18081611. doi: 10.3390/ijms18081611.
7. miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. Widlansky ME, etal., EMBO Mol Med. 2018 Mar;10(3). pii: emmm.201708046. doi: 10.15252/emmm.201708046.
8. MicroRNA-29a-5p is a novel predictor for early recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection. Zhu HT, etal., PLoS One. 2012;7(12):e52393. doi: 10.1371/journal.pone.0052393. Epub 2012 Dec 20.
Additional References at PubMed
PMID:12007417   PMID:12919684   PMID:15538371   PMID:16381832   PMID:16766679   PMID:16943360   PMID:17369397   PMID:17604727   PMID:18434550   PMID:18452032   PMID:18723672   PMID:18762567  
PMID:19559694   PMID:19726871   PMID:19906860   PMID:19933188   PMID:20164119   PMID:20212066   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20890893   PMID:20943204   PMID:20971881  
PMID:21037258   PMID:21267068   PMID:21324893   PMID:21522133   PMID:21646425   PMID:21718763   PMID:21784902   PMID:21822254   PMID:21903938   PMID:21930776   PMID:21965375   PMID:22167021  
PMID:22179202   PMID:22194605   PMID:22308400   PMID:22469499   PMID:22772450   PMID:23111009   PMID:23139829   PMID:23143395   PMID:23185045   PMID:23315977   PMID:23426367   PMID:23646144  
PMID:23825366   PMID:23960076   PMID:24052410   PMID:24074615   PMID:24085298   PMID:24096265   PMID:24103556   PMID:24401748   PMID:24457907   PMID:24535747   PMID:24578127   PMID:24816265  
PMID:24844433   PMID:24958907   PMID:25131933   PMID:25190143   PMID:25277410   PMID:25294817   PMID:25406379   PMID:25454218   PMID:25674218   PMID:25857925   PMID:25858512   PMID:25866874  
PMID:25923107   PMID:26003733   PMID:26020233   PMID:26305546   PMID:26608362   PMID:26696639   PMID:26750440   PMID:26808714   PMID:26844226   PMID:26903137   PMID:26934100   PMID:26938532  
PMID:26972749   PMID:27328306   PMID:27449105   PMID:27460630   PMID:27477273   PMID:27553862   PMID:27591939   PMID:27797453   PMID:27910161   PMID:28038351   PMID:28106784   PMID:28124096  
PMID:28342862   PMID:28404597   PMID:28404883   PMID:28460473   PMID:28637396   PMID:28811129   PMID:29074464   PMID:29105510   PMID:29138751   PMID:29158499   PMID:29366780   PMID:29462611  
PMID:29670089   PMID:29693165   PMID:29967491   PMID:30015903   PMID:30264370   PMID:30267383   PMID:30346946   PMID:30580435   PMID:30628716   PMID:30642005   PMID:30742779   PMID:30745801  
PMID:30781750   PMID:30827505   PMID:30876926   PMID:30917489   PMID:31014673   PMID:31153636   PMID:31252405   PMID:31292861   PMID:31495934   PMID:31627291   PMID:31652636   PMID:31662451  
PMID:31747615   PMID:31892308   PMID:32084395   PMID:32961796   PMID:32964047   PMID:33032631   PMID:33406428   PMID:33420578   PMID:33826889   PMID:33840587   PMID:34135859   PMID:34192317  
PMID:34255539   PMID:34464354   PMID:34476508   PMID:34502056   PMID:34615595   PMID:34758312   PMID:35008854   PMID:35219894   PMID:35288486   PMID:35490865   PMID:35946473   PMID:36322719  
PMID:36326553   PMID:36576412   PMID:36939367   PMID:37115401   PMID:37118999   PMID:37262956   PMID:37280619   PMID:37283037   PMID:37511199   PMID:37981221   PMID:37989983   PMID:38103809  
PMID:38311943   PMID:38821373   PMID:39191864   PMID:39209098   PMID:39269689  


Genomics

Comparative Map Data
Mir29a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39631,039,595 - 31,039,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl631,039,595 - 31,039,682 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38631,062,660 - 31,062,747 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl631,062,660 - 31,062,747 (-)Ensemblmm10GRCm38
MGSCv37631,012,660 - 31,012,747 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera631,048,423 - 31,048,510 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.55NCBI
MIR29A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387130,876,747 - 130,876,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7130,876,747 - 130,876,810 (-)Ensemblhg38GRCh38
GRCh377130,561,506 - 130,561,569 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367130,212,045 - 130,212,108 (-)NCBIBuild 36Build 36hg18NCBI36
Celera7125,312,587 - 125,312,650 (-)NCBICelera
Cytogenetic Map7q32.3NCBI
HuRef7124,876,998 - 124,877,061 (-)NCBIHuRef
CHM1_17130,495,162 - 130,495,225 (-)NCBICHM1_1
T2T-CHM13v2.07132,194,239 - 132,194,302 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27129,901,214 - 129,901,277 (-)NCBI
Mir29a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8460,617,955 - 60,618,042 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2459,650,608 - 59,650,695 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx464,621,101 - 64,621,188 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0460,537,282 - 60,537,369 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,939,224 - 58,939,311 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0458,343,931 - 58,344,018 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0458,099,674 - 58,099,761 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera454,744,230 - 54,744,317 (-)NCBICelera
Cytogenetic Map4q22NCBI
MIR29A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1146,184,844 - 6,184,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl146,184,830 - 6,184,916 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha145,845,114 - 5,845,173 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0145,919,035 - 5,919,094 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1146,124,590 - 6,124,649 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0145,869,856 - 5,869,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0146,013,045 - 6,013,104 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR29A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,040,032 - 18,040,118 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11818,040,032 - 18,040,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21819,035,225 - 19,035,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mir29a
2 total Variants
miRNA Target Status (No longer updated)

Predicted Targets
Summary Value
Count of predictions:24090
Count of gene targets:10153
Count of transcripts:16813
Interacting mature miRNAs:mmu-miR-29a-3p, mmu-miR-29a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000083676
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl631,039,595 - 31,039,682 (-)Ensembl
GRCm38.p6 Ensembl631,062,660 - 31,062,747 (-)Ensembl
RefSeq Acc Id: NR_029744
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39631,039,595 - 31,039,682 (-)NCBI
GRCm38631,062,660 - 31,062,747 (-)ENTREZGENE
MGSCv37631,012,660 - 31,012,747 (-)RGD
Celera631,048,423 - 31,048,510 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Promoters
RGD ID:6889252
Promoter ID:EPDNEW_M8077
Type:single initiation site
Name:Mir29a_1
Description:Mus musculus microRNA 29a , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38631,062,670 - 31,062,730EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676904 AgrOrtholog
Ensembl Genes ENSMUSG00000065610 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083676 ENTREZGENE
MGD MGI:2676904 ENTREZGENE
miRBase MI0000576 ENTREZGENE
NCBI Gene 387222 ENTREZGENE
PhenoGen Mir29a PhenoGen
RNAcentral URS0000076995 RNACentral
  URS00002F4D78 RNACentral
  URS000075D2D5 RNACentral