MIR223 (microRNA 223) - Rat Genome Database

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Gene: MIR223 (microRNA 223) Homo sapiens
Analyze
Symbol: MIR223
Name: microRNA 223
RGD ID: 1342661
HGNC Page HGNC:31603
Description: Enables lncRNA binding activity; mRNA 3'-UTR binding activity; and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of high-density lipoprotein particle clearance; and regulation of gene expression. Located in extracellular exosome. Implicated in lung non-small cell carcinoma. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); liver disease (multiple); and lung disease (multiple).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-223; MIRN223; miRNA223
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X66,018,870 - 66,018,979 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX66,018,870 - 66,018,979 (+)EnsemblGRCh38hg38GRCh38
GRCh37X65,238,712 - 65,238,821 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X65,155,436 - 65,155,545 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX65,585,857 - 65,585,966 (+)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX59,065,818 - 59,065,927 (+)NCBIHuRef
CHM1_1X65,131,742 - 65,131,851 (+)NCBICHM1_1
T2T-CHM13v2.0X64,445,366 - 64,445,475 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Hepatitis  (ISO)
Acute Liver Failure  (IEP,ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult respiratory distress syndrome  (IEP)
Alcoholic Liver Diseases  (ISO)
aortic atherosclerosis  (ISO)
atherosclerosis  (IEP)
autistic disorder  (IAGP)
autoimmune hepatitis  (ISO)
Barrett's esophagus  (IEP)
Binge Drinking  (IEP,ISO)
brain infarction  (ISO)
brain ischemia  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (IEP)
Colonic Neoplasms  (EXP)
colorectal cancer  (IEP)
coronary artery disease  (IEP)
diabetes mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Febrile Seizures  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hypercholesterolemia  (ISO)
Intervertebral Disc Displacement  (IEP)
Knee Osteoarthritis  (ISO)
liver cirrhosis  (IEP)
Liver Injury  (ISO)
Liver Metastasis  (IEP)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (IDA,IEP)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
myocardial infarction  (ISO)
Neuralgia  (ISO)
obesity  (IEP)
peptic esophagitis  (ISO)
primary biliary cholangitis  (IEP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
Schistosomiasis Japonica  (IEP,ISO)
Sepsis  (IEP)
Sleep Deprivation  (ISO)
stomach cancer  (IEP)
syndromic X-linked intellectual disability Lubs type  (IAGP)
Systemic Inflammatory Response Syndrome  (IEP)
thrombophlebitis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IEP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell proliferation in bone marrow  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IMP,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
defense response to bacterium  (ISS)
granulocyte differentiation  (ISO)
inflammatory response  (IMP)
miRNA-mediated gene silencing by mRNA destabilization  (IDA)
miRNA-mediated post-transcriptional gene silencing  (IDA,ISO)
negative regulation of autophagy  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell size  (ISO)
negative regulation of high-density lipoprotein particle clearance  (IDA)
negative regulation of inflammatory response  (ISS)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-18 production  (ISO)
negative regulation of necroptotic process  (ISS)
negative regulation of neutrophil chemotaxis  (ISS)
negative regulation of non-canonical NF-kappaB signal transduction  (ISS)
negative regulation of pyroptosis  (IMP)
negative regulation of Rho protein signal transduction  (IDA)
negative regulation of vascular associated smooth muscle cell migration  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (IDA,ISO)
physiological cardiac muscle hypertrophy  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of fibroblast chemotaxis  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of glucose import  (IDA)
positive regulation of granulocyte differentiation  (ISO)
positive regulation of myofibroblast differentiation  (ISO)
positive regulation of protein localization to plasma membrane  (IDA)
regulation of dendritic cell differentiation  (ISS)
regulation of gene expression  (ISO)
regulation of macrophage differentiation  (ISS)
regulation of vasculature development  (IDA)
response to bacterium  (ISO)
response to gravity  (ISO)
response to hypoxia  (IDA)
response to oxygen levels  (ISO)
response to psychosocial stress  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Autism  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cytokine and microRNA levels during different periods of paradoxical sleep deprivation and sleep recovery in rats. Brianza-Padilla M, etal., PeerJ. 2018 Sep 13;6:e5567. doi: 10.7717/peerj.5567. eCollection 2018.
2. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. Calvente CJ, etal., J Clin Invest. 2019 Jul 11;130:4091-4109. doi: 10.1172/JCI122258.
3. BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis. Chen L, etal., Mol Immunol. 2018 Jan;93:38-46. doi: 10.1016/j.molimm.2017.11.008. Epub 2017 Nov 13.
4. Association of plasma miR-223 and platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy: A preliminary report. Chyrchel B, etal., Platelets. 2015;26(6):593-7. doi: 10.3109/09537104.2014.974527. Epub 2014 Oct 28.
5. Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats. Cuomo O, etal., Mol Ther Nucleic Acids. 2019 Dec 6;18:1063-1071. doi: 10.1016/j.omtn.2019.10.022. Epub 2019 Oct 28.
6. miR-223-5p Suppresses Tumor Growth and Metastasis in Non-Small Cell Lung Cancer by Targeting E2F8. Dou L, etal., Oncol Res. 2019 Feb 5;27(2):261-268. doi: 10.3727/096504018X15219188894056. Epub 2018 Apr 3.
7. Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma. Giray BG, etal., Mol Biol Rep. 2014 Jul;41(7):4513-9. doi: 10.1007/s11033-014-3322-3. Epub 2014 Mar 5.
8. 2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension through regulating microRNA-223. Hao S, etal., J Cell Physiol. 2019 May;234(5):6324-6335. doi: 10.1002/jcp.27363. Epub 2018 Sep 24.
9. Host serum miR-223 is a potential new biomarker for Schistosoma japonicum infection and the response to chemotherapy. He X, etal., Parasit Vectors. 2013 Sep 20;6:272. doi: 10.1186/1756-3305-6-272.
10. MicroRNA-223 Ameliorates Nonalcoholic Steatohepatitis and Cancer by Targeting Multiple Inflammatory and Oncogenic Genes in Hepatocytes. He Y, etal., Hepatology. 2019 Oct;70(4):1150-1167. doi: 10.1002/hep.30645. Epub 2019 Jun 5.
11. Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9. Hyrina A, etal., EBioMedicine. 2017 Sep;23:68-78. doi: 10.1016/j.ebiom.2017.08.020. Epub 2017 Aug 24.
12. miR-223 and Stathmin-1 Expression in Non-tumor Liver Tissue of Patients with Hepatocellular Carcinoma. Imura S, etal., Anticancer Res. 2017 Oct;37(10):5877-5883. doi: 10.21873/anticanres.12033.
13. Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. Ji D, etal., Aging (Albany NY). 2020 Jan 29;12(2):1643-1655. doi: 10.18632/aging.102705. Epub 2020 Jan 29.
14. MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. Jimenez Calvente C, etal., Mol Ther. 2020 Feb 5;28(2):653-663. doi: 10.1016/j.ymthe.2019.09.013. Epub 2019 Sep 13.
15. Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. Kawashita Y, etal., J Hepatobiliary Pancreat Sci. 2017 Oct;24(10):576-583. doi: 10.1002/jhbp.500. Epub 2017 Oct 12.
16. Expression profiling of microRNAs in lipopolysaccharide-induced acute lung injury after hypothermia treatment. Lee W, etal., Mol Cell Toxicol. 2016;12(3):243-253. doi: 10.1007/s13273-016-0029-7. Epub 2016 Oct 7.
17. Effect of miR-223 on thrombophlebitis rats through regulating Toll-like receptor signaling pathway. Li HL, etal., Eur Rev Med Pharmacol Sci. 2020 Feb;24(4):2020-2027. doi: 10.26355/eurrev_202002_20380.
18. MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. Li M, etal., Gut. 2017 Apr;66(4):705-715. doi: 10.1136/gutjnl-2016-311861. Epub 2016 Sep 27.
19. miRNA-223-3p and let-7b-3p as potential blood biomarkers associated with the ischemic penumbra in rats. Li S, etal., Acta Neurobiol Exp (Wars). 2019;79(2):205-216.
20. MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways. Li Y, etal., J Biol Chem. 2019 Jul 5;294(27):10438-10448. doi: 10.1074/jbc.RA119.007755. Epub 2019 May 22.
21. Role of miR-223-3p in pulmonary arterial hypertension via targeting ITGB3 in the ECM pathway. Liu A, etal., Cell Prolif. 2019 Mar;52(2):e12550. doi: 10.1111/cpr.12550. Epub 2018 Dec 3.
22. MicroRNA-223 Regulates Cardiac Fibrosis After Myocardial Infarction by Targeting RASA1. Liu X, etal., Cell Physiol Biochem. 2018;46(4):1439-1454. doi: 10.1159/000489185. Epub 2018 Apr 19.
23. MicroRNA-223 protects neonatal rat cardiomyocytes and H9c2 cells from hypoxia-induced apoptosis and excessive autophagy via the Akt/mTOR pathway by targeting PARP-1. Liu X, etal., J Mol Cell Cardiol. 2018 May;118:133-146. doi: 10.1016/j.yjmcc.2018.03.018. Epub 2018 Mar 31.
24. The Expression of microRNA-223 and FAM5C in Cerebral Infarction Patients with Diabetes Mellitus. Long Y, etal., Cardiovasc Toxicol. 2017 Jan;17(1):42-48. doi: 10.1007/s12012-015-9354-7.
25. Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p. Lu FB, etal., Mol Cells. 2019 Dec 31;42(12):906-918. doi: 10.14348/molcells.2019.2283.
26. miR-223 reverses experimental pulmonary arterial hypertension. Meloche J, etal., Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C363-72. doi: 10.1152/ajpcell.00149.2015. Epub 2015 Jun 17.
27. MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation. Moen A, etal., J Transl Med. 2017 May 1;15(1):89. doi: 10.1186/s12967-017-1194-8.
28. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Neudecker V, etal., Sci Transl Med. 2017 Sep 20;9(408). pii: 9/408/eaah5360. doi: 10.1126/scitranslmed.aah5360.
29. Serum microRNAs; miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers for HCV-positive cirrhosis and hepatocellular carcinoma. Oksuz Z, etal., Mol Biol Rep. 2015 Mar;42(3):713-20. doi: 10.1007/s11033-014-3819-9. Epub 2014 Nov 13.
30. miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insulin-Like Growth Factor 1 Receptor. Qadir XV, etal., Am J Pathol. 2015 Dec;185(12):3141-51. doi: 10.1016/j.ajpath.2015.08.020.
31. Expression and significance of miR-223 in rats with pulmonary fibrosis. Qu SJ, etal., Eur Rev Med Pharmacol Sci. 2020 Apr;24(7):3951-3958. doi: 10.26355/eurrev_202004_20864.
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. miR-223 represents a biomarker in acute and chronic liver injury. Schueller F, etal., Clin Sci (Lond). 2017 Jul 13;131(15):1971-1987. doi: 10.1042/CS20170218. Print 2017 Aug 1.
34. Electroacupuncture Alleviates Ischemic Brain Injury by Inhibiting the miR-223/NLRP3 Pathway. Sha R, etal., Med Sci Monit. 2019 Jun 25;25:4723-4733. doi: 10.12659/MSM.917213.
35. Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients. Shaker OG and Senousy MA, J Viral Hepat. 2017 Aug;24(8):636-644. doi: 10.1111/jvh.12696. Epub 2017 Mar 13.
36. An Endocrine Genetic Signal Between Blood Cells and Vascular Smooth Muscle Cells: Role of MicroRNA-223 in Smooth Muscle Function and Atherogenesis. Shan Z, etal., J Am Coll Cardiol. 2015 Jun 16;65(23):2526-37. doi: 10.1016/j.jacc.2015.03.570.
37. MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1. Streppel MM, etal., Clin Cancer Res. 2013 Aug 1;19(15):4067-78. doi: 10.1158/1078-0432.CCR-13-0601. Epub 2013 Jun 11.
38. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
39. Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis. Uemura R, etal., Int J Mol Sci. 2017 Jul 25;18(8). pii: ijms18081611. doi: 10.3390/ijms18081611.
40. MicroRNA-223 coordinates cholesterol homeostasis. Vickers KC, etal., Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14518-23. doi: 10.1073/pnas.1215767111. Epub 2014 Sep 22.
41. Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway. Wang B, etal., Biomed Pharmacother. 2019 Jun;114:108683. doi: 10.1016/j.biopha.2019.108683. Epub 2019 Apr 1.
42. MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. Wang X, etal., PLoS One. 2017 Sep 8;12(9):e0184292. doi: 10.1371/journal.pone.0184292. eCollection 2017.
43. [Relationship between expression of microRNA and inflammatory cytokines plasma level in pediatric patients with sepsis]. Wu Y, etal., Zhonghua Er Ke Za Zhi. 2014 Jan;52(1):28-33.
44. Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain. Xie XJ, etal., Mol Pain. 2017 Jan-Dec;13:1744806917706582. doi: 10.1177/1744806917706582.
45. Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Xu J, etal., Mol Carcinog. 2011 Feb;50(2):136-42. doi: 10.1002/mc.20712. Epub 2010 Dec 10.
46. NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression. Yang F, etal., Cell Death Dis. 2018 Jan 9;9(1):12. doi: 10.1038/s41419-017-0020-9.
47. MicroRNA-223 acts as an important regulator to Kupffer cells activation at the early stage of Con A-induced acute liver failure via AIM2 signaling pathway. Yang F, etal., Cell Physiol Biochem. 2014;34(6):2137-52. doi: 10.1159/000369658. Epub 2014 Dec 2.
48. Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy. Yang L, etal., J Biol Chem. 2016 Jul 22;291(30):15700-13. doi: 10.1074/jbc.M116.715805. Epub 2016 May 20.
49. Association of MicroRNA-223 expression with hepatic ischemia/reperfusion injury in mice. Yu CH, etal., Dig Dis Sci. 2009 Nov;54(11):2362-6. doi: 10.1007/s10620-008-0629-8. Epub 2008 Dec 23.
50. EPO-cyclosporine combination therapy reduced brain infarct area in rat after acute ischemic stroke: role of innate immune-inflammatory response, micro-RNAs and MAPK family signaling pathway. Yuen CM, etal., Am J Transl Res. 2017 Apr 15;9(4):1651-1666. eCollection 2017.
51. Differential miRNAomics of the synovial membrane in knee osteoarthritis induced by bilateral anterior cruciate ligament transection in rats. Zhou J, etal., Mol Med Rep. 2018 Oct;18(4):4051-4057. doi: 10.3892/mmr.2018.9385. Epub 2018 Aug 13.
Additional References at PubMed
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PMID:21037258   PMID:21213211   PMID:21453483   PMID:21628394   PMID:21939504   PMID:22006119   PMID:22032299   PMID:22145958   PMID:22238823   PMID:22270966   PMID:22424712   PMID:22470493  
PMID:22569260   PMID:22903258   PMID:22932402   PMID:22984081   PMID:22984082   PMID:23026916   PMID:23056289   PMID:23094093   PMID:23144169   PMID:23174904   PMID:23208072   PMID:23436935  
PMID:23444217   PMID:23459944   PMID:23489116   PMID:23584479   PMID:23601845   PMID:23857984   PMID:23886700   PMID:23897768   PMID:23925649   PMID:23946414   PMID:23953883   PMID:23970099  
PMID:23978443   PMID:24048714   PMID:24078287   PMID:24084739   PMID:24141720   PMID:24202700   PMID:24227773   PMID:24250812   PMID:24284509   PMID:24304814   PMID:24307738   PMID:24324762  
PMID:24333181   PMID:24390317   PMID:24400121   PMID:24438193   PMID:24576947   PMID:24708646   PMID:24727161   PMID:24727676   PMID:24784921   PMID:24816316   PMID:24819398   PMID:24909097  
PMID:25036956   PMID:25040542   PMID:25159729   PMID:25177699   PMID:25181337   PMID:25233400   PMID:25270282   PMID:25367852   PMID:25388103   PMID:25463083   PMID:25519054   PMID:25637573  
PMID:25662703   PMID:25710580   PMID:25819175   PMID:25824152   PMID:25842981   PMID:25867276   PMID:25880332   PMID:25881295   PMID:25888377   PMID:25944670   PMID:25950115   PMID:26002284  
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PMID:28719355   PMID:28883474   PMID:29079174   PMID:29083107   PMID:29144508   PMID:29145789   PMID:29158064   PMID:29414804   PMID:29444433   PMID:29459239   PMID:29506638   PMID:29518547  
PMID:29526844   PMID:29540855   PMID:29628305   PMID:29660302   PMID:29668922   PMID:29701752   PMID:29707897   PMID:29794437   PMID:29888618   PMID:29943706   PMID:29979415   PMID:30033329  
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PMID:30962309   PMID:31026096   PMID:31088429   PMID:31096070   PMID:31144545   PMID:31300703   PMID:31311397   PMID:31318097   PMID:31395736   PMID:31486492   PMID:31488416   PMID:31525642  
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PMID:31912865   PMID:31926946   PMID:32013852   PMID:32102516   PMID:32169441   PMID:32196591   PMID:32233593   PMID:32330203   PMID:32341353   PMID:32421465   PMID:32487772   PMID:32516127  
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PMID:33145937   PMID:33155933   PMID:33157494   PMID:33236445   PMID:33238267   PMID:33287944   PMID:33327275   PMID:33373321   PMID:33382770   PMID:33478974   PMID:33481334   PMID:33522355  
PMID:33574820   PMID:33604647   PMID:33617143   PMID:33650318   PMID:33677796   PMID:33710119   PMID:33744257   PMID:33839256   PMID:33904674   PMID:33932136   PMID:33951281   PMID:34048709  
PMID:34077008   PMID:34098766   PMID:34101224   PMID:34115574   PMID:34151668   PMID:34237309   PMID:34239357   PMID:34259105   PMID:34332589   PMID:34344968   PMID:34381015   PMID:34410579  
PMID:34421892   PMID:34470587   PMID:34539244   PMID:34637033   PMID:34668437   PMID:34698362   PMID:34753389   PMID:34766549   PMID:34843004   PMID:34851479   PMID:34857901   PMID:34893101  
PMID:34953047   PMID:35015850   PMID:35068331   PMID:35132909   PMID:35194762   PMID:35202001   PMID:35227836   PMID:35229259   PMID:35272010   PMID:35275525   PMID:35355424   PMID:35490837  
PMID:35588441   PMID:35588895   PMID:35636636   PMID:35698848   PMID:35780881   PMID:35793763   PMID:35880619   PMID:36012644   PMID:36139082   PMID:36192429   PMID:36221121   PMID:36355210  
PMID:36430468   PMID:36579994   PMID:36640195   PMID:36730544   PMID:36731227   PMID:36792357   PMID:36980300   PMID:37070323   PMID:37164919   PMID:37364375   PMID:37506144   PMID:37548713  
PMID:37622669   PMID:37637249   PMID:37715968   PMID:37833790   PMID:37924447   PMID:38071964   PMID:38421705   PMID:38425288   PMID:38448875   PMID:38494770  


Genomics

Comparative Map Data
MIR223
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X66,018,870 - 66,018,979 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX66,018,870 - 66,018,979 (+)EnsemblGRCh38hg38GRCh38
GRCh37X65,238,712 - 65,238,821 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X65,155,436 - 65,155,545 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX65,585,857 - 65,585,966 (+)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX59,065,818 - 59,065,927 (+)NCBIHuRef
CHM1_1X65,131,742 - 65,131,851 (+)NCBICHM1_1
T2T-CHM13v2.0X64,445,366 - 64,445,475 (+)NCBIT2T-CHM13v2.0
Mir223
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X95,286,423 - 95,286,532 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX95,286,423 - 95,286,532 (+)EnsemblGRCm39 Ensembl
GRCm38X96,242,817 - 96,242,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX96,242,817 - 96,242,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X93,438,156 - 93,438,265 (+)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX83,247,617 - 83,247,726 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.69NCBI
Mir223
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X65,151,383 - 65,151,492 (+)NCBIGRCr8
mRatBN7.2X61,141,887 - 61,141,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX61,141,887 - 61,141,996 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX62,615,555 - 62,615,664 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X66,116,079 - 66,116,188 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X63,673,322 - 63,673,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X65,367,812 - 65,367,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX65,367,812 - 65,367,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X66,205,958 - 66,206,067 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX61,554,814 - 61,554,923 (+)NCBICelera
Cytogenetic MapXq22NCBI
MIR223
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X50,838,131 - 50,838,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX50,838,131 - 50,838,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX41,675,998 - 41,676,100 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X51,802,379 - 51,802,481 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X49,766,866 - 49,766,968 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X51,114,791 - 51,114,893 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X51,030,133 - 51,030,235 (+)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003242)x3 copy number gain See cases [RCV000133911] ChrX:10701..156003242 [GRCh38]
ChrX:60701..155232907 [GRCh37]
ChrX:701..154886101 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|likely pathogenic|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x1 copy number loss See cases [RCV000050811] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x3 copy number gain See cases [RCV000050810] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:3092486-155699618)x2 copy number gain See cases [RCV000050889] ChrX:3092486..155699618 [GRCh38]
ChrX:3010527..154929279 [GRCh37]
ChrX:3020527..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x1 copy number loss See cases [RCV000050699] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|See cases [RCV000050385] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x1 copy number loss Global developmental delay [RCV000050386]|See cases [RCV000050386] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x3 copy number gain See cases [RCV000050697] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xq11.1-28(chrX:63279794-155939524)x1 copy number loss See cases [RCV000051666] ChrX:63279794..155939524 [GRCh38]
ChrX:62499671..155169188 [GRCh37]
ChrX:62416396..154822382 [NCBI36]
ChrX:Xq11.1-28		 pathogenic
GRCh38/hg38 Xp11.21-q28(chrX:57372584-155996431)x1 copy number loss See cases [RCV000051665] ChrX:57372584..155996431 [GRCh38]
ChrX:57399017..155226096 [GRCh37]
ChrX:57415742..154879290 [NCBI36]
ChrX:Xp11.21-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:40704-156022362)x3 copy number gain See cases [RCV000052325] ChrX:40704..156022362 [GRCh38]
ChrX:90704..155252027 [GRCh37]
ChrX:30704..154905221 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26101-155999293)x3 copy number gain See cases [RCV000052322] ChrX:26101..155999293 [GRCh38]
ChrX:76101..155228958 [GRCh37]
ChrX:16101..154882152 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2790845-155699618)x3 copy number gain See cases [RCV000052359] ChrX:2790845..155699618 [GRCh38]
ChrX:2708886..154929279 [GRCh37]
ChrX:2718886..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xq11.1-13.1(chrX:62712219-71136309)x2 copy number gain See cases [RCV000052415] ChrX:62712219..71136309 [GRCh38]
ChrX:61931689..70356159 [GRCh37]
ChrX:61848414..70272884 [NCBI36]
ChrX:Xq11.1-13.1		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:237659-156022362)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052327]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052327]|See cases [RCV000052327] ChrX:237659..156022362 [GRCh38]
ChrX:154326..155252027 [GRCh37]
ChrX:94326..154905221 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:27245-155996431)x3 copy number gain See cases [RCV000052324] ChrX:27245..155996431 [GRCh38]
ChrX:77245..155226096 [GRCh37]
ChrX:17245..154879290 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x1 copy number loss Global developmental delay [RCV000052986]|Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052987]|Intellectual functioning disability [RCV000052988]|Global developmental delay [RCV000052989]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052987]|See cases [RCV000052986] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q22.1(chrX:675360-100368517)x1 copy number loss See cases [RCV000053005] ChrX:675360..100368517 [GRCh38]
ChrX:636095..99623515 [GRCh37]
ChrX:556095..99510171 [NCBI36]
ChrX:Xp22.33-q22.1		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:14245-155999293)x1 copy number loss Hypoplastic left heart [RCV000052982]|See cases [RCV000052982] ChrX:14245..155999293 [GRCh38]
ChrX:64245..155228958 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x3 copy number gain Global developmental delay [RCV000052984]|Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052985]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052985]|See cases [RCV000052984] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-155978689)x1 copy number loss See cases [RCV000133792] ChrX:10701..155978689 [GRCh38]
ChrX:60701..155208354 [GRCh37]
ChrX:701..154861548 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x1 copy number loss See cases [RCV000050386] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:679..154896026 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x3 copy number gain See cases [RCV000050385] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:679..154896026 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:14245-155999293)x1 copy number loss See cases [RCV000052982] ChrX:14245..155999293 [GRCh38]
ChrX:64245..155228958 [GRCh37]
ChrX:4245..154882152 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x1 copy number loss See cases [RCV000052986] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:16102..154879290 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x3 copy number gain See cases [RCV000052984] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:16102..154879290 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022826)x4 copy number gain See cases [RCV000133654] ChrX:10679..156022826 [GRCh38]
ChrX:60679..155252491 [GRCh37]
ChrX:679..154905685 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xq11.1-21.1(chrX:62712219-78605009)x3 copy number gain See cases [RCV000134569] ChrX:62712219..78605009 [GRCh38]
ChrX:61931689..77860506 [GRCh37]
ChrX:61848414..77747162 [NCBI36]
ChrX:Xq11.1-21.1		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-155999253)x3 copy number gain See cases [RCV000134564] ChrX:20297..155999253 [GRCh38]
ChrX:70297..155228918 [GRCh37]
ChrX:10297..154882112 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003242)x1 copy number loss See cases [RCV000133947] ChrX:10701..156003242 [GRCh38]
ChrX:60701..155232907 [GRCh37]
ChrX:701..154886101 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xq11.1-28(chrX:62712230-155978888)x3 copy number gain See cases [RCV000134025] ChrX:62712230..155978888 [GRCh38]
ChrX:61931700..155208553 [GRCh37]
ChrX:61848425..154861747 [NCBI36]
ChrX:Xq11.1-28		 pathogenic
GRCh38/hg38 Xp21.1-q28(chrX:37076284-156016920)x1 copy number loss See cases [RCV000135300] ChrX:37076284..156016920 [GRCh38]
ChrX:37094357..155246585 [GRCh37]
ChrX:37004278..154899779 [NCBI36]
ChrX:Xp21.1-q28		 pathogenic
GRCh38/hg38 Xp11.22-q21.31(chrX:53985575-92203108)x1 copy number loss See cases [RCV000135306] ChrX:53985575..92203108 [GRCh38]
ChrX:54012008..91458107 [GRCh37]
ChrX:54028733..91344763 [NCBI36]
ChrX:Xp11.22-q21.31		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-156026127)x1 copy number loss See cases [RCV000135321] ChrX:20297..156026127 [GRCh38]
ChrX:70297..155255792 [GRCh37]
ChrX:10297..154908986 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp21.1-q28(chrX:36237706-156022206)x1 copy number loss See cases [RCV000135552] ChrX:36237706..156022206 [GRCh38]
ChrX:36255823..155251871 [GRCh37]
ChrX:36165744..154905065 [NCBI36]
ChrX:Xp21.1-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:40904-155998166)x1 copy number loss See cases [RCV000136478] ChrX:40904..155998166 [GRCh38]
ChrX:90904..155227831 [GRCh37]
ChrX:30904..154881025 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003229)x1 copy number loss See cases [RCV000136097] ChrX:10701..156003229 [GRCh38]
ChrX:60701..155232894 [GRCh37]
ChrX:701..154886088 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q25(chrX:10701-128393708) copy number loss See cases [RCV000136094] ChrX:10701..128393708 [GRCh38]
ChrX:60701..127527686 [GRCh37]
ChrX:701..127355367 [NCBI36]
ChrX:Xp22.33-q25		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10001-156030895)x1 copy number loss See cases [RCV000136005] ChrX:10001..156030895 [GRCh38]
ChrX:60001..155260560 [GRCh37]
ChrX:1..154913754 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2782275-155611794)x2 copy number gain See cases [RCV000136841] ChrX:2782275..155611794 [GRCh38]
ChrX:2700316..154785891 [GRCh37]
ChrX:2710316..154494649 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2765636-155522304)x3 copy number gain See cases [RCV000136791] ChrX:2765636..155522304 [GRCh38]
ChrX:2683677..154751965 [GRCh37]
ChrX:2693677..154405159 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xq11.1-28(chrX:62561604-156003242)x3 copy number gain See cases [RCV000137553] ChrX:62561604..156003242 [GRCh38]
ChrX:61781074..155232907 [GRCh37]
ChrX:61697799..154886101 [NCBI36]
ChrX:Xq11.1-28		 pathogenic
GRCh38/hg38 Xp11.23-q22.1(chrX:49100536-102174742)x1 copy number loss See cases [RCV000137414] ChrX:49100536..102174742 [GRCh38]
ChrX:48957474..101429714 [GRCh37]
ChrX:48844418..101316370 [NCBI36]
ChrX:Xp11.23-q22.1		 pathogenic|likely benign
GRCh38/hg38 Xp22.33-q13.3(chrX:10679-76420505)x3 copy number gain See cases [RCV000137137] ChrX:10679..76420505 [GRCh38]
ChrX:60679..75640898 [GRCh37]
ChrX:679..75557302 [NCBI36]
ChrX:Xp22.33-q13.3		 pathogenic|likely benign
GRCh38/hg38 Xp22.33-q22.3(chrX:10701-106113403)x1 copy number loss See cases [RCV000137886] ChrX:10701..106113403 [GRCh38]
ChrX:60701..105357395 [GRCh37]
ChrX:701..105244051 [NCBI36]
ChrX:Xp22.33-q22.3		 pathogenic
GRCh38/hg38 Xp22.2-q27.3(chrX:13020141-143473520)x1 copy number loss See cases [RCV000138678] ChrX:13020141..143473520 [GRCh38]
ChrX:13038260..142561303 [GRCh37]
ChrX:12948181..142388969 [NCBI36]
ChrX:Xp22.2-q27.3		 pathogenic
GRCh38/hg38 Xp22.33-q21.31(chrX:10701-88318651)x1 copy number loss See cases [RCV000139352] ChrX:10701..88318651 [GRCh38]
ChrX:60701..87573652 [GRCh37]
ChrX:701..87460308 [NCBI36]
ChrX:Xp22.33-q21.31		 pathogenic
GRCh38/hg38 Xq11.1-28(chrX:62712219-156003242)x3 copy number gain See cases [RCV000139416] ChrX:62712219..156003242 [GRCh38]
ChrX:61931689..155232907 [GRCh37]
ChrX:61848414..154886101 [NCBI36]
ChrX:Xq11.1-28		 pathogenic|likely benign
GRCh38/hg38 Xp22.33-q28(chrX:1085618-155699644)x1 copy number loss See cases [RCV000139278] ChrX:1085618..155699644 [GRCh38]
ChrX:1118268..154929305 [GRCh37]
ChrX:1038268..154582499 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004181)x3 copy number gain See cases [RCV000139888] ChrX:251880..156004181 [GRCh38]
ChrX:168547..155233846 [GRCh37]
ChrX:108547..154887040 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2299223-155992188)x3 copy number gain See cases [RCV000141400] ChrX:2299223..155992188 [GRCh38]
ChrX:2217264..155221853 [GRCh37]
ChrX:2227264..154875047 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-156016920)x3 copy number gain See cases [RCV000141401] ChrX:20297..156016920 [GRCh38]
ChrX:70297..155246585 [GRCh37]
ChrX:10297..154899779 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x4 copy number gain See cases [RCV000140786] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x1 copy number loss See cases [RCV000140787] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic|conflicting data from submitters
GRCh38/hg38 Xq12(chrX:65901792-66733457)x2 copy number gain See cases [RCV000141544] ChrX:65901792..66733457 [GRCh38]
ChrX:65121634..65953299 [GRCh37]
ChrX:65038359..65870024 [NCBI36]
ChrX:Xq12		 uncertain significance
GRCh38/hg38 Xp11.22-q24(chrX:50289384-119297604) copy number loss See cases [RCV000141742] ChrX:50289384..119297604 [GRCh38]
ChrX:50032384..118431567 [GRCh37]
ChrX:50049124..118315595 [NCBI36]
ChrX:Xp11.22-q24		 pathogenic
GRCh38/hg38 Xp22.33-q12(chrX:251880-66445845)x1 copy number loss See cases [RCV000142334] ChrX:251880..66445845 [GRCh38]
ChrX:168547..65665687 [GRCh37]
ChrX:108547..65582412 [NCBI36]
ChrX:Xp22.33-q12		 pathogenic
GRCh38/hg38 Xp22.33-q24(chrX:251879-118847157)x3 copy number gain See cases [RCV000142134] ChrX:251879..118847157 [GRCh38]
ChrX:168546..117981120 [GRCh37]
ChrX:108546..117865148 [NCBI36]
ChrX:Xp22.33-q24		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003229)x3 copy number gain See cases [RCV000142625] ChrX:10701..156003229 [GRCh38]
ChrX:60701..155232894 [GRCh37]
ChrX:701..154886088 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp11.22-q28(chrX:53144751-156003242)x1 copy number loss See cases [RCV000143349] ChrX:53144751..156003242 [GRCh38]
ChrX:53321095..155232907 [GRCh37]
ChrX:53190658..154886101 [NCBI36]
ChrX:Xp11.22-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251879-156004066)x1 copy number loss See cases [RCV000143441] ChrX:251879..156004066 [GRCh38]
ChrX:168546..155233731 [GRCh37]
ChrX:108546..154886925 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251879-156004066)x3 copy number gain See cases [RCV000143433] ChrX:251879..156004066 [GRCh38]
ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp11.21-q13.3(chrX:56431359-76557419)x1 copy number loss See cases [RCV000143131] ChrX:56431359..76557419 [GRCh38]
ChrX:56457792..75777827 [GRCh37]
ChrX:56474517..75694231 [NCBI36]
ChrX:Xp11.21-q13.3		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x3 copy number gain See cases [RCV000143219] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:108547..154886925 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x1 copy number loss See cases [RCV000148135] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x3 copy number gain See cases [RCV000148141] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155246643)x3 copy number gain See cases [RCV000240122] ChrX:71267..155246643 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xq11.1-28(chrX:62063537-155246643)x3 copy number gain See cases [RCV000240143] ChrX:62063537..155246643 [GRCh37]
ChrX:Xq11.1-28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:176426-155250222)x3 copy number gain See cases [RCV000239843] ChrX:176426..155250222 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155255839)x1 copy number loss See cases [RCV000239832] ChrX:71267..155255839 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.2-q28(chrX:13147668-155250222)x3 copy number gain See cases [RCV000239798] ChrX:13147668..155250222 [GRCh37]
ChrX:Xp22.2-q28		 pathogenic
GRCh37/hg19 Xp11.21-q21.1(chrX:55240087-78225374)x1 copy number loss See cases [RCV000511311] ChrX:55240087..78225374 [GRCh37]
ChrX:Xp11.21-q21.1		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255839)x3 copy number gain See cases [RCV000239934] ChrX:70297..155255839 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:150002-155234036)x2 copy number gain See cases [RCV000240106] ChrX:150002..155234036 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60701-155246271)x3 copy number gain See cases [RCV000239989] ChrX:60701..155246271 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:553069-155233731)x1 copy number loss See cases [RCV000446026] ChrX:553069..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155224766)x1 copy number loss See cases [RCV000239902] ChrX:71267..155224766 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp11.22-q12(chrX:53085607-67176333)x2 copy number gain See cases [RCV000239889] ChrX:53085607..67176333 [GRCh37]
ChrX:Xp11.22-q12		 pathogenic
GRCh37/hg19 Xq12-13.1(chrX:64927267-69276852)x3 copy number gain See cases [RCV000239973] ChrX:64927267..69276852 [GRCh37]
ChrX:Xq12-13.1		 uncertain significance
GRCh37/hg19 Xp22.33-q28(chrX:71267-155234036)x2 copy number gain See cases [RCV000239874] ChrX:71267..155234036 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp11.3-q21.1(chrX:44734936-79676121)x3 copy number gain See cases [RCV000240019] ChrX:44734936..79676121 [GRCh37]
ChrX:Xp11.3-q21.1		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:225816-155234036)x2 copy number gain See cases [RCV000240464] ChrX:225816..155234036 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:176426-155236656)x3 copy number gain See cases [RCV000240552] ChrX:176426..155236656 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:150002-155234036)x3 copy number gain See cases [RCV000240314] ChrX:150002..155234036 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xq11.1-28(chrX:62063537-155250222)x3 copy number gain See cases [RCV000240148] ChrX:62063537..155250222 [GRCh37]
ChrX:Xq11.1-28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:2707626-155250222)x2 copy number gain See cases [RCV000240541] ChrX:2707626..155250222 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.2-q25(chrX:11692290-121187337)x2 copy number gain not provided [RCV000488046] ChrX:11692290..121187337 [GRCh37]
ChrX:Xp22.2-q25		 uncertain significance
Single allele duplication Syndromic X-linked intellectual disability Lubs type [RCV000768455] ChrX:15323210..153542100 [GRCh37]
ChrX:Xp22.2-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-154930047)x3 copy number gain See cases [RCV000449437] ChrX:168546..154930047 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x3 copy number gain See cases [RCV000449330] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255792) copy number loss See cases [RCV000449461] ChrX:70297..155255792 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60701-155246225)x3 copy number gain See cases [RCV000446270] ChrX:60701..155246225 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:2703632-155233731)x1 copy number loss See cases [RCV000446712] ChrX:2703632..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155255792)x1 copy number loss See cases [RCV000446197] ChrX:71267..155255792 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:318707-155224707)x1 copy number loss See cases [RCV000446667] ChrX:318707..155224707 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp11.1-q28(chrX:58140271-155046703)x3 copy number gain See cases [RCV000446151] ChrX:58140271..155046703 [GRCh37]
ChrX:Xp11.1-q28		 pathogenic
GRCh37/hg19 Xq12(chrX:65057519-66020568)x3 copy number gain See cases [RCV000447036] ChrX:65057519..66020568 [GRCh37]
ChrX:Xq12		 uncertain significance
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x4 copy number gain See cases [RCV000446932] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155196888)x3 copy number gain See cases [RCV000446310] ChrX:168546..155196888 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155081533)x3 copy number gain See cases [RCV000447253] ChrX:168546..155081533 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168566-155233731)x1 copy number loss See cases [RCV000445720] ChrX:168566..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x1 copy number loss See cases [RCV000448393] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255792)x4 copy number gain See cases [RCV000448034] ChrX:70297..155255792 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155246585)x1 copy number loss See cases [RCV000448652] ChrX:70297..155246585 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:55532799-150239235)x1 copy number loss See cases [RCV000448870] ChrX:55532799..150239235 [GRCh37]
ChrX:Xp11.21-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168547-151304063)x1 copy number loss See cases [RCV000510382] ChrX:168547..151304063 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q23(chrX:168547-112474026)x1 copy number loss See cases [RCV000510419] ChrX:168547..112474026 [GRCh37]
ChrX:Xp22.33-q23		 pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:55000501-155230750)x3 copy number gain See cases [RCV000511787] ChrX:55000501..155230750 [GRCh37]
ChrX:Xp11.21-q28		 pathogenic
GRCh37/hg19 Xp21.1-q22.1(chrX:37521774-98488534)x1 copy number loss See cases [RCV000512026] ChrX:37521774..98488534 [GRCh37]
ChrX:Xp21.1-q22.1		 pathogenic
GRCh37/hg19 Xp21.2-q28(chrX:31088082-155233731)x1 copy number loss See cases [RCV000511413] ChrX:31088082..155233731 [GRCh37]
ChrX:Xp21.2-q28		 pathogenic|uncertain significance
GRCh37/hg19 Xp22.33-q28(chrX:168547-155233731) copy number gain See cases [RCV000512020] ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:57511767-155233731)x3 copy number gain See cases [RCV000510826] ChrX:57511767..155233731 [GRCh37]
ChrX:Xp11.21-q28		 pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:56457791-155233731)x3 copy number gain See cases [RCV000511307] ChrX:56457791..155233731 [GRCh37]
ChrX:Xp11.21-q28		 pathogenic
GRCh37/hg19 Xp22.33-q13.3(chrX:168546-74549686) copy number loss See cases [RCV000512142] ChrX:168546..74549686 [GRCh37]
ChrX:Xp22.33-q13.3		 pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:57415659-155233731)x3 copy number gain See cases [RCV000512173] ChrX:57415659..155233731 [GRCh37]
ChrX:Xp11.21-q28		 pathogenic
GRCh37/hg19 Xp22.31-q21.31(chrX:7841947-90815333)x1,2 copy number gain not provided [RCV000684261] ChrX:7841947..90815333 [GRCh37]
ChrX:Xp22.31-q21.31		 pathogenic
GRCh37/hg19 Xp11.23-q13.2(chrX:48115450-73424191)x1 copy number loss not provided [RCV000753535] ChrX:48115450..73424191 [GRCh37]
ChrX:Xp11.23-q13.2		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60262-155245765)x1 copy number loss not provided [RCV000753271] ChrX:60262..155245765 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60262-155245765)x3 copy number gain not provided [RCV000753272] ChrX:60262..155245765 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:181779-155171702)x1 copy number loss not provided [RCV000753278] ChrX:181779..155171702 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60814-155254881)x2 copy number gain not provided [RCV000753277] ChrX:60814..155254881 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
Single allele duplication Autism [RCV000754365] ChrX:1..156040895 [GRCh38]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60814-155236712)x2 copy number gain not provided [RCV000753276] ChrX:60814..155236712 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xq11.1-28(chrX:61694576-155254881)x1 copy number loss not provided [RCV000753556] ChrX:61694576..155254881 [GRCh37]
ChrX:Xq11.1-28		 pathogenic
NC_000023.10:g.36649710_136649711del100000002insG indel Heterotaxy, visceral, 1, X-linked [RCV000754886] ChrX:36649710..136649711 [GRCh37]
ChrX:Xp21.1-q26.3		 pathogenic
46,Y,inv(X)(p21.1q13.3) inversion Elevated circulating creatine kinase concentration [RCV000856573] ChrX:32196272..75245806 [GRCh37]
ChrX:Xp21.1-q13.3		 likely pathogenic
GRCh37/hg19 Xp11.4-q21.32(chrX:40572613-92796528)x1 copy number loss not provided [RCV000845670] ChrX:40572613..92796528 [GRCh37]
ChrX:Xp11.4-q21.32		 pathogenic
GRCh37/hg19 Xq11.1-13.1(chrX:61882086-69173640)x1 copy number loss not provided [RCV000849932] ChrX:61882086..69173640 [GRCh37]
ChrX:Xq11.1-13.1		 pathogenic
GRCh37/hg19 Xp11.1-q28(chrX:58455352-155233731)x1 copy number loss not provided [RCV000846274] ChrX:58455352..155233731 [GRCh37]
ChrX:Xp11.1-q28		 pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:54941868-155233731)x1 copy number loss not provided [RCV000848218] ChrX:54941868..155233731 [GRCh37]
ChrX:Xp11.21-q28		 uncertain significance
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x1 copy number loss not provided [RCV000848828] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x4 copy number gain not provided [RCV000846039] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:55507789-155198481)x3 copy number gain See cases [RCV001263024] ChrX:55507789..155198481 [GRCh37]
ChrX:Xp11.21-q28		 pathogenic
GRCh37/hg19 Xq11.1-28(chrX:62685885-155233731) copy number loss Turner syndrome [RCV002280672] ChrX:62685885..155233731 [GRCh37]
ChrX:Xq11.1-28		 pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:56469080-155233731)x3 copy number gain not provided [RCV001281359] ChrX:56469080..155233731 [GRCh37]
ChrX:Xp11.21-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60000-155234966)x1 copy number loss not provided [RCV001537933] ChrX:60000..155234966 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xq11.1-21.1(chrX:61877278-79123671) copy number gain not specified [RCV002053135] ChrX:61877278..79123671 [GRCh37]
ChrX:Xq11.1-21.1		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x3 copy number gain not provided [RCV001829212] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x1 copy number loss not provided [RCV001834509] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xq12(chrX:65057519-66020568) copy number gain not specified [RCV002053138] ChrX:65057519..66020568 [GRCh37]
ChrX:Xq12		 uncertain significance
GRCh37/hg19 Xq11.1-21.1(chrX:61974855-79123671) copy number gain not specified [RCV002053136] ChrX:61974855..79123671 [GRCh37]
ChrX:Xq11.1-21.1		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:200855-155240074) copy number gain Klinefelter syndrome [RCV003236730] ChrX:200855..155240074 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:1-155270560) copy number loss Turner syndrome [RCV002280668] ChrX:1..155270560 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:1-155270560) copy number gain 46,XX sex reversal 1 [RCV002280665]|Hypotonia [RCV002280667]|Trisomy X syndrome [RCV002280666] ChrX:1..155270560 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xp22.2-q28(chrX:11522765-155233731)x1 copy number loss See cases [RCV002286357] ChrX:11522765..155233731 [GRCh37]
ChrX:Xp22.2-q28		 pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:61545-155226048)x2 copy number gain Klinefelter syndrome [RCV002282732] ChrX:61545..155226048 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh37/hg19 Xq11.1-21.1(chrX:61877278-79122848) copy number gain not specified [RCV003986211] ChrX:61877278..79122848 [GRCh37]
ChrX:Xq11.1-21.1		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
HSP90B1hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23208072
MEF2Chsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18278031
MEF2Chsa-miR-223-3pMirtarbaseexternal_infoImmunofluorescence//qRT-PCR//Western blotNon-Functional MTI23094093
STMN1hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18555017
STMN1hsa-miR-223-3pMirtarbaseexternal_infoFlow//Immunohistochemistry//Luciferase reporter asFunctional MTI22470493
LMO2hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19278969
LMO2hsa-miR-223-3pMirtarbaseexternal_infoReporter assayFunctional MTI19017354
EPB41L3hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21628394
E2F1hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20029046
RHOBhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19850724
RHOBhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22080513
IGF1Rhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22073238
FBXW7hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22270966
SLC2A4hsa-miR-223-3pMirtarbaseexternal_infoFlow//Immunoblot//Immunofluorescence//ImmunohistocFunctional MTI20080987
NFIXhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19850724
NFIAhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17996649
NFIAhsa-miR-223-3pMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)17260024
NFIAhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI16325577
ARID4Bhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI21305051
CHUKhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20711193
ARTNhsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21453483
FOXO1hsa-miR-223-3pMirtarbaseexternal_infoFlow//Immunocytochemistry//Luciferase reporter assFunctional MTI22569260
SCARB1hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23459944
PARP1hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI23757351
SMARCD1hsa-miR-223-3pMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)23757351
NFIAhsa-miR-223-3pTarbaseexternal_infoReporter GenePOSITIVE
HSP90B1hsa-miR-223-3pOncomiRDBexternal_infoNANA23208072
FOXO1hsa-miR-223-3pOncomiRDBexternal_infoNANA22569260
STMN1hsa-miR-223-3pOncomiRDBexternal_infoNANA22470493
FBXW7hsa-miR-223-3pOncomiRDBexternal_infoNANA22270966
FBXW7hsa-miR-223-3pOncomiRDBexternal_infoNANA22108521
EPB41L3hsa-miR-223-3pOncomiRDBexternal_infoNANA21628394
ARTNhsa-miR-223-3pOncomiRDBexternal_infoNANA21453483
CXCL12hsa-miR-223-3pOncomiRDBexternal_infoNANA21343399
E2F1hsa-miR-223-3pOncomiRDBexternal_infoNANA20029046
STMN1hsa-miR-223-3pOncomiRDBexternal_infoNANA18555017
NFIAhsa-miR-223-5pMirecordsexternal_infoNANA16325577
LMO2hsa-miR-223-5pMirecordsexternal_info{changed}NA19017354
LMO2hsa-miR-223-5pMirecordsexternal_info{changed}NA19278969
STMN1hsa-miR-223-5pMirecordsexternal_infoNANA18555017
RHOBhsa-miR-223-5pMirecordsexternal_infoNANA19850724
IRS1hsa-miR-223-5pMirecordsexternal_infoNANA19502786
EPB41L3hsa-miR-223-5pMirecordsexternal_infoNANA21628394

Predicted Targets
Summary Value
Count of predictions:24777
Count of gene targets:9066
Count of transcripts:17546
Interacting mature miRNAs:hsa-miR-223-3p, hsa-miR-223-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385204
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 EnsemblX66,018,870 - 66,018,979 (+)Ensembl
RefSeq Acc Id: NR_029637
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X66,018,870 - 66,018,979 (+)NCBI
GRCh37X65,238,712 - 65,238,821 (+)ENTREZGENE
HuRefX59,065,818 - 59,065,927 (+)ENTREZGENE
CHM1_1X65,131,742 - 65,131,851 (+)NCBI
T2T-CHM13v2.0X64,445,366 - 64,445,475 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31603 AgrOrtholog
COSMIC MIR223 COSMIC
Ensembl Genes ENSG00000284567 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385204 ENTREZGENE
GTEx ENSG00000284567 GTEx
HGNC ID HGNC:31603 ENTREZGENE
Human Proteome Map MIR223 Human Proteome Map
miRBase MI0000300 ENTREZGENE
NCBI Gene 407008 ENTREZGENE
OMIM 300694 OMIM
PharmGKB PA164722611 PharmGKB
RNAcentral URS00000B7E30 RNACentral
  URS000037EC34 RNACentral
  URS0000485CBB RNACentral