RGD Reference Report - Pentraxin-3: A new parameter in predicting the severity of diabetic foot infection? - Rat Genome Database

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Pentraxin-3: A new parameter in predicting the severity of diabetic foot infection?

Authors: Ozer Balin, Safak  Sagmak Tartar, Ayse  Uğur, Kader  Kilinç, Faruk  Telo, Selda  Bal, Ali  Balin, Mehmet  Akbulut, Ayhan 
Citation: Ozer Balin S, etal., Int Wound J. 2019 Jun;16(3):659-664. doi: 10.1111/iwj.13075. Epub 2019 Feb 15.
RGD ID: 38501100
Pubmed: (View Article at PubMed) PMID:30767386
DOI: Full-text: DOI:10.1111/iwj.13075

This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin-3 (PTX-3) in patients with infected diabetic foot ulcers (IDFU) as well as to assess the association between PTX-3 levels and IDFU severity. This study included 60 IDFU patients (Group 1), 45 diabetic patients without DFU (Group 2), and 45 healthy controls. Patients with IDFU were divided into mild, moderate, and severe subgroups based on classification of clinical severity. Patients who underwent amputation were also documented. Blood samples were collected to determine PTX-3 levels. PTX-3 levels in healthy controls, Group 1, and Group 2 were 5.83 (3.41-20) ng/mL, 1.47 (0.61-15.13) ng/mL, and 3.26 (0.67-20) ng/mL, respectively. A negative correlation between plasma PTX-3 and glucose levels was found. There were significant differences in terms of procalcitonin (PCT) and PTX-3 levels in the subgroup analysis of Group 1. The PTX-3 level in patients who did or did not undergo amputation was 4.1 (0.8-13.7) and 1 (0.6-15.1) ng/mL, respectively. Results suggest that PTX-3 is a particularly effective marker in patients with IDFU, both in terms of predicting disease severity and assisting in the decision to perform amputation.


Disease Annotations    
Diabetic Foot  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Ptx3  (pentraxin 3)

Genes (Mus musculus)
Ptx3  (pentraxin related gene)

Genes (Homo sapiens)
PTX3  (pentraxin 3)

Additional Information