RGD Reference Report - [Changes in the activities of lysosomal enzyme (glycosidase) in experimental acute gastric mucosal lesion]. - Rat Genome Database

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[Changes in the activities of lysosomal enzyme (glycosidase) in experimental acute gastric mucosal lesion].

Authors: Watanabe, K 
Citation: Watanabe K, Nihon Geka Gakkai Zasshi. 1986 Apr;87(4):395-402.
RGD ID: 12910841
Pubmed: PMID:3713687   (View Abstract at PubMed)

In order to study the pathogenesis of stress-induced ulcer, we induced experimental acute gastric mucosal lesion (AGML) by loading the rats with heat-burn stress, and we monitored the activities of four glycosidases having mucolytic action. The activity of beta-N-Acetyl-D-glucosaminidase was 59.50 +/- 3.27 micrograms 4 MU/h/mg protein before stress, increasing significantly one to three hours after burn, and that of beta-N-Acetyl-D-galactosaminidase was 17.50 +/- 1.60 micrograms 4 MU/h/mg protein before stress, increasing significantly two hours after burn. The activities of two uronic acid exoglycosidases, alpha-L-Iduronidase and beta-D-Glucuronidase were 4.52 +/- 0.37 and 8.68 +/- 0.89 micrograms phenol/h/mg protein before stress; both increased significantly one to three hours after burn. Burn stress caused microcirculatory disturbance in the gastric mucosa, release of histamine and other vasoactive substances, and accelerated release of lysosomal enzymes. Triggered by these reaction, glycosidases were released to cause the degradation of glycoprotein in the tissue and resulted in the breakdown of the defense mechanisms.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IDUAHumangastric ulcer  ISOIdua (Rattus norvegicus) RGD 
IduaRatgastric ulcer  IEP  RGD 
IduaMousegastric ulcer  ISOIdua (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Idua  (alpha-L-iduronidase)

Genes (Mus musculus)
Idua  (iduronidase, alpha-L)

Genes (Homo sapiens)
IDUA  (alpha-L-iduronidase)


Additional Information