Idua (alpha-L-iduronidase) - Rat Genome Database
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Gene: Idua (alpha-L-iduronidase) Rattus norvegicus
Analyze
Symbol: Idua
Name: alpha-L-iduronidase
RGD ID: 1310943
Description: Exhibits L-iduronidase activity and signaling receptor binding activity. Involved in glycosaminoglycan catabolic process. Localizes to coated vesicle and lysosome. Biomarker of gastric ulcer. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Idual; iduronidase, alpha-L-; iduronidase, alpha-L-like; LOC360904
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,031,588 - 1,059,494 (-)NCBI
Rnor_6.0 Ensembl142,042,411 - 2,056,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0142,041,828 - 2,056,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,037,369 - 2,052,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera141,071,517 - 1,085,862 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
1. Aronovich EL, etal., J Gene Med. 2007 May;9(5):403-15.
2. Boado RJ, etal., Mol Pharm. 2011 Aug 1;8(4):1342-50. doi: 10.1021/mp200136x. Epub 2011 Jun 17.
3. Bunge S, etal., Hum Mol Genet. 1994 Jun;3(6):861-6.
4. Campbell CH and Rome LH, J Biol Chem. 1983 Nov 10;258(21):13347-52.
5. Clarke LA, etal., Hum Mol Genet. 1997 Apr;6(4):503-11.
6. Garcia-Rivera MF, etal., Brain Res Bull. 2007 Nov 1;74(6):429-38. Epub 2007 Aug 6.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. GOA data from the GO Consortium
9. Hartung SD, etal., Mol Ther. 2004 Jun;9(6):866-75.
10. Laradi S, etal., J Inherit Metab Dis. 2005;28(6):1019-26.
11. MGD data from the GO Consortium
12. OMIM Disease Annotation Pipeline
13. Osborn MJ, etal., Mol Ther. 2008 Aug;16(8):1459-66. doi: 10.1038/mt.2008.119. Epub 2008 Jun 3.
14. Ou L, etal., Mol Genet Metab. 2014 Feb;111(2):116-22. doi: 10.1016/j.ymgme.2013.09.008. Epub 2013 Sep 19.
15. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. RGD automated import pipeline for gene-chemical interactions
17. Scott HS, etal., Hum Mutat. 1992;1(2):103-8.
18. Scott HS, etal., Hum Mutat. 1992;1(4):333-9.
19. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
20. Staba SL, etal., N Engl J Med. 2004 May 6;350(19):1960-9.
21. Stilhano RS, etal., J Gene Med. 2015 Jan-Feb;17(1-2):1-13. doi: 10.1002/jgm.2818.
22. Sun L, etal., Genet Mol Biol. 2011 Apr;34(2):195-200. Epub 2011 Apr 1.
23. Uttarilli A, etal., Clin Genet. 2016 Dec;90(6):496-508. doi: 10.1111/cge.12795. Epub 2016 May 26.
24. Wang D, etal., Mol Genet Metab. 2010 Jan;99(1):62-71. doi: 10.1016/j.ymgme.2009.08.002.
25. Watanabe K, Nihon Geka Gakkai Zasshi. 1986 Apr;87(4):395-402.
26. Weber W, etal., J Clin Chem Clin Biochem. 1983 May;21(5):287-93.
27. Wraith JE, etal., J Pediatr. 2004 May;144(5):581-8.
28. Yamagishi A, etal., Hum Mutat. 1996;7(1):23-9.
29. Zheng Y, etal., Mol Genet Metab. 2003 Aug;79(4):233-44.
Additional References at PubMed
PMID:12477932   PMID:16979922   PMID:18022143   PMID:19834056   PMID:21873421   PMID:22580166   PMID:23376485   PMID:23533145   PMID:24036510   PMID:25410057  


Genomics

Comparative Map Data
Idua
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,031,588 - 1,059,494 (-)NCBI
Rnor_6.0 Ensembl142,042,411 - 2,056,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0142,041,828 - 2,056,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,037,369 - 2,052,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera141,071,517 - 1,085,862 (-)NCBICelera
Cytogenetic Map14p22NCBI
IDUA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4986,997 - 1,004,564 (+)EnsemblGRCh38hg38GRCh38
GRCh384986,997 - 1,004,564 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374980,785 - 998,352 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364970,785 - 988,317 (+)NCBINCBI36hg18NCBI36
Build 344970,614 - 988,146NCBI
Celera4917,731 - 935,177 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef4952,003 - 969,463 (+)NCBIHuRef
CHM1_14980,568 - 998,128 (+)NCBICHM1_1
Idua
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,808,197 - 108,833,312 (+)NCBIGRCm39mm39
GRCm39 Ensembl5108,808,197 - 108,832,423 (+)Ensembl
GRCm385108,660,331 - 108,685,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,660,331 - 108,684,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv375109,098,125 - 109,113,577 (+)NCBIGRCm37mm9NCBIm37
MGSCv365108,909,667 - 108,924,856 (+)NCBImm8
Celera5105,791,051 - 105,807,497 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.24NCBI
Idua
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514475,731 - 488,007 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955514474,830 - 488,007 (+)NCBIChiLan1.0ChiLan1.0
IDUA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.141,020,519 - 1,037,990 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,020,582 - 1,037,877 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v041,102,288 - 1,120,973 (+)NCBIMhudiblu_PPA_v0panPan3
IDUA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,517,225 - 91,534,593 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,522,035 - 91,534,593 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha393,988,643 - 94,001,108 (-)NCBI
ROS_Cfam_1.0392,515,340 - 92,532,617 (-)NCBI
UMICH_Zoey_3.1391,693,928 - 91,706,431 (-)NCBI
UNSW_CanFamBas_1.0391,746,826 - 91,759,387 (-)NCBI
UU_Cfam_GSD_1.0392,130,626 - 92,143,201 (-)NCBI
Idua
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,493,659 - 68,512,811 (-)NCBI
SpeTri2.0NW_00493647722,200,471 - 22,215,473 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDUA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8334,599 - 351,970 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18334,604 - 351,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IDUA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,778,220 - 47,794,435 (-)NCBI
ChlSab1.1 Ensembl2747,778,335 - 47,794,352 (-)Ensembl
Idua
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475526,151,302 - 26,169,324 (-)NCBI

Position Markers
RH140328  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0142,041,926 - 2,042,122NCBIRnor6.0
Rnor_5.0142,037,467 - 2,037,663UniSTSRnor5.0
RGSC_v3.4141,572,710 - 1,572,906UniSTSRGSC3.4
Celera141,071,032 - 1,071,228UniSTS
Cytogenetic Map14p22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14134403399Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:300
Count of miRNA genes:207
Interacting mature miRNAs:230
Transcripts:ENSRNOT00000000048
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 45 29 19 29 2 72 35 36 11
Low 7 12 12 12 8 9 2 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000048   ⟹   ENSRNOP00000000048
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl142,042,411 - 2,056,762 (-)Ensembl
RefSeq Acc Id: NM_001172084   ⟹   NP_001165555
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,032,171 - 1,046,522 (-)NCBI
Rnor_6.0142,042,411 - 2,056,762 (-)NCBI
Rnor_5.0142,037,369 - 2,052,405 (-)NCBI
Celera141,071,517 - 1,085,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769938   ⟹   XP_008768160
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,031,588 - 1,045,685 (-)NCBI
Rnor_6.0142,041,828 - 2,052,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092145   ⟹   XP_038948073
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,031,588 - 1,059,494 (-)NCBI
RefSeq Acc Id: XM_039092146   ⟹   XP_038948074
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,031,588 - 1,045,686 (-)NCBI
RefSeq Acc Id: XM_039092147   ⟹   XP_038948075
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,031,588 - 1,046,692 (-)NCBI
RefSeq Acc Id: XM_039092149   ⟹   XP_038948077
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,031,588 - 1,046,692 (-)NCBI
RefSeq Acc Id: XR_005492982
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,032,831 - 1,046,539 (-)NCBI
RefSeq Acc Id: XR_005492983
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,031,588 - 1,046,539 (-)NCBI
RefSeq Acc Id: XR_005492984
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,034,027 - 1,046,539 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001165555   ⟸   NM_001172084
- Peptide Label: precursor
- UniProtKB: D3ZE16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768160   ⟸   XM_008769938
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000000048   ⟸   ENSRNOT00000000048
RefSeq Acc Id: XP_038948073   ⟸   XM_039092145
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948075   ⟸   XM_039092147
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038948077   ⟸   XM_039092149
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038948074   ⟸   XM_039092146
- Peptide Label: isoform X2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699144
Promoter ID:EPDNEW_R9668
Type:initiation region
Name:Idua_1
Description:iduronidase, alpha-L-
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0142,056,737 - 2,056,797EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 2040994 2040995 G A snv ACI/EurMcwi (MCW), SBH/Ygl (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), LL/MavRrrc (KNAW), LN/MavRrrc (KNAW), MHS/Gib (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), ACI/N (KNAW), ACI/EurMcwi (KNAW), BBDP/WorN (KNAW), BN/SsN (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), SHR/NCrlPrin (KNAW), SHR/NHsd (KNAW), SHR/OlaIpcv (KNAW), SHR/OlaIpcvPrin (KNAW), SHRSP/Gcrc (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), GK/Ox (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), MNS/Gib (KNAW), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), Crl:SD (UDEL), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), HTX/Kyo (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), HWY/Slc (KyushuU), BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), ZFDM (KyushuU)
14 2050307 2050308 A C snv ACI/EurMcwi (MCW), ZFDM (KyushuU), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), LL/MavRrrc (KNAW), LN/MavRrrc (KNAW), MHS/Gib (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), ACI/N (KNAW), ACI/EurMcwi (KNAW), BBDP/WorN (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), SHR/NCrlPrin (KNAW), SHR/NHsd (KNAW), SHR/OlaIpcv (KNAW), SHR/OlaIpcvPrin (KNAW), SHRSP/Gcrc (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), GK/Ox (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), MNS/Gib (KNAW), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), Crl:SD (UDEL), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), HTX/Kyo (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), HWY/Slc (KyushuU), BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), KFRS3B/Kyo (KyushuU), SBH/Ygl (MCW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 2045453 2045454 G A snv LEW/NCrlBR (RGD), CDS, LEW/Crl (RGD), WKY/NCrl (RGD), SBN/Ygl (MCW), WAG/Rij (RGD), CDR, GK/Ox (RGD), SS/JrHsdMcwi (RGD), BBDP/Wor (RGD), SS/Jr (RGD), SBH/Ygl (MCW), SR/JrHsd (RGD), SHRSP/Gcrc (RGD), ACI/EurMcwi (RGD), SHR/NHsd (RGD), SS/JrHsdMcwi (MCW), SBN/Ygl (RGD), SR/JrHsd (MCW), WKY/N (MCW), SBH/Ygl (RGD), MR/N (MCW), MNS/Gib (RGD), MHS/Gib (RGD), M520/N (MCW), ACI/N (MCW), LL/MavRrrc (RGD), LN/MavRrrc (RGD), ACI/EurMcwi (MCW), LH/MavRrrc (RGD), WKY/NHsd (RGD), WKY/Gcrc (RGD)
14 2054766 2054767 A C snv WKY/NHsd (RGD), WKY/Gcrc (RGD), WKY/NCrl (RGD), WAG/Rij (RGD), SS/JrHsdMcwi (RGD), SS/Jr (RGD), SR/JrHsd (RGD), SHRSP/Gcrc (RGD), SHR/NHsd (RGD), SBN/Ygl (RGD), SBH/Ygl (RGD), MNS/Gib (RGD), MHS/Gib (RGD), LL/MavRrrc (RGD), LN/MavRrrc (RGD), LEW/NCrlBR (RGD), LEW/Crl (RGD), GK/Ox (RGD), BBDP/Wor (RGD), ACI/EurMcwi (RGD), WKY/N (MCW), CDS, CDR, SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), SBN/Ygl (MCW), SBH/Ygl (MCW), ACI/EurMcwi (MCW), LH/MavRrrc (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310943 AgrOrtholog
Ensembl Genes ENSRNOG00000000043 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000048 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000048 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Glyco_hydro_39 UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
KEGG Report rno:360904 UniProtKB/TrEMBL
NCBI Gene Idua ENTREZGENE
OMIM 252800
Pfam Glyco_hydro_39 UniProtKB/TrEMBL
PhenoGen Idua PhenoGen
PRINTS GLHYDRLASE39 UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F39 UniProtKB/TrEMBL
Superfamily-SCOP Glyco_hydro_cat UniProtKB/TrEMBL
UniProt D3ZE16 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-03 Idua  alpha-L-iduronidase  Idua  iduronidase, alpha-L-  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-25 Idua  iduronidase, alpha-L-  Idual  iduronidase, alpha-L-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-09 Idual  iduronidase, alpha-L-like  Idua  iduronidase, alpha-L-  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 Idua  iduronidase, alpha-L-  Idua  iduronidase, alpha-L-  Gene reactivated at release of RGSC5.0 assembly 2298974 REACTIVATED
2008-04-30 Idua  iduronidase, alpha-L-   Idua_predicted  iduronidase, alpha-L- (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Idua_predicted  iduronidase, alpha-L- (predicted)      Symbol and Name status set to approved 70820 APPROVED