Idua (iduronidase, alpha-L) - Rat Genome Database

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Gene: Idua (iduronidase, alpha-L) Mus musculus
Analyze
Symbol: Idua
Name: iduronidase, alpha-L
RGD ID: 1322130
MGI Page MGI
Description: Enables L-iduronidase activity. Acts upstream of or within several processes, including glycosaminoglycan catabolic process; learning or memory; and skeletal system development. Located in extracellular space. Used to study mucopolysaccharidosis I and otitis media. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6030426D08; alpha-L-iduronidase; iduronidase, alpha-L-
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,808,197 - 108,833,312 (+)NCBIGRCm39mm39
GRCm39 Ensembl5108,808,197 - 108,832,423 (+)Ensembl
GRCm385108,660,331 - 108,685,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,660,331 - 108,684,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv375109,098,125 - 109,113,577 (+)NCBIGRCm37mm9NCBIm37
MGSCv365108,909,667 - 108,924,856 (+)NCBImm8
Celera5105,791,051 - 105,807,497 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta elastic fiber morphology  (IAGP)
abnormal aorta smooth muscle morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal avoidance learning behavior  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal cerebellar cortex morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal circadian behavior  (IAGP)
abnormal circadian regulation of heart rate  (IAGP)
abnormal circadian temperature homeostasis  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal external auditory canal morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal foam cell morphology  (IAGP)
abnormal foramen magnum morphology  (IAGP)
abnormal gait  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal heart left ventricle outflow tract morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal limb morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal long term spatial reference memory  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal mitral valve morphology  (IAGP)
abnormal motor learning  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal QRS complex  (IAGP)
abnormal response to novel object  (IAGP)
abnormal rib morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal tricuspid valve morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
aortic valve regurgitation  (IAGP)
broad face  (IAGP)
broad head  (IAGP)
broad snout  (IAGP)
cochlear ganglion degeneration  (IAGP)
cochlear hair cell degeneration  (IAGP)
congestive heart failure  (IAGP)
deafness  (IAGP)
decreased body temperature  (IAGP)
decreased bone trabecular spacing  (IAGP)
decreased cardiac output  (IAGP)
decreased heart rate variability  (IAGP)
decreased locomotor activity  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased startle reflex  (IAGP)
decreased survivor rate  (IAGP)
decreased ventricle muscle contractility  (IAGP)
decreased vertical activity  (IAGP)
disheveled coat  (IAGP)
enlarged heart  (IAGP)
enophthalmos  (IAGP)
female infertility  (IAGP)
hip dislocation  (IAGP)
impaired coordination  (IAGP)
increased anxiety-related response  (IAGP)
increased body weight  (IAGP)
increased bone mineral density  (IAGP)
increased bone trabecula number  (IAGP)
increased collagen deposition in the muscles  (IAGP)
increased cranium width  (IAGP)
increased diameter of femur  (IAGP)
increased left ventricle weight  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased osteoblast cell number  (IAGP)
increased susceptibility to otitis media  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased trabecular bone volume  (IAGP)
increased urine glycosaminoglycan level  (IAGP)
kyphosis  (IAGP)
lysosomal protein accumulation  (IAGP)
mitral valve regurgitation  (IAGP)
ocular hypertelorism  (IAGP)
organ of Corti degeneration  (IAGP)
pale liver  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prolonged P wave  (IAGP)
prolonged QRS complex duration  (IAGP)
prominent nasal bridge  (IAGP)
pup cannibalization  (IAGP)
Purkinje cell degeneration  (IAGP)
rough coat  (IAGP)
sensorineural hearing loss  (IAGP)
short femur  (IAGP)
short snout  (IAGP)
small ears  (IAGP)
sparse hair  (IAGP)
spiral ligament degeneration  (IAGP)
thick interventricular septum  (IAGP)
thick ventricular wall  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses. Aronovich EL, etal., J Gene Med. 2007 May;9(5):403-15.
2. Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein. Boado RJ, etal., Mol Pharm. 2011 Aug 1;8(4):1342-50. doi: 10.1021/mp200136x. Epub 2011 Jun 17.
3. Mucopolysaccharidosis type I: identification of 8 novel mutations and determination of the frequency of the two common alpha-L-iduronidase mutations (W402X and Q70X) among European patients. Bunge S, etal., Hum Mol Genet. 1994 Jun;3(6):861-6.
4. Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene. Clarke LA, etal., Hum Mol Genet. 1997 Apr;6(4):503-11.
5. Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy. Garcia-Rivera MF, etal., Brain Res Bull. 2007 Nov 1;74(6):429-38. Epub 2007 Aug 6.
6. Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene. Hartung SD, etal., Mol Ther. 2004 Jun;9(6):866-75.
7. Mucopolysaccharidosis I: Alpha-L-Iduronidase mutations in three Tunisian families. Laradi S, etal., J Inherit Metab Dis. 2005;28(6):1019-26.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Targeting of the CNS in MPS-IH using a nonviral transferrin-alpha-L-iduronidase fusion gene product. Osborn MJ, etal., Mol Ther. 2008 Aug;16(8):1459-66. doi: 10.1038/mt.2008.119. Epub 2008 Jun 3.
13. High-dose enzyme replacement therapy in murine Hurler syndrome. Ou L, etal., Mol Genet Metab. 2014 Feb;111(2):116-22. doi: 10.1016/j.ymgme.2013.09.008. Epub 2013 Sep 19.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. A common mutation for mucopolysaccharidosis type I associated with a severe Hurler syndrome phenotype. Scott HS, etal., Hum Mutat. 1992;1(2):103-8.
18. alpha-L-iduronidase mutations (Q70X and P533R) associate with a severe Hurler phenotype. Scott HS, etal., Hum Mutat. 1992;1(4):333-9.
19. Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. Staba SL, etal., N Engl J Med. 2004 May 6;350(19):1960-9.
20. a- L-iduronidase gene-based therapy using the phiC31 system to treat mucopolysaccharidose type I mice. Stilhano RS, etal., J Gene Med. 2015 Jan-Feb;17(1-2):1-13. doi: 10.1002/jgm.2818.
21. Three novel a-L-iduronidase mutations in 10 unrelated Chinese mucopolysaccharidosis type I families. Sun L, etal., Genet Mol Biol. 2011 Apr;34(2):195-200. Epub 2011 Apr 1.
22. Identification and characterization of 20 novel pathogenic variants in 60 unrelated Indian patients with mucopolysaccharidoses type I and type II. Uttarilli A, etal., Clin Genet. 2016 Dec;90(6):496-508. doi: 10.1111/cge.12795. Epub 2016 May 26.
23. Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation. Wang D, etal., Mol Genet Metab. 2010 Jan;99(1):62-71. doi: 10.1016/j.ymgme.2009.08.002.
24. [Changes in the activities of lysosomal enzyme (glycosidase) in experimental acute gastric mucosal lesion]. Watanabe K, Nihon Geka Gakkai Zasshi. 1986 Apr;87(4):395-402.
25. Changes in the catalytic activities of proteoglycan-degrading lysosomal enzymes in parenchymal and non-parenchymal liver cells and in serum during the development of experimental liver fibrosis. Weber W, etal., J Clin Chem Clin Biochem. 1983 May;21(5):287-93.
26. Enzyme replacement therapy for mucopolysaccharidosis I: a randomized, double-blinded, placebo-controlled, multinational study of recombinant human alpha-L-iduronidase (laronidase). Wraith JE, etal., J Pediatr. 2004 May;144(5):581-8.
27. Mucopolysaccharidosis type I: identification of common mutations that cause Hurler and Scheie syndromes in Japanese populations. Yamagishi A, etal., Hum Mutat. 1996;7(1):23-9.
28. Treatment of the mouse model of mucopolysaccharidosis I with retrovirally transduced bone marrow. Zheng Y, etal., Mol Genet Metab. 2003 Aug;79(4):233-44.
Additional References at PubMed
PMID:1533802   PMID:2220820   PMID:7698753   PMID:7919654   PMID:7959767   PMID:8889548   PMID:9660052   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932  
PMID:12576554   PMID:14681479   PMID:15111796   PMID:15585404   PMID:15979918   PMID:16141072   PMID:16141073   PMID:16473336   PMID:16497528   PMID:16979922   PMID:17101178   PMID:18022143  
PMID:18511319   PMID:19375967   PMID:19637231   PMID:19834056   PMID:19903883   PMID:19926322   PMID:20847202   PMID:21076027   PMID:21873421   PMID:21873635   PMID:22096577   PMID:22420937  
PMID:22580166   PMID:23562162   PMID:23774686   PMID:24550296   PMID:25298037   PMID:25410057   PMID:26052536   PMID:26427607   PMID:26710715   PMID:27228099   PMID:28171706   PMID:28842642  
PMID:29487322   PMID:29763456   PMID:31492863   PMID:31834922   PMID:33905568   PMID:34257302   PMID:34783964  


Genomics

Comparative Map Data
Idua
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,808,197 - 108,833,312 (+)NCBIGRCm39mm39
GRCm39 Ensembl5108,808,197 - 108,832,423 (+)Ensembl
GRCm385108,660,331 - 108,685,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,660,331 - 108,684,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv375109,098,125 - 109,113,577 (+)NCBIGRCm37mm9NCBIm37
MGSCv365108,909,667 - 108,924,856 (+)NCBImm8
Celera5105,791,051 - 105,807,497 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.24NCBI
IDUA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384986,997 - 1,008,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4986,997 - 1,004,564 (+)EnsemblGRCh38hg38GRCh38
GRCh374980,785 - 998,352 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364970,785 - 988,317 (+)NCBINCBI36hg18NCBI36
Build 344970,614 - 988,146NCBI
Celera4917,731 - 935,177 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef4952,003 - 969,463 (+)NCBIHuRef
CHM1_14980,568 - 998,100 (+)NCBICHM1_1
T2T-CHM13v2.04985,128 - 1,002,611 (+)NCBI
Idua
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,031,588 - 1,059,494 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl141,032,171 - 1,046,522 (-)Ensembl
Rnor_6.0142,041,828 - 2,056,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,042,411 - 2,056,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,037,369 - 2,052,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera141,071,517 - 1,085,862 (-)NCBICelera
Cytogenetic Map14p22NCBI
Idua
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514475,731 - 488,007 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955514474,830 - 488,007 (+)NCBIChiLan1.0ChiLan1.0
IDUA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.141,020,519 - 1,037,990 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,020,582 - 1,037,877 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v041,102,288 - 1,120,973 (+)NCBIMhudiblu_PPA_v0panPan3
IDUA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,517,225 - 91,534,593 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,522,035 - 91,534,593 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha393,988,643 - 94,001,108 (-)NCBI
ROS_Cfam_1.0392,515,340 - 92,532,617 (-)NCBI
ROS_Cfam_1.0 Ensembl392,519,804 - 92,532,813 (-)Ensembl
UMICH_Zoey_3.1391,693,928 - 91,706,431 (-)NCBI
UNSW_CanFamBas_1.0391,746,826 - 91,759,387 (-)NCBI
UU_Cfam_GSD_1.0392,130,626 - 92,143,201 (-)NCBI
Idua
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,493,659 - 68,512,811 (-)NCBI
SpeTri2.0NW_00493647722,200,471 - 22,215,473 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDUA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8334,599 - 351,970 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18334,604 - 351,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IDUA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,778,220 - 47,794,435 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,778,335 - 47,794,352 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366680862,223 - 78,429 (+)NCBIVero_WHO_p1.0
Idua
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475526,154,186 - 26,169,365 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475526,151,302 - 26,169,324 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
L34111  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385108,684,120 - 108,684,220UniSTSGRCm38
MGSCv375109,113,139 - 109,113,239UniSTSGRCm37
Celera5105,807,059 - 105,807,159UniSTS
Cytogenetic Map5E3-FUniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map5E5UniSTS
cM Map557.0UniSTS
Whitehead/MRC_RH51338.9UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined598019649114021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1301877Bbaa3_mB.burgdorferi-associated arthritis 3 (mouse)Not determined599455285112465722Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5103047866115538059Mouse
25314317Sccor3_msynaptonemal complex length to mean MLH1 count ratio 3 (mouse)5104347866114738061Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104498738115101540Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1357901Mdmsc2_mmodifier of muscularity 2 (mouse)Not determined5107561006112434786Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3311
Count of miRNA genes:700
Interacting mature miRNAs:883
Transcripts:ENSMUST00000071650, ENSMUST00000112563, ENSMUST00000119212, ENSMUST00000133482, ENSMUST00000139734, ENSMUST00000140620, ENSMUST00000151445, ENSMUST00000159464
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006534797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ175218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY749834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000071650   ⟹   ENSMUSP00000071577
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5108,808,197 - 108,832,418 (+)Ensembl
GRCm38.p6 Ensembl5108,660,331 - 108,684,552 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112563   ⟹   ENSMUSP00000108182
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5108,816,972 - 108,832,423 (+)Ensembl
GRCm38.p6 Ensembl5108,669,106 - 108,684,557 (+)Ensembl
RefSeq Acc Id: ENSMUST00000119212   ⟹   ENSMUSP00000113190
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5108,817,177 - 108,832,418 (+)Ensembl
GRCm38.p6 Ensembl5108,669,311 - 108,684,552 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133482
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5108,830,471 - 108,831,183 (+)Ensembl
GRCm38.p6 Ensembl5108,682,605 - 108,683,317 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139734   ⟹   ENSMUSP00000117694
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5108,817,213 - 108,832,265 (+)Ensembl
GRCm38.p6 Ensembl5108,669,347 - 108,684,399 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140620   ⟹   ENSMUSP00000119624
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5108,816,972 - 108,832,418 (+)Ensembl
GRCm38.p6 Ensembl5108,669,106 - 108,684,552 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151445
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5108,817,161 - 108,829,619 (+)Ensembl
GRCm38.p6 Ensembl5108,669,295 - 108,681,753 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159464
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5108,817,325 - 108,828,115 (+)Ensembl
GRCm38.p6 Ensembl5108,669,459 - 108,680,249 (+)Ensembl
RefSeq Acc Id: NM_008325   ⟹   NP_032351
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395108,808,197 - 108,833,312 (+)NCBI
GRCm385108,660,331 - 108,685,446 (+)NCBI
MGSCv375109,098,125 - 109,113,577 (+)RGD
Celera5105,781,910 - 105,808,385 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_172997   ⟹   NP_766585
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395108,808,197 - 108,833,312 (+)NCBI
GRCm385108,660,331 - 108,685,446 (+)NCBI
Celera5105,781,910 - 105,808,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006534797   ⟹   XP_006534860
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395108,817,756 - 108,831,888 (+)NCBI
GRCm385108,670,028 - 108,684,553 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164821   ⟹   XP_036020714
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395108,817,342 - 108,831,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164822   ⟹   XP_036020715
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395108,817,756 - 108,831,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164823   ⟹   XP_036020716
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395108,817,756 - 108,831,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164824   ⟹   XP_036020717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395108,817,206 - 108,831,888 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032351   ⟸   NM_008325
- Peptide Label: isoform 1 precursor
- UniProtKB: Q3U1Z0 (UniProtKB/TrEMBL),   Q8BLF6 (UniProtKB/TrEMBL),   Q8BMG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006534860   ⟸   XM_006534797
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_766585   ⟸   NM_172997
- Peptide Label: isoform 2 precursor
- UniProtKB: Q3U1Z0 (UniProtKB/TrEMBL),   Q8BLF6 (UniProtKB/TrEMBL),   Q8BMG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071577   ⟸   ENSMUST00000071650
RefSeq Acc Id: ENSMUSP00000117694   ⟸   ENSMUST00000139734
RefSeq Acc Id: ENSMUSP00000113190   ⟸   ENSMUST00000119212
RefSeq Acc Id: ENSMUSP00000108182   ⟸   ENSMUST00000112563
RefSeq Acc Id: ENSMUSP00000119624   ⟸   ENSMUST00000140620
RefSeq Acc Id: XP_036020717   ⟸   XM_036164824
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036020714   ⟸   XM_036164821
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036020715   ⟸   XM_036164822
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036020716   ⟸   XM_036164823
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48441-F1-model_v2 AlphaFold P48441 1-634 view protein structure

Promoters
RGD ID:6887480
Promoter ID:EPDNEW_M7191
Type:initiation region
Name:Idua_1
Description:Mus musculus iduronidase, alpha-L- , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385108,669,308 - 108,669,368EPDNEW
RGD ID:6837730
Promoter ID:MM_KWN:43303
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008325,   OTTMUST00000066818,   OTTMUST00000066819,   OTTMUST00000066821,   UC008YOW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365109,098,026 - 109,098,526 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96418 AgrOrtholog
Ensembl Genes ENSMUSG00000033540 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000071577 ENTREZGENE
  ENSMUSP00000071577.7 UniProtKB/TrEMBL
  ENSMUSP00000108182.3 UniProtKB/TrEMBL
  ENSMUSP00000113190 ENTREZGENE
  ENSMUSP00000113190.2 UniProtKB/TrEMBL
  ENSMUSP00000117694.2 UniProtKB/TrEMBL
  ENSMUSP00000119624.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000071650 ENTREZGENE
  ENSMUST00000071650.13 UniProtKB/TrEMBL
  ENSMUST00000112563.9 UniProtKB/TrEMBL
  ENSMUST00000119212 ENTREZGENE
  ENSMUST00000119212.8 UniProtKB/TrEMBL
  ENSMUST00000139734.2 UniProtKB/TrEMBL
  ENSMUST00000140620.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  Glyco_hydro_39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15932 UniProtKB/TrEMBL
MGD MGI:96418 ENTREZGENE
NCBI Gene 15932 ENTREZGENE
Pfam Glyco_hydro_39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Idua PhenoGen
PRINTS GLHYDRLASE39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
  SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6REH5_MOUSE UniProtKB/TrEMBL
  D6RIN7_MOUSE UniProtKB/TrEMBL
  IDUA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TDU4_MOUSE UniProtKB/TrEMBL
  Q3U1Z0 ENTREZGENE, UniProtKB/TrEMBL
  Q6PEP9_MOUSE UniProtKB/TrEMBL
  Q8BLF6 ENTREZGENE, UniProtKB/TrEMBL
  Q8BMG0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3Z6V9 UniProtKB/TrEMBL
  E9QM17 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-15 Idua  iduronidase, alpha-L    iduronidase, alpha-L-  Symbol and/or name change 5135510 APPROVED