Etfa (electron transferring flavoprotein, alpha polypeptide) - Rat Genome Database

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Gene: Etfa (electron transferring flavoprotein, alpha polypeptide) Mus musculus
Analyze
Symbol: Etfa
Name: electron transferring flavoprotein, alpha polypeptide
RGD ID: 735340
MGI Page MGI
Description: Predicted to enable electron transfer activity and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFA (electron transfer flavoprotein subunit alpha); PARTICIPATES IN fatty acid beta degradation pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010200I21Rik; Alpha-ETF; D9Ertd394; D9Ertd394e; electron transfer flavoprotein subunit alpha, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm19075  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39955,361,720 - 55,419,528 (-)NCBIGRCm39mm39
GRCm39 Ensembl955,361,792 - 55,419,527 (-)Ensembl
GRCm38955,454,436 - 55,512,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,454,508 - 55,512,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37955,302,243 - 55,360,050 (-)NCBIGRCm37mm9NCBIm37
MGSCv36955,252,660 - 55,310,380 (-)NCBImm8
Celera952,696,302 - 52,754,125 (-)NCBICelera
Cytogenetic Map9BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
choline  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
cocaine  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fenofibrate  (ISO)
fenvalerate  (ISO)
folic acid  (EXP)
furan  (ISO)
gentamycin  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
metronidazole  (ISO)
N-nitrosomorpholine  (ISO)
n-propyl gallate  (ISO)
neomycin  (ISO)
nicotine  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (EXP)
resveratrol  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8617498   PMID:8889548   PMID:8975718   PMID:9069126   PMID:9110173   PMID:9166585   PMID:9250878   PMID:9339368   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18614015   PMID:21267068   PMID:21278135   PMID:21677750   PMID:21873635  
PMID:22079573   PMID:22496890   PMID:26025364   PMID:28378742   PMID:29111324   PMID:30068389   PMID:30457570   PMID:30550785   PMID:31112734   PMID:31941714   PMID:32325033  


Genomics

Comparative Map Data
Etfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39955,361,720 - 55,419,528 (-)NCBIGRCm39mm39
GRCm39 Ensembl955,361,792 - 55,419,527 (-)Ensembl
GRCm38955,454,436 - 55,512,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,454,508 - 55,512,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37955,302,243 - 55,360,050 (-)NCBIGRCm37mm9NCBIm37
MGSCv36955,252,660 - 55,310,380 (-)NCBImm8
Celera952,696,302 - 52,754,125 (-)NCBICelera
Cytogenetic Map9BNCBI
ETFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1576,215,353 - 76,311,472 (-)EnsemblGRCh38hg38GRCh38
GRCh381576,215,353 - 76,311,469 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371576,507,694 - 76,603,810 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361574,295,636 - 74,390,865 (-)NCBINCBI36hg18NCBI36
Build 341574,295,690 - 74,390,784NCBI
Celera1553,434,725 - 53,530,031 (-)NCBI
Cytogenetic Map15q24.2-q24.3NCBI
HuRef1553,265,219 - 53,360,736 (-)NCBIHuRef
CHM1_11576,628,067 - 76,723,216 (-)NCBICHM1_1
Etfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2855,835,115 - 55,891,890 (-)NCBI
Rnor_6.0 Ensembl860,028,789 - 60,086,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0860,028,786 - 60,086,352 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0858,608,416 - 58,665,383 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4859,013,798 - 59,072,013 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1859,032,895 - 59,091,022 (-)NCBI
Celera855,318,874 - 55,375,436 (-)NCBICelera
Cytogenetic Map8q24NCBI
Etfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554501,392,479 - 1,451,591 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554501,392,526 - 1,451,591 (-)NCBIChiLan1.0ChiLan1.0
ETFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11574,720,198 - 74,818,494 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1574,720,198 - 74,818,494 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01555,128,686 - 55,227,369 (-)NCBIMhudiblu_PPA_v0panPan3
ETFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13039,848,241 - 39,925,809 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3039,848,270 - 39,964,823 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3039,707,332 - 39,784,202 (+)NCBI
ROS_Cfam_1.03040,052,278 - 40,129,606 (+)NCBI
UMICH_Zoey_3.13040,001,191 - 40,078,170 (+)NCBI
UNSW_CanFamBas_1.03040,047,242 - 40,124,599 (+)NCBI
UU_Cfam_GSD_1.03040,285,034 - 40,362,157 (+)NCBI
Etfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,020,782 - 118,094,606 (+)NCBI
SpeTri2.0NW_00493647135,868,851 - 35,942,662 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ETFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl756,440,620 - 56,540,253 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1756,450,508 - 56,540,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,946,251 - 61,036,017 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ETFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1266,970,593 - 7,075,077 (+)NCBI
ChlSab1.1 Ensembl266,970,584 - 7,076,049 (+)Ensembl
Vero_WHO_p1.0NW_023666048134,642,527 - 134,750,547 (-)NCBI
Etfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248941,874,859 - 1,935,587 (+)NCBI

Position Markers
UniSTS:236123  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38955,511,707 - 55,511,931UniSTSGRCm38
MGSCv37955,359,514 - 55,359,738UniSTSGRCm37
Celera952,753,589 - 52,753,813UniSTS
Cytogenetic Map9BUniSTS
RH127128  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38955,454,508 - 55,454,747UniSTSGRCm38
MGSCv37955,302,315 - 55,302,554UniSTSGRCm37
Celera952,696,374 - 52,696,613UniSTS
Cytogenetic Map9BUniSTS
cM Map929.0UniSTS
Whitehead/MRC_RH9544.67UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94089776474897921Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94357343177573577Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94357343177573577Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4668637365923895Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94763172657897921Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94892377482923895Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94892377482923895Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94950899863332570Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94950899867244166Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
14746993Manh66_mmandible shape 66 (mouse)94990676683906766Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95024403884244166Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95251479868648726Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95465267888652678Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:136
Interacting mature miRNAs:147
Transcripts:ENSMUST00000034866, ENSMUST00000139342, ENSMUST00000142587, ENSMUST00000153186
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034866   ⟹   ENSMUSP00000034866
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl955,454,508 - 55,512,243 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139342
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl955,474,537 - 55,487,513 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142587
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl955,488,826 - 55,511,808 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153186
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl955,486,737 - 55,512,120 (-)Ensembl
RefSeq Acc Id: NM_145615   ⟹   NP_663590
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39955,361,720 - 55,419,527 (-)NCBI
GRCm38955,454,436 - 55,512,243 (-)ENTREZGENE
MGSCv37955,302,243 - 55,360,050 (-)RGD
Celera952,696,302 - 52,754,125 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036154563   ⟹   XP_036010456
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39955,373,720 - 55,419,528 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_663590   ⟸   NM_145615
- UniProtKB: Q99LC5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034866   ⟸   ENSMUST00000034866
RefSeq Acc Id: XP_036010456   ⟸   XM_036154563
- Peptide Label: isoform X1

Promoters
RGD ID:6844508
Promoter ID:MM_KWN:57475
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_145615,   OTTMUST00000065341,   OTTMUST00000065342
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36955,359,581 - 55,360,282 (-)MPROMDB
RGD ID:8669676
Promoter ID:EPDNEW_M12869
Type:initiation region
Name:Etfa_1
Description:Mus musculus electron transferring flavoprotein, alpha polypeptide, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38955,512,162 - 55,512,222EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106092 AgrOrtholog
Ensembl Genes ENSMUSG00000032314 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034866 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034866 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot
  ETF_a/b_N UniProtKB/Swiss-Prot
  ETF_a/FixB UniProtKB/Swiss-Prot
  ETF_alpha_N UniProtKB/Swiss-Prot
  ETF_asu_C UniProtKB/Swiss-Prot
  ETF_asu_C_CS UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
KEGG Report mmu:110842 UniProtKB/Swiss-Prot
MGD MGI:106092 ENTREZGENE
NCBI Gene 110842 ENTREZGENE
Pfam ETF UniProtKB/Swiss-Prot
  ETF_alpha UniProtKB/Swiss-Prot
PhenoGen Etfa PhenoGen
PIRSF Electra_flavoP_a UniProtKB/Swiss-Prot
PROSITE ETF_ALPHA UniProtKB/Swiss-Prot
SMART ETF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot
UniProt ETFA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3THD7 UniProtKB/Swiss-Prot
  Q3V000 UniProtKB/Swiss-Prot
  Q4V9X5 UniProtKB/Swiss-Prot
  Q8BMD3 UniProtKB/Swiss-Prot
  Q8BMU7 UniProtKB/Swiss-Prot