RGD Reference Report - Effects of sterigmatocystin on esophageal epithelium and experimental reflux esophagitis in rats. - Rat Genome Database

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Effects of sterigmatocystin on esophageal epithelium and experimental reflux esophagitis in rats.

Authors: Tong, PZ  Zhang, GJ  Zhang, XH  Yan, X  Wang, JL 
Citation: Tong PZ, etal., Mol Med Rep. 2013 Oct;8(4):1043-8. doi: 10.3892/mmr.2013.1631. Epub 2013 Aug 14.
RGD ID: 9854630
Pubmed: PMID:23942904   (View Abstract at PubMed)
DOI: DOI:10.3892/mmr.2013.1631   (Journal Full-text)

Patients with reflux esophagitis experience an increased incidence of esophageal cancer. In China, this may be the result of contamination of the food supply by Aspergillus fungi, which is known to harbor sterigmatocystin, a carcinogenic mycotoxin. To delineate the potential link between sterigmatocystin and esophageal cancer, an experimental model of reflux esophagitis was developed in rats that had undergone a cardiectomy and partial pylorus ligation. The rats were treated with sterigmatocystin or saline, and esophageal squamous cell hyperplasia was assessed based on the pathological evaluation. The expression of proliferating cell nuclear antigen (PCNA), transporter associated with antigen processing 1 (TAP1) and low molecular weight protein 2 (LMP2) was determined by immunohistochemistry. Intraperitoneal administration of sterigmatocystin promoted the proliferation of squamous epithelium. In addition, it also increased the expression of PCNA in esophageal epithelial cells in rats with reflux esophagitis and was correlated with the increased severity of epithelial hyperplasia. The expression levels of TAP1 and LMP2, which are located in the cytoplasm of esophageal epithelial cells, were reduced in rats with reflux esophagitis, and sterigmatocystin exposure further decreased the expression. Thus, the downregulation of TAP1 and LMP2 proteins by sterigmatocystin may directly affect tumor immunity by allowing transformed cells to escape the host immune surveillance, thereby promoting esophageal cancer.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PSMB9Humanpeptic esophagitis  ISOPsmb9 (Rattus norvegicus)protein:decreased expression:esophageal epithelium (rat)RGD 
Psmb9Ratpeptic esophagitis  IEP protein:decreased expression:esophageal epithelium (rat)RGD 
Psmb9Mousepeptic esophagitis  ISOPsmb9 (Rattus norvegicus)protein:decreased expression:esophageal epithelium (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Psmb9  (proteasome 20S subunit beta 9)

Genes (Mus musculus)
Psmb9  (proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2))

Genes (Homo sapiens)
PSMB9  (proteasome 20S subunit beta 9)


Additional Information