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Gene: Stat4 (signal transducer and activator of transcription 4) Mus musculus
Symbol: Stat4
Name: signal transducer and activator of transcription 4
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of transcription by RNA polymerase II; and protein phosphorylation. Localizes to nucleus. Is expressed in several structures, including axial skeleton; cranium; early conceptus; genitourinary system; and thymus primordium. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; IgA glomerulonephritis; autoimmune hypersensitivity disease (multiple); liver disease (multiple); and systemic scleroderma (multiple). Orthologous to human STAT4 (signal transducer and activator of transcription 4).
Type: protein-coding
RefSeq Status: REVIEWED
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl151,987,148 - 52,107,189 (+)EnsemblGRCm38mm10GRCm38
GRCm38151,987,106 - 52,107,189 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37152,065,088 - 52,164,028 (+)NCBIGRCm37mm9NCBIm37
MGSCv36151,952,789 - 52,051,729 (+)NCBImm8
Celera152,546,764 - 52,645,629 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Stat4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313965
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.