Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Hfe (homeostatic iron regulator) Mus musculus
Symbol: Hfe
Name: homeostatic iron regulator
Description: Exhibits transferrin receptor binding activity. Involved in hormone biosynthetic process; multicellular organismal iron ion homeostasis; and positive regulation of gene expression. Localizes to the HFE-transferrin receptor complex. Used to study hemochromatosis type 1. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Is expressed in brain; choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human HFE (homeostatic iron regulator); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hemochromatosis; hereditary hemochromatosis protein homolog; MGC151121; MGC151123; MR2
Homo sapiens (human) : HFE (homeostatic iron regulator)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hfe (homeostatic iron regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hfe (homeostatic iron regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : HFE (homeostatic iron regulator)
Canis lupus familiaris (dog) : HFE (homeostatic iron regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hfe (homeostatic iron regulator)
Sus scrofa (pig) : HFE (homeostatic iron regulator)
Chlorocebus sabaeus (green monkey) : HFE (homeostatic iron regulator)
Heterocephalus glaber (naked mole-rat) : Hfe (homeostatic iron regulator)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1323,702,034 - 23,710,854 (-)Ensembl
GRCm381323,702,034 - 23,710,854 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371323,795,710 - 23,802,680 (-)NCBIGRCm37mm9NCBIm37
MGSCv361323,711,306 - 23,718,276 (-)NCBImm8
Celera1323,935,174 - 23,942,163 (-)NCBICelera
Cytogenetic Map13 A3.1NCBI
cM Map139.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Hfe
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736272
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.