RGD Reference Report - Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity. - Rat Genome Database

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Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity.

Authors: Tuttolomondo, A  La Placa, S  Di Raimondo, D  Bellia, C  Caruso, A  Lo Sasso, B  Guercio, G  Diana, G  Ciaccio, M  Licata, G  Pinto, A 
Citation: Tuttolomondo A, etal., Cardiovasc Diabetol. 2010 Sep 13;9:50.
RGD ID: 5686889
Pubmed: (View Article at PubMed) PMID:20836881
DOI: Full-text: DOI:10.1186/1475-2840-9-50

INTRODUCTION: It is very suggestive that diabetic foot is characterized by a pronounced inflammatory reaction and the pathogenic significance of this inflammation has received little attention. On this basis the aim of our study was to evaluate plasma levels of adiponectin, resistin and IL-6 in subjects with diabetic foot in comparison with subjects without foot complications. MATERIALS AND METHODS: We recruited 34 subjects with type 2 diabetes mellitus and foot ulceration hospitalized for every condition related to diabetic disease, but not for new vascular events (group A). As controls we recruited 37 patients with type 2 diabetes mellitus without foot ulceration (group B) hospitalized for every condition related to diabetic disease, but not for new vascular events. Adiponectin, Resistin and IL-6 serum levels were evaluated. RESULTS: Subjects of group A showed lower median plasma levels of adiponectin [7.7450 (4.47-12.17) mug/ml vs 8.480 (5.15-12.87) mug/ml], higher median plasma levels of IL-6 [3.21 (1.23-5.34) pg/ml vs 2.73 (1.24-3.97 pg/ml)] and of resistin [3.860 (2.96-6.29 ng/ml) vs 3.690 (2.,37-6.5 ng/ml)]. CONCLUSION: Our study demonstrated that diabetic subjects with diabetic foot showed in comparison with diabetics without diabetic foot higher IL-6 and resistin plasma levels, lower adiponectin plasma levels.

Annotation

Disease Annotations    
Diabetic Foot  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)


Additional Information