Cblif (cobalamin binding intrinsic factor) - Rat Genome Database

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Gene: Cblif (cobalamin binding intrinsic factor) Mus musculus
Analyze
Symbol: Cblif
Name: cobalamin binding intrinsic factor
RGD ID: 62376
MGI Page MGI
Description: Enables cargo receptor ligand activity and cobalamin binding activity. Involved in cobalamin transport. Is active in extracellular space. Is expressed in gut and lung. Human ortholog(s) of this gene implicated in congenital intrinsic factor deficiency and pernicious anemia. Orthologous to human CBLIF (cobalamin binding intrinsic factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AV073125; gastric intrinsic factor; Gi; Gif; IF; INF; intrinsic factor; MGC144768
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,724,907 - 11,740,811 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,724,918 - 11,740,811 (+)EnsemblGRCm39 Ensembl
GRCm381911,747,543 - 11,763,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,747,554 - 11,763,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv371911,822,049 - 11,837,937 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,814,604 - 11,830,492 (+)NCBIMGSCv36mm8
Celera1912,421,676 - 12,437,553 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IEA,ISO)
endosome  (IEA,ISO)
extracellular space  (IBA,IDA,ISO)
microvillus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Urinary excretion of intrinsic factor and the receptor for its cobalamin complex in Grasbeck-Imerslund patients: the disease may have subsets. Dugue B, etal., J Pediatr Gastroenterol Nutr. 1999 Aug;29(2):227-30.
2. A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency. Gordon MM, etal., Hum Mutat. 2004 Jan;23(1):85-91.
3. Effect of prolonged administration of homologous and heterologous intrinsic factor antibodies on the parietal and peptic cell masses and the secretory function of the rat gastric mucosa. Inada M and Glass GB, Gastroenterology. 1975 Aug;69(2):396-408.
4. Cell-mediated immunity to intrinsic factor in autoimmune disorders. James D, etal., Br Med J. 1974 Nov 30;4(5943):494-6.
5. Transcriptome Reveals 1400-Fold Upregulation of APOA4-APOC3 and 1100-Fold Downregulation of GIF in the Patients with Polycythemia-Induced Gastric Injury. Li K, etal., PLoS One. 2015 Oct 20;10(10):e0140534. doi: 10.1371/journal.pone.0140534. eCollection 2015.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene. Tanner SM, etal., Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4130-3. Epub 2005 Feb 28.
14. [Search for anti-intrinsic factor antibodies in the diagnosis of Biermer's anemia]. Zittoun J, etal., Sem Hop. 1975 Jan 20;51(4):229-32.
Additional References at PubMed
PMID:8253786   PMID:9530637   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12163410   PMID:12477932   PMID:14321840   PMID:15003629   PMID:15809042   PMID:16141072  
PMID:16141073   PMID:16247775   PMID:17855428   PMID:18173746   PMID:18242217   PMID:18558092   PMID:19208343   PMID:21307095   PMID:21402740   PMID:21677750   PMID:21873635   PMID:24911144  
PMID:26057579   PMID:27329747   PMID:28052057   PMID:29700203   PMID:30973865   PMID:32325033   PMID:32878924   PMID:33759575   PMID:34111600   PMID:34391772   PMID:34497145   PMID:35523142  
PMID:38272100   PMID:38355793  


Genomics

Comparative Map Data
Cblif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,724,907 - 11,740,811 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,724,918 - 11,740,811 (+)EnsemblGRCm39 Ensembl
GRCm381911,747,543 - 11,763,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,747,554 - 11,763,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv371911,822,049 - 11,837,937 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,814,604 - 11,830,492 (+)NCBIMGSCv36mm8
Celera1912,421,676 - 12,437,553 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.51NCBI
CBLIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,829,273 - 59,845,499 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,829,273 - 59,845,499 (-)EnsemblGRCh38hg38GRCh38
GRCh371159,596,746 - 59,612,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,353,322 - 59,369,550 (-)NCBINCBI36Build 36hg18NCBI36
Build 341159,353,323 - 59,369,550NCBI
Celera1156,959,492 - 56,975,732 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1155,944,132 - 55,960,372 (-)NCBIHuRef
CHM1_11159,462,735 - 59,478,963 (-)NCBICHM1_1
T2T-CHM13v2.01159,780,568 - 59,796,806 (-)NCBIT2T-CHM13v2.0
Cblif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81218,030,756 - 218,045,004 (+)NCBIGRCr8
mRatBN7.21208,605,983 - 208,620,231 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1208,605,983 - 208,620,344 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,980,694 - 216,994,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,974,554 - 223,988,811 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01216,735,131 - 216,749,369 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01228,118,048 - 228,132,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1228,118,048 - 228,132,404 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01235,185,900 - 235,200,148 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,519,329 - 214,533,578 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11214,677,758 - 214,692,008 (+)NCBI
Celera1206,076,631 - 206,090,861 (+)NCBICelera
Cytogenetic Map1q43NCBI
Cblif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555114,231,466 - 4,251,975 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555114,234,470 - 4,251,583 (-)NCBIChiLan1.0ChiLan1.0
CBLIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2960,958,637 - 60,974,926 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11162,002,300 - 62,018,611 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01155,052,839 - 55,069,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,500,878 - 58,517,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,500,878 - 58,517,094 (-)Ensemblpanpan1.1panPan2
CBLIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12150,334,769 - 50,350,598 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2150,334,769 - 50,350,598 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2149,776,075 - 49,791,632 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02151,507,892 - 51,523,880 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2151,507,892 - 51,523,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12150,555,189 - 50,571,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02150,652,926 - 50,668,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02151,277,695 - 51,293,212 (-)NCBIUU_Cfam_GSD_1.0
Cblif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494712,806,500 - 12,819,735 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,920,355 - 2,933,403 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,919,793 - 2,933,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBLIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl211,655,767 - 11,674,302 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1211,655,726 - 11,674,357 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2211,108,689 - 11,126,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CBLIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1113,833,762 - 13,849,727 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl113,834,330 - 13,849,516 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038111,166,368 - 111,181,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cblif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248641,028,982 - 1,040,731 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cblif
481 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:74
Interacting mature miRNAs:75
Transcripts:ENSMUST00000025585
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
L24191  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381911,763,282 - 11,763,392UniSTSGRCm38
MGSCv371911,837,772 - 11,837,882UniSTSGRCm37
Celera1912,437,388 - 12,437,498UniSTS
Cytogenetic Map19AUniSTS
Whitehead/MRC_RH19128.98UniSTS
AV073125  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381911,763,244 - 11,763,387UniSTSGRCm38
MGSCv371911,837,734 - 11,837,877UniSTSGRCm37
Celera1912,437,350 - 12,437,493UniSTS
Cytogenetic Map19AUniSTS
Whitehead/MRC_RH19133.18UniSTS
UniSTS:225149  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381911,763,319 - 11,763,421UniSTSGRCm38
MGSCv371911,837,809 - 11,837,911UniSTSGRCm37
Celera1912,437,425 - 12,437,527UniSTS
Cytogenetic Map19AUniSTS
Gif  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371911,822,060 - 11,822,181UniSTSGRCm37
Celera1912,421,687 - 12,421,808UniSTS
Cytogenetic Map19AUniSTS
cM Map19 UniSTS
Gif  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381911,747,570 - 11,747,691UniSTSGRCm38
MGSCv371911,822,060 - 11,822,181UniSTSGRCm37
Celera1912,421,687 - 12,421,808UniSTS
Cytogenetic Map19AUniSTS
cM Map19 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025585   ⟹   ENSMUSP00000025585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1911,724,918 - 11,740,811 (+)Ensembl
GRCm38.p6 Ensembl1911,747,554 - 11,763,447 (+)Ensembl
RefSeq Acc Id: NM_008118   ⟹   NP_032144
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391911,724,923 - 11,740,811 (+)NCBI
GRCm381911,747,559 - 11,763,447 (+)NCBI
MGSCv371911,822,049 - 11,837,937 (+)RGD
Celera1912,421,676 - 12,437,553 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526688   ⟹   XP_006526751
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391911,724,907 - 11,737,684 (+)NCBI
GRCm381911,747,543 - 11,760,320 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032144   ⟸   NM_008118
- Peptide Label: precursor
- UniProtKB: Q8C5C1 (UniProtKB/Swiss-Prot),   P52787 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526751   ⟸   XM_006526688
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000025585   ⟸   ENSMUST00000025585

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52787-F1-model_v2 AlphaFold P52787 1-417 view protein structure

Promoters
RGD ID:13678992
Promoter ID:EPDNEW_M23645
Type:initiation region
Name:Gif_1
Description:Mus musculus gastric intrinsic factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381911,747,559 - 11,747,619EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1202394 AgrOrtholog
Ensembl Genes ENSMUSG00000024682 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025585 ENTREZGENE
  ENSMUST00000025585.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot
  2.170.130.30 UniProtKB/Swiss-Prot
InterPro Cbl-bd_prot UniProtKB/Swiss-Prot
  Cobalamin_Transport UniProtKB/Swiss-Prot
KEGG Report mmu:14603 UniProtKB/Swiss-Prot
MGD MGI:1202394 ENTREZGENE
NCBI Gene 14603 ENTREZGENE
PANTHER COBALAMIN BINDING INTRINSIC FACTOR UniProtKB/Swiss-Prot
  TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR UniProtKB/Swiss-Prot
Pfam Cobalamin_bind UniProtKB/Swiss-Prot
PhenoGen Cblif PhenoGen
PROSITE COBALAMIN_BINDING UniProtKB/Swiss-Prot
UniProt IF_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C5C1 ENTREZGENE
UniProt Secondary Q8C5C1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 Cblif  cobalamin binding intrinsic factor  Gif  gastric intrinsic factor  Symbol and/or name change 5135510 APPROVED