RGD Reference Report - PLA1/A2 polymorphism of the platelet glycoprotein receptors IIIA in Behcet's disease. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

PLA1/A2 polymorphism of the platelet glycoprotein receptors IIIA in Behcet's disease.

Authors: Atzeni, F  Boiardi, L  Nicoli, D  Farnetti, E  Casali, B  Sarzi-Puttini, P  Pipitone, N  Olivieri, I  Cantini, F  Salvi, F  La Corte, R  Triolo, G  Filippini, D  Paolazzi, G  Salvarani, C 
Citation: Atzeni F, etal., Clin Exp Rheumatol. 2011 Jul-Aug;29(4 Suppl 67):S38-43. Epub 2011 Sep 27.
RGD ID: 8693342
Pubmed: (View Article at PubMed) PMID:21813062

OBJECTIVES: To investigate potential associations between the PlA1/A2 polymorphism of the platelet glycoprotein receptor IIIA (GpIIIa) gene and venous thrombosis and other clinical manifestations in Italian patients with Behcet's disease (BD). METHODS: Two hundred consecutive Italian patients satisfying the International Study Group criteria for BD who were followed up for seven years and 241 healthy Italian age- and gender-matched blood donors were molecularly genotyped for the PlA1/A2 polymorphism of the platelet GpIIIa gene; 118 and 117 of the 200 BD patients were also respectively genotyped for factor V Leiden and prothrombin gene G20210A polymorphisms. A standard microlymphocytotoxicity technique was used to type serological HLA class B51. The patients were grouped on the basis of the presence or absence of clinical manifestations. The diagnoses of deep vein thrombosis (DVT) and superficial thrombophlebitis were initially made clinically, and then confirmed by means of ultrasonography or contrast venography. The distribution of the PlA1/A2 genotype was investigated, and odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. RESULTS: The allele and genotype frequency of the PlA1/A2 polymorphism were not significantly different in the BD patients and controls, but the PlA2 allele was significantly more frequent in the BD patients with DVT than the controls (p=0.023; Pcorr=0.046; OR 2.0, 95% CI 1.1-3.7). There were no associations between thrombotic events and the PlA1/A2 polymorphism in the BD patients carrying factor V Leiden or prothrombin gene G20210A mutations. The PlA2 allele was significantly less frequent in the BD patients with genital genital ulcers than in those without (26.9% vs. 43.2%; p=0.022; P corr 0.044; OR 0.48, CI 0.27-0.88). CONCLUSIONS: The PlA1/A2 polymorphism of the GpIIIa gene was associated with DVT in our Italian BD patients, but does not seem to increase the risk of DVT due to factor V Leiden or prothrombin gene G20210A mutations. There was a negative association between the A2 allele and genital ulcers.

Annotation

Disease Annotations    
Ulcer  (IAGP,ISO)
Venous Thrombosis  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Itgb3  (integrin subunit beta 3)

Genes (Mus musculus)
Itgb3  (integrin beta 3)

Genes (Homo sapiens)
ITGB3  (integrin subunit beta 3)


Additional Information