Ghrl (ghrelin) - Rat Genome Database

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Gene: Ghrl (ghrelin) Mus musculus
Analyze
Symbol: Ghrl
Name: ghrelin
RGD ID: 732655
MGI Page MGI
Description: Predicted to enable ghrelin receptor binding activity; growth hormone-releasing hormone activity; and protein tyrosine kinase activator activity. Involved in adult feeding behavior and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including energy homeostasis; negative regulation of insulin secretion; and positive regulation of appetite. Located in cytoplasm and extracellular region. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and skeleton. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2210006E23Rik; appetite-regulating hormone; Gh; Ghr; growth hormone secretagogue; growth hormone-releasing peptide; m46; motilin-related peptide; MT; MTLRP; MTLRPAP; preproghrelin; proghrelin; uncharacterized protein LOC58991
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,693,080 - 113,696,872 (-)NCBIGRCm39mm39
GRCm39 Ensembl6113,693,080 - 113,696,841 (-)Ensembl
GRCm386113,716,119 - 113,719,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,716,119 - 113,719,880 (-)EnsemblGRCm38mm10GRCm38
MGSCv376113,666,113 - 113,669,874 (-)NCBIGRCm37mm9NCBIm37
MGSCv366113,681,896 - 113,685,657 (-)NCBImm8
Celera6115,541,628 - 115,545,391 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atropine  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
carbon nanotube  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cysteamine  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP)
dexloxiglumide  (ISO)
dextran sulfate  (EXP)
dopamine  (ISO)
doxorubicin  (ISO)
famotidine  (ISO)
flavonoids  (ISO)
fructose  (ISO)
furan  (ISO)
glucose  (ISO)
histamine  (ISO)
homoeriodictyol  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
malonaldehyde  (ISO)
mercaptopurine  (ISO)
metformin  (EXP)
methylmercury chloride  (EXP)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
olanzapine  (EXP)
oleanolic acid  (EXP)
orlistat  (ISO)
paraquat  (ISO)
pentobarbital  (ISO)
pirinixic acid  (EXP)
prostaglandin E2  (ISO)
prostaglandins E  (ISO)
prostaglandins F  (ISO)
purine-6-thiol  (ISO)
rotenone  (ISO)
ruthenium red  (EXP)
serotonin  (ISO)
sodium arsenite  (EXP,ISO)
Sodium oleate  (ISO)
streptozocin  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
uranium atom  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin polymerization or depolymerization  (ISO)
adult feeding behavior  (IDA)
decidualization  (ISO)
dendrite development  (IMP,ISO)
energy homeostasis  (IDA)
excitatory postsynaptic potential  (IMP)
G protein-coupled receptor signaling pathway  (ISO)
gastric acid secretion  (IBA,ISO)
gastric emptying  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of circadian sleep/wake cycle, REM sleep  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of inflammatory response  (IBA,ISO)
negative regulation of insulin secretion  (IMP,ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of locomotion  (IMP)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of appetite  (IDA,IGI,IMP,ISO)
positive regulation of bone development  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of corticotropin secretion  (ISO)
positive regulation of cortisol secretion  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of feeding behavior  (ISO)
positive regulation of gastric mucosal blood circulation  (ISO)
positive regulation of gastro-intestinal system smooth muscle contraction  (ISO)
positive regulation of growth  (ISO)
positive regulation of growth hormone secretion  (IBA,ISO)
positive regulation of growth rate  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of response to food  (ISO)
positive regulation of small intestinal transit  (ISO)
positive regulation of small intestine smooth muscle contraction  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of synapse assembly  (IMP,ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
regulation of cell population proliferation  (ISO)
regulation of gastric motility  (ISO)
regulation of postsynapse organization  (ISO)
regulation of response to food  (IBA,ISO)
regulation of transmission of nerve impulse  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hormone  (ISO)
response to nutrient levels  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Arbeiter AK, etal., Nephrol Dial Transplant. 2009 Feb;24(2):643-6. doi: 10.1093/ndt/gfn529. Epub 2008 Sep 22.
2. Berthold HK, etal., Clin Chim Acta. 2009 Jan;399(1-2):112-6. Epub 2008 Sep 25.
3. Bizzarri C, etal., Horm Metab Res. 2004 Mar;36(3):164-9.
4. Chou CC, etal., Intern Med. 2010;49(19):2057-64. Epub 2010 Oct 1.
5. Huda MS, etal., Int J Obes (Lond). 2009 Mar;33(3):317-25. Epub 2009 Feb 3.
6. Hwang S, etal., Endocr J. 2009;56(4):609-17. Epub 2009 Apr 7.
7. IƱiguez G, etal., Horm Res Paediatr. 2011 Feb;75(2):94-100. doi: 10.1159/000317429. Epub 2010 Sep 23.
8. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
9. Kojima M and Kangawa K, Physiol Rev. 2005 Apr;85(2):495-522.
10. Kos K, etal., Diabet Med. 2008 Dec;25(12):1400-5.
11. Kyoraku I, etal., Biochem Biophys Res Commun. 2009 Nov 20;389(3):405-8. Epub 2009 Sep 3.
12. Lee CC, etal., Arch Med Res. 2008 Nov;39(8):785-90.
13. Lee CJ, etal., Perit Dial Int. 2008 Jun;28 Suppl 3:S196-200.
14. Li L, etal., Acta Pharmacol Sin. 2006 May;27(5):527-35.
15. MGD data from the GO Consortium
16. MGD IEA
17. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline
19. RGD automated import pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Shimizu Y, etal., Clin Cancer Res. 2003 Feb;9(2):774-8.
23. Steinle NI, etal., J Clin Endocrinol Metab. 2005 Dec;90(12):6672-7. Epub 2005 Oct 4.
24. Tarasiuk A, etal., Sleep. 2016 Apr 1;39(4):887-97. doi: 10.5665/sleep.5648.
25. Theil MM, etal., J Immunol. 2009 Aug 15;183(4):2859-66. doi: 10.4049/jimmunol.0803362. Epub 2009 Jul 20.
26. Ueno H, etal., Endocr J. 2007 Dec;54(6):895-902. Epub 2007 Nov 16.
27. Verhulst PJ, etal., Gastroenterology. 2008 Oct;135(4):1267-76. Epub 2008 Jun 25.
28. Wang W, etal., Am J Physiol Renal Physiol. 2009 Oct;297(4):F1032-7. doi: 10.1152/ajprenal.00044.2009. Epub 2009 Jul 22.
29. Wiedemann T, etal., Diabetes. 2016 Feb;65(2):406-20. doi: 10.2337/db15-0374. Epub 2015 Oct 28.
30. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
31. Wu R, etal., Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1296-302. Epub 2004 May 20.
32. Xu L, etal., Peptides. 2013 Oct;48:137-46. doi: 10.1016/j.peptides.2013.08.010. Epub 2013 Aug 18.
33. Yang HM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jul;12(7):563-8.
34. Zaniolo K, etal., Invest Ophthalmol Vis Sci. 2011 Jul 23;52(8):5376-86. doi: 10.1167/iovs.10-7152.
Additional References at PubMed
PMID:10349636   PMID:10930375   PMID:11042159   PMID:11076861   PMID:11306336   PMID:11718902   PMID:12039068   PMID:12193546   PMID:12456641   PMID:12477932   PMID:12650860   PMID:12660874  
PMID:12746326   PMID:14530511   PMID:14585959   PMID:14681479   PMID:14681847   PMID:14708415   PMID:14970313   PMID:15031110   PMID:15070777   PMID:15082713   PMID:15148384   PMID:15178745  
PMID:15284202   PMID:15471959   PMID:15471962   PMID:15548585   PMID:15561944   PMID:15576457   PMID:15591499   PMID:15677766   PMID:15680365   PMID:15701644   PMID:15746259   PMID:15870394  
PMID:15944193   PMID:15946750   PMID:16002530   PMID:16015681   PMID:16109802   PMID:16141072   PMID:16141073   PMID:16203827   PMID:16210421   PMID:16322794   PMID:16322795   PMID:16376425  
PMID:16399505   PMID:16418280   PMID:16430857   PMID:16476508   PMID:16491079   PMID:16601073   PMID:16602821   PMID:16679295   PMID:16825418   PMID:16825606   PMID:16887115   PMID:16951258  
PMID:17050541   PMID:17060947   PMID:17130496   PMID:17134539   PMID:17196193   PMID:17202186   PMID:17202410   PMID:17204551   PMID:17255209   PMID:17290011   PMID:17400205   PMID:17400914  
PMID:17409264   PMID:17496153   PMID:17575083   PMID:17595213   PMID:17646721   PMID:17762192   PMID:17804764   PMID:17823656   PMID:17876540   PMID:17909095   PMID:17913260   PMID:17945362  
PMID:17975746   PMID:17988662   PMID:18006636   PMID:18048479   PMID:18058910   PMID:18070755   PMID:18071756   PMID:18173746   PMID:18199433   PMID:18202139   PMID:18267071   PMID:18270302  
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PMID:18694323   PMID:18723011   PMID:18981425   PMID:18987169   PMID:19054770   PMID:19114069   PMID:19151202   PMID:19160422   PMID:19223466   PMID:19268691   PMID:19299626   PMID:19324904  
PMID:19401456   PMID:19406939   PMID:19426541   PMID:19502415   PMID:19503064   PMID:19506321   PMID:19564604   PMID:19602582   PMID:19633195   PMID:19666521   PMID:19759004   PMID:19793886  
PMID:19805515   PMID:19906954   PMID:19939974   PMID:19944124   PMID:19965928   PMID:20003319   PMID:20043902   PMID:20044999   PMID:20063013   PMID:20148032   PMID:20185766   PMID:20206170  
PMID:20213045   PMID:20362013   PMID:20377917   PMID:20413507   PMID:20501433   PMID:20526334   PMID:20713709   PMID:20856820   PMID:20857084   PMID:20876580   PMID:20883684   PMID:20933579  
PMID:21029370   PMID:21054685   PMID:21081123   PMID:21124019   PMID:21163280   PMID:21173230   PMID:21220053   PMID:21264794   PMID:21298106   PMID:21325042   PMID:21386086   PMID:21464907  
PMID:21521750   PMID:21600256   PMID:21699961   PMID:21750032   PMID:21786021   PMID:21788571   PMID:21835225   PMID:21856296   PMID:21873635   PMID:21880149   PMID:21907183   PMID:21912454  
PMID:21939391   PMID:21947380   PMID:21958715   PMID:21963822   PMID:22013016   PMID:22114024   PMID:22114179   PMID:22119755   PMID:22178591   PMID:22211783   PMID:22284186   PMID:22338071  
PMID:22363801   PMID:22387004   PMID:22414807   PMID:22434868   PMID:22461559   PMID:22474325   PMID:22521145   PMID:22535766   PMID:22539496   PMID:22601779   PMID:22641088   PMID:22669248  
PMID:22700774   PMID:22764048   PMID:22768248   PMID:22815958   PMID:22982020   PMID:23056203   PMID:23177622   PMID:23193182   PMID:23220294   PMID:23232360   PMID:23251675   PMID:23297228  
PMID:23307790   PMID:23385580   PMID:23408910   PMID:23411585   PMID:23417423   PMID:23428971   PMID:23469081   PMID:23494546   PMID:23509933   PMID:23515286   PMID:23576609   PMID:23590608  
PMID:23610061   PMID:23630616   PMID:23804489   PMID:23820307   PMID:23823474   PMID:23832961   PMID:23861368   PMID:23921150   PMID:23940571   PMID:23996959   PMID:24124572   PMID:24222669  
PMID:24236044   PMID:24285267   PMID:24288687   PMID:24295570   PMID:24308935   PMID:24309634   PMID:24390927   PMID:24735326   PMID:24853426   PMID:24888783   PMID:24937751   PMID:24949662  
PMID:25004095   PMID:25029956   PMID:25060361   PMID:25322462   PMID:25329803   PMID:25368096   PMID:25447526   PMID:25490146   PMID:25543537   PMID:25583513   PMID:25605129   PMID:25607843  
PMID:25631345   PMID:25645492   PMID:25645493   PMID:25646463   PMID:25652387   PMID:25732068   PMID:25735661   PMID:25801577   PMID:25828736   PMID:25918232   PMID:25979074   PMID:26066847  
PMID:26071307   PMID:26269506   PMID:26283199   PMID:26357899   PMID:26385180   PMID:26490687   PMID:26554594   PMID:26631740   PMID:26658466   PMID:26752640   PMID:26771085   PMID:26812158  
PMID:26872221   PMID:26874559   PMID:26884874   PMID:26944677   PMID:26961958   PMID:26991015   PMID:27026049   PMID:27032885   PMID:27270601   PMID:27303049   PMID:27431015   PMID:27474249  
PMID:27490185   PMID:27548523   PMID:27740873   PMID:28071588   PMID:28120848   PMID:28204197   PMID:28338217   PMID:28361877   PMID:28436144   PMID:28542403   PMID:28547758   PMID:28576773  
PMID:28585250   PMID:28793255   PMID:29024407   PMID:29066728   PMID:29070587   PMID:29155981   PMID:29328403   PMID:29330353   PMID:29378186   PMID:29655655   PMID:29688375   PMID:29846901  
PMID:29907775   PMID:29966658   PMID:30141265   PMID:30204871   PMID:30254276   PMID:30268780   PMID:30276663   PMID:30380028   PMID:30407483   PMID:30487608   PMID:30590051   PMID:30620902  
PMID:30682769   PMID:30718736   PMID:30735697   PMID:30742723   PMID:30776164   PMID:31179562   PMID:31201280   PMID:31237372   PMID:31276248   PMID:31469195   PMID:31525456   PMID:31604927  
PMID:31611477   PMID:31668390   PMID:31685528   PMID:31830702   PMID:31918060   PMID:31926478   PMID:31984635   PMID:32084395   PMID:32128814   PMID:32165492   PMID:32350257   PMID:32357262  
PMID:32467243   PMID:32994489   PMID:33042003   PMID:33116243   PMID:33658226   PMID:34289060  


Genomics

Comparative Map Data
Ghrl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,693,080 - 113,696,872 (-)NCBIGRCm39mm39
GRCm39 Ensembl6113,693,080 - 113,696,841 (-)Ensembl
GRCm386113,716,119 - 113,719,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,716,119 - 113,719,880 (-)EnsemblGRCm38mm10GRCm38
MGSCv376113,666,113 - 113,669,874 (-)NCBIGRCm37mm9NCBIm37
MGSCv366113,681,896 - 113,685,657 (-)NCBImm8
Celera6115,541,628 - 115,545,391 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.84NCBI
GHRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl310,285,666 - 10,292,947 (-)EnsemblGRCh38hg38GRCh38
GRCh38310,285,666 - 10,292,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37310,327,350 - 10,334,631 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,302,434 - 10,307,409 (-)NCBINCBI36hg18NCBI36
Build 34310,302,433 - 10,307,409NCBI
Celera310,263,242 - 10,270,439 (-)NCBI
Cytogenetic Map3p25.3NCBI
HuRef310,262,844 - 10,269,999 (-)NCBIHuRef
CHM1_1310,277,571 - 10,284,767 (-)NCBICHM1_1
Ghrl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24146,865,712 - 146,869,621 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4146,865,712 - 146,869,621 (-)Ensembl
Rnor_6.04145,674,157 - 145,678,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,674,157 - 145,678,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,969,963 - 208,976,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,622,566 - 149,628,111 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,867,406 - 149,872,952 (-)NCBI
Celera4135,420,041 - 135,423,946 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ghrl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,676,576 - 1,681,812 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,676,475 - 1,682,205 (-)NCBIChiLan1.0ChiLan1.0
GHRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1310,573,537 - 10,580,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl310,573,537 - 10,580,723 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0310,221,829 - 10,229,229 (-)NCBIMhudiblu_PPA_v0panPan3
GHRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,092,921 - 8,097,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,092,957 - 8,097,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,127,316 - 8,131,869 (+)NCBI
ROS_Cfam_1.0208,122,116 - 8,127,217 (+)NCBI
UMICH_Zoey_3.1207,844,540 - 7,849,093 (+)NCBI
UNSW_CanFamBas_1.0208,190,266 - 8,194,819 (+)NCBI
UU_Cfam_GSD_1.0208,163,907 - 8,168,460 (+)NCBI
Ghrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,867,085 - 15,872,024 (-)NCBI
SpeTri2.0NW_0049366023,037,862 - 3,044,863 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,316,436 - 66,452,917 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,442,106 - 66,453,576 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,453,082 - 73,480,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q31NCBI
GHRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12246,326,458 - 46,332,906 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2246,325,913 - 46,330,962 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041120,205,064 - 120,210,786 (+)NCBIVero_WHO_p1.0
Ghrl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247315,257,813 - 5,262,878 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Ghrl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6E3UniSTS
cM Map649.7UniSTS
D6Oda23  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386113,717,974 - 113,718,116UniSTSGRCm38
MGSCv376113,667,968 - 113,668,110UniSTSGRCm37
Celera6115,543,485 - 115,543,627UniSTS
Cytogenetic Map6E3UniSTS
cM Map649.42UniSTS
PMC262394P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386113,716,246 - 113,717,155UniSTSGRCm38
MGSCv376113,666,240 - 113,667,149UniSTSGRCm37
Celera6115,541,755 - 115,542,666UniSTS
Cytogenetic Map6E3UniSTS
cM Map649.7UniSTS
PMC262394P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386113,719,112 - 113,719,385UniSTSGRCm38
MGSCv376113,669,106 - 113,669,379UniSTSGRCm37
Celera6115,544,623 - 115,544,896UniSTS
Cytogenetic Map6E3UniSTS
cM Map649.7UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103777444136423692Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104503360127042975Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104503360136423692Mouse
1357793Pnhdlc1_mplasma non-HDL cholesterol 1 (mouse)Not determined6105564822114368849Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined106005405120917141Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110838217144838360Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111165485145165578Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112269957125356785Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112269957147052561Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:168
Interacting mature miRNAs:172
Transcripts:ENSMUST00000064993
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_138135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB035701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB060078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB111891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV079302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY179430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY149645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK137452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ993169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ355940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ355941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ355942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ355943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ355944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ355945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ914266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000064993   ⟹   ENSMUSP00000069567
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6113,693,080 - 113,696,841 (-)Ensembl
GRCm38.p6 Ensembl6113,716,119 - 113,719,880 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203363   ⟹   ENSMUSP00000145366
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6113,693,085 - 113,696,419 (-)Ensembl
GRCm38.p6 Ensembl6113,716,124 - 113,719,458 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203588   ⟹   ENSMUSP00000145514
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6113,693,211 - 113,696,390 (-)Ensembl
GRCm38.p6 Ensembl6113,716,250 - 113,719,429 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203770   ⟹   ENSMUSP00000145281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6113,693,093 - 113,696,809 (-)Ensembl
GRCm38.p6 Ensembl6113,716,132 - 113,719,848 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204163   ⟹   ENSMUSP00000145096
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6113,693,133 - 113,696,408 (-)Ensembl
GRCm38.p6 Ensembl6113,716,172 - 113,719,447 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204191
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6113,696,138 - 113,696,415 (-)Ensembl
GRCm38.p6 Ensembl6113,719,177 - 113,719,454 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204533   ⟹   ENSMUSP00000145046
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6113,693,080 - 113,694,653 (-)Ensembl
GRCm38.p6 Ensembl6113,716,119 - 113,717,692 (-)Ensembl
RefSeq Acc Id: NM_001286404   ⟹   NP_001273333
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396113,693,080 - 113,696,415 (-)NCBI
GRCm386113,716,119 - 113,719,454 (-)NCBI
Celera6115,541,628 - 115,545,422 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286405   ⟹   NP_001273334
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396113,693,080 - 113,696,415 (-)NCBI
GRCm386113,716,119 - 113,719,454 (-)NCBI
Celera6115,541,628 - 115,545,422 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286406   ⟹   NP_001273335
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396113,693,080 - 113,696,415 (-)NCBI
GRCm386113,716,119 - 113,719,454 (-)NCBI
Celera6115,541,628 - 115,545,422 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001379129   ⟹   NP_001366058
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396113,693,085 - 113,696,426 (-)NCBI
GRCm386113,716,124 - 113,719,465 (-)NCBI
RefSeq Acc Id: NM_021488   ⟹   NP_067463
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396113,693,080 - 113,696,872 (-)NCBI
GRCm386113,716,119 - 113,719,911 (-)NCBI
MGSCv376113,666,113 - 113,669,874 (-)RGD
Celera6115,541,628 - 115,545,422 (-)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_138135
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396113,693,080 - 113,694,653 (-)NCBI
GRCm386113,716,119 - 113,717,692 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067463   ⟸   NM_021488
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q9EQX0 (UniProtKB/Swiss-Prot),   A2RSS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273335   ⟸   NM_001286406
- Peptide Label: isoform 4 precursor
- UniProtKB: Q9EQX0 (UniProtKB/Swiss-Prot),   Q7TSD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273333   ⟸   NM_001286404
- Peptide Label: isoform 2 preproprotein
- UniProtKB: Q9EQX0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273334   ⟸   NM_001286405
- Peptide Label: isoform 3 precursor
- UniProtKB: Q9EQX0 (UniProtKB/Swiss-Prot),   Q811T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001366058   ⟸   NM_001379129
- Peptide Label: isoform 1 preproprotein
RefSeq Acc Id: ENSMUSP00000145096   ⟸   ENSMUST00000204163
RefSeq Acc Id: ENSMUSP00000145281   ⟸   ENSMUST00000203770
RefSeq Acc Id: ENSMUSP00000145514   ⟸   ENSMUST00000203588
RefSeq Acc Id: ENSMUSP00000145366   ⟸   ENSMUST00000203363
RefSeq Acc Id: ENSMUSP00000145046   ⟸   ENSMUST00000204533
RefSeq Acc Id: ENSMUSP00000069567   ⟸   ENSMUST00000064993
Protein Domains
Motilin_assoc   Motilin_ghrelin

Promoters
RGD ID:6839342
Promoter ID:MM_KWN:47209
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   MEF_B6
Transcripts:ENSMUST00000080745,   ENSMUST00000082099,   NM_021488,   UC009DHJ.1,   UC009DHK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366113,669,421 - 113,670,622 (-)MPROMDB
RGD ID:6890684
Promoter ID:EPDNEW_M8790
Type:multiple initiation site
Name:Ghrl_1
Description:Mus musculus ghrelin , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386113,719,465 - 113,719,525EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930008 AgrOrtholog
Ensembl Genes ENSMUSG00000064177 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000069567 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145046 UniProtKB/TrEMBL
  ENSMUSP00000145096 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145281 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145366 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000145514 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064993 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000203363 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000203588 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000203770 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000204163 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000204533 ENTREZGENE, UniProtKB/TrEMBL
InterPro Motilin_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Motilin_ghrelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Preproghrelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58991 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1930008 ENTREZGENE
NCBI Gene 58991 ENTREZGENE
PANTHER PTHR14122 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Motilin_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Motilin_ghrelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ghrl PhenoGen
PRINTS GHRELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SVC9_MOUSE UniProtKB/TrEMBL
  A2RSS9 ENTREZGENE, UniProtKB/TrEMBL
  GHRL_MOUSE UniProtKB/Swiss-Prot
  Q7TSD1 ENTREZGENE, UniProtKB/TrEMBL
  Q811T4 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQX0 ENTREZGENE
UniProt Secondary Q9WUZ1 UniProtKB/Swiss-Prot