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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chrysin
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Accession:CHEBI:75095 term browser browse the term
Definition:A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
Synonyms:related_synonym: 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one;   5,7-Dihydroxy-2-phenyl-4H-benzo(b)pyran-4-one;   5,7-Dihydroxyflavone;   5,7-dihydroxy-2-phenylchromen-4-one;   Formula=C15H10O4;   InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H;   InChIKey=RTIXKCRFFJGDFG-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
 alt_id: CHEBI:3683
 xref: Beilstein:233276;   CAS:480-40-0;   HMDB:HMDB0036619;   KEGG:C10028;   KNApSAcK:C00003794;   LINCS:LSM-6566;   LIPID_MAPS_instance:LMPK12110189
 xref_mesh: MESH:C043561
 xref: MetaCyc:CPD-8184;   PDBeChem:57D;   PMID:1772594;   PMID:21544919;   PMID:22864849;   PMID:22991264;   PMID:23104078;   PMID:23125118;   PMID:23194824;   PMID:23256457;   PMID:23296950;   PMID:23357962;   PMID:23468207;   PMID:23536316;   PMID:23636231;   PMID:23744338;   PMID:23888052;   PMID:23945741;   PMID:23962900;   Reaxys:233276;   Wikipedia:Chrysin


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chrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity
multiple interactions
increases expression
affects activity		 EXP
ISO		 chrysin results in decreased activity of ABCB1 protein
[chrysin results in decreased activity of ABCB1 protein] which results in decreased export of Topotecan
chrysin results in increased expression of ABCB1 protein
chrysin affects the activity of ABCB1 protein		 CTD PMID:15796199 PMID:20457140 PMID:27996361 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) multiple interactions EXP ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione] CTD PMID:21856323 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
decreases activity		 EXP [chrysin results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]
chrysin results in increased expression of ABCC2 protein		 CTD PMID:15955639 PMID:20457140 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions EXP ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione] CTD PMID:21856323 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 multiple interactions
decreases expression		 EXP ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione]
chrysin results in decreased expression of ABCC5 mRNA; chrysin results in decreased expression of ABCC5 protein		 CTD PMID:21856323 PMID:23994249 NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) multiple interactions
decreases activity
increases expression
decreases expression		 EXP
ISO		 [chrysin results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]
chrysin results in increased expression of ABCG2 mRNA; chrysin results in increased expression of ABCG2 protein
chrysin results in decreased expression of ABCG2 mRNA
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]		 CTD PMID:17077187 PMID:17093006 PMID:19732493 PMID:20457140 PMID:20816778 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO chrysin inhibits the reaction [Aluminum Chloride results in increased activity of ACHE protein] CTD PMID:34774662 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] CTD PMID:26297989 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression ISO chrysin results in increased expression of ADIPOQ protein CTD PMID:30445784 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AFP alpha fetoprotein affects binding ISO chrysin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174 		JBrowse link
G AHR aryl hydrocarbon receptor affects activity
multiple interactions		 EXP
ISO		 chrysin affects the activity of AHR protein
chrysin binds to and results in increased activity of AHR protein
[chrysin co-treated with Methylcholanthrene] affects the activity of AHR protein; [chrysin co-treated with Tetrachlorodibenzodioxin] affects the activity of AHR protein; chrysin binds to and results in increased activity of AHR protein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]		 CTD PMID:14644660 PMID:16972788 PMID:17256720 PMID:19286049 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 decreases expression EXP chrysin results in decreased expression of AKR1B10 mRNA; chrysin results in decreased expression of AKR1B10 protein CTD PMID:23994249 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 EXP BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]; chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
chrysin results in decreased phosphorylation of AKT1 protein		 CTD PMID:16215670 PMID:18455702 PMID:24122885 PMID:30578657 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALB albumin multiple interactions ISO chrysin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein] CTD PMID:30794797 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G APOB apolipoprotein B multiple interactions ISO chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB mRNA]; chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB protein] CTD PMID:32220030 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions EXP chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter] CTD PMID:16972788 NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708 		JBrowse link
G ARRB2 arrestin beta 2 multiple interactions ISO chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein] CTD PMID:21167192 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]; chrysin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]; chrysin promotes the reaction [Diethylnitrosamine results in increased expression of BAX protein]
[Cisplatin co-treated with chrysin] results in increased expression of BAX protein		 CTD PMID:21167192 PMID:25770930 PMID:29247772 PMID:33121995 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCHE butyrylcholinesterase multiple interactions ISO chrysin inhibits the reaction [Aluminum Chloride results in increased activity of BCHE protein] CTD PMID:34774662 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases response to substance		 EXP
ISO		 BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]; BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein]; chrysin inhibits the reaction [Cisplatin results in increased expression of BCL2 protein]
chrysin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
BCL2 protein results in decreased susceptibility to chrysin		 CTD PMID:16215670 PMID:25770930 PMID:29247772 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21167192 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
increases expression		 ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of BDNF protein]
chrysin results in increased expression of BDNF protein		 CTD PMID:29054324 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CASP1 caspase 1 multiple interactions EXP chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP1 protein] CTD PMID:21515303 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage		 EXP
ISO		 [Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein]; chrysin inhibits the reaction [Topotecan results in increased activity of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin results in increased cleavage of and results in increased activity of CASP3 protein
chrysin results in increased cleavage of CASP3 protein
[Diethylnitrosamine co-treated with chrysin] results in increased expression of CASP3 protein; chrysin inhibits the reaction [Acetaminophen results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Testosterone results in decreased cleavage of CASP3 protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of CASP3 protein]		 CTD PMID:16215670 PMID:18331776 PMID:19397994 PMID:20457140 PMID:21167192 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 multiple interactions
increases cleavage		 EXP [Cisplatin co-treated with chrysin] results in increased cleavage of CASP8 protein; chrysin inhibits the reaction [Topotecan results in increased activity of CASP8 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased cleavage of CASP8 protein		 CTD PMID:20457140 PMID:21195158 PMID:25770930 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases cleavage
multiple interactions		 EXP chrysin results in increased cleavage of CASP9 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of CASP9 protein		 CTD PMID:18331776 PMID:25770930 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions
decreases activity		 ISO chrysin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein]; chrysin inhibits the reaction [Testosterone results in decreased activity of CAT protein]
chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased activity of CAT protein]; chrysin inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein]
chrysin results in decreased activity of CAT protein		 CTD PMID:10647909 PMID:23194824 PMID:28682524 PMID:29247772 PMID:30273961 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCNB1 cyclin B1 decreases expression EXP chrysin results in decreased expression of CCNB1 mRNA; chrysin results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CDH1 cadherin 1 increases expression EXP chrysin results in increased expression of CDH1 protein CTD PMID:24122885 PMID:30578657 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDH2 cadherin 2 decreases expression EXP chrysin results in decreased expression of CDH2 protein CTD PMID:30578657 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions		 EXP
ISO		 chrysin results in increased expression of CDKN1A mRNA; chrysin results in increased expression of CDKN1A protein
chrysin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]		 CTD PMID:19397994 PMID:29247772 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C decreases expression EXP chrysin results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha increases expression ISO chrysin results in increased expression of CEBPA protein CTD PMID:30445784 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP chrysin inhibits the reaction [Topotecan results in increased cleavage of CTNNB1 protein] CTD PMID:20457140 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions ISO chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression		 EXP chrysin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
chrysin results in increased expression of CXCL8 mRNA		 CTD PMID:18377686 PMID:18457675 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases activity
multiple interactions		 EXP chrysin results in decreased activity of CYP19A1 protein
chrysin binds to and results in decreased activity of CYP19A1 protein		 CTD PMID:9435150 PMID:10403137 PMID:15319488 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases oxidation
increases expression
increases metabolic processing
decreases activity
increases activity		 EXP
ISO		 [CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]
CYP1A1 protein results in increased oxidation of chrysin
chrysin results in increased expression of CYP1A1 mRNA
chrysin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
chrysin results in increased expression of CYP1A1 mRNA; chrysin results in increased expression of CYP1A1 protein
chrysin results in decreased activity of CYP1A1 protein
chrysin results in increased activity of CYP1A1 protein		 CTD PMID:11752233 PMID:16972788 PMID:17012224 PMID:17256720 PMID:19666078 More... NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases metabolic processing
increases oxidation
multiple interactions
decreases activity		 EXP CYP1A2 protein results in increased metabolism of chrysin
CYP1A2 protein results in increased oxidation of chrysin
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein
chrysin results in decreased activity of CYP1A2 protein		 CTD PMID:19666078 PMID:20806393 PMID:21053930 PMID:30964977 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
increases oxidation
increases metabolic processing
decreases activity		 EXP [CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin binds to and results in decreased activity of CYP1B1 protein
CYP1B1 protein alternative form results in increased oxidation of chrysin
chrysin results in decreased activity of CYP1B1 protein		 CTD PMID:19666078 PMID:21053930 PMID:21482471 PMID:30964977 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 increases oxidation EXP CYP2A13 protein results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions EXP [CYP2A6 protein co-treated with POR protein] results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
increases expression		 ISO
EXP		 NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA]
chrysin results in increased expression of CYP2B6 mRNA		 CTD PMID:25625231 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP chrysin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] CTD PMID:21053930 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases activity		 EXP [[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; chrysin binds to and results in decreased activity of CYP3A4 protein; chrysin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] CTD PMID:19766177 PMID:21053930 PMID:31756459 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G EDN1 endothelin 1 increases expression EXP chrysin results in increased expression of EDN1 mRNA CTD PMID:18457675 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EGF epidermal growth factor multiple interactions EXP chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G ELK1 ETS transcription factor ELK1 multiple interactions EXP chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604 		JBrowse link
G EPO erythropoietin increases expression EXP chrysin results in increased expression of EPO mRNA CTD PMID:37348668 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP chrysin binds to and results in increased activity of ESR1 protein; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:9751507 PMID:16972788 PMID:29162470 PMID:33049310 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 affects binding
multiple interactions		 EXP chrysin binds to ESR2 protein
chrysin binds to and results in increased activity of ESR2 protein		 CTD PMID:9751507 PMID:12224631 PMID:33049310 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FADS2 fatty acid desaturase 2 decreases expression EXP chrysin results in decreased expression of FADS2 mRNA CTD PMID:20816778 NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354 		JBrowse link
G FASLG Fas ligand multiple interactions ISO chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FASLG mRNA] CTD PMID:24932515 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FBP1 fructose-bisphosphatase 1 decreases expression EXP chrysin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249 		JBrowse link
G FN1 fibronectin 1 increases expression EXP chrysin results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] CTD PMID:15322261 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOXP3 forkhead box P3 multiple interactions ISO chrysin inhibits the reaction [Diazinon results in decreased expression of FOXP3 mRNA] CTD PMID:36114367 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FSHB protein] CTD PMID:24932515 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G GADD45B growth arrest and DNA damage inducible beta increases expression EXP chrysin results in increased expression of GADD45B mRNA; chrysin results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr19:2,476,127...2,478,257
Ensembl chr19:2,476,122...2,478,259 		JBrowse link
G GATA3 GATA binding protein 3 multiple interactions ISO chrysin inhibits the reaction [Diazinon results in increased expression of GATA3 mRNA] CTD PMID:36114367 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases expression		 ISO [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]
chrysin results in increased expression of GCLC mRNA; chrysin results in increased expression of GCLC protein		 CTD PMID:22864849 PMID:33121995 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
increases expression		 ISO [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]
chrysin results in increased expression of GCLM mRNA; chrysin results in increased expression of GCLM protein		 CTD PMID:22864849 PMID:33121995 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GDNF glial cell derived neurotrophic factor multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of GDNF protein] CTD PMID:29054324 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein] CTD PMID:33121995 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO chrysin inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:28682524 PMID:30794797 PMID:31625388 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GRB2 growth factor receptor bound protein 2 decreases expression EXP chrysin results in decreased expression of GRB2 protein CTD PMID:30578657 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709 		JBrowse link
G GREB1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 EXP Fulvestrant inhibits the reaction [chrysin results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 2:11,482,888...11,642,788
Ensembl chr 2:11,482,341...11,642,788 		JBrowse link
G GSR glutathione-disulfide reductase decreases activity ISO chrysin results in decreased activity of GSR protein CTD PMID:10647909 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 EXP chrysin results in decreased degradation of and results in increased expression of HIF1A protein modified form
chrysin results in increased expression of HIF1A mRNA; chrysin results in increased expression of HIF1A protein		 CTD PMID:37348668 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HLA-DRA major histocompatibility complex, class II, DR alpha decreases expression EXP chrysin results in decreased expression of HLA-DRA mRNA CTD PMID:20816778 NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 [chrysin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin results in decreased expression of HMOX1 mRNA; chrysin results in decreased expression of HMOX1 protein
chrysin results in increased expression of HMOX1 mRNA; chrysin results in increased expression of HMOX1 protein		 CTD PMID:22864849 PMID:23994249 PMID:33121995 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha multiple interactions EXP
ISO		 chrysin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HNF4A mRNA]; chrysin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of HNF4A protein]
chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased phosphorylation of and affects the localization of HNF4A protein]		 CTD PMID:32220030 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15322261 PMID:16987811 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions ISO chrysin inhibits the reaction [Diazinon results in decreased expression of IFNG mRNA]; chrysin inhibits the reaction [Diazinon results in decreased expression of IFNG protein]; chrysin inhibits the reaction [Oxidopamine results in increased expression of IFNG protein] CTD PMID:29054324 PMID:36114367 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO chrysin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA] CTD PMID:29247772 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions ISO chrysin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA] CTD PMID:29247772 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein] CTD PMID:30016632 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO
EXP		 chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL10 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of IL10 protein]
chrysin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
chrysin inhibits the reaction [Diazinon results in increased expression of IL10 mRNA]; chrysin inhibits the reaction [Oxidopamine results in decreased expression of IL10 protein]		 CTD PMID:24932515 PMID:29054324 PMID:30016632 PMID:36114367 PMID:37263553 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL15 interleukin 15 decreases expression EXP chrysin results in decreased expression of IL15 mRNA CTD PMID:20816778 NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987 		JBrowse link
G IL17A interleukin 17A multiple interactions ISO chrysin inhibits the reaction [Diazinon results in increased expression of IL17A mRNA] CTD PMID:36114367 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
decreases expression		 EXP
ISO		 chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1B mRNA]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL1B protein]
chrysin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA]
chrysin results in decreased expression of IL1B mRNA		 CTD PMID:18377686 PMID:20816778 PMID:21515303 PMID:28682524 PMID:29054324 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 decreases expression EXP chrysin results in decreased expression of IL1R1 mRNA CTD PMID:20816778 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874 		JBrowse link
G IL4 interleukin 4 multiple interactions EXP
ISO		 chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 mRNA]
chrysin inhibits the reaction [Diazinon results in increased expression of IL4 mRNA]		 CTD PMID:21515303 PMID:36114367 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
decreases expression		 EXP
ISO		 chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL6 protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
chrysin results in increased expression of IL6 mRNA
chrysin results in decreased expression of IL6 mRNA		 CTD PMID:18457675 PMID:20816778 PMID:21515303 PMID:23194824 PMID:29054324 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein]]; chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein] CTD PMID:25169908 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G IRF3 interferon regulatory factor 3 multiple interactions ISO chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] CTD PMID:19426678 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases phosphorylation		 EXP chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]
chrysin results in decreased phosphorylation of JUN protein		 CTD PMID:15322261 PMID:30578657 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KLF4 KLF transcription factor 4 multiple interactions EXP chrysin inhibits the reaction [angiotensin II increases expression of KLF4 protein in vascular smooth muscle cells] RGD PMID:29127880 RGD:155230825 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482 		JBrowse link
G LAMB2 laminin subunit beta 2 increases expression EXP chrysin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 3:49,121,114...49,133,050
Ensembl chr 3:49,121,114...49,133,118 		JBrowse link
G LEP leptin decreases expression ISO chrysin results in decreased expression of LEP protein CTD PMID:30445784 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of LHB protein] CTD PMID:24932515 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO chrysin inhibits the reaction [Acetaminophen results in increased expression of MAP1LC3B protein]; chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] CTD PMID:28682524 PMID:30273961 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity		 ISO
EXP		 MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
[chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK1 protein
chrysin results in increased phosphorylation of MAPK1 protein
chrysin results in increased activity of MAPK1 protein		 CTD PMID:22864849 PMID:25770930 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO chrysin inhibits the reaction [Cyclophosphamide results in increased expression of MAPK14 protein] CTD PMID:37263553 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP [chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK3 protein
chrysin results in increased phosphorylation of MAPK3 protein		 CTD PMID:25770930 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MMP1 matrix metallopeptidase 1 decreases expression EXP chrysin results in decreased expression of MMP1 protein CTD PMID:30578657 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP10 matrix metallopeptidase 10 multiple interactions
decreases expression		 EXP chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]
chrysin results in decreased expression of MMP10 protein		 CTD PMID:24122885 NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases activity		 EXP chrysin results in decreased expression of and results in decreased activity of MMP2 protein
chrysin results in decreased activity of MMP2 protein		 CTD PMID:26408079 PMID:30578657 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP chrysin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:30016632 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of MPO protein] CTD PMID:24932515 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MYBL1 MYB proto-oncogene like 1 increases expression
multiple interactions		 EXP chrysin results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of MYBL1 mRNA]		 CTD PMID:33405908 NCBI chr 8:66,562,175...66,613,218
Ensembl chr 8:66,562,175...66,614,247 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein] CTD PMID:30016632 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 ISO
EXP		 chrysin affects the localization of and results in increased activity of NFE2L2 protein; chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Doxorubicin]
chrysin results in decreased expression of NFE2L2 mRNA; chrysin results in decreased expression of NFE2L2 protein		 CTD PMID:22864849 PMID:23994249 PMID:33121995 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of NFKB1 protein] CTD PMID:30500344 PMID:33121995 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
decreases expression		 EXP chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]
chrysin results in decreased expression of NFKBIA protein		 CTD PMID:18377686 PMID:21515303 PMID:30016632 PMID:30578657 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NGF nerve growth factor multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of NGF protein] CTD PMID:29054324 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO
EXP		 chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 protein]		 CTD PMID:11343698 PMID:16934226 PMID:17570322 PMID:23194824 PMID:24932515 More... NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO chrysin inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 mRNA] CTD PMID:30974023 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA] CTD PMID:33121995 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases expression ISO Chrysin increases expression of Nr1h3 mRNA in macrophages RGD PMID:25857322 RGD:401850558 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP chrysin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions ISO
EXP		 chrysin binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects localization
multiple interactions		 EXP
ISO		 chrysin affects the localization of NR1I3 protein
NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA]		 CTD PMID:25625231 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 EXP
ISO		 chrysin results in increased cleavage of PARP1 protein
chrysin inhibits the reaction [Cyclophosphamide results in increased expression of PARP1 protein]
[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein]		 CTD PMID:18455702 PMID:25770930 PMID:37263553 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; chrysin inhibits the reaction [Testosterone results in increased expression of PCNA protein] CTD PMID:23194824 PMID:29247772 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PGD phosphogluconate dehydrogenase decreases activity EXP chrysin results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511 		JBrowse link
G PLAU plasminogen activator, urokinase decreases expression EXP chrysin results in decreased expression of PLAU protein CTD PMID:30578657 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PLCG1 phospholipase C gamma 1 multiple interactions
increases degradation		 EXP BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801 		JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions EXP [CYP2A6 protein co-treated with POR protein] results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression EXP chrysin results in decreased expression of PPARA mRNA CTD PMID:20816778 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP		 chrysin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] CTD PMID:11343698 PMID:33049310 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PSCA prostate stem cell antigen decreases expression EXP chrysin results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 8:142,670,297...142,682,725
Ensembl chr 8:142,670,308...142,682,725 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 chrysin results in increased expression of PTGS2 mRNA
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]
chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]		 CTD PMID:11343698 PMID:18457675 PMID:21167192 PMID:23194824 PMID:24932515 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTK2 protein tyrosine kinase 2 decreases phosphorylation EXP chrysin results in decreased phosphorylation of PTK2 protein CTD PMID:30578657 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G RBP4 retinol binding protein 4 decreases expression ISO chrysin results in decreased expression of RBP4 protein CTD PMID:30445784 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
increases activity		 EXP
ISO		 Acetylcysteine inhibits the reaction [chrysin results in increased activity of RELA protein]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of RELA protein]; chrysin inhibits the reaction [nickel chloride affects the localization of RELA protein]; SB 203580 inhibits the reaction [chrysin results in increased activity of RELA protein]
chrysin results in decreased expression of RELA protein
chrysin inhibits the reaction [Oxidopamine results in increased phosphorylation of RELA protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein]; chrysin inhibits the reaction [Testosterone results in increased activity of RELA protein]		 CTD PMID:18457675 PMID:21167192 PMID:21515303 PMID:23194824 PMID:29054324 More... NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RHOA ras homolog family member A decreases expression EXP chrysin results in decreased expression of RHOA protein CTD PMID:30578657 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G RORC RAR related orphan receptor C multiple interactions ISO chrysin inhibits the reaction [Diazinon results in increased expression of RORC mRNA] CTD PMID:36114367 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
G S100B S100 calcium binding protein B multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in increased expression of S100B protein] CTD PMID:29054324 NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208 		JBrowse link
G SC5D sterol-C5-desaturase decreases expression EXP chrysin results in decreased expression of SC5D mRNA CTD PMID:20816778 NCBI chr11:121,292,771...121,313,410
Ensembl chr11:121,292,681...121,313,410 		JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP chrysin results in decreased expression of SCD mRNA CTD PMID:20816778 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826 		JBrowse link
G SELE selectin E multiple interactions EXP chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SFN stratifin increases expression EXP chrysin results in increased expression of SFN mRNA; chrysin results in increased expression of SFN protein CTD PMID:18331776 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456 		JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions		 EXP chrysin results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of SGK1 mRNA]		 CTD PMID:33405908 NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112 		JBrowse link
G SHBG sex hormone binding globulin affects binding EXP chrysin binds to SHBG protein CTD PMID:25349334 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382 		JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions ISO [chrysin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593 		JBrowse link
G SMAD2 SMAD family member 2 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA] CTD PMID:26297989 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:26297989 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 decreases expression
multiple interactions		 EXP chrysin results in decreased expression of SNAI1 protein
chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]		 CTD PMID:24122885 PMID:30578657 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 decreases expression EXP chrysin results in decreased expression of SNAI2 protein CTD PMID:24122885 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression EXP chrysin results in decreased expression of SOS1 protein CTD PMID:30578657 NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345 		JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of STAR mRNA] CTD PMID:24932515 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO chrysin inhibits the reaction [Cyclophosphamide results in increased phosphorylation of STAT3 protein] CTD PMID:37263553 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 increases sulfation EXP SULT1A1 protein SNP results in increased sulfation of chrysin CTD PMID:17293380 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 multiple interactions EXP SULT1E1 protein results in increased sulfation of and results in decreased activity of chrysin CTD PMID:17293380 NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145 		JBrowse link
G TBK1 TANK binding kinase 1 decreases activity EXP chrysin results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114 		JBrowse link
G TBX21 T-box transcription factor 21 multiple interactions ISO chrysin inhibits the reaction [Diazinon results in decreased expression of TBX21 mRNA] CTD PMID:36114367 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122 		JBrowse link
G TFF1 trefoil factor 1 multiple interactions EXP chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:16972788 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; chrysin inhibits the reaction [Diazinon results in increased expression of TGFB1 mRNA] CTD PMID:26297989 PMID:36114367 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP chrysin binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G THRB thyroid hormone receptor beta multiple interactions EXP chrysin binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP
ISO		 chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]
chrysin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA]		 CTD PMID:30016632 PMID:30500344 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein]; chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
chrysin results in decreased expression of TNF protein
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Silymarin promotes the reaction [chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]]
chrysin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; chrysin inhibits the reaction [Oxidopamine results in increased expression of TNF protein]		 CTD PMID:15322261 PMID:16934226 PMID:16987811 PMID:21515303 PMID:23194824 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b multiple interactions EXP [Cisplatin co-treated with chrysin] results in increased expression of TNFRSF10B protein CTD PMID:25770930 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions
increases response to substance		 EXP chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased susceptibility to TNFSF10 protein		 CTD PMID:21195158 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TP53 tumor protein p53 increases degradation
affects activity
multiple interactions		 EXP
ISO		 chrysin results in increased degradation of TP53 protein
chrysin affects the activity of TP53 protein
[Cisplatin co-treated with chrysin] affects the localization of TP53 protein; [Cisplatin co-treated with chrysin] results in increased phosphorylation of and results in increased expression of TP53 protein; chrysin results in increased phosphorylation of and affects the localization of TP53 protein; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] affects the localization of TP53 protein]; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased phosphorylation of TP53 protein]
[Diethylnitrosamine co-treated with chrysin] results in increased expression of TP53 protein; chrysin inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]; chrysin inhibits the reaction [Testosterone results in decreased expression of TP53 mRNA]		 CTD PMID:14634213 PMID:21167192 PMID:25770930 PMID:29247772 PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 increases expression EXP chrysin results in increased expression of TP53I3 mRNA; chrysin results in increased expression of TP53I3 protein CTD PMID:18331776 PMID:19397994 NCBI chr 2:24,077,433...24,084,834
Ensembl chr 2:24,077,433...24,085,861 		JBrowse link
G TP63 tumor protein p63 increases expression EXP chrysin results in increased expression of TP63 protein CTD PMID:18331776 PMID:19397994 NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276 		JBrowse link
G TP73 tumor protein p73 increases expression EXP chrysin results in increased expression of TP73 protein CTD PMID:18331776 PMID:19397994 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201 		JBrowse link
G TYR tyrosinase increases expression ISO chrysin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
affects glucuronidation
increases glucuronidation
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Quercetin]; pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; SB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; U 0126 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]
UGT1A1 protein affects the glucuronidation of chrysin
UGT1A1 protein results in increased glucuronidation of chrysin
chrysin results in increased expression of UGT1A1; chrysin results in increased expression of UGT1A1 mRNA; chrysin results in increased expression of UGT1A1 protein		 CTD PMID:10950852 PMID:11442279 PMID:14557274 PMID:15104253 PMID:16003560 More... NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of chrysin CTD PMID:14557274 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 affects glucuronidation EXP UGT1A6 protein affects the glucuronidation of chrysin CTD PMID:10950852 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of chrysin CTD PMID:14557274 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of chrysin CTD PMID:14557274 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
affects glucuronidation		 EXP UGT1A9 protein results in increased glucuronidation of chrysin
UGT1A9 protein affects the glucuronidation of chrysin		 CTD PMID:10950852 PMID:14557274 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of chrysin CTD PMID:7835232 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
G UTRN utrophin increases expression EXP chrysin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 6:144,285,335...144,853,034
Ensembl chr 6:144,285,335...144,853,034 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression
multiple interactions		 EXP chrysin results in increased expression of VCAM1 mRNA
chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]		 CTD PMID:16987811 PMID:18457675 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression
multiple interactions		 EXP
ISO		 chrysin results in decreased expression of VEGFA protein
chrysin inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA mRNA]		 CTD PMID:30578657 PMID:30974023 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VIM vimentin decreases expression EXP chrysin results in decreased expression of VIM protein CTD PMID:24122885 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression
multiple interactions		 EXP chrysin results in decreased expression of XIAP protein
BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]		 CTD PMID:16215670 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
chrysin 5,7-dimethyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5,7-dimethoxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] CTD PMID:34217736 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein CTD PMID:21554863 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21554863 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] CTD PMID:21554863 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCND1 cyclin D1 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:21554863 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CSNK2B casein kinase 2 beta multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein] CTD PMID:21554863 NCBI chr 6:31,666,080...31,670,067
Ensembl chr 6:31,665,227...31,670,343 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA] CTD PMID:21554863 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:24134915 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity		 EXP 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein		 CTD PMID:15661813 PMID:15905203 PMID:16484233 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
decreases activity		 EXP 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein		 CTD PMID:15905203 PMID:16484233 PMID:16530937 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein] CTD PMID:21554863 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein] CTD PMID:21554863 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein] CTD PMID:21554863 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form] CTD PMID:21554863 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein CTD PMID:21554863 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G WNT3A Wnt family member 3A multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein] CTD PMID:21554863 NCBI chr 1:228,006,998...228,061,271
Ensembl chr 1:228,006,998...228,061,271 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      chemical role 24249
        antioxidant 17501
          chrysin 178
            6,8-di-(3,3-dimethylallyl)chrysin 0
            6-(3,3-dimethylallyl)chrysin 0
            6-geranylchrysin 0
            8-(3,3-dimethylallyl)chrysin 0
            8-geranylchrysin 0
            chrysin 5,7-dimethyl ether 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic heterocyclic compound 22324
                                  oxacycle 20001
                                    benzopyran 12753
                                      1-benzopyran 12488
                                        flavonoid 7605
                                          anthoxanthin 4702
                                            flavones 4702
                                              hydroxyflavone 4681
                                                flavonols 4567
                                                  7-hydroxyflavonol 4542
                                                    chrysin 178
                                                      6,8-di-(3,3-dimethylallyl)chrysin 0
                                                      6-(3,3-dimethylallyl)chrysin 0
                                                      6-geranylchrysin 0
                                                      8-(3,3-dimethylallyl)chrysin 0
                                                      8-geranylchrysin 0
                                                      chrysin 5,7-dimethyl ether 19
paths to the root