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Gene: AFP (alpha fetoprotein) Homo sapiens
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Symbol: AFP
Name: alpha fetoprotein
Description: Predicted to have fatty acid binding activity and zinc ion binding activity. Predicted to be involved in post-translational protein modification. Predicted to localize to the cytoplasm. Biomarker of carcinoma (multiple); germ cell cancer (multiple); and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AFPD; alpha-1-fetoprotein; alpha-fetoglobulin; alpha-fetoprotein; FETA; HPAFP
Orthologs:
Mus musculus (house mouse) : Afp (alpha fetoprotein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Afp (alpha-fetoprotein)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : AFP (alpha fetoprotein)
Canis lupus familiaris (dog) : AFP (alpha fetoprotein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afp (alpha fetoprotein)
Sus scrofa (pig) : AFP (alpha fetoprotein)
Chlorocebus sabaeus (African green monkey) : AFP (alpha fetoprotein)
Heterocephalus glaber (naked mole-rat) : Afp (alpha fetoprotein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl473,431,138 - 73,456,174 (+)Ensembl
GRCh38473,436,221 - 73,456,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37474,301,933 - 74,321,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,520,797 - 74,540,356 (+)NCBINCBI36hg18NCBI36
Build 34474,666,967 - 74,686,527NCBI
Celera471,661,745 - 71,681,240 (+)NCBI
Cytogenetic Map4q13.3ENTREZGENE
HuRef470,113,467 - 70,132,962 (+)NCBIHuRef
CHM1_1474,338,125 - 74,357,625 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AFP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736278
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.