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Gene: TBX21 (T-box transcription factor 21) Homo sapiens
Symbol: TBX21
Name: T-box transcription factor 21
Description: Exhibits sequence-specific DNA binding activity and transcription regulatory region DNA binding activity. Involved in lymphocyte migration; regulation of transcription, DNA-templated; and response to virus. Predicted to localize to the nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: T-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; TBET; TBLYM; transcription factor TBLYM
Mus musculus (house mouse) : Tbx21 (T-box 21)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tbx21 (T-box transcription factor 21)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbx21 (T-box transcription factor 21)
Pan paniscus (bonobo/pygmy chimpanzee) : TBX21 (T-box transcription factor 21)
Canis lupus familiaris (dog) : TBX21 (T-box transcription factor 21)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbx21 (T-box transcription factor 21)
Sus scrofa (pig) : TBX21 (T-box transcription factor 21)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381747,733,236 - 47,746,122 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371745,810,610 - 45,823,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,165,609 - 43,178,484 (+)NCBINCBI36hg18NCBI36
Build 341743,165,608 - 43,178,484NCBI
Celera1742,263,420 - 42,276,290 (+)NCBI
Cytogenetic Map17q21.32NCBI
HuRef1741,179,683 - 41,192,556 (+)NCBIHuRef
CHM1_11745,875,536 - 45,888,411 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TBX21
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317938
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.