ACHE (acetylcholinesterase (Cartwright blood group)) - Rat Genome Database

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Gene: ACHE (acetylcholinesterase (Cartwright blood group)) Homo sapiens
Analyze
Symbol: ACHE
Name: acetylcholinesterase (Cartwright blood group)
RGD ID: 735878
HGNC Page HGNC
Description: Enables several functions, including acetylcholine binding activity; acetylcholinesterase activity; and protein homodimerization activity. Involved in acetylcholine catabolic process; cell adhesion; and osteoblast development. Located in several cellular components, including Golgi apparatus; extracellular region; and perinuclear region of cytoplasm. Implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Biomarker of Hirschsprung's disease; bacterial meningitis; neurodegenerative disease (multiple); and type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACEE; acetylcholinesterase; acetylcholinesterase (Yt blood group); apoptosis-related acetylcholinesterase; ARACHE; N-ACHE; YT; Yt blood group
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7100,889,994 - 100,896,974 (-)EnsemblGRCh38hg38GRCh38
GRCh387100,889,994 - 100,896,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,487,615 - 100,494,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,325,551 - 100,331,477 (-)NCBINCBI36hg18NCBI36
Build 347100,132,268 - 100,138,147NCBI
Celera795,218,191 - 95,224,120 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,117,968 - 95,123,900 (-)NCBIHuRef
CHM1_17100,418,205 - 100,424,133 (-)NCBICHM1_1
CRA_TCAGchr7v2799,847,220 - 99,853,146 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,4-dihydroxybenzaldehyde  (EXP)
3,4-dihydroxybenzoic acid  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP,ISO)
3,5,6-trichloropyridine-2-one  (EXP,ISO)
3-(3-ethyl-1-methyl-3-azepanyl)phenol  (EXP,ISO)
3-nitropropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-Acetylmorphine  (EXP)
6-propyl-2-thiouracil  (ISO)
9-aminoacridine  (EXP)
acephate  (ISO)
acepromazine  (ISO)
acetaldehyde  (EXP)
acetaldehyde oxime  (EXP)
acetamide  (ISO)
acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester  (ISO)
acetic acid [4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] ester  (EXP)
acetylcholine  (EXP,ISO)
acrylamide  (ISO)
alachlor  (EXP,ISO)
aldehydo-D-glucose  (EXP)
aldicarb  (EXP,ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP)
alpha-D-galactose  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ambenonium chloride  (EXP)
aminocarb  (ISO)
amisulpride  (EXP)
amitriptyline  (ISO)
amodiaquine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
atropine  (EXP,ISO)
azamethiphos  (EXP,ISO)
azelastine  (EXP)
azinphos-ethyl  (EXP)
azinphos-methyl  (EXP)
bacitracin  (ISO)
baicalin  (ISO)
bambuterol  (EXP,ISO)
barium chloride  (ISO)
barium(0)  (ISO)
bendiocarb  (EXP,ISO)
benfuracarb  (EXP)
Bensulide  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (EXP,ISO)
Besigomsin  (ISO)
bexarotene  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
Bromophos-ethyl  (EXP)
bucladesine  (ISO)
butyrylthiocholine  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calycosin  (ISO)
canagliflozin  (ISO)
carbachol  (EXP)
carbamate ester  (EXP,ISO)
carbaryl  (EXP,ISO)
carbendazim  (ISO)
carbofuran  (EXP,ISO)
Carbophenothion  (EXP,ISO)
carbosulfan  (EXP,ISO)
carnosine  (EXP)
carvacrol  (ISO)
catalpol  (ISO)
celecoxib  (ISO)
Chebulinic acid  (EXP)
chlorfenvinfos  (EXP,ISO)
chlorhexidine  (EXP)
chlorite  (EXP)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corticosterone  (ISO)
coumaphos  (EXP)
coumarin  (ISO)
Crotoxyphos  (EXP)
Cryptotanshinone  (EXP)
cucurbit[7]uril  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cyfluthrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
daidzein 7-O-beta-D-glucoside  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
demethoxycurcumin  (ISO)
demeton-S-methyl  (EXP)
dequalinium  (EXP)
desipramine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diacetylmonoxime  (EXP)
Dialifor  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
diazoxon  (EXP,ISO)
dichlorvos  (EXP,ISO)
diclofop-methyl  (ISO)
dicrotophos  (EXP,ISO)
difenoconazole  (ISO)
dihydroactinidiolide  (EXP)
diisopropyl fluorophosphate  (EXP,ISO)
dimethoate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dimethylmercury  (ISO)
dimethylselenide  (EXP)
dioxygen  (EXP,ISO)
Diphosphoramide, N,N',N'',N'''-tetrakis(1-methylethyl)-  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
disulfoton  (ISO)
dithionite(2-)  (EXP)
donepezil hydrochloride  (EXP,ISO)
doxepin  (ISO)
doxorubicin  (EXP)
DPCPX  (ISO)
dyclonine  (EXP)
ecothiopate iodide  (ISO)
edrophonium  (EXP)
elemental selenium  (ISO)
endosulfan  (ISO)
EPTC  (ISO)
ergothioneine  (ISO)
eseroline  (ISO)
ethanol  (EXP,ISO)
ethoprophos  (EXP,ISO)
ethylbenzene  (ISO)
ethylenediaminetetraacetic acid  (ISO)
Ethylenethiourea  (EXP,ISO)
eugenol  (ISO)
fenamiphos  (EXP,ISO)
fenitrothion  (ISO)
fenoxycarb  (ISO)
fenthion  (EXP,ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
ferulic acid  (ISO)
folic acid  (EXP,ISO)
formetanate  (ISO)
fructose  (ISO)
Fusaric acid  (ISO)
galactose  (ISO)
galangin  (ISO)
galanthamine  (EXP,ISO)
galanthamine Trifluoroacetic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
heptenophos  (EXP,ISO)
herbicide  (ISO)
heroin  (EXP)
hesperidin  (ISO)
hexachlorophene  (EXP)
high-density lipoprotein cholesterol  (EXP)
HLo7  (EXP,ISO)
homocysteine  (EXP)
huperzine A  (EXP,ISO)
hydrazinecarbothioamide  (EXP)
hypochlorous acid  (EXP)
ifosfamide  (ISO)
imidacloprid  (ISO)
imipramine  (EXP,ISO)
indinavir  (ISO)
indole-3-butyric acid  (ISO)
irinotecan  (ISO)
Irisflorentin  (ISO)
Isazofos  (EXP)
isocarbophos  (EXP,ISO)
kaempferol  (ISO)
Kokusaginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-glutamic acid  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
leptophos  (EXP)
Levallorphan  (ISO)
Levorphanol  (ISO)
Licochalcone B  (EXP)
lipoic acid  (ISO)
lisinopril dihydrate  (ISO)
lithium chloride  (EXP)
loganin  (ISO)
luteolin  (ISO)
lycopene  (ISO)
malaoxon  (EXP,ISO)
malathion  (EXP,ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese dioxide  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
melatonin  (ISO)
memantine  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
metazocine  (ISO)
metformin  (ISO)
methamidophos  (EXP,ISO)
methanol  (EXP,ISO)
methiocarb  (ISO)
methomyl  (EXP,ISO)
methotrexate  (EXP)
methylene blue  (EXP)
methylmercury chloride  (ISO)
metoclopramide  (EXP)
mevinphos  (EXP,ISO)
Mipafox  (EXP,ISO)
monocrotophos  (EXP,ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
morphine  (EXP)
Muscarine  (EXP,ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naled  (EXP,ISO)
naringin  (ISO)
Neferine  (ISO)
neostigmine  (EXP,ISO)
nickel atom  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
O-acetyl-L-carnitine  (ISO)
O-methyleugenol  (EXP)
omethoate  (EXP,ISO)
organophosphorus compound  (EXP,ISO)
orlistat  (EXP)
oxamyl  (EXP,ISO)
Oxotremorine  (ISO)
oxydemeton-methyl  (EXP)
pancuronium  (EXP)
paraoxon  (EXP,ISO)
Paraoxon-methyl  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP,ISO)
parathion-methyl  (EXP,ISO)
PCB138  (ISO)
pentazocine  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenthoate  (EXP)
phenylmethanesulfonyl fluoride  (ISO)
phenytoin  (ISO)
phloretin  (ISO)
phorate  (EXP,ISO)
phosalone  (EXP)
phosmet  (EXP,ISO)
phosphamidon  (EXP)
phosphoryl trichloride  (ISO)
phoxim  (EXP,ISO)
physostigmine  (EXP,ISO)
physostigmine salicylate  (ISO)
phytoestrogen  (ISO)
piperazines  (ISO)
piperidine  (EXP)
Piracetam  (ISO)
pirimicarb  (EXP)
Pirimiphos-ethyl  (EXP)
pirimiphos-methyl  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pralidoxime  (EXP,ISO)
proanthocyanidin  (ISO)
prochlorperazine  (ISO)
profenofos  (EXP,ISO)
propamocarb  (ISO)
propiconazole  (ISO)
propidium  (EXP,ISO)
propoxur  (EXP,ISO)
puerarin  (ISO)
pyrazophos  (EXP)
Pyridostigmine bromide  (EXP,ISO)
pyrimidines  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinalphos  (EXP,ISO)
raloxifene  (EXP)
ranitidine  (EXP,ISO)
rapacuronium  (EXP)
reactive oxygen species  (EXP)
reserpine  (ISO)
resveratrol  (ISO)
rhodamine 6G  (EXP)
rivastigmine  (EXP,ISO)
rotenone  (ISO)
rutin  (ISO)
sarin  (EXP,ISO)
scopolamine  (EXP,ISO)
selenium atom  (ISO)
serotonin  (ISO)
silicon atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sodium nitrite  (EXP)
Soman  (EXP,ISO)
staurosporine  (EXP)
stevioside  (ISO)
streptozocin  (ISO)
tacrine  (EXP,ISO)
Tariquidar  (ISO)
taurine  (ISO)
Tellimagrandin I  (EXP)
telmisartan  (ISO)
terbufos  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachlorohydroquinone  (EXP)
tetrachloromethane  (ISO)
tetrachlorvinphos  (EXP)
tetraethyllead  (ISO)
tetramethylpyrazine  (ISO)
thiacloprid  (EXP,ISO)
thiazolidines  (EXP)
Thiobencarb  (ISO)
thiodicarb  (EXP,ISO)
thioflavine T  (EXP)
thymoquinone  (ISO)
Tiapamil  (EXP)
tilorone  (EXP)
titanium dioxide  (ISO)
tolonium chloride  (EXP)
toluene  (EXP)
trandolapril  (ISO)
trans-caffeic acid  (ISO)
triazoles  (EXP)
triazophos  (EXP)
tribufos  (EXP)
tributyl phosphate  (ISO)
trichlorfon  (EXP,ISO)
trichloroacetaldehyde  (EXP)
trifluoperazine  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP,ISO)
tubocurarine  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vanillin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
VX nerve agent  (EXP,ISO)
xaliproden  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zineb  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Anuradha H, etal., Pharm Biol. 2010 May;48(5):499-503.
2. Bajgar J Acta Medica (Hradec Kralove). 2008;51(4):223-8.
3. Balakrishnan S, etal., Eur J Pharmacol. 2009 Apr 17;608(1-3):14-22. doi: 10.1016/j.ejphar.2009.01.047.
4. Balakrishnan S, etal., Eur J Pharmacol. 2009 Feb 5.
5. Basu PS, etal., Clin Chim Acta. 1995 Feb 28;235(1):107-12.
6. Ben Assayag E, etal., Mol Med. 2010 Jul-Aug;16(7-8):278-86. doi: 10.2119/molmed.2010.00015. Epub 2010 Apr 14.
7. Berg RM, etal., Scand J Clin Lab Invest. 2011 Jul;71(4):350-2. doi: 10.3109/00365513.2011.558107. Epub 2011 Feb 8.
8. Chowdhary S, etal., Clin Chim Acta. 2014 Apr 20;431C:66-76. doi: 10.1016/j.cca.2014.01.024. Epub 2014 Feb 7.
9. da Silva CB, etal., J Med Microbiol. 2012 Feb;61(Pt 2):278-84. doi: 10.1099/jmm.0.035501-0. Epub 2011 Sep 15.
10. Dabrowski Z, etal., Pol Tyg Lek 1978 Jul 10;33(28):1093-5.
11. Dolgov VS, Veterinariia. 1978 Dec;(12):61-3.
12. Feng G, etal., J Cell Biol 1999 Mar 22;144(6):1349-60.
13. GOA_HUMAN data from the GO Consortium
14. Godfrey DA and Matschinsky FM, J Histochem Cytochem. 1975 Sep;23(9):645-51.
15. Juel VC and Massey JM, Orphanet J Rare Dis. 2007 Nov 6;2:44.
16. KEGG
17. McCorry LK Am J Pharm Educ. 2007 Aug 15;71(4):78.
18. Money TT, etal., CNS Neurol Disord Drug Targets. 2010 Apr;9(2):241-56.
19. Ofek K, etal., J Mol Med (Berl). 2007 Nov;85(11):1239-51. Epub 2007 Jul 27.
20. Packman PM, etal., J Histochem Cytochem. 1977 Nov;25(11):1237-46.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Pipeline to import SMPDB annotations from SMPDB into RGD
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Ruberg M, etal., J Neurol Neurosurg Psychiatry. 1987 May;50(5):538-43.
26. Santoro A, etal., CNS Drugs. 2010 Feb 1;24(2):163-76. doi: 10.2165/11310960-000000000-00000.
27. Schmatz R, etal., Eur J Pharmacol. 2009 May 21;610(1-3):42-8. Epub 2009 Mar 19.
28. Shimada H, etal., Neurology. 2009 Jul 28;73(4):273-8. Epub 2009 May 27.
29. Suhail M and Rizvi SI, Biochem J. 1989 May 1;259(3):897-9.
30. Wahba ZZ, etal., Exp Clin Endocrinol. 1992;99(1):26-30.
31. Winblad B, etal., Lancet. 2006 Apr 1;367(9516):1057-65.
32. Yin H, etal., Pediatr Dev Pathol. 2011 Oct 12.
33. Zarros A, etal., Metab Brain Dis. 2009 Jun;24(2):337-48. Epub 2009 Mar 19.
34. Zhou J, etal., Neurosci Lett. 2001 Jun 22;306(1-2):53-6.
Additional References at PubMed
PMID:1380483   PMID:1391965   PMID:1517212   PMID:1609795   PMID:1744105   PMID:1748670   PMID:2263619   PMID:2714437   PMID:2734315   PMID:3319614   PMID:3954986   PMID:7085778  
PMID:7836436   PMID:8125298   PMID:8248502   PMID:8280063   PMID:8299725   PMID:8349597   PMID:8449945   PMID:8460160   PMID:8488842   PMID:9579781   PMID:9640563   PMID:9689136  
PMID:9811904   PMID:9847074   PMID:10800960   PMID:10837146   PMID:11002295   PMID:11053835   PMID:11239002   PMID:11283752   PMID:11799248   PMID:11804574   PMID:12009429   PMID:12069617  
PMID:12081473   PMID:12140295   PMID:12427014   PMID:12466963   PMID:12477932   PMID:12524166   PMID:12548360   PMID:12604711   PMID:12609505   PMID:12690205   PMID:12769797   PMID:12811800  
PMID:12851386   PMID:12853948   PMID:12928915   PMID:12963741   PMID:14766237   PMID:15060281   PMID:15078872   PMID:15123727   PMID:15161650   PMID:15454088   PMID:15459952   PMID:15474030  
PMID:15488495   PMID:15526038   PMID:15629887   PMID:15690550   PMID:15715671   PMID:15783300   PMID:15974894   PMID:15974920   PMID:16213467   PMID:16256091   PMID:16256968   PMID:16262697  
PMID:16289501   PMID:16344560   PMID:16375580   PMID:16429485   PMID:16516310   PMID:16801396   PMID:16832351   PMID:16909200   PMID:16996687   PMID:17038428   PMID:17192624   PMID:17192630  
PMID:17192673   PMID:17272501   PMID:17320203   PMID:17335779   PMID:17370251   PMID:17476278   PMID:17503475   PMID:17606622   PMID:17702992   PMID:17729290   PMID:17948252   PMID:17984143  
PMID:18161504   PMID:18194455   PMID:18215127   PMID:18258603   PMID:18299393   PMID:18344198   PMID:18454940   PMID:18457821   PMID:18470725   PMID:18612832   PMID:18769671   PMID:18780301  
PMID:19019080   PMID:19051205   PMID:19086053   PMID:19156168   PMID:19185568   PMID:19294450   PMID:19327769   PMID:19371630   PMID:19371631   PMID:19468687   PMID:19730683   PMID:19912576  
PMID:19913121   PMID:20138030   PMID:20156100   PMID:20173328   PMID:20193849   PMID:20338155   PMID:20356562   PMID:20398640   PMID:20398908   PMID:20431033   PMID:20433814   PMID:20529763  
PMID:20602615   PMID:20628086   PMID:20883446   PMID:20964587   PMID:21274871   PMID:21377978   PMID:21473860   PMID:21490949   PMID:21493754   PMID:21530001   PMID:21576115   PMID:21621296  
PMID:21730071   PMID:21795704   PMID:21873635   PMID:22142546   PMID:22560633   PMID:22805525   PMID:22990020   PMID:23047022   PMID:23047027   PMID:23063927   PMID:23072732   PMID:23119107  
PMID:23440190   PMID:23466605   PMID:23583979   PMID:23625910   PMID:23711548   PMID:23748235   PMID:23897820   PMID:23936791   PMID:23974008   PMID:23981668   PMID:24249815   PMID:24402754  
PMID:24594013   PMID:24905476   PMID:25239202   PMID:25240274   PMID:25240585   PMID:25766324   PMID:25919665   PMID:25956553   PMID:26002584   PMID:26051873   PMID:26200596   PMID:26202430  
PMID:26210933   PMID:26299326   PMID:26369587   PMID:26494253   PMID:26929400   PMID:27138800   PMID:27230386   PMID:27258420   PMID:27490385   PMID:27551784   PMID:27977009   PMID:28180311  
PMID:28334147   PMID:28427893   PMID:28465191   PMID:28518050   PMID:28544359   PMID:28613396   PMID:28852920   PMID:28885588   PMID:29017007   PMID:29123130   PMID:29358722   PMID:29749305  
PMID:30093245   PMID:30201403   PMID:30626059   PMID:30787102   PMID:31129131   PMID:31202795   PMID:31595611   PMID:31703329   PMID:31820491   PMID:32006676   PMID:32393512   PMID:32414087  
PMID:32580406   PMID:32590127   PMID:32705955   PMID:32992925   PMID:33020403   PMID:33402146   PMID:33650116   PMID:34203347   PMID:34299650  


Genomics

Comparative Map Data
ACHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7100,889,994 - 100,896,974 (-)EnsemblGRCh38hg38GRCh38
GRCh387100,889,994 - 100,896,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,487,615 - 100,494,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,325,551 - 100,331,477 (-)NCBINCBI36hg18NCBI36
Build 347100,132,268 - 100,138,147NCBI
Celera795,218,191 - 95,224,120 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,117,968 - 95,123,900 (-)NCBIHuRef
CHM1_17100,418,205 - 100,424,133 (-)NCBICHM1_1
CRA_TCAGchr7v2799,847,220 - 99,853,146 (-)NCBI
Ache
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,286,516 - 137,292,728 (+)NCBIGRCm39mm39
GRCm39 Ensembl5137,285,781 - 137,292,728 (+)Ensembl
GRCm385137,288,247 - 137,294,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,287,519 - 137,294,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv375137,729,505 - 137,735,691 (+)NCBIGRCm37mm9NCBIm37
MGSCv365137,518,065 - 137,524,251 (+)NCBImm8
Celera5134,271,243 - 134,277,456 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.32NCBI
Ache
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21219,407,359 - 19,413,713 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1219,407,360 - 19,413,651 (-)Ensembl
Rnor_6.01222,472,358 - 22,477,052 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,472,358 - 22,478,753 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,487,632 - 24,491,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1221,207,976 - 21,212,604 (-)NCBICelera
Cytogenetic Map12q12NCBI
Ache
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495557380,298 - 85,799 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495557379,606 - 85,799 (+)NCBIChiLan1.0ChiLan1.0
ACHE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17106,311,944 - 106,318,190 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,311,944 - 106,318,184 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0792,915,065 - 92,922,079 (-)NCBIMhudiblu_PPA_v0panPan3
ACHE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,874,747 - 8,879,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,873,584 - 8,879,702 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,580,127 - 10,585,994 (+)NCBI
ROS_Cfam_1.068,809,869 - 8,815,742 (+)NCBI
UMICH_Zoey_3.168,661,436 - 8,668,230 (+)NCBI
UNSW_CanFamBas_1.068,640,504 - 8,646,368 (+)NCBI
UU_Cfam_GSD_1.068,822,240 - 8,828,117 (+)NCBI
Ache
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,174,520 - 133,179,854 (+)NCBI
SpeTri2.0NW_004936543856,678 - 862,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACHE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,732,324 - 8,739,149 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,732,451 - 8,738,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.238,159,377 - 8,165,197 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACHE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,328,304 - 12,335,302 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,331,039 - 12,335,076 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660703,993,802 - 4,000,839 (-)NCBIVero_WHO_p1.0
Ache
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474016,275,108 - 16,280,639 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH17909  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377100,488,258 - 100,488,400UniSTSGRCh37
Build 367100,326,194 - 100,326,336RGDNCBI36
Celera795,218,834 - 95,218,976RGD
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map7q22UniSTS
HuRef795,118,611 - 95,118,753UniSTS
CRA_TCAGchr7v2799,847,863 - 99,848,005UniSTS
GeneMap99-GB4 RH Map7517.11UniSTS
NCBI RH Map71062.2UniSTS
STS-M55040  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377100,487,727 - 100,487,826UniSTSGRCh37
Build 367100,325,663 - 100,325,762RGDNCBI36
Celera795,218,303 - 95,218,402RGD
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map7q22UniSTS
HuRef795,118,080 - 95,118,179UniSTS
CRA_TCAGchr7v2799,847,332 - 99,847,431UniSTS
GeneMap99-GB4 RH Map7516.61UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6017
Count of miRNA genes:957
Interacting mature miRNAs:1179
Transcripts:ENST00000241069, ENST00000302913, ENST00000411582, ENST00000412389, ENST00000419336, ENST00000426415, ENST00000428317, ENST00000430554, ENST00000440755, ENST00000441605, ENST00000442452, ENST00000445236, ENST00000454485, ENST00000497647
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 268 122 204 57 184 33 659 642 2023 26 265 149 24 5 627 2
Low 2008 2273 1335 484 1372 348 3189 1414 1612 313 1100 1345 145 1077 1814 1
Below cutoff 140 583 181 81 237 84 502 137 74 77 82 103 2 122 347 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_007474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001367915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001367917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001367918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001367919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_160407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_160408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF002993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF312032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF334270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI831696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY389977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY750146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG707892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA205851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU048096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF194018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH253764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH253765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT431643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000241069   ⟹   ENSP00000241069
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,889,994 - 100,895,888 (-)Ensembl
RefSeq Acc Id: ENST00000302913   ⟹   ENSP00000303211
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,889,995 - 100,895,920 (-)Ensembl
RefSeq Acc Id: ENST00000411582   ⟹   ENSP00000404865
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,889,994 - 100,895,888 (-)Ensembl
RefSeq Acc Id: ENST00000412389   ⟹   ENSP00000394976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,889,997 - 100,894,388 (-)Ensembl
RefSeq Acc Id: ENST00000419336   ⟹   ENSP00000403474
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,889,994 - 100,895,886 (-)Ensembl
RefSeq Acc Id: ENST00000426415   ⟹   ENSP00000397143
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,890,211 - 100,894,233 (-)Ensembl
RefSeq Acc Id: ENST00000428317   ⟹   ENSP00000414858
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,889,994 - 100,896,129 (-)Ensembl
RefSeq Acc Id: ENST00000430554   ⟹   ENSP00000399725
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,890,211 - 100,894,233 (-)Ensembl
RefSeq Acc Id: ENST00000440755   ⟹   ENSP00000410380
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,890,211 - 100,894,233 (-)Ensembl
RefSeq Acc Id: ENST00000441605   ⟹   ENSP00000396360
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,893,757 - 100,896,974 (-)Ensembl
RefSeq Acc Id: ENST00000442452   ⟹   ENSP00000415901
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,890,211 - 100,894,233 (-)Ensembl
RefSeq Acc Id: ENST00000445236   ⟹   ENSP00000400933
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,894,149 - 100,896,919 (-)Ensembl
RefSeq Acc Id: ENST00000454485   ⟹   ENSP00000390004
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,890,211 - 100,894,233 (-)Ensembl
RefSeq Acc Id: ENST00000651875
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7100,891,255 - 100,895,878 (-)Ensembl
RefSeq Acc Id: NM_000665   ⟹   NP_000656
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,895,888 (-)NCBI
GRCh377100,487,615 - 100,493,754 (-)NCBI
Build 367100,325,551 - 100,331,477 (-)NCBI Archive
HuRef795,117,968 - 95,123,951 (-)NCBI
CHM1_17100,418,205 - 100,424,194 (-)NCBI
CRA_TCAGchr7v2799,847,220 - 99,853,146 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001282449   ⟹   NP_001269378
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,895,888 (-)NCBI
HuRef795,117,968 - 95,123,951 (-)NCBI
CHM1_17100,418,205 - 100,424,194 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302621   ⟹   NP_001289550
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,895,888 (-)NCBI
CHM1_17100,418,927 - 100,424,194 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302622   ⟹   NP_001289551
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,896,129 (-)NCBI
CHM1_17100,418,205 - 100,424,356 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001367915   ⟹   NP_001354844
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,895,888 (-)NCBI
RefSeq Acc Id: NM_001367917   ⟹   NP_001354846
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,894,606 (-)NCBI
RefSeq Acc Id: NM_001367918   ⟹   NP_001354847
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,896,994 (-)NCBI
RefSeq Acc Id: NM_001367919   ⟹   NP_001354848
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,896,994 (-)NCBI
RefSeq Acc Id: NR_160407
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,896,994 (-)NCBI
RefSeq Acc Id: NR_160408
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,889,994 - 100,895,888 (-)NCBI
Protein Sequences
Protein RefSeqs NP_000656 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269378 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289550 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289551 (Get FASTA)   NCBI Sequence Viewer  
  NP_001354844 (Get FASTA)   NCBI Sequence Viewer  
  NP_001354846 (Get FASTA)   NCBI Sequence Viewer  
  NP_001354847 (Get FASTA)   NCBI Sequence Viewer  
  NP_001354848 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53473 (Get FASTA)   NCBI Sequence Viewer  
  AAA68151 (Get FASTA)   NCBI Sequence Viewer  
  AAC60618 (Get FASTA)   NCBI Sequence Viewer  
  AAH36813 (Get FASTA)   NCBI Sequence Viewer  
  AAI05061 (Get FASTA)   NCBI Sequence Viewer  
  AAI05063 (Get FASTA)   NCBI Sequence Viewer  
  AAI43470 (Get FASTA)   NCBI Sequence Viewer  
  AAK21003 (Get FASTA)   NCBI Sequence Viewer  
  AAO32948 (Get FASTA)   NCBI Sequence Viewer  
  AAP22364 (Get FASTA)   NCBI Sequence Viewer  
  AAP22365 (Get FASTA)   NCBI Sequence Viewer  
  AAR26654 (Get FASTA)   NCBI Sequence Viewer  
  AAU43801 (Get FASTA)   NCBI Sequence Viewer  
  ANA11642 (Get FASTA)   NCBI Sequence Viewer  
  AWF93928 (Get FASTA)   NCBI Sequence Viewer  
  BAD97163 (Get FASTA)   NCBI Sequence Viewer  
  BAF84010 (Get FASTA)   NCBI Sequence Viewer  
  EAL23812 (Get FASTA)   NCBI Sequence Viewer  
  EAL23813 (Get FASTA)   NCBI Sequence Viewer  
  EAW76460 (Get FASTA)   NCBI Sequence Viewer  
  EAW76461 (Get FASTA)   NCBI Sequence Viewer  
  EAW76462 (Get FASTA)   NCBI Sequence Viewer  
  EAW76463 (Get FASTA)   NCBI Sequence Viewer  
  EAW76464 (Get FASTA)   NCBI Sequence Viewer  
  P22303 (Get FASTA)   NCBI Sequence Viewer  
  QBA82783 (Get FASTA)   NCBI Sequence Viewer  
  QBA82784 (Get FASTA)   NCBI Sequence Viewer  
  QJX19968 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_000656   ⟸   NM_000665
- Peptide Label: isoform E4-E6 precursor
- UniProtKB: P22303 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001269378   ⟸   NM_001282449
- Peptide Label: isoform 3 precursor
- UniProtKB: P22303 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001289551   ⟸   NM_001302622
- Peptide Label: isoform E4-E6 precursor
- UniProtKB: P22303 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001289550   ⟸   NM_001302621
- Peptide Label: isoform E4-E5 precursor
- UniProtKB: P22303 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001354848   ⟸   NM_001367919
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001354847   ⟸   NM_001367918
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001354844   ⟸   NM_001367915
- Peptide Label: isoform E4-E6 precursor
RefSeq Acc Id: NP_001354846   ⟸   NM_001367917
- Peptide Label: isoform E4-E6 precursor
RefSeq Acc Id: ENSP00000404865   ⟸   ENST00000411582
RefSeq Acc Id: ENSP00000397143   ⟸   ENST00000426415
RefSeq Acc Id: ENSP00000394976   ⟸   ENST00000412389
RefSeq Acc Id: ENSP00000241069   ⟸   ENST00000241069
RefSeq Acc Id: ENSP00000414858   ⟸   ENST00000428317
RefSeq Acc Id: ENSP00000410380   ⟸   ENST00000440755
RefSeq Acc Id: ENSP00000390004   ⟸   ENST00000454485
RefSeq Acc Id: ENSP00000396360   ⟸   ENST00000441605
RefSeq Acc Id: ENSP00000415901   ⟸   ENST00000442452
RefSeq Acc Id: ENSP00000403474   ⟸   ENST00000419336
RefSeq Acc Id: ENSP00000399725   ⟸   ENST00000430554
RefSeq Acc Id: ENSP00000400933   ⟸   ENST00000445236
RefSeq Acc Id: ENSP00000303211   ⟸   ENST00000302913
Protein Domains
COesterase

Promoters
RGD ID:6805190
Promoter ID:HG_KWN:58989
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000347196,   OTTHUMT00000347197,   OTTHUMT00000347198,   OTTHUMT00000347199,   OTTHUMT00000347200,   UC003UXD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367100,330,351 - 100,330,851 (-)MPROMDB
RGD ID:6805189
Promoter ID:HG_KWN:58990
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid
Transcripts:ENST00000357451,   NM_000665,   NM_015831,   OTTHUMT00000347193,   OTTHUMT00000347194,   OTTHUMT00000347195,   UC003UXG.1,   UC003UXH.1,   UC003UXJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367100,331,466 - 100,332,867 (-)MPROMDB
RGD ID:7211427
Promoter ID:EPDNEW_H11460
Type:initiation region
Name:ACHE_1
Description:acetylcholinesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11461  EPDNEW_H11462  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,895,888 - 100,895,948EPDNEW
RGD ID:7211429
Promoter ID:EPDNEW_H11461
Type:initiation region
Name:ACHE_3
Description:acetylcholinesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11460  EPDNEW_H11462  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,896,094 - 100,896,154EPDNEW
RGD ID:7211433
Promoter ID:EPDNEW_H11462
Type:initiation region
Name:ACHE_2
Description:acetylcholinesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11460  EPDNEW_H11461  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,896,994 - 100,897,054EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000665.5(ACHE):c.1057C>A (p.His353Asn) single nucleotide variant YT BLOOD GROUP POLYMORPHISM [RCV000020001] Chr7:100893176 [GRCh38]
Chr7:100490797 [GRCh37]
Chr7:7q22.1
benign
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1
pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1
pathogenic
GRCh38/hg38 7q22.1(chr7:100419914-102482826)x1 copy number loss See cases [RCV000054155] Chr7:100419914..102482826 [GRCh38]
Chr7:100017537..102123273 [GRCh37]
Chr7:99855473..101910278 [NCBI36]
Chr7:7q22.1
pathogenic
NM_015831.2(ACHE):c.423C>T (p.Ser141=) single nucleotide variant Malignant melanoma [RCV000067533] Chr7:100893810 [GRCh38]
Chr7:100491431 [GRCh37]
Chr7:100329367 [NCBI36]
Chr7:7q22.1
not provided
NM_015831.2(ACHE):c.284C>T (p.Thr95Ile) single nucleotide variant Malignant melanoma [RCV000067534] Chr7:100893949 [GRCh38]
Chr7:100491570 [GRCh37]
Chr7:100329506 [NCBI36]
Chr7:7q22.1
not provided
NM_015831.2(ACHE):c.216C>T (p.Pro72=) single nucleotide variant Malignant melanoma [RCV000067535] Chr7:100894017 [GRCh38]
Chr7:100491638 [GRCh37]
Chr7:100329574 [NCBI36]
Chr7:7q22.1
not provided
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1
pathogenic|uncertain significance
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q22.1(chr7:99932610-102473188)x3 copy number gain See cases [RCV000138109] Chr7:99932610..102473188 [GRCh38]
Chr7:99530233..102113635 [GRCh37]
Chr7:99368169..101900640 [NCBI36]
Chr7:7q22.1
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Speech-language disorder 1 [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:100141861-100552714)x1 copy number loss not provided [RCV000746918] Chr7:100141861..100552714 [GRCh37]
Chr7:7q22.1
likely benign
GRCh37/hg19 7q22.1(chr7:100487135-100493000)x1 copy number loss not provided [RCV000746929] Chr7:100487135..100493000 [GRCh37]
Chr7:7q22.1
benign
GRCh37/hg19 7q22.1(chr7:100492322-100493711)x3 copy number gain not provided [RCV000746930] Chr7:100492322..100493711 [GRCh37]
Chr7:7q22.1
benign
GRCh37/hg19 7q22.1(chr7:100492412-100493711)x3 copy number gain not provided [RCV000746931] Chr7:100492412..100493711 [GRCh37]
Chr7:7q22.1
benign
NM_000665.5(ACHE):c.1044C>T (p.Asn348=) single nucleotide variant not provided [RCV000917854] Chr7:100893189 [GRCh38]
Chr7:100490810 [GRCh37]
Chr7:7q22.1
likely benign
NM_000665.5(ACHE):c.846G>C (p.Leu282=) single nucleotide variant not provided [RCV000925653] Chr7:100893387 [GRCh38]
Chr7:100491008 [GRCh37]
Chr7:7q22.1
likely benign
NM_000665.5(ACHE):c.266G>A (p.Gly89Glu) single nucleotide variant not provided [RCV000900724] Chr7:100893967 [GRCh38]
Chr7:100491588 [GRCh37]
Chr7:7q22.1
benign
NM_000665.5(ACHE):c.1032G>A (p.Glu344=) single nucleotide variant not provided [RCV000947051] Chr7:100893201 [GRCh38]
Chr7:100490822 [GRCh37]
Chr7:7q22.1
benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NM_000665.5(ACHE):c.101G>A (p.Arg34Gln) single nucleotide variant not provided [RCV000967061] Chr7:100894132 [GRCh38]
Chr7:100491753 [GRCh37]
Chr7:7q22.1
benign
NM_000665.5(ACHE):c.807G>A (p.Thr269=) single nucleotide variant not provided [RCV000908994] Chr7:100893426 [GRCh38]
Chr7:100491047 [GRCh37]
Chr7:7q22.1
benign
NM_000665.5(ACHE):c.403C>G (p.Pro135Ala) single nucleotide variant not provided [RCV000961807] Chr7:100893830 [GRCh38]
Chr7:100491451 [GRCh37]
Chr7:7q22.1
likely benign
NM_000665.5(ACHE):c.1434C>T (p.His478=) single nucleotide variant not provided [RCV000913071] Chr7:100892453 [GRCh38]
Chr7:100490074 [GRCh37]
Chr7:7q22.1
likely benign
NM_000665.5(ACHE):c.1323C>T (p.Pro441=) single nucleotide variant not provided [RCV000891247] Chr7:100892564 [GRCh38]
Chr7:100490185 [GRCh37]
Chr7:7q22.1
likely benign
GRCh37/hg19 7q22.1(chr7:99593346-102470275)x1 copy number loss See cases [RCV001195072] Chr7:99593346..102470275 [GRCh37]
Chr7:7q22.1
likely pathogenic
NM_000665.5(ACHE):c.1033G>A (p.Ala345Thr) single nucleotide variant not provided [RCV001356563] Chr7:100893200 [GRCh38]
Chr7:100490821 [GRCh37]
Chr7:7q22.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:108 AgrOrtholog
COSMIC ACHE COSMIC
Ensembl Genes ENSG00000087085 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000241069 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000303211 UniProtKB/Swiss-Prot
  ENSP00000390004 UniProtKB/TrEMBL
  ENSP00000394976 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000396360 UniProtKB/TrEMBL
  ENSP00000397143 UniProtKB/TrEMBL
  ENSP00000399725 UniProtKB/TrEMBL
  ENSP00000400933 UniProtKB/TrEMBL
  ENSP00000403474 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000404865 ENTREZGENE, UniProtKB/Swiss-Prot