GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GCLC | increases expression | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | chrysin results in increased expression of GCLC mRNA; chrysin results in increased expression of GCLC protein | PMID:22864849 | GCLC | multiple interactions | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein] | PMID:22864849 PMID:33121995 | | ||||||||||||||||||||||
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