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Gene: ARNT (aryl hydrocarbon receptor nuclear translocator) Homo sapiens
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Symbol: ARNT
Name: aryl hydrocarbon receptor nuclear translocator
RGD ID: 732739
Description: Exhibits aryl hydrocarbon receptor binding activity; cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in positive regulation of vascular endothelial growth factor production; regulation of cellular biosynthetic process; and response to hypoxia. Localizes to RNA polymerase II transcription regulator complex and nuclear body. Implicated in renal cell carcinoma. Biomarker of type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe2; class E basic helix-loop-helix protein 2; dioxin receptor, nuclear translocator; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; TANGO
Orthologs:
Mus musculus (house mouse) : Arnt (aryl hydrocarbon receptor nuclear translocator)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arnt (aryl hydrocarbon receptor nuclear translocator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arnt (aryl hydrocarbon receptor nuclear translocator)
Pan paniscus (bonobo/pygmy chimpanzee) : ARNT (aryl hydrocarbon receptor nuclear translocator)
Canis lupus familiaris (dog) : ARNT (aryl hydrocarbon receptor nuclear translocator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arnt (aryl hydrocarbon receptor nuclear translocator)
Sus scrofa (pig) : ARNT (aryl hydrocarbon receptor nuclear translocator)
Chlorocebus sabaeus (African green monkey) : ARNT (aryl hydrocarbon receptor nuclear translocator)
Heterocephalus glaber (naked mole-rat) : Arnt (aryl hydrocarbon receptor nuclear translocator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1150,809,713 - 150,876,708 (-)EnsemblGRCh38hg38GRCh38
GRCh381150,809,713 - 150,876,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371150,782,181 - 150,849,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,048,810 - 149,115,810 (-)NCBINCBI36hg18NCBI36
Build 341147,595,258 - 147,662,259NCBI
Celera1123,898,224 - 123,964,878 (-)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1122,159,809 - 122,226,754 (-)NCBIHuRef
CHM1_11152,177,524 - 152,244,584 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ARNT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732739
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.