ARRB2 (arrestin beta 2) - Rat Genome Database

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Gene: ARRB2 (arrestin beta 2) Homo sapiens
Analyze
Symbol: ARRB2
Name: arrestin beta 2
RGD ID: 731570
HGNC Page HGNC:712
Description: Enables G protein-coupled receptor binding activity; molecular adaptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of receptor internalization; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Located in several cellular components, including cytosol; endocytic vesicle; and nucleoplasm. Implicated in glioblastoma; heroin dependence; nicotine dependence; and opiate dependence. Biomarker of liver cirrhosis; opiate dependence; and portal hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ARB2; ARR2; arrestin 3; arrestin beta-2; arrestin, beta 2; BARR2; beta-arrestin-2; DKFZp686L0365; non-visual arrestin-3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,710,632 - 4,721,497 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,710,596 - 4,721,499 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,613,927 - 4,624,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,560,538 - 4,571,544 (+)NCBINCBI36Build 36hg18NCBI36
Build 34174,560,537 - 4,571,543NCBI
Celera174,629,166 - 4,639,975 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,502,952 - 4,513,866 (+)NCBIHuRef
CHM1_1174,622,557 - 4,633,518 (+)NCBICHM1_1
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-arachidonoylglycerol  (EXP)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (ISO)
acrolein  (EXP)
Aflatoxin B2 alpha  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
alprenolol  (EXP)
ammonium chloride  (ISO)
anandamide  (EXP)
antirheumatic drug  (EXP)
ATP  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carteolol  (EXP)
carvedilol  (EXP,ISO)
celastrol  (EXP)
CGP 52608  (EXP)
chrysin  (ISO)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dobutamine  (EXP)
dopamine  (EXP)
Endomorphin-2  (ISO)
enzyme inhibitor  (EXP)
ethanol  (ISO)
fentanyl  (EXP,ISO)
fenthion  (ISO)
flavonoids  (ISO)
fluoxetine  (ISO)
gentamycin  (ISO)
hydromorphone  (ISO)
ICI 118551  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (EXP)
leukotriene D4  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methoxyacetic acid  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
morphine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
ozone  (EXP,ISO)
pamoic acid  (EXP)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
propranolol  (EXP)
resveratrol  (EXP)
rimonabant  (EXP)
S-nitroso-L-cysteine  (EXP)
silicon dioxide  (ISO)
sodium chloride  (EXP)
superoxide  (ISO)
T-2 toxin  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
WIN 55212-2  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (IEA)
cell chemotaxis  (IMP)
circadian rhythm  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
dopamine receptor signaling pathway  (NAS)
endocytosis  (ISO)
excitatory postsynaptic potential  (NAS)
follicle-stimulating hormone signaling pathway  (ISO)
G protein-coupled receptor internalization  (IBA,IDA,IEA,IMP,TAS)
G protein-coupled receptor signaling pathway  (ISO)
modulation of chemical synaptic transmission  (IEA)
negative regulation of canonical NF-kappaB signal transduction  (IDA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of interleukin-1 beta production  (IEA)
negative regulation of interleukin-12 production  (IEA)
negative regulation of interleukin-6 production  (IEA)
negative regulation of natural killer cell mediated cytotoxicity  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of opioid receptor signaling pathway  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (NAS)
negative regulation of protein phosphorylation  (IEA)
negative regulation of protein ubiquitination  (IDA,ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of signal transduction  (IEA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of toll-like receptor signaling pathway  (IEA)
negative regulation of tumor necrosis factor production  (IEA)
obsolete desensitization of G protein-coupled receptor signaling pathway by arrestin  (IMP,ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cardiac muscle cell differentiation  (IEA)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of epithelial cell apoptotic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IDA,IEA,IMP,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glial cell proliferation  (ISO)
positive regulation of opioid receptor signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of receptor internalization  (IMP,ISO)
positive regulation of synaptic transmission, dopaminergic  (IEA)
postsynaptic signal transduction  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IMP)
protein transport  (IEA)
protein ubiquitination  (IMP)
receptor internalization  (IDA)
regulation of G protein-coupled receptor signaling pathway  (IEA,ISO)
regulation of protein phosphorylation  (IEA,ISO)
response to morphine  (ISO)
signal transduction  (IEA)
transcription by RNA polymerase II  (IDA)
transforming growth factor beta receptor signaling pathway  (IDA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma. Bae WY, etal., Cell Death Differ. 2021 Nov;28(11):3092-3104. doi: 10.1038/s41418-021-00802-2. Epub 2021 May 18.
2. Beta-arrestins: multifunctional cellular mediators. Barki-Harrington L and Rockman HA, Physiology (Bethesda). 2008 Feb;23:17-22.
3. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
4. Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension. Chen W, etal., Int J Biol Sci. 2014 Mar 15;10(4):386-95. doi: 10.7150/ijbs.8081. eCollection 2014.
5. Gender related alterations of beta-adrenoceptor mechanisms in heart failure due to arteriovenous fistula. Dent MR, etal., J Cell Physiol. 2011 Oct 20. doi: 10.1002/jcp.23058.
6. GRK mythology: G-protein receptor kinases in cardiovascular disease. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
7. Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. Ferrer-Alcón M, etal., Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):114-22. doi: 10.1016/j.molbrainres.2003.11.009.
8. Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Fong AM, etal., Proc Natl Acad Sci U S A 2002 May 28;99(11):7478-83.
9. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
10. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. Hauger RL, etal., CNS Neurol Disord Drug Targets. 2006 Aug;5(4):453-79.
11. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hennenberg M, etal., Hepatology. 2007 Feb;45(2):495-506.
12. β-Arrestin 2 (ARRB2) Polymorphism is Associated With Adverse Consequences of Chronic Heroin Use. Karavidha KK, etal., Am J Addict. 2021 Jul;30(4):351-357. doi: 10.1111/ajad.13150. Epub 2021 Mar 30.
13. Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats. Khan MS, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):85-94. Epub 2010 Dec 15.
14. Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats. Li JB, etal., J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):877-85. doi: 10.1007/s11596-013-1215-7. Epub 2013 Dec 13.
15. Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter. Li Y, etal., Int J Mol Sci. 2009 Mar;10(3):954-63. doi: 10.3390/ijms10030954. Epub 2009 Mar 5.
16. Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. Luo R, etal., Pharmacogenomics. 2017 Dec;18(18):1659-1670. doi: 10.2217/pgs-2017-0072. Epub 2017 Nov 27.
17. Disrupted circadian expression of β-arrestin 2 affects reward-related µ-opioid receptor function in alcohol dependence. Meinhardt MW, etal., J Neurochem. 2022 Feb;160(4):454-468. doi: 10.1111/jnc.15559. Epub 2022 Jan 4.
18. G protein-coupled receptor kinase 6/beta-arrestin 2 system in a rat model of dopamine supersensitivity psychosis. Oda Y, etal., J Psychopharmacol. 2015 Dec;29(12):1308-13. doi: 10.1177/0269881115593903. Epub 2015 Jul 14.
19. β-Arrestin2 influences the response to methadone in opioid-dependent patients. Oneda B, etal., Pharmacogenomics J. 2011 Aug;11(4):258-66. doi: 10.1038/tpj.2010.37. Epub 2010 Jun 1.
20. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control. Sadek K, etal., Iran J Pharm Res. 2020 Fall;19(4):372-386. doi: 10.22037/ijpr.2020.1101292.
26. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
27. Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers. Sun D, etal., Mol Psychiatry. 2008 Apr;13(4):398-406. doi: 10.1038/sj.mp.4002036. Epub 2007 Jun 19.
28. Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver. Sun YY, etal.
29. Biased agonism of the calcium-sensing receptor. Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20.
30. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12.
31. β-arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke. Wang H, etal., J Neuroinflammation. 2018 Apr 10;15(1):102. doi: 10.1186/s12974-018-1142-4.
32. The expression change of beta-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony. Wang QT, etal., J Ethnopharmacol. 2011 Jan 27;133(2):511-6. Epub 2010 Oct 19.
33. Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats. Wang T, etal., J Hypertens. 2017 Mar;35(3):538-545. doi: 10.1097/HJH.0000000000001179.
34. ß-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis. Wang Y, etal., Am J Physiol Renal Physiol. 2017 Jul 1;313(1):F1-F8. doi: 10.1152/ajprenal.00588.2016. Epub 2017 Mar 8.
35. ß-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling. Wang Y, etal., Cardiovasc Res. 2017 Nov 1;113(13):1615-1626. doi: 10.1093/cvr/cvx147.
36. The contribution of rare and common variants in 30 genes to risk nicotine dependence. Yang J, etal., Mol Psychiatry. 2015 Nov;20(11):1467-78. doi: 10.1038/mp.2014.156. Epub 2014 Dec 2.
37. Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Zakrzewicz A, etal., Immunobiology. 2011 Jul;216(7):854-61. doi: 10.1016/j.imbio.2010.11.005. Epub 2010 Dec 3.
38. Role of ssarrestins in bradykinin B2 receptor-mediated signalling. Zimmerman B, etal., Cell Signal. 2011 Apr;23(4):648-59. doi: 10.1016/j.cellsig.2010.11.016. Epub 2010 Dec 8.
Additional References at PubMed
PMID:1517224   PMID:1587386   PMID:7695743   PMID:8486659   PMID:9037196   PMID:9169477   PMID:9346876   PMID:9668034   PMID:9852134   PMID:10097102   PMID:10644702   PMID:10858453  
PMID:11090355   PMID:11226259   PMID:11259507   PMID:11279203   PMID:11356842   PMID:11418617   PMID:11533043   PMID:11535606   PMID:11588219   PMID:11723231   PMID:11729201   PMID:11867621  
PMID:11877451   PMID:12070169   PMID:12105416   PMID:12186555   PMID:12370187   PMID:12393857   PMID:12464600   PMID:12473660   PMID:12477932   PMID:12488444   PMID:12538596   PMID:12582207  
PMID:12654503   PMID:12949261   PMID:12958364   PMID:12958365   PMID:14500724   PMID:14602721   PMID:14702039   PMID:14711824   PMID:14769794   PMID:15125834   PMID:15173580   PMID:15231748  
PMID:15355986   PMID:15361545   PMID:15364949   PMID:15489220   PMID:15489334   PMID:15528268   PMID:15611106   PMID:15618519   PMID:15626751   PMID:15634674   PMID:15635042   PMID:15687500  
PMID:15699045   PMID:15699339   PMID:15728711   PMID:15817468   PMID:15878855   PMID:15888437   PMID:16038799   PMID:16051150   PMID:16103897   PMID:16169070   PMID:16181421   PMID:16308565  
PMID:16325578   PMID:16378096   PMID:16412099   PMID:16513835   PMID:16524428   PMID:16580177   PMID:16605244   PMID:16611986   PMID:16689683   PMID:16820410   PMID:16894395   PMID:16956790  
PMID:16968782   PMID:17005854   PMID:17038311   PMID:17148612   PMID:17233643   PMID:17272726   PMID:17353931   PMID:17377064   PMID:17500066   PMID:17540773   PMID:17565992   PMID:17620599  
PMID:17713785   PMID:17761157   PMID:17846866   PMID:17855543   PMID:17947233   PMID:17978999   PMID:17984062   PMID:18006496   PMID:18036556   PMID:18039931   PMID:18191226   PMID:18408005  
PMID:18435604   PMID:18445652   PMID:18544533   PMID:18604210   PMID:18621717   PMID:18691971   PMID:18703513   PMID:18768750   PMID:18787115   PMID:18801735   PMID:18802075   PMID:18937294  
PMID:18940181   PMID:19008961   PMID:19049562   PMID:19060904   PMID:19071087   PMID:19122674   PMID:19165858   PMID:19171933   PMID:19188335   PMID:19202075   PMID:19219857   PMID:19239323  
PMID:19262695   PMID:19279230   PMID:19306926   PMID:19363159   PMID:19416857   PMID:19424180   PMID:19453261   PMID:19458261   PMID:19531493   PMID:19730683   PMID:19782076   PMID:19794961  
PMID:19846537   PMID:19874574   PMID:19955404   PMID:20035620   PMID:20056609   PMID:20100572   PMID:20228252   PMID:20360068   PMID:20457218   PMID:20478633   PMID:20497256   PMID:20505072  
PMID:20656684   PMID:20664520   PMID:20734064   PMID:20801186   PMID:20802461   PMID:20864483   PMID:20936779   PMID:21081496   PMID:21112970   PMID:21118812   PMID:21149639   PMID:21152433  
PMID:21256133   PMID:21258807   PMID:21296876   PMID:21306178   PMID:21318602   PMID:21321125   PMID:21378163   PMID:21389118   PMID:21466165   PMID:21502318   PMID:21589858   PMID:21642958  
PMID:21644508   PMID:21645452   PMID:21708946   PMID:21711983   PMID:21833475   PMID:21873635   PMID:21952200   PMID:21988832   PMID:22006018   PMID:22190034   PMID:22242112   PMID:22282525  
PMID:22300987   PMID:22333895   PMID:22369787   PMID:22457824   PMID:22472784   PMID:22523395   PMID:22562249   PMID:22610101   PMID:22735336   PMID:22773819   PMID:22871966   PMID:23011268  
PMID:23069267   PMID:23077507   PMID:23139825   PMID:23188799   PMID:23208550   PMID:23236378   PMID:23242524   PMID:23266473   PMID:23290307   PMID:23297229   PMID:23302795   PMID:23341447  
PMID:23382074   PMID:23449980   PMID:23527545   PMID:23541635   PMID:23782696   PMID:23809162   PMID:23818521   PMID:23820308   PMID:23826079   PMID:23985900   PMID:24056371   PMID:24069330  
PMID:24157794   PMID:24169548   PMID:24265322   PMID:24377933   PMID:24386388   PMID:24561123   PMID:24568448   PMID:24635845   PMID:24658140   PMID:24733850   PMID:24817116   PMID:24817122  
PMID:24867953   PMID:24898255   PMID:25038452   PMID:25134464   PMID:25162404   PMID:25170081   PMID:25241761   PMID:25281560   PMID:25354317   PMID:25402006   PMID:25416956   PMID:25425640  
PMID:25752515   PMID:25766502   PMID:25973019   PMID:26077142   PMID:26157145   PMID:26186194   PMID:26211463   PMID:26211551   PMID:26257302   PMID:26324936   PMID:26344197   PMID:26371162  
PMID:26372541   PMID:26399832   PMID:26449263   PMID:26467309   PMID:26496610   PMID:26545496   PMID:26638075   PMID:26673895   PMID:26829388   PMID:26839314   PMID:26850854   PMID:26852662  
PMID:26885983   PMID:26898829   PMID:26927499   PMID:26957205   PMID:27007855   PMID:27155323   PMID:27188791   PMID:27226565   PMID:27468652   PMID:27502035   PMID:27523794   PMID:27561318  
PMID:27657826   PMID:27818291   PMID:27835898   PMID:27895162   PMID:28062183   PMID:28140695   PMID:28169830   PMID:28298427   PMID:28300069   PMID:28325822   PMID:28388416   PMID:28427767  
PMID:28472170   PMID:28485809   PMID:28514442   PMID:28515276   PMID:28581517   PMID:28611215   PMID:28652403   PMID:28733084   PMID:28947386   PMID:29031912   PMID:29054428   PMID:29330504  
PMID:29377493   PMID:29467282   PMID:29515120   PMID:29620228   PMID:29658513   PMID:29734363   PMID:29999490   PMID:30196744   PMID:30354204   PMID:30355935   PMID:30462309   PMID:30504423  
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PMID:33187986   PMID:33204724   PMID:33288675   PMID:33339432   PMID:33367479   PMID:33571431   PMID:33649538   PMID:33710266   PMID:33741415   PMID:33811988   PMID:33961781   PMID:34001657  
PMID:34031190   PMID:34189428   PMID:34450275   PMID:34484125   PMID:34507982   PMID:34597346   PMID:34709266   PMID:34710848   PMID:34887409   PMID:35044719   PMID:35189719   PMID:35256949  
PMID:35788718   PMID:36095012   PMID:36215168   PMID:36284990   PMID:36398662   PMID:36744494   PMID:36853120   PMID:37100034   PMID:37100772   PMID:38113892  


Genomics

Comparative Map Data
ARRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,710,632 - 4,721,497 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,710,596 - 4,721,499 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,613,927 - 4,624,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,560,538 - 4,571,544 (+)NCBINCBI36Build 36hg18NCBI36
Build 34174,560,537 - 4,571,543NCBI
Celera174,629,166 - 4,639,975 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,502,952 - 4,513,866 (+)NCBIHuRef
CHM1_1174,622,557 - 4,633,518 (+)NCBICHM1_1
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBIT2T-CHM13v2.0
Arrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,323,051 - 70,331,654 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,323,461 - 70,331,654 (+)EnsemblGRCm39 Ensembl
GRCm381170,432,485 - 70,440,828 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,432,635 - 70,440,828 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,246,155 - 70,254,176 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,248,893 - 70,257,018 (+)NCBIMGSCv36mm8
Celera1177,978,619 - 77,986,640 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Arrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,645,539 - 55,653,485 (+)NCBIGRCr8
mRatBN7.21055,146,887 - 55,154,854 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,146,818 - 55,154,850 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,825,196 - 59,833,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,313,709 - 59,321,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,812,911 - 54,820,795 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,040,252 - 57,048,045 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,040,267 - 57,048,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,797,489 - 56,805,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,244,071 - 57,284,166 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,289,995 - 57,297,789 (+)NCBI
Celera1054,285,120 - 54,301,063 (+)NCBICelera
Cytogenetic Map10q24NCBI
Arrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,110,003 - 10,123,022 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,109,985 - 10,118,687 (+)NCBIChiLan1.0ChiLan1.0
ARRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,328,333 - 12,339,069 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,296,695 - 14,307,332 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,766,616 - 4,777,253 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,757,048 - 4,767,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,757,048 - 4,767,517 (+)Ensemblpanpan1.1panPan2
ARRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,831,208 - 31,838,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,829,864 - 31,839,454 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,968,270 - 31,977,918 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,934,052 - 31,943,706 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,934,872 - 31,943,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,900,361 - 31,910,009 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,860,046 - 31,869,691 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,036,284 - 32,045,935 (-)NCBIUU_Cfam_GSD_1.0
Arrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560252,719,545 - 52,727,921 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366773,172,925 - 3,181,520 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366773,173,054 - 3,181,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,161,778 - 52,170,342 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,161,776 - 52,170,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,280,938 - 54,286,249 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,191,040 - 4,202,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,191,172 - 4,202,385 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605917,439,881 - 17,451,765 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247868,568,198 - 8,577,914 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247868,568,102 - 8,576,445 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARRB2
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17p13.3-13.2(chr17:193307-5652222)x1 copy number loss See cases [RCV000053384] Chr17:193307..5652222 [GRCh38]
Chr17:45835..5555542 [GRCh37]
Chr17:43098..5496266 [NCBI36]
Chr17:17p13.3-13.2
pathogenic
GRCh38/hg38 17p13.2-13.1(chr17:3601515-7178024)x1 copy number loss See cases [RCV000053406] Chr17:3601515..7178024 [GRCh38]
Chr17:3504809..7081343 [GRCh37]
Chr17:3451558..7022067 [NCBI36]
Chr17:17p13.2-13.1
pathogenic
GRCh38/hg38 17p13.2(chr17:4141725-4841701)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054003]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054003]|See cases [RCV000054003] Chr17:4141725..4841701 [GRCh38]
Chr17:4045019..4744996 [GRCh37]
Chr17:3991768..4691654 [NCBI36]
Chr17:17p13.2
uncertain significance
NM_004313.3(ARRB2):c.541C>T (p.Pro181Ser) single nucleotide variant Malignant melanoma [RCV000071558] Chr17:4717943 [GRCh38]
Chr17:4621238 [GRCh37]
Chr17:4567987 [NCBI36]
Chr17:17p13.2
not provided
NM_004313.3(ARRB2):c.542C>T (p.Pro181Leu) single nucleotide variant Malignant melanoma [RCV000071559] Chr17:4717944 [GRCh38]
Chr17:4621239 [GRCh37]
Chr17:4567988 [NCBI36]
Chr17:17p13.2
not provided
GRCh38/hg38 17p13.3-13.2(chr17:2062380-5258340)x1 copy number loss See cases [RCV000133721] Chr17:2062380..5258340 [GRCh38]
Chr17:1965674..5161635 [GRCh37]
Chr17:1912424..5102359 [NCBI36]
Chr17:17p13.3-13.2
pathogenic
GRCh38/hg38 17p13.3-13.1(chr17:162088-6959050)x1 copy number loss See cases [RCV000134135] Chr17:162088..6959050 [GRCh38]
Chr17:45835..6862369 [GRCh37]
Chr17:11879..6803093 [NCBI36]
Chr17:17p13.3-13.1
pathogenic
GRCh38/hg38 17p13.3-13.1(chr17:198748-7491129)x3 copy number gain See cases [RCV000134970] Chr17:198748..7491129 [GRCh38]
Chr17:50690..7394448 [GRCh37]
Chr17:48539..7335172 [NCBI36]
Chr17:17p13.3-13.1
pathogenic
GRCh38/hg38 17p13.2(chr17:4044302-5943772)x1 copy number loss See cases [RCV000135548] Chr17:4044302..5943772 [GRCh38]
Chr17:3947596..5847092 [GRCh37]
Chr17:3894345..5787816 [NCBI36]
Chr17:17p13.2
likely pathogenic
GRCh38/hg38 17p13.2(chr17:4141725-4778120)x1 copy number loss See cases [RCV000137514] Chr17:4141725..4778120 [GRCh38]
Chr17:4045019..4681415 [GRCh37]
Chr17:3991768..4628164 [NCBI36]
Chr17:17p13.2
uncertain significance
GRCh38/hg38 17p13.3-13.1(chr17:162016-7697012)x1 copy number loss See cases [RCV000138214] Chr17:162016..7697012 [GRCh38]
Chr17:45835..7600330 [GRCh37]
Chr17:11807..7541055 [NCBI36]
Chr17:17p13.3-13.1
pathogenic
GRCh38/hg38 17p13.3-12(chr17:162016-12343901)x3 copy number gain See cases [RCV000138531] Chr17:162016..12343901 [GRCh38]
Chr17:45835..12247218 [GRCh37]
Chr17:11807..12187943 [NCBI36]
Chr17:17p13.3-12
pathogenic
GRCh38/hg38 17p13.2(chr17:4092608-5354473)x3 copy number gain See cases [RCV000139650] Chr17:4092608..5354473 [GRCh38]
Chr17:3995902..5257768 [GRCh37]
Chr17:3942651..5198492 [NCBI36]
Chr17:17p13.2
likely benign
GRCh38/hg38 17p13.3-13.2(chr17:150732-5935377)x1 copy number loss See cases [RCV000141658] Chr17:150732..5935377 [GRCh38]
Chr17:525..5838697 [GRCh37]
Chr17:525..5779421 [NCBI36]
Chr17:17p13.3-13.2
pathogenic
GRCh38/hg38 17p13.3-13.2(chr17:237248-4735533)x1 copy number loss See cases [RCV000141559] Chr17:237248..4735533 [GRCh38]
Chr17:396627..4638828 [GRCh37]
Chr17:87039..4585577 [NCBI36]
Chr17:17p13.3-13.2
pathogenic
GRCh38/hg38 17p13.3-12(chr17:150732-14764202)x3 copy number gain See cases [RCV000142236] Chr17:150732..14764202 [GRCh38]
Chr17:525..14667519 [GRCh37]
Chr17:525..14608244 [NCBI36]
Chr17:17p13.3-12
pathogenic
GRCh38/hg38 17p13.2(chr17:4141725-4873241)x3 copy number gain See cases [RCV000143014] Chr17:4141725..4873241 [GRCh38]
Chr17:4045019..4776536 [GRCh37]
Chr17:3991768..4722711 [NCBI36]
Chr17:17p13.2
uncertain significance
GRCh37/hg19 17p13.2(chr17:4475016-4648525)x1 copy number loss See cases [RCV000449426] Chr17:4475016..4648525 [GRCh37]
Chr17:17p13.2
uncertain significance
GRCh37/hg19 17p13.3-13.2(chr17:1751557-5378509)x1 copy number loss See cases [RCV000445994] Chr17:1751557..5378509 [GRCh37]
Chr17:17p13.3-13.2
pathogenic
GRCh37/hg19 17p13.3-13.1(chr17:1113102-6742486) copy number gain See cases [RCV000445679] Chr17:1113102..6742486 [GRCh37]
Chr17:17p13.3-13.1
pathogenic
GRCh37/hg19 17p13.2(chr17:4389607-4829150)x3 copy number gain See cases [RCV000448511] Chr17:4389607..4829150 [GRCh37]
Chr17:17p13.2
uncertain significance
GRCh37/hg19 17p13.3-12(chr17:525-15027737)x3 copy number gain See cases [RCV000511786] Chr17:525..15027737 [GRCh37]
Chr17:17p13.3-12
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-13.2(chr17:47546-6287620) copy number gain Chromosome 17P13.3, telomeric, duplication syndrome [RCV000767586] Chr17:47546..6287620 [GRCh37]
Chr17:17p13.3-13.2
pathogenic
NM_004313.4(ARRB2):c.340C>A (p.His114Asn) single nucleotide variant not specified [RCV004313305] Chr17:4716591 [GRCh38]
Chr17:4619886 [GRCh37]
Chr17:17p13.2
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-12(chr17:525-11186432)x3 copy number gain not provided [RCV000683866] Chr17:525..11186432 [GRCh37]
Chr17:17p13.3-12
pathogenic
GRCh37/hg19 17p13.2(chr17:4475016-4884701)x3 copy number gain not provided [RCV000683882] Chr17:4475016..4884701 [GRCh37]
Chr17:17p13.2
uncertain significance
GRCh37/hg19 17p13.2(chr17:4036861-5174346)x3 copy number gain not provided [RCV000683881] Chr17:4036861..5174346 [GRCh37]
Chr17:17p13.2
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.2(chr17:3336162-4918458)x1 copy number loss not provided [RCV000739374] Chr17:3336162..4918458 [GRCh37]
Chr17:17p13.2
likely pathogenic
GRCh37/hg19 17p13.3-13.2(chr17:8547-5627408)x1 copy number loss See cases [RCV001007429] Chr17:8547..5627408 [GRCh37]
Chr17:17p13.3-13.2
pathogenic
GRCh37/hg19 17p13.2(chr17:3759126-6128911)x1 copy number loss not provided [RCV000849625] Chr17:3759126..6128911 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.1099G>A (p.Val367Ile) single nucleotide variant not specified [RCV004303051] Chr17:4720603 [GRCh38]
Chr17:4623898 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.647A>G (p.Asn216Ser) single nucleotide variant not specified [RCV004285844] Chr17:4718286 [GRCh38]
Chr17:4621581 [GRCh37]
Chr17:17p13.2
likely benign
NM_004313.4(ARRB2):c.246C>T (p.Ile82=) single nucleotide variant not provided [RCV000888200] Chr17:4716497 [GRCh38]
Chr17:4619792 [GRCh37]
Chr17:17p13.2
benign
NM_004313.4(ARRB2):c.864C>T (p.Leu288=) single nucleotide variant not provided [RCV000888201] Chr17:4719367 [GRCh38]
Chr17:4622662 [GRCh37]
Chr17:17p13.2
benign
NM_004313.4(ARRB2):c.443G>A (p.Arg148Gln) single nucleotide variant not specified [RCV004267128] Chr17:4717710 [GRCh38]
Chr17:4621005 [GRCh37]
Chr17:17p13.2
uncertain significance
GRCh37/hg19 17p13.2(chr17:4113551-5023913) copy number loss not specified [RCV002052580] Chr17:4113551..5023913 [GRCh37]
Chr17:17p13.2
uncertain significance
GRCh37/hg19 17p13.2(chr17:4475016-4648525) copy number loss not specified [RCV002052581] Chr17:4475016..4648525 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.1063C>T (p.Leu355Phe) single nucleotide variant not specified [RCV004330724] Chr17:4720454 [GRCh38]
Chr17:4623749 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.38C>T (p.Ser13Leu) single nucleotide variant not specified [RCV004177674] Chr17:4715027 [GRCh38]
Chr17:4618322 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.847C>T (p.Arg283Trp) single nucleotide variant not specified [RCV004173876] Chr17:4719350 [GRCh38]
Chr17:4622645 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.1145C>T (p.Thr382Ile) single nucleotide variant not specified [RCV004202026] Chr17:4720954 [GRCh38]
Chr17:4624249 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.1061C>T (p.Pro354Leu) single nucleotide variant not specified [RCV004129580] Chr17:4720452 [GRCh38]
Chr17:4623747 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.747G>T (p.Gln249His) single nucleotide variant not specified [RCV004144755] Chr17:4718652 [GRCh38]
Chr17:4621947 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.1216G>A (p.Asp406Asn) single nucleotide variant not specified [RCV004156862] Chr17:4721025 [GRCh38]
Chr17:4624320 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.287G>A (p.Arg96Gln) single nucleotide variant not specified [RCV004326801] Chr17:4716538 [GRCh38]
Chr17:4619833 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.617A>G (p.Lys206Arg) single nucleotide variant not specified [RCV004322761] Chr17:4718019 [GRCh38]
Chr17:4621314 [GRCh37]
Chr17:17p13.2
uncertain significance
GRCh38/hg38 17p13.3-12(chr17:165730-11404096)x3 copy number gain Chromosome 17p13.3 duplication syndrome [RCV003327726] Chr17:165730..11404096 [GRCh38]
Chr17:17p13.3-12
pathogenic
NM_004313.4(ARRB2):c.918C>T (p.Ile306=) single nucleotide variant not specified [RCV004336742] Chr17:4720216 [GRCh38]
Chr17:4623511 [GRCh37]
Chr17:17p13.2
likely benign
GRCh37/hg19 17p13.3-13.2(chr17:9474-6017500)x1 copy number loss not specified [RCV003987214] Chr17:9474..6017500 [GRCh37]
Chr17:17p13.3-13.2
pathogenic
GRCh37/hg19 17p13.3-11.2(chr17:525-21510992)x3 copy number gain not specified [RCV003987215] Chr17:525..21510992 [GRCh37]
Chr17:17p13.3-11.2
pathogenic
NM_004313.4(ARRB2):c.1084G>A (p.Ala362Thr) single nucleotide variant not specified [RCV004418188] Chr17:4720588 [GRCh38]
Chr17:4623883 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.515T>C (p.Val172Ala) single nucleotide variant not specified [RCV004418189] Chr17:4717917 [GRCh38]
Chr17:4621212 [GRCh37]
Chr17:17p13.2
uncertain significance
NM_004313.4(ARRB2):c.992C>T (p.Ser331Phe) single nucleotide variant not specified [RCV004418191] Chr17:4720290 [GRCh38]
Chr17:4623585 [GRCh37]
Chr17:17p13.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6542
Count of miRNA genes:1080
Interacting mature miRNAs:1410
Transcripts:ENST00000269260, ENST00000346341, ENST00000381488, ENST00000412477, ENST00000570718, ENST00000570739, ENST00000571206, ENST00000571428, ENST00000571791, ENST00000572457, ENST00000572497, ENST00000572782, ENST00000573886, ENST00000574502, ENST00000574888, ENST00000574954, ENST00000575131, ENST00000575877, ENST00000576235, ENST00000577054
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D17S1272  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37174,622,896 - 4,623,018UniSTSGRCh37
Build 36174,569,645 - 4,569,767RGDNCBI36
Celera174,638,076 - 4,638,198RGD
Cytogenetic Map17p13UniSTS
HuRef174,511,967 - 4,512,089UniSTS
ARRB2_8210  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37174,624,313 - 4,624,990UniSTSGRCh37
Build 36174,571,062 - 4,571,739RGDNCBI36
Celera174,639,493 - 4,640,170RGD
HuRef174,513,384 - 4,514,061UniSTS
RH18345  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37174,624,584 - 4,624,764UniSTSGRCh37
Build 36174,571,333 - 4,571,513RGDNCBI36
Celera174,639,764 - 4,639,944RGD
Cytogenetic Map17p13UniSTS
HuRef174,513,655 - 4,513,835UniSTS
GeneMap99-GB4 RH Map1742.11UniSTS
NCBI RH Map1754.6UniSTS
WI-11146  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37174,624,534 - 4,624,723UniSTSGRCh37
Build 36174,571,283 - 4,571,472RGDNCBI36
Celera174,639,714 - 4,639,903RGD
Cytogenetic Map17p13UniSTS
HuRef174,513,605 - 4,513,794UniSTS
GeneMap99-GB4 RH Map1744.76UniSTS
Whitehead-RH Map1755.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 205 205
Medium 2416 2311 1625 537 1728 395 3481 1223 3525 350 1266 1558 155 1203 1971 3
Low 20 470 98 85 18 70 875 971 195 68 183 51 17 1 817 1
Below cutoff 1 1 11 1 4 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001257328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001257329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001257330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001257331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_047516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF106941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG723452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR450310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ314866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ664180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU883572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000269260   ⟹   ENSP00000269260
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,632 - 4,721,497 (+)Ensembl
RefSeq Acc Id: ENST00000346341   ⟹   ENSP00000341895
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,634 - 4,721,499 (+)Ensembl
RefSeq Acc Id: ENST00000381488   ⟹   ENSP00000370898
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,693 - 4,721,061 (+)Ensembl
RefSeq Acc Id: ENST00000412477   ⟹   ENSP00000403701
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,693 - 4,721,496 (+)Ensembl
RefSeq Acc Id: ENST00000570718
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,632 - 4,716,539 (+)Ensembl
RefSeq Acc Id: ENST00000570739
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,632 - 4,717,941 (+)Ensembl
RefSeq Acc Id: ENST00000571206   ⟹   ENSP00000460607
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,715,589 - 4,721,138 (+)Ensembl
RefSeq Acc Id: ENST00000571428   ⟹   ENSP00000465877
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,697 - 4,719,418 (+)Ensembl
RefSeq Acc Id: ENST00000571791
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,682 - 4,717,062 (+)Ensembl
RefSeq Acc Id: ENST00000572457   ⟹   ENSP00000465296
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,643 - 4,721,482 (+)Ensembl
RefSeq Acc Id: ENST00000572497   ⟹   ENSP00000458946
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,691 - 4,716,515 (+)Ensembl
RefSeq Acc Id: ENST00000572782
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,714,551 - 4,716,002 (+)Ensembl
RefSeq Acc Id: ENST00000573886
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,691 - 4,718,370 (+)Ensembl
RefSeq Acc Id: ENST00000574502   ⟹   ENSP00000458371
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,596 - 4,719,413 (+)Ensembl
RefSeq Acc Id: ENST00000574888
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,655 - 4,716,473 (+)Ensembl
RefSeq Acc Id: ENST00000574954   ⟹   ENSP00000466344
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,630 - 4,721,096 (+)Ensembl
RefSeq Acc Id: ENST00000575131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,661 - 4,717,379 (+)Ensembl
RefSeq Acc Id: ENST00000575877   ⟹   ENSP00000466857
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,699 - 4,721,496 (+)Ensembl
RefSeq Acc Id: ENST00000576235   ⟹   ENSP00000460879
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,710,724 - 4,720,407 (+)Ensembl
RefSeq Acc Id: ENST00000577054
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl174,717,436 - 4,718,149 (+)Ensembl
RefSeq Acc Id: NM_001257328   ⟹   NP_001244257
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
GRCh37174,613,789 - 4,624,795 (+)NCBI
HuRef174,502,952 - 4,513,866 (+)NCBI
CHM1_1174,622,557 - 4,633,518 (+)NCBI
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001257329   ⟹   NP_001244258
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
GRCh37174,613,789 - 4,624,795 (+)NCBI
HuRef174,502,952 - 4,513,866 (+)NCBI
CHM1_1174,622,557 - 4,633,518 (+)NCBI
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001257330   ⟹   NP_001244259
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
GRCh37174,613,789 - 4,624,795 (+)NCBI
HuRef174,502,952 - 4,513,866 (+)NCBI
CHM1_1174,622,557 - 4,633,518 (+)NCBI
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001257331   ⟹   NP_001244260
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
GRCh37174,613,789 - 4,624,795 (+)NCBI
HuRef174,502,952 - 4,513,866 (+)NCBI
CHM1_1174,622,557 - 4,633,518 (+)NCBI
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001330064   ⟹   NP_001316993
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004313   ⟹   NP_004304
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
GRCh37174,613,789 - 4,624,795 (+)ENTREZGENE
Build 36174,560,538 - 4,571,544 (+)NCBI Archive
HuRef174,502,952 - 4,513,866 (+)ENTREZGENE
CHM1_1174,622,557 - 4,633,518 (+)NCBI
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
Sequence:
RefSeq Acc Id: NM_199004   ⟹   NP_945355
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
GRCh37174,613,789 - 4,624,795 (+)ENTREZGENE
Build 36174,560,538 - 4,571,544 (+)NCBI Archive
HuRef174,502,952 - 4,513,866 (+)ENTREZGENE
CHM1_1174,622,557 - 4,633,518 (+)NCBI
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
Sequence:
RefSeq Acc Id: NR_047516
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
GRCh37174,613,789 - 4,624,795 (+)NCBI
HuRef174,502,952 - 4,513,866 (+)NCBI
CHM1_1174,622,557 - 4,633,518 (+)NCBI
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011523858   ⟹   XP_011522160
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,759 - 4,721,497 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017024645   ⟹   XP_016880134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,715,186 - 4,721,497 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024450752   ⟹   XP_024306520
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024450753   ⟹   XP_024306521
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047436062   ⟹   XP_047292018
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,811 - 4,721,497 (+)NCBI
RefSeq Acc Id: XM_047436063   ⟹   XP_047292019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,811 - 4,721,497 (+)NCBI
RefSeq Acc Id: XM_047436064   ⟹   XP_047292020
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,811 - 4,721,497 (+)NCBI
RefSeq Acc Id: XM_047436065   ⟹   XP_047292021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,811 - 4,721,497 (+)NCBI
RefSeq Acc Id: XM_047436066   ⟹   XP_047292022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
RefSeq Acc Id: XM_047436067   ⟹   XP_047292023
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,632 - 4,721,497 (+)NCBI
RefSeq Acc Id: XM_054316119   ⟹   XP_054172094
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,600,498 - 4,611,146 (+)NCBI
RefSeq Acc Id: XM_054316120   ⟹   XP_054172095
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,604,651 - 4,611,146 (+)NCBI
RefSeq Acc Id: XM_054316121   ⟹   XP_054172096
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
RefSeq Acc Id: XM_054316122   ⟹   XP_054172097
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
RefSeq Acc Id: XM_054316123   ⟹   XP_054172098
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
RefSeq Acc Id: XM_054316124   ⟹   XP_054172099
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBI
RefSeq Acc Id: XM_054316125   ⟹   XP_054172100
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,604,693 - 4,611,146 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001244257 (Get FASTA)   NCBI Sequence Viewer  
  NP_001244258 (Get FASTA)   NCBI Sequence Viewer  
  NP_001244259 (Get FASTA)   NCBI Sequence Viewer  
  NP_001244260 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316993 (Get FASTA)   NCBI Sequence Viewer  
  NP_004304 (Get FASTA)   NCBI Sequence Viewer  
  NP_945355 (Get FASTA)   NCBI Sequence Viewer  
  XP_011522160 (Get FASTA)   NCBI Sequence Viewer  
  XP_016880134 (Get FASTA)   NCBI Sequence Viewer  
  XP_024306520 (Get FASTA)   NCBI Sequence Viewer  
  XP_024306521 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292018 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292019 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292020 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292021 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292022 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292023 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172094 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172095 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172096 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172097 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172098 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172099 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172100 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC99468 (Get FASTA)   NCBI Sequence Viewer  
  AAH07427 (Get FASTA)   NCBI Sequence Viewer  
  AAH67368 (Get FASTA)   NCBI Sequence Viewer  
  ABC40725 (Get FASTA)   NCBI Sequence Viewer  
  ABG47460 (Get FASTA)   NCBI Sequence Viewer  
  ACG60646 (Get FASTA)   NCBI Sequence Viewer  
  BAC05094 (Get FASTA)   NCBI Sequence Viewer  
  BAD93023 (Get FASTA)   NCBI Sequence Viewer  
  BAF83640 (Get FASTA)   NCBI Sequence Viewer  
  BAG59581 (Get FASTA)   NCBI Sequence Viewer  
  BAG59672 (Get FASTA)   NCBI Sequence Viewer  
  CAA77577 (Get FASTA)   NCBI Sequence Viewer  
  CAG29306 (Get FASTA)   NCBI Sequence Viewer  
  CAH18075 (Get FASTA)   NCBI Sequence Viewer  
  CCQ43257 (Get FASTA)   NCBI Sequence Viewer  
  EAW90419 (Get FASTA)   NCBI Sequence Viewer  
  EAW90420 (Get FASTA)   NCBI Sequence Viewer  
  EAW90421 (Get FASTA)   NCBI Sequence Viewer  
  EAW90422 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000269260
  ENSP00000269260.2
  ENSP00000341895
  ENSP00000341895.2
  ENSP00000370898
  ENSP00000370898.6
  ENSP00000403701
  ENSP00000403701.3
  ENSP00000458371.1
  ENSP00000458946.1
  ENSP00000460607.1
  ENSP00000460879.1
  ENSP00000465296
  ENSP00000465296.1
  ENSP00000465877.1
  ENSP00000466344.1
  ENSP00000466857
  ENSP00000466857.1
GenBank Protein P32121 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_004304   ⟸   NM_004313
- Peptide Label: isoform 1
- UniProtKB: Q8N7Y2 (UniProtKB/Swiss-Prot),   Q6ICT3 (UniProtKB/Swiss-Prot),   Q2PP19 (UniProtKB/Swiss-Prot),   Q0Z8D3 (UniProtKB/Swiss-Prot),   H0Y688 (UniProtKB/Swiss-Prot),   D3DTK2 (UniProtKB/Swiss-Prot),   B7WPL3 (UniProtKB/Swiss-Prot),   B5B0C0 (UniProtKB/Swiss-Prot),   B4DLW0 (UniProtKB/Swiss-Prot),   Q9UEQ6 (UniProtKB/Swiss-Prot),   P32121 (UniProtKB/Swiss-Prot),   A8K4I6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_945355   ⟸   NM_199004
- Peptide Label: isoform 2
- UniProtKB: A8K4I6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001244257   ⟸   NM_001257328
- Peptide Label: isoform 3
- UniProtKB: A8K4I6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001244259   ⟸   NM_001257330
- Peptide Label: isoform 5
- UniProtKB: A8K4I6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001244258   ⟸   NM_001257329
- Peptide Label: isoform 4
- UniProtKB: K7ENA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001244260   ⟸   NM_001257331
- Peptide Label: isoform 6
- UniProtKB: A8K4I6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011522160   ⟸   XM_011523858
- Peptide Label: isoform X2
- UniProtKB: A8K4I6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016880134   ⟸   XM_017024645
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001316993   ⟸   NM_001330064
- Peptide Label: isoform 7
- UniProtKB: Q68DZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024306520   ⟸   XM_024450752
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024306521   ⟸   XM_024450753
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000341895   ⟸   ENST00000346341
RefSeq Acc Id: ENSP00000269260   ⟸   ENST00000269260
RefSeq Acc Id: ENSP00000403701   ⟸   ENST00000412477
RefSeq Acc Id: ENSP00000460607   ⟸   ENST00000571206
RefSeq Acc Id: ENSP00000465877   ⟸   ENST00000571428
RefSeq Acc Id: ENSP00000458946   ⟸   ENST00000572497
RefSeq Acc Id: ENSP00000465296   ⟸   ENST00000572457
RefSeq Acc Id: ENSP00000466344   ⟸   ENST00000574954
RefSeq Acc Id: ENSP00000458371   ⟸   ENST00000574502
RefSeq Acc Id: ENSP00000466857   ⟸   ENST00000575877
RefSeq Acc Id: ENSP00000460879   ⟸   ENST00000576235
RefSeq Acc Id: ENSP00000370898   ⟸   ENST00000381488
RefSeq Acc Id: XP_047292022   ⟸   XM_047436066
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047292023   ⟸   XM_047436067
- Peptide Label: isoform X3
- UniProtKB: Q68DZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047292018   ⟸   XM_047436062
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047292021   ⟸   XM_047436065
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047292019   ⟸   XM_047436063
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047292020   ⟸   XM_047436064
- Peptide Label: isoform X3
- UniProtKB: Q68DZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172096   ⟸   XM_054316121
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054172097   ⟸   XM_054316122
- Peptide Label: isoform X3
- UniProtKB: Q68DZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172098   ⟸   XM_054316123
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054172099   ⟸   XM_054316124
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054172094   ⟸   XM_054316119
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054172095   ⟸   XM_054316120
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054172100   ⟸   XM_054316125
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32121-F1-model_v2 AlphaFold P32121 1-409 view protein structure

Promoters
RGD ID:6793753
Promoter ID:HG_KWN:24741
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000381488,   NM_004313,   NM_199004,   UC002FYM.1,   UC002FYN.1,   UC010CKQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36174,560,131 - 4,560,787 (+)MPROMDB
RGD ID:7233429
Promoter ID:EPDNEW_H22460
Type:initiation region
Name:ARRB2_2
Description:arrestin beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22461  EPDNEW_H22463  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,427 - 4,710,487EPDNEW
RGD ID:7233431
Promoter ID:EPDNEW_H22461
Type:initiation region
Name:ARRB2_1
Description:arrestin beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22460  EPDNEW_H22463  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,710,682 - 4,710,742EPDNEW
RGD ID:7233435
Promoter ID:EPDNEW_H22463
Type:initiation region
Name:ARRB2_3
Description:arrestin beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22460  EPDNEW_H22461  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38174,714,891 - 4,714,951EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:712 AgrOrtholog
COSMIC ARRB2 COSMIC
Ensembl Genes ENSG00000141480 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000269260 ENTREZGENE
  ENST00000269260.7 UniProtKB/Swiss-Prot
  ENST00000346341 ENTREZGENE
  ENST00000346341.6 UniProtKB/Swiss-Prot
  ENST00000381488 ENTREZGENE
  ENST00000381488.10 UniProtKB/Swiss-Prot
  ENST00000412477 ENTREZGENE
  ENST00000412477.7 UniProtKB/Swiss-Prot
  ENST00000571206.1 UniProtKB/TrEMBL
  ENST00000571428.5 UniProtKB/TrEMBL
  ENST00000572457 ENTREZGENE
  ENST00000572457.5 UniProtKB/TrEMBL
  ENST00000572497.5 UniProtKB/TrEMBL
  ENST00000574502.5 UniProtKB/TrEMBL
  ENST00000574954.5 UniProtKB/TrEMBL
  ENST00000575877 ENTREZGENE
  ENST00000575877.5 UniProtKB/TrEMBL
  ENST00000576235.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000141480 GTEx
HGNC ID HGNC:712 ENTREZGENE
Human Proteome Map ARRB2 Human Proteome Map
InterPro Arrestin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:409 UniProtKB/Swiss-Prot
NCBI Gene 409 ENTREZGENE
OMIM 107941 OMIM
PANTHER BETA-ARRESTIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11792 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA60 PharmGKB
PRINTS ARRESTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARRESTINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K4I6 ENTREZGENE, UniProtKB/TrEMBL
  ARRB2_HUMAN UniProtKB/Swiss-Prot
  B4DLW0 ENTREZGENE
  B5B0C0 ENTREZGENE
  B7WPL3 ENTREZGENE
  D3DTK2 ENTREZGENE
  H0Y688 ENTREZGENE
  I3L0V6_HUMAN UniProtKB/TrEMBL
  I3L1M6_HUMAN UniProtKB/TrEMBL
  I3L412_HUMAN UniProtKB/TrEMBL
  K7EL17_HUMAN UniProtKB/TrEMBL
  K7ENA6 ENTREZGENE, UniProtKB/TrEMBL
  L8ECB1_HUMAN UniProtKB/TrEMBL
  P32121 ENTREZGENE
  Q0Z8D3 ENTREZGENE
  Q2PP19 ENTREZGENE
  Q59EM5_HUMAN UniProtKB/TrEMBL
  Q68DZ5 ENTREZGENE, UniProtKB/TrEMBL
  Q6ICT3 ENTREZGENE
  Q8N7Y2 ENTREZGENE
  Q9UEQ6 ENTREZGENE
UniProt Secondary B4DLW0 UniProtKB/Swiss-Prot
  B5B0C0 UniProtKB/Swiss-Prot
  B7WPL3 UniProtKB/Swiss-Prot
  D3DTK2 UniProtKB/Swiss-Prot
  E7EMN1 UniProtKB/TrEMBL
  H0Y688 UniProtKB/Swiss-Prot
  Q0Z8D3 UniProtKB/Swiss-Prot
  Q2PP19 UniProtKB/Swiss-Prot
  Q6ICT3 UniProtKB/Swiss-Prot
  Q8N7Y2 UniProtKB/Swiss-Prot
  Q9UEQ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-04 ARRB2  arrestin beta 2    arrestin, beta 2  Symbol and/or name change 5135510 APPROVED