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Gene: ARRB2 (arrestin beta 2) Homo sapiens
Symbol: ARRB2
Name: arrestin beta 2
Description: Exhibits angiotensin receptor binding activity; molecular adaptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular protein metabolic process; regulation of protein ubiquitination; and regulation of signal transduction. Localizes to endocytic vesicle; nucleus; and plasma membrane. Biomarker of portal hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARB2; ARR2; arrestin 3; arrestin beta-2; arrestin, beta 2; BARR2; beta-arrestin-2; DKFZp686L0365; non-visual arrestin-3
Mus musculus (house mouse) : Arrb2 (arrestin, beta 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arrb2 (arrestin, beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arrb2 (arrestin beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ARRB2 (arrestin beta 2)
Canis lupus familiaris (dog) : ARRB2 (arrestin beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arrb2 (arrestin beta 2)
Sus scrofa (pig) : ARRB2 (arrestin beta 2)
Chlorocebus sabaeus (African green monkey) : ARRB2 (arrestin beta 2)
Heterocephalus glaber (naked mole-rat) : Arrb2 (arrestin beta 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl174,710,596 - 4,721,499 (+)EnsemblGRCh38hg38GRCh38
GRCh38174,710,619 - 4,721,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37174,613,789 - 4,624,795 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,560,538 - 4,571,544 (+)NCBINCBI36hg18NCBI36
Build 34174,560,537 - 4,571,543NCBI
Celera174,629,166 - 4,639,975 (+)NCBI
Cytogenetic Map17p13.2NCBI
HuRef174,502,952 - 4,513,866 (+)NCBIHuRef
CHM1_1174,622,557 - 4,633,518 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ARRB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731570
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-04-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.