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ONTOLOGY REPORT - ANNOTATIONS


Term:TOR signaling
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Accession:GO:0031929 term browser browse the term
Definition:The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
Comment:Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
Synonyms:exact_synonym: TOR signal transduction;   TOR signaling pathway;   TOR signalling pathway;   target of rapamycin signaling pathway;   target of rapamycin signalling pathway
 related_synonym: TOR signaling cascade



show annotations for term's descendants           Sort by:
TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc88a coiled coil domain containing 88A involved_in ISO (PMID:19778506) RGD PMID:19778506 NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368
JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO MGI:2677631 (PMID:30816216), (PMID:31874168) RGD PMID:30816216 PMID:31874168 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027
JBrowse link
G Csf2 colony stimulating factor 2 acts_upstream_of_positive_effect ISO (PMID:24520418) RGD PMID:24520418 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Disc1 DISC1 scaffold protein involved_in ISO (PMID:19778506) RGD PMID:19778506 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:12150926), (PMID:22578813)
UniProt
RGD
PMID:12150926 PMID:22578813 GO_REF:0000024 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 acts_upstream_of_or_within
involved_in
ISO (PMID:8939971)
(PMID:20347422)
RGD PMID:8939971 PMID:20347422 NCBI chr20:29,379,444...29,400,110
Ensembl chr20:29,382,668...29,399,946
JBrowse link
G Eva1a eva-1 homolog A, regulator of programmed cell death acts_upstream_of_or_within ISO (PMID:28151473) RGD PMID:28151473 NCBI chr 4:114,593,773...114,643,011
Ensembl chr 4:114,593,341...114,643,011
JBrowse link
G Flcn folliculin acts_upstream_of ISO MGI:3774414|MGI:3829641|MGI:3842151|MGI:4348628 (PMID:18182616), (PMID:18974783), (PMID:19234517), (PMID:21258407) RGD PMID:18182616 PMID:18974783 PMID:19234517 PMID:21258407 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
JBrowse link
G Fnip1 folliculin interacting protein 1 acts_upstream_of ISO MGI:5437714 (PMID:22608497) RGD PMID:22608497 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824
JBrowse link
G Gata3 GATA binding protein 3 involved_in ISO (PMID:20696860) RGD PMID:20696860 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
MGI:2384429 (PMID:20808783)
Ensembl
RGD
PMID:20808783 GO_REF:0000107 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase acts_upstream_of_or_within ISO MGI:3033709 (PMID:23686339) RGD PMID:23686339 NCBI chr 5:162,804,368...162,811,129
Ensembl chr 5:162,804,368...162,811,128
JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator involved_in ISO (PMID:24532714) RGD PMID:24532714 NCBI chr10:42,191,378...42,246,361
Ensembl chr10:42,191,325...42,243,371
JBrowse link
G Lipa lipase A, lysosomal acid type involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2451080 (PMID:22383970), (PMID:24287405), (PMID:25807535)
Ensembl
RGD
PMID:22383970 PMID:24287405 PMID:25807535 GO_REF:0000107 NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
JBrowse link
G Meak7 MTOR associated protein, eak-7 homolog involved_in ISO
IBA
(PMID:29750193)
GO_REF:0000033
RGD
GO_Central
PMID:29750193 GO_REF:0000033 NCBI chr19:47,813,899...47,836,830
Ensembl chr19:47,811,416...47,841,278
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog involved_in IEA
IBA
GO_REF:0000104
GO_REF:0000033
UniProt
GO_Central
GO_REF:0000033 GO_REF:0000104 NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128
JBrowse link
G Mtm1 myotubularin 1 acts_upstream_of ISO MGI:2450997 (PMID:23695157) RGD PMID:23695157 NCBI chr 6:488,923...506,882
Ensembl chr 6:488,969...506,860
JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO
ISS
(PMID:15467718), (PMID:17028174), (PMID:18762023), (PMID:26018084), (PMID:29750193)
RNAcentral:URS0000554A4F_10090 (PMID:15485918), (PMID:26160071)
GO_REF:0000024
RGD
UniProt
PMID:15467718 PMID:15485918 PMID:17028174 PMID:18762023 PMID:26018084 More... GO_REF:0000024 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ppdpf pancreatic progenitor cell differentiation and proliferation factor acts_upstream_of_or_within ISO (PMID:34031390) RGD PMID:34031390 NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:168,299,791...168,301,036
JBrowse link
G Rhebl1 RHEB like 1 involved_in ISO (PMID:12869548) RGD PMID:12869548 NCBI chr 7:130,026,255...130,031,127
Ensembl chr 7:130,026,341...130,030,248
JBrowse link
G Rps6 ribosomal protein S6 involved_in ISO (PMID:16428328) RGD PMID:16428328 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 involved_in ISO
ISS
(PMID:12150926), (PMID:28178239), (PMID:29750193)
GO_REF:0000024
RGD
UniProt
PMID:12150926 PMID:28178239 PMID:29750193 GO_REF:0000024 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 involved_in ISO (PMID:29750193) RGD PMID:29750193 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 involved_in ISO (PMID:20381137) RGD PMID:20381137 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Tiprl TOR signaling pathway regulator involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:77,527,176...77,552,026
Ensembl chr13:77,527,176...77,552,074
JBrowse link
negative regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 involved_in ISO (PMID:17386266) RGD PMID:17386266 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:24481314)
UniProt
RGD
PMID:24481314 GO_REF:0000024 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Cryba1 crystallin, beta A1 IMP RGD PMID:21993393 RGD:10059647 NCBI chr10:62,608,373...62,614,726
Ensembl chr10:62,608,383...62,614,726
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
IMP
GO_REF:0000107
(PMID:18198340)
GO_REF:0000033
PMID:21368030
(PMID:20166753)
Ensembl
RGD
GO_Central
PMID:18198340 PMID:20166753 PMID:21368030 GO_REF:0000033 GO_REF:0000107, RGD:8554300 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein involved_in ISO (PMID:19446321) RGD PMID:19446321 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
JBrowse link
G Endog endonuclease G involved_in ISO (PMID:33473107) RGD PMID:33473107 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Epm2a EPM2A glucan phosphatase, laforin acts_upstream_of_or_within ISO (PMID:20453062) RGD PMID:20453062 NCBI chr 1:5,727,111...5,845,338
Ensembl chr 1:5,727,066...5,920,555
JBrowse link
G Flcn folliculin involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:3774414|MGI:3829641|MGI:4348628 (PMID:18182616), (PMID:18974783), (PMID:21258407)
UniProt
RGD
PMID:18182616 PMID:18974783 PMID:21258407 GO_REF:0000024 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
JBrowse link
G Fnip1 folliculin interacting protein 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:5437714 (PMID:22608497)
UniProt
RGD
PMID:22608497 GO_REF:0000024 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IEA
IBA
ISO
GO_REF:0000107
GO_REF:0000033
(PMID:20516643)
Ensembl
GO_Central
RGD
PMID:20516643 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO
IBA
RNAcentral:URS0000554A4F_10090 (PMID:26160071)
GO_REF:0000033
RGD
GO_Central
PMID:26160071 GO_REF:0000033 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2384429 (PMID:20808783)
Ensembl
RGD
PMID:20808783 GO_REF:0000107 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 involved_in IBA
ISO
GO_REF:0000033
(PMID:21336308)
GO_Central
RGD
PMID:21336308 GO_REF:0000033 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052
JBrowse link
G Minar1 membrane integral NOTCH2 associated receptor 1 involved_in ISO
IBA
IEA
IMP
(PMID:30080879)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:30080879 PMID:30080879 GO_REF:0000033 GO_REF:0000107, RGD:13825189 NCBI chr 8:90,137,374...90,169,152
Ensembl chr 8:90,137,374...90,169,137
JBrowse link
G Mirlet7f-1 microRNA let7f-1 involved_in ISO (PMID:21962509) RGD PMID:21962509 NCBI chr17:16,114,130...16,114,226
Ensembl chr17:16,114,130...16,114,226
JBrowse link
G Mirlet7f2 microRNA let-7f-2 involved_in ISO (PMID:21962509) RGD PMID:21962509 NCBI chr  X:20,980,632...20,980,714
Ensembl chr  X:20,980,632...20,980,714
JBrowse link
G Mtm1 myotubularin 1 acts_upstream_of_or_within ISO MGI:2450997 (PMID:23695157) RGD PMID:23695157 NCBI chr 6:488,923...506,882
Ensembl chr 6:488,969...506,860
JBrowse link
G Pdcd6 programmed cell death 6 involved_in ISO (PMID:21893193) RGD PMID:21893193 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189
JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:155,306,950...155,456,688
Ensembl chr 3:155,306,950...155,456,688
JBrowse link
G Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:18439900)
UniProt
RGD
PMID:18439900 GO_REF:0000024 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:18439900)
UniProt
RGD
PMID:18439900 GO_REF:0000024 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 involved_in ISO
IEA
(PMID:35772404)
GO_REF:0000107
RGD
Ensembl
PMID:35772404 GO_REF:0000107 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Sh3bp4 SH3-domain binding protein 4 involved_in ISO
IEA
ISS
(PMID:22575674)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:22575674 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:89,660,156...89,739,163
Ensembl chr 9:89,660,156...89,739,163
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA
(PMID:20169165)
GO_REF:0000107
RGD
Ensembl
PMID:20169165 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tbc1d7 TBC1 domain family, member 7 involved_in ISO
IBA
(PMID:22795129)
GO_REF:0000033
RGD
GO_Central
PMID:22795129 GO_REF:0000033 NCBI chr17:21,530,709...21,548,556
Ensembl chr17:21,531,016...21,548,553
JBrowse link
G Tmem127 transmembrane protein 127 involved_in ISO (PMID:20154675) RGD PMID:20154675 NCBI chr 3:114,466,095...114,478,894
Ensembl chr 3:114,466,171...114,477,519
JBrowse link
G Tmem127l1 transmembrane protein 127 like 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:37,679,675...37,680,635
Ensembl chr11:37,680,010...37,680,474
JBrowse link
G Tnfaip8l1 TNF alpha induced protein 8 like 1 involved_in IBA
ISO
GO_REF:0000033
(PMID:21600655)
GO_Central
RGD
PMID:21600655 GO_REF:0000033 NCBI chr 9:988,587...999,342
Ensembl chr 9:988,594...1,002,254
JBrowse link
G Tsc1 TSC complex subunit 1 involved_in IMP
IBA
ISO
PMID:23435171
GO_REF:0000033
(PMID:17308101), (PMID:22795129), (PMID:28215400)
GO_Central
RGD
PMID:17308101 PMID:22795129 PMID:28215400 PMID:23435171 GO_REF:0000033, RGD:10448950 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
JBrowse link
G Tsc2 TSC complex subunit 2 involved_in
acts_upstream_of_or_within
IDA
IBA
ISO
IEA
GO_REF:0000033
UniProtKB:P49815 (PMID:23778976)
(PMID:18198340)
UniProtKB:Q61037 (PMID:22795129), (PMID:23778976)
GO_REF:0000002
GO_Central
RGD
InterPro
PMID:18198340 PMID:22795129 PMID:23778976 PMID:12869586 GO_REF:0000002 GO_REF:0000033, RGD:1580520 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Tsc2_v2 TSC complex subunit 2, variant 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 involved_in ISO (PMID:20298436) RGD PMID:20298436 NCBI chr 3:107,813,721...107,921,701
Ensembl chr 3:107,811,392...107,922,204
JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 involved_in ISO (PMID:20298436) RGD PMID:20298436 NCBI chr 9:13,982,427...14,062,315
Ensembl chr 9:13,982,329...14,062,139
JBrowse link
negative regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 involved_in ISO
IBA
(PMID:17386266), (PMID:17510057), (PMID:18372248), (PMID:29236692)
GO_REF:0000033
RGD
GO_Central
PMID:17386266 PMID:17510057 PMID:18372248 PMID:29236692 GO_REF:0000033 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
JBrowse link
G Alg13 ALG13, UDP-N-acetylglucosaminyltransferase subunit acts_upstream_of_or_within ISO MGI:6358168 (PMID:30872163) RGD PMID:30872163 NCBI chr  X:107,906,320...107,968,232
Ensembl chr  X:107,885,093...107,942,695
JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO
IBA
(PMID:23878245)
GO_REF:0000033
RGD
GO_Central
PMID:23878245 GO_REF:0000033 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atxn3 ataxin 3 involved_in ISO
IBA
ISS
(PMID:33157014)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:33157014 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 involved_in ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:26972053), (PMID:33594058)
UniProt
GO_Central
RGD
PMID:26972053 PMID:33594058 GO_REF:0000024 GO_REF:0000033 NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548
JBrowse link
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 involved_in ISO
IBA
(PMID:26972053)
GO_REF:0000033
RGD
GO_Central
PMID:26972053 GO_REF:0000033 NCBI chr12:22,577,504...22,620,182
Ensembl chr12:22,577,512...22,620,182
JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit involved_in ISO
IBA
(PMID:25457612), (PMID:29590090), (PMID:29769719), (PMID:35338845)
GO_REF:0000033
RGD
GO_Central
PMID:25457612 PMID:29590090 PMID:29769719 PMID:35338845 GO_REF:0000033 NCBI chr14:77,732,297...77,862,924
Ensembl chr14:77,732,297...77,862,794
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein involved_in ISO
IBA
UniProtKB:Q96G74 (PMID:22017875), (PMID:22017876), (PMID:22017877), (PMID:25936805), (PMID:33110214), (PMID:33865870), (PMID:34519268), (PMID:34519269), (PMID:34634301)
GO_REF:0000033
RGD
GO_Central
PMID:22017875 PMID:22017876 PMID:22017877 PMID:25936805 PMID:33110214 More... GO_REF:0000033 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 involved_in ISO (PMID:28199306) RGD PMID:28199306 NCBI chr 4:161,684,249...161,698,315
Ensembl chr 4:161,684,249...161,698,422
JBrowse link
G Kics2 KICSTOR subunit 2 involved_in ISO
IBA
(PMID:28199306)
GO_REF:0000033
RGD
GO_Central
PMID:28199306 GO_REF:0000033 NCBI chr 7:57,284,213...57,299,070
Ensembl chr 7:57,284,192...57,297,486
JBrowse link
G Kptn kaptin (actin binding protein) involved_in ISO (PMID:28199306) RGD PMID:28199306 NCBI chr 1:76,808,737...76,809,531 JBrowse link
G Mapk3 mitogen activated protein kinase 3 involved_in ISO (PMID:35216969) RGD PMID:35216969 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nlk nemo like kinase involved_in ISO
ISS
(PMID:26588989)
GO_REF:0000024
RGD
UniProt
PMID:26588989 GO_REF:0000024 NCBI chr10:63,467,388...63,590,960
Ensembl chr10:63,438,222...63,589,730
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 involved_in ISO (PMID:28336668) RGD PMID:28336668 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit involved_in ISO
IBA
(PMID:29590090), (PMID:30651352), (PMID:35338845)
(PMID:26166573), (PMID:29768191)
GO_REF:0000033
RGD
GO_Central
PMID:26166573 PMID:29590090 PMID:29768191 PMID:30651352 PMID:35338845 GO_REF:0000033 NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996
JBrowse link
G Nprl3 NPR3-like, GATOR1 complex subunit involved_in ISO
IBA
(PMID:29590090), (PMID:35338845)
GO_REF:0000033
RGD
GO_Central
PMID:29590090 PMID:35338845 GO_REF:0000033 NCBI chr10:15,355,361...15,395,812
Ensembl chr10:15,355,355...15,395,810
JBrowse link
G Otud7b OTU deubiquitinase 7B involved_in ISO (PMID:28489822) RGD PMID:28489822 NCBI chr 2:183,661,955...183,722,584
Ensembl chr 2:183,662,163...183,718,674
JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 involved_in ISO (PMID:33215753) RGD PMID:33215753 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285
Ensembl chr 1:95,254,589...95,308,285
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 involved_in ISO
IBA
ISS
(PMID:14651849), (PMID:18439900), (PMID:36732624), (PMID:37079666)
GO_REF:0000033
(PMID:32912901)
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:14651849 PMID:18439900 PMID:32912901 PMID:36732624 PMID:37079666 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 involved_in ISO
IBA
ISS
IEA
(PMID:14651849), (PMID:18439900), (PMID:36732624), (PMID:37079666)
GO_REF:0000033
(PMID:32912901)
GO_REF:0000024
GO_REF:0000107
RGD
GO_Central
UniProt
Ensembl
PMID:14651849 PMID:18439900 PMID:32912901 PMID:36732624 PMID:37079666 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in ISO
IEA
ISS
(PMID:31112131)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:31112131 GO_REF:0000024 GO_REF:0000107 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta involved_in ISO
IEA
ISS
(PMID:31112131)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:31112131 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO MGI:2385927|MGI:2679886 (PMID:29057879) RGD PMID:29057879 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rnf152 ring finger protein 152 involved_in ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:25936802)
(PMID:25936802), (PMID:30514904)
UniProt
GO_Central
RGD
PMID:25936802 PMID:30514904 GO_REF:0000024 GO_REF:0000033 NCBI chr13:21,324,039...21,403,405
Ensembl chr13:21,323,824...21,403,113
JBrowse link
G Rnf167 ring finger protein 167 involved_in ISS
ISO
GO_REF:0000024
(PMID:35114100)
UniProt
RGD
PMID:35114100 GO_REF:0000024 NCBI chr10:55,360,603...55,364,927
Ensembl chr10:55,360,543...55,364,927
JBrowse link
G Samtor S-adenosylmethionine sensor upstream of mTORC1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539
JBrowse link
G Sar1a secretion associated, Ras related GTPase 1A involved_in ISO (PMID:34290409) RGD PMID:34290409 NCBI chr20:29,623,529...29,635,935
Ensembl chr20:29,623,553...29,635,935
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B involved_in ISO (PMID:34290409) RGD PMID:34290409 NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066
JBrowse link
G Sesn1 sestrin 1 involved_in ISO
IBA
(PMID:18692468), (PMID:25263562)
(PMID:25259925)
GO_REF:0000033
RGD
GO_Central
PMID:18692468 PMID:25259925 PMID:25263562 GO_REF:0000033 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sesn2 sestrin 2 involved_in ISO
IBA
(PMID:18692468), (PMID:24947615), (PMID:25263562), (PMID:25457612), (PMID:26449471), (PMID:26586190), (PMID:26612684), (PMID:35114100)
(PMID:24947615), (PMID:25259925)
GO_REF:0000033
RGD
GO_Central
PMID:18692468 PMID:24947615 PMID:25259925 PMID:25263562 PMID:25457612 More... GO_REF:0000033 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Sesn3 sestrin 3 involved_in ISO
IBA
(PMID:25263562)
(PMID:25259925)
GO_REF:0000033
RGD
GO_Central
PMID:25259925 PMID:25263562 GO_REF:0000033 NCBI chr 8:11,133,822...11,189,436
Ensembl chr 8:11,133,678...11,185,842
JBrowse link
G Spaar small regulatory polypeptide of amino acid response involved_in ISO (PMID:28024296) RGD PMID:28024296 NCBI chr 5:57,985,423...57,987,482 JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:23878245) RGD PMID:23878245 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Szt2 SZT2 subunit of KICSTOR complex involved_in ISO (PMID:28199306), (PMID:28199315) RGD PMID:28199306 PMID:28199315 NCBI chr 5:131,897,250...131,943,953
Ensembl chr 5:131,897,275...131,943,904
JBrowse link
G Tbc1d7 TBC1 domain family, member 7 involved_in ISO (PMID:24529379) RGD PMID:24529379 NCBI chr17:21,530,709...21,548,556
Ensembl chr17:21,531,016...21,548,553
JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in ISO (PMID:31530866) RGD PMID:31530866 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Tsc1 TSC complex subunit 1 involved_in ISO
ISS
IEA
(PMID:12172553), (PMID:12842888), (PMID:12906785), (PMID:24529379)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:12172553 PMID:12842888 PMID:12906785 PMID:24529379 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
JBrowse link
G Tsc2 TSC complex subunit 2 involved_in ISO
IEA
ISS
(PMID:12172553), (PMID:12842888), (PMID:12906785), (PMID:22819219), (PMID:24529379), (PMID:33436626), (PMID:9045618)
(PMID:12820960), (PMID:23878245), (PMID:24529379)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:9045618 PMID:12172553 PMID:12820960 PMID:12842888 PMID:12906785 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024
G Tsc2_v2 TSC complex subunit 2, variant 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 involved_in ISO
IEA
(PMID:35927303)
GO_REF:0000107
RGD
Ensembl
PMID:35927303 GO_REF:0000107 NCBI chr20:17,309,315...17,343,770
Ensembl chr20:17,309,315...17,342,295
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N involved_in ISO (PMID:35927303) RGD PMID:35927303 NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W involved_in ISO (PMID:35927303) RGD PMID:35927303 NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965
JBrowse link
G Ube3a ubiquitin protein ligase E3A involved_in ISO (PMID:30020076) RGD PMID:30020076 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
JBrowse link
G Usp7 ubiquitin specific peptidase 7 involved_in ISO
IEA
(PMID:35216969)
GO_REF:0000107
RGD
Ensembl
PMID:35216969 GO_REF:0000107 NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor involved_in ISO
ISS
(PMID:34290272)
GO_REF:0000024
RGD
UniProt
PMID:34290272 GO_REF:0000024 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma involved_in ISO (PMID:36732624) RGD PMID:36732624 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta involved_in ISO
IEA
(PMID:18439900)
GO_REF:0000107
RGD
Ensembl
PMID:18439900 GO_REF:0000107 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
JBrowse link
negative regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Deptor DEP domain containing MTOR-interacting protein involved_in ISO
IBA
UniProtKB:Q96G74 (PMID:25936805), (PMID:33110214), (PMID:33865870), (PMID:34519268), (PMID:34634301)
GO_REF:0000033
RGD
GO_Central
PMID:25936805 PMID:33110214 PMID:33865870 PMID:34519268 PMID:34634301 GO_REF:0000033 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO
IEA
ISS
(PMID:21343617)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:21343617 GO_REF:0000024 GO_REF:0000107 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 involved_in ISO
ISS
(PMID:19720745), (PMID:19935711), (PMID:19995915)
(PMID:24161930)
GO_REF:0000024
RGD
UniProt
PMID:19720745 PMID:19935711 PMID:19995915 PMID:24161930 GO_REF:0000024 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
positive regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt3 AKT serine/threonine kinase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3574346 (PMID:15713641)
Ensembl
RGD
PMID:15713641 GO_REF:0000107 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 involved_in ISO (PMID:18337562) RGD PMID:18337562 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G ENSRNOG00000066475 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 7:1,169,039...1,178,734 JBrowse link
G F10 coagulation factor X involved_in IEA
ISO
GO_REF:0000107
(PMID:18612547)
Ensembl
RGD
PMID:18612547 GO_REF:0000107 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F3 coagulation factor III, tissue factor involved_in ISO (PMID:18612547) RGD PMID:18612547 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G F7 coagulation factor VII involved_in ISO (PMID:18612547) RGD PMID:18612547 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Flcn folliculin involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:3842151 (PMID:19234517)
(PMID:24081491), (PMID:24095279), (PMID:31672913), (PMID:31704029)
UniProt
RGD
PMID:19234517 PMID:24081491 PMID:24095279 PMID:31672913 PMID:31704029 GO_REF:0000024 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
JBrowse link
G Fnip1 folliculin interacting protein 1 involved_in ISO (PMID:24081491) RGD PMID:24081491 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824
JBrowse link
G Gas6 growth arrest specific 6 involved_in IDA PMID:18374201 UniProt PMID:18374201 RGD:8554638 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Golph3 golgi phosphoprotein 3 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19553991)
UniProt
Ensembl
RGD
PMID:19553991 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:61,348,030...61,376,051
Ensembl chr 2:61,348,030...61,376,049
JBrowse link
G Hdac3 histone deacetylase 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:25190803)
UniProt
RGD
PMID:25190803 GO_REF:0000024 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 involved_in ISO
ISS
(PMID:23027611)
GO_REF:0000024
RGD
UniProt
PMID:23027611 GO_REF:0000024 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
JBrowse link
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISO
IEA
ISS
(PMID:20381137)
GO_REF:0000002
GO_REF:0000024
RGD
InterPro
UniProt
PMID:20381137 GO_REF:0000002 GO_REF:0000024 NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179
JBrowse link
G Lamtor1l1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 involved_in ISS
IEA
GO_REF:0000024
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002 GO_REF:0000024 NCBI chr  X:34,637,460...34,638,509
Ensembl chr  X:34,637,459...34,638,516
JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 involved_in ISO
IBA
(PMID:20381137)
GO_REF:0000033
RGD
GO_Central
PMID:20381137 GO_REF:0000033 NCBI chr 2:174,008,556...174,011,950
Ensembl chr 2:174,008,548...174,013,013
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 involved_in ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:20381137)
UniProt
GO_Central
RGD
PMID:20381137 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 involved_in ISO
IBA
(PMID:22980980)
GO_REF:0000033
RGD
GO_Central
PMID:22980980 GO_REF:0000033 NCBI chr12:17,258,656...17,262,478
Ensembl chr12:17,258,623...17,262,480
JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 involved_in ISO (PMID:22980980) RGD PMID:22980980 NCBI chr 2:194,900,038...194,905,394
Ensembl chr 2:194,900,038...194,905,395
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 involved_in ISO (PMID:22424946) RGD PMID:22424946 NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
JBrowse link
G Lep leptin involved_in ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:25060689)
UniProt
GO_Central
RGD
PMID:25060689 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lin28a lin-28 homolog A involved_in ISO (PMID:21962509) RGD PMID:21962509 NCBI chr 5:146,227,119...146,244,122
Ensembl chr 5:146,227,119...146,244,122
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog involved_in ISO
IEA
(PMID:15467718)
GO_REF:0000107
RGD
Ensembl
PMID:15467718 GO_REF:0000107 NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128
JBrowse link
G Reln reelin involved_in IEA
ISO
GO_REF:0000107
(PMID:21664258)
Ensembl
RGD
PMID:21664258 GO_REF:0000107 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rheb Ras homolog, mTORC1 binding involved_in ISO
ISS
(PMID:20381137)
(PMID:21336308)
GO_REF:0000024
RGD
UniProt
PMID:20381137 PMID:21336308 GO_REF:0000024 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 involved_in ISO (PMID:15467718) RGD PMID:15467718 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 involved_in ISO (PMID:12150926), (PMID:18439900) RGD PMID:12150926 PMID:18439900 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Rraga Ras-related GTP binding A involved_in ISO (PMID:23263183) RGD PMID:23263183 NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510
JBrowse link
G RragB Ras-related GTP binding B involved_in ISO
IEA
ISS
(PMID:22575674)
GO_REF:0000104
GO_REF:0000024
RGD
UniProt
PMID:22575674 GO_REF:0000024 GO_REF:0000104 NCBI chr  X:18,184,619...18,234,639
Ensembl chr  X:18,184,992...18,234,639
JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:146,877,739...146,891,130
Ensembl chr 4:146,875,524...146,891,173
JBrowse link
G Sec13-ps2 SEC13 homolog, nuclear pore and COPII coat complex component, pseudogene 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:967,396...968,674
Ensembl chr18:967,394...968,680
Ensembl chr18:967,394...968,680
JBrowse link
G Slc38a9 solute carrier family 38, member 9 involved_in ISO
ISS
(PMID:25561175), (PMID:25567906)
GO_REF:0000024
RGD
UniProt
PMID:25561175 PMID:25567906 GO_REF:0000024 NCBI chr 2:44,291,637...44,374,897
Ensembl chr 2:44,291,989...44,368,955
JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO (PMID:28195531) RGD PMID:28195531 NCBI chr10:45,457,962...45,465,101
Ensembl chr10:45,457,605...45,468,876
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:28802038) RGD PMID:28802038 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Wdr24 WD repeat domain 24 involved_in ISO (PMID:27166823) RGD PMID:27166823 NCBI chr10:14,844,089...14,848,871
Ensembl chr10:14,843,728...14,848,864
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25190803) RGD PMID:25190803 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
positive regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:12172553), (PMID:17386266), (PMID:24529379), (PMID:30514904), (PMID:31548394), (PMID:33594058)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:12172553 PMID:17386266 PMID:24529379 PMID:30514904 PMID:31548394 More... GO_REF:0000024 GO_REF:0000107 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 involved_in ISO (PMID:26972053) RGD PMID:26972053 NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548
JBrowse link
G Clec16a C-type lectin domain containing 16A involved_in ISO (PMID:28223137) RGD PMID:28223137 NCBI chr10:4,927,799...5,123,749
Ensembl chr10:4,928,030...5,123,578
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 involved_in ISO
IEA
(PMID:22017875), (PMID:22017877)
GO_REF:0000107
RGD
Ensembl
PMID:22017875 PMID:22017877 GO_REF:0000107 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
JBrowse link
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:26449607) RGD PMID:26449607 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
JBrowse link
G Cul3 cullin 3 involved_in ISO
IEA
(PMID:29769719)
GO_REF:0000107
RGD
Ensembl
PMID:29769719 GO_REF:0000107 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:30197302), (PMID:32561715) RGD PMID:30197302 PMID:32561715 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Flcn folliculin involved_in ISO
IBA
ISS
(PMID:32612235), (PMID:36103527), (PMID:37079666)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:32612235 PMID:36103527 PMID:37079666 GO_REF:0000024 GO_REF:0000033 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
JBrowse link
G Fnip1 folliculin interacting protein 1 involved_in ISO (PMID:24081491), (PMID:37079666) RGD PMID:24081491 PMID:37079666 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824
JBrowse link
G Fnip2 folliculin interacting protein 2 involved_in ISO (PMID:36103527) RGD PMID:36103527 NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901
JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:109583|MGI:1919421 (PMID:29057879) RGD PMID:29057879 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Gpr137 G protein-coupled receptor 137 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:204,129,636...204,132,622
Ensembl chr 1:204,129,636...204,133,082
JBrowse link
G Gpr137b G protein-coupled receptor 137B involved_in ISO
IBA
(PMID:31036939)
GO_REF:0000033
RGD
GO_Central
PMID:31036939 GO_REF:0000033 NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835
JBrowse link
G Gpr137c G protein-coupled receptor 137C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:18,425,939...18,492,588
Ensembl chr15:18,426,223...18,490,807
JBrowse link
G Gpr155 G protein-coupled receptor 155 involved_in ISO (PMID:36007018) RGD PMID:36007018 NCBI chr 3:58,216,422...58,270,350
Ensembl chr 3:58,216,423...58,270,275
JBrowse link
G Klhl22 kelch-like family member 22 involved_in ISS
ISO
IBA
IEA
GO_REF:0000024
(PMID:29769719)
GO_REF:0000033
GO_REF:0000107
UniProt
RGD
GO_Central
Ensembl
PMID:29769719 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISO
ISS
(PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31001086), (PMID:32686708)
(PMID:30020076)
GO_REF:0000024
RGD
UniProt
PMID:28935770 PMID:29123114 PMID:29158492 PMID:30020076 PMID:31001086 More... GO_REF:0000024 NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179
JBrowse link
G Lamtor1l1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:34,637,460...34,638,509
Ensembl chr  X:34,637,459...34,638,516
JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 involved_in ISO (PMID:28935770), (PMID:29123114), (PMID:29158492) RGD PMID:28935770 PMID:29123114 PMID:29158492 NCBI chr 2:174,008,556...174,011,950
Ensembl chr 2:174,008,548...174,013,013
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 involved_in ISO
ISS
IEA
(PMID:28935770), (PMID:29123114), (PMID:29158492)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:28935770 PMID:29123114 PMID:29158492 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 involved_in ISO (PMID:28935770), (PMID:29123114), (PMID:29158492) RGD PMID:28935770 PMID:29123114 PMID:29158492 NCBI chr12:17,258,656...17,262,478
Ensembl chr12:17,258,623...17,262,480
JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 involved_in ISO
IBA
(PMID:28935770), (PMID:29123114), (PMID:29158492)
GO_REF:0000033
RGD
GO_Central
PMID:28935770 PMID:29123114 PMID:29158492 GO_REF:0000033 NCBI chr 2:194,900,038...194,905,394
Ensembl chr 2:194,900,038...194,905,395
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 involved_in ISO (PMID:22424946) RGD PMID:22424946 NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
JBrowse link
G Mat2a methionine adenosyltransferase 2A involved_in ISO (PMID:38006878) RGD PMID:38006878 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
JBrowse link
G Mios meiosis regulator for oocyte development involved_in ISO
IBA
(PMID:35831510), (PMID:36528027)
(PMID:35022234)
GO_REF:0000033
RGD
GO_Central
PMID:35022234 PMID:35831510 PMID:36528027 GO_REF:0000033 NCBI chr 4:36,263,419...36,289,546
Ensembl chr 4:36,263,968...36,289,544
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:37541260)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:37541260 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 involved_in ISO
ISS
(PMID:35927303)
GO_REF:0000024
RGD
UniProt
PMID:35927303 GO_REF:0000024 NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
JBrowse link
G Otud5 OTU deubiquitinase 5 involved_in ISO
IBA
IEA
(PMID:33110214)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:33110214 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:14,626,173...14,659,331
Ensembl chr  X:14,626,164...14,659,573
JBrowse link
G Pih1d1 PIH1 domain containing 1 involved_in ISO (PMID:24036451) RGD PMID:24036451 NCBI chr 1:95,639,597...95,645,295
Ensembl chr 1:95,639,592...95,645,290
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase involved_in ISO
IBA
ISS
(PMID:31548394)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:31548394 GO_REF:0000024 GO_REF:0000033 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 involved_in ISO
ISS
(PMID:29644770)
GO_REF:0000024
RGD
UniProt
PMID:29644770 GO_REF:0000024 NCBI chr15:24,146,854...24,150,739
Ensembl chr15:24,146,856...24,150,702
JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:38006878)
UniProt
RGD
PMID:38006878 GO_REF:0000024 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Rbx1 ring-box 1 involved_in ISO (PMID:29769719) RGD PMID:29769719 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
JBrowse link
G Rheb Ras homolog, mTORC1 binding involved_in ISO
IEA
ISS
(PMID:12172553), (PMID:12842888), (PMID:12906785), (PMID:15340059), (PMID:22819219), (PMID:24529379), (PMID:29236692), (PMID:29416044), (PMID:30514904), (PMID:32470140), (PMID:33157014)
(PMID:12820960), (PMID:16631613), (PMID:21321084)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:12172553 PMID:12820960 PMID:12842888 PMID:12906785 PMID:15340059 More... GO_REF:0000024 GO_REF:0000107 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Rnf167 ring finger protein 167 involved_in ISO (PMID:33594058) RGD PMID:33594058 NCBI chr10:55,360,603...55,364,927
Ensembl chr10:55,360,543...55,364,927
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 involved_in ISO (PMID:22017876) RGD PMID:22017876 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rraga Ras-related GTP binding A involved_in ISS
IBA
ISO
IEA
GO_REF:0000024
GO_REF:0000033
(PMID:25936802), (PMID:31601708), (PMID:31601764)
GO_REF:0000107
UniProt
GO_Central
RGD
Ensembl
PMID:25936802 PMID:31601708 PMID:31601764 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510
JBrowse link
G RragB Ras-related GTP binding B involved_in ISO
IBA
(PMID:22424946)
GO_REF:0000033
RGD
GO_Central
PMID:22424946 GO_REF:0000033 NCBI chr  X:18,184,619...18,234,639
Ensembl chr  X:18,184,992...18,234,639
JBrowse link
G Rragc Ras-related GTP binding C involved_in IBA
ISO
GO_REF:0000033
(PMID:26691987), (PMID:31601708), (PMID:31601764), (PMID:32612235), (PMID:34071043), (PMID:36608670), (PMID:37057673)
GO_Central
RGD
PMID:26691987 PMID:31601708 PMID:31601764 PMID:32612235 PMID:34071043 More... GO_REF:0000033 NCBI chr 5:136,148,239...136,167,773
Ensembl chr 5:136,148,276...136,167,767
JBrowse link
G Rragd Ras-related GTP binding D involved_in ISO
IBA
(PMID:22424946), (PMID:34607910)
GO_REF:0000033
RGD
GO_Central
PMID:22424946 PMID:34607910 GO_REF:0000033 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
JBrowse link
G Samtor S-adenosylmethionine sensor upstream of mTORC1 involved_in ISO (PMID:29123071) RGD PMID:29123071 NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539
JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component involved_in ISO
ISS
(PMID:35831510), (PMID:36528027)
GO_REF:0000024
RGD
UniProt
PMID:35831510 PMID:36528027 GO_REF:0000024 NCBI chr 4:146,877,739...146,891,130
Ensembl chr 4:146,875,524...146,891,173
JBrowse link
G Seh1l SEH1-like nucleoporin involved_in ISO (PMID:25457612), (PMID:35831510), (PMID:36528027) RGD PMID:25457612 PMID:35831510 PMID:36528027 NCBI chr18:61,346,986...61,369,987
Ensembl chr18:61,332,158...61,458,379
JBrowse link
G Sesn2 sestrin 2 involved_in ISO (PMID:26449471), (PMID:26586190) RGD PMID:26449471 PMID:26586190 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Shq1 SHQ1, H/ACA ribonucleoprotein assembly factor acts_upstream_of_or_within ISO MGI:109583|MGI:1914004 (PMID:29057879) RGD PMID:29057879 NCBI chr 4:133,213,357...133,305,586
Ensembl chr 4:133,213,361...133,305,586
JBrowse link
G Sik3 SIK family kinase 3 involved_in ISO (PMID:30232230) RGD PMID:30232230 NCBI chr 8:46,312,253...46,522,444
Ensembl chr 8:46,311,989...46,522,444
JBrowse link
G Slc38a9 solute carrier family 38, member 9 involved_in ISS
ISO
GO_REF:0000024
(PMID:28336668), (PMID:30181260)
UniProt
RGD
PMID:28336668 PMID:30181260 GO_REF:0000024 NCBI chr 2:44,291,637...44,374,897
Ensembl chr 2:44,291,989...44,368,955
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:35927303) RGD PMID:35927303 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites involved_in ISO (PMID:35927303) RGD PMID:35927303 NCBI chr 3:168,318,511...168,324,915
Ensembl chr 3:168,318,512...168,324,915
JBrowse link
G Stambpl1 STAM binding protein-like 1 involved_in ISO
IBA
(PMID:35114100)
GO_REF:0000033
RGD
GO_Central
PMID:35114100 GO_REF:0000033 NCBI chr 1:231,699,620...231,745,034
Ensembl chr 1:231,699,995...231,745,032
JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA
(PMID:34634301)
GO_REF:0000107
RGD
Ensembl
PMID:34634301 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in ISO (PMID:29150432) RGD PMID:29150432 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Usp32 ubiquitin specific peptidase 32 involved_in ISO (PMID:36476874) RGD PMID:36476874 NCBI chr10:69,855,895...70,029,075
Ensembl chr10:69,855,885...70,029,137
JBrowse link
G Usp4 ubiquitin specific peptidase 4 involved_in ISO
ISS
(PMID:30514904)
GO_REF:0000024
RGD
UniProt
PMID:30514904 GO_REF:0000024 NCBI chr 8:109,035,402...109,079,382
Ensembl chr 8:109,036,099...109,080,427
JBrowse link
G Wac WW domain containing adaptor with coiled-coil involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:55,922,686...55,984,286
Ensembl chr17:55,923,123...55,982,301
JBrowse link
G Wdr24 WD repeat domain 24 involved_in ISO
IBA
(PMID:35831510), (PMID:36528027), (PMID:36577058), (PMID:36732624)
(PMID:36732624)
GO_REF:0000033
RGD
GO_Central
PMID:35831510 PMID:36528027 PMID:36577058 PMID:36732624 GO_REF:0000033 NCBI chr10:14,844,089...14,848,871
Ensembl chr10:14,843,728...14,848,864
JBrowse link
G Wdr59 WD repeat domain 59 involved_in ISO
IBA
(PMID:35831510), (PMID:36528027)
GO_REF:0000033
RGD
GO_Central
PMID:35831510 PMID:36528027 GO_REF:0000033 NCBI chr19:39,416,432...39,483,773
Ensembl chr19:39,416,429...39,483,698
JBrowse link
positive regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO
IEA
(PMID:23684622), (PMID:26235620)
GO_REF:0000107
RGD
Ensembl
PMID:23684622 PMID:26235620 GO_REF:0000107 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:22084251) RGD PMID:22084251 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO (PMID:32647003) RGD PMID:32647003 NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934
JBrowse link
G Otud5 OTU deubiquitinase 5 involved_in ISO
IEA
IBA
(PMID:33110214)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:33110214 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:14,626,173...14,659,331
Ensembl chr  X:14,626,164...14,659,573
JBrowse link
G Otud7b OTU deubiquitinase 7B involved_in ISO (PMID:28489822) RGD PMID:28489822 NCBI chr 2:183,661,955...183,722,584
Ensembl chr 2:183,662,163...183,718,674
JBrowse link
G Sik3 SIK family kinase 3 involved_in ISO (PMID:30232230) RGD PMID:30232230 NCBI chr 8:46,312,253...46,522,444
Ensembl chr 8:46,311,989...46,522,444
JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in ISO
IEA
(PMID:34245780)
GO_REF:0000107
RGD
Ensembl
PMID:34245780 GO_REF:0000107 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Usp9x ubiquitin specific peptidase 9, X-linked involved_in ISO (PMID:33378666) RGD PMID:33378666 NCBI chr  X:9,588,825...9,726,993
Ensembl chr  X:9,588,825...9,696,711
JBrowse link
regulation of TOR signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Araf A-Raf proto-oncogene, serine/threonine kinase involved_in ISS
ISO
GO_REF:0000024
(PMID:22609986)
UniProt
RGD
PMID:22609986 GO_REF:0000024 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073
JBrowse link
G Fam83d family with sequence similarity 83, member D involved_in ISO
IBA
(PMID:24344117)
GO_REF:0000033
RGD
GO_Central
PMID:24344117 GO_REF:0000033 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
JBrowse link
G Fbxo9 f-box protein 9 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:23263282)
UniProt
Ensembl
RGD
PMID:23263282 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949
JBrowse link
G Flcn folliculin involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:3842151 (PMID:19843504)
UniProt
RGD
PMID:19843504 GO_REF:0000024 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:27378698) RGD PMID:27378698 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Gna12 G protein subunit alpha 12 involved_in ISS
ISO
GO_REF:0000024
(PMID:22609986)
UniProt
RGD
PMID:22609986 GO_REF:0000024 NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 involved_in ISO (PMID:17002884) RGD PMID:17002884 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:161,684,249...161,698,315
Ensembl chr 4:161,684,249...161,698,422
JBrowse link
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin involved_in ISO (PMID:19524688) RGD PMID:19524688 NCBI chr 9:22,547,396...23,037,443
Ensembl chr 9:22,549,513...23,037,381
JBrowse link
G Rheb Ras homolog, mTORC1 binding involved_in ISO (PMID:19258434) RGD PMID:19258434 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase involved_in ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:16885344)
UniProt
GO_Central
RGD
PMID:16885344 GO_REF:0000024 GO_REF:0000033 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865
JBrowse link
G RragB Ras-related GTP binding B involved_in ISO UniProtKB:Q9HB90 (PMID:23723238) RGD PMID:23723238 NCBI chr  X:18,184,619...18,234,639
Ensembl chr  X:18,184,992...18,234,639
JBrowse link
G Rragc Ras-related GTP binding C involved_in ISO UniProtKB:Q5VZM2 (PMID:23723238) RGD PMID:23723238 NCBI chr 5:136,148,239...136,167,773
Ensembl chr 5:136,148,276...136,167,767
JBrowse link
G Slc7a1 solute carrier family 7 member 1 IMP RGD PMID:17234578 RGD:1642930 NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849
JBrowse link
G Slc7a3 solute carrier family 7 member 3 IMP RGD PMID:17234578 RGD:1642930 NCBI chr  X:66,210,071...66,216,482
Ensembl chr  X:66,210,081...66,215,708
JBrowse link
G Tbck TBC1 domain containing kinase involved_in ISO (PMID:23977024) RGD PMID:23977024 NCBI chr 2:221,175,749...221,348,058
Ensembl chr 2:221,175,785...221,348,126
JBrowse link
G Tmem127 transmembrane protein 127 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:5581337 (PMID:24334765)
GO_Central
RGD
PMID:24334765 GO_REF:0000033 NCBI chr 3:114,466,095...114,478,894
Ensembl chr 3:114,466,171...114,477,519
JBrowse link
G Tmem127l1 transmembrane protein 127 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:37,679,675...37,680,635
Ensembl chr11:37,680,010...37,680,474
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:28802038) RGD PMID:28802038 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Tti1 TELO2 interacting protein 1 involved_in ISO (PMID:23263282) RGD PMID:23263282 NCBI chr 3:146,639,048...146,682,945
Ensembl chr 3:146,639,054...146,682,847
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO MGI:2180033 (PMID:18443001) RGD PMID:18443001 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110
JBrowse link
regulation of TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:36113465) RGD PMID:36113465 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
JBrowse link
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:23767959) RGD PMID:23767959 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131
JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 involved_in ISO
IEA
ISS
(PMID:23415227)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23415227 GO_REF:0000024 GO_REF:0000107 NCBI chr13:42,594,120...42,604,898
Ensembl chr13:42,594,121...42,604,778
JBrowse link
G RGD1359108 similar to RIKEN cDNA 3110043O21 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:27875531)
GO_REF:0000107
(PMID:27559131)
UniProt
RGD
Ensembl
PMID:27559131 PMID:27875531 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:49,766,340...49,791,434
Ensembl chr 5:49,766,325...49,791,408
JBrowse link
G Rraga Ras-related GTP binding A involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510
JBrowse link
G Rragc Ras-related GTP binding C involved_in ISO (PMID:27222292) RGD PMID:27222292 NCBI chr 5:136,148,239...136,167,773
Ensembl chr 5:136,148,276...136,167,767
JBrowse link
G Samtor S-adenosylmethionine sensor upstream of mTORC1 involved_in ISO (PMID:29123071), (PMID:35776786) RGD PMID:29123071 PMID:35776786 NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539
JBrowse link
G Sar1a secretion associated, Ras related GTPase 1A involved_in ISO (PMID:34290409) RGD PMID:34290409 NCBI chr20:29,623,529...29,635,935
Ensembl chr20:29,623,553...29,635,935
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B involved_in ISO (PMID:34290409) RGD PMID:34290409 NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066
JBrowse link
G Sesn2 sestrin 2 involved_in ISO (PMID:36528027) RGD PMID:36528027 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO (PMID:27559131) RGD PMID:27559131 NCBI chr10:45,457,962...45,465,101
Ensembl chr10:45,457,605...45,468,876
JBrowse link
regulation of TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Armh4 armadillo-like helical domain containing 4 involved_in ISO (PMID:25418727) RGD PMID:25418727 NCBI chr15:22,975,895...23,076,986
Ensembl chr15:22,975,895...23,076,949
JBrowse link
G Pih1d1 PIH1 domain containing 1 NOT|involved_in ISO (PMID:24036451) RGD PMID:24036451 NCBI chr 1:95,639,597...95,645,295
Ensembl chr 1:95,639,592...95,645,290
JBrowse link
TORC1 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 involved_in ISO (PMID:28628108) RGD PMID:28628108 NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112
JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator involved_in ISO (PMID:25940091) RGD PMID:25940091 NCBI chr10:42,191,378...42,246,361
Ensembl chr10:42,191,325...42,243,371
JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO (PMID:29514215) RGD PMID:29514215 NCBI chr 2:123,822,042...123,847,808
Ensembl chr 2:123,816,614...123,857,971
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog involved_in IEA
ISO
GO_REF:0000107
(PMID:12718876), (PMID:28489822)
Ensembl
RGD
PMID:12718876 PMID:28489822 GO_REF:0000107 NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128
JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
IBA
ISO
ISS
GO_REF:0000107
GO_REF:0000033
(PMID:12087098), (PMID:12718876), (PMID:17517883), (PMID:18372248), (PMID:22017875), (PMID:22017876), (PMID:22017877), (PMID:22424946), (PMID:24403073), (PMID:24448649), (PMID:28223137), (PMID:29236692), (PMID:29750193), (PMID:31112131), (PMID:32612235), (PMID:36608670), (PMID:38006878)
GO_REF:0000024
Ensembl
GO_Central
RGD
UniProt
PMID:12087098 PMID:12718876 PMID:17517883 PMID:18372248 PMID:22017875 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ppdpf pancreatic progenitor cell differentiation and proliferation factor acts_upstream_of_or_within ISO (PMID:34031390) RGD PMID:34031390 NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:168,299,791...168,301,036
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207
JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:204,021,805...204,032,781
Ensembl chr 1:204,021,806...204,032,761
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:76,353,316...76,454,502
Ensembl chr  X:76,353,760...76,454,484
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 involved_in ISO
IBA
(PMID:12150926), (PMID:12718876), (PMID:12747827), (PMID:24403073), (PMID:26588989), (PMID:30197302), (PMID:31112131), (PMID:32561715), (PMID:35927303)
(PMID:27879318), (PMID:32912901)
GO_REF:0000033
RGD
GO_Central
PMID:12150926 PMID:12718876 PMID:12747827 PMID:24403073 PMID:26588989 More... GO_REF:0000033 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
TORC2 signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapkap1 MAPK associated protein 1 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:21177249), (PMID:21376236), (PMID:21806543), (PMID:26293922), (PMID:28264193), (PMID:28968999), (PMID:29424687), (PMID:29567957), (PMID:31130364), (PMID:33158864), (PMID:35926713)
GO_REF:0000033
(PMID:23142081), (PMID:23684622), (PMID:26235620), (PMID:33850054)
UniProt
RGD
GO_Central
PMID:21177249 PMID:21376236 PMID:21806543 PMID:23142081 PMID:23684622 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 3:17,715,813...17,918,387
Ensembl chr 3:17,715,834...17,918,384
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog involved_in ISO
IEA
ISS
(PMID:28489822), (PMID:29424687), (PMID:29567957), (PMID:31085701), (PMID:33158864), (PMID:35926713)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:28489822 PMID:29424687 PMID:29567957 PMID:31085701 PMID:33158864 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128
JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO
IEA
ISS
(PMID:21376236), (PMID:24670654), (PMID:29424687), (PMID:29567957), (PMID:33158864), (PMID:35926713)
GO_REF:0000107
(PMID:18566586), (PMID:18566587), (PMID:21321111), (PMID:23142081), (PMID:23388827), (PMID:24670654), (PMID:29232555), (PMID:31548312), (PMID:33850054), (PMID:34245780)
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:18566586 PMID:18566587 PMID:21321111 PMID:21376236 PMID:23142081 More... GO_REF:0000024 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:21177249) RGD PMID:21177249 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prr5 proline rich 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:115,795,351...115,837,880
Ensembl chr 7:115,813,954...115,834,834
JBrowse link
G Prr5l proline rich 5 like involved_in IEA
ISO
IBA
ISS
GO_REF:0000107
(PMID:22609986)
GO_REF:0000033
GO_REF:0000024
Ensembl
RGD
GO_Central
UniProt
PMID:22609986 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:88,001,951...88,173,532
Ensembl chr 3:88,003,617...88,082,763
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 involved_in ISO
IBA
(PMID:24670654), (PMID:29232555), (PMID:33850054)
(PMID:16221682), (PMID:21177249), (PMID:21343617), (PMID:21376236), (PMID:22084251), (PMID:29424687), (PMID:29567957), (PMID:31130364), (PMID:33158864), (PMID:35926713)
GO_REF:0000033
RGD
GO_Central
PMID:16221682 PMID:21177249 PMID:21343617 PMID:21376236 PMID:22084251 More... GO_REF:0000033 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
JBrowse link
G Sesn3 sestrin 3 involved_in ISO (PMID:25377878) RGD PMID:25377878 NCBI chr 8:11,133,822...11,189,436
Ensembl chr 8:11,133,678...11,185,842
JBrowse link
G Syap1 synapse associated protein 1 involved_in ISO
IBA
(PMID:23300339)
GO_REF:0000033
RGD
GO_Central
PMID:23300339 GO_REF:0000033 NCBI chr  X:31,792,180...31,826,672
Ensembl chr  X:31,792,193...31,826,667
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20535
    cellular process 19524
      signal transduction 7250
        intracellular signal transduction 3149
          TOR signaling 194
            TORC1 signaling + 118
            TORC2 signaling + 22
            negative regulation of TOR signaling + 75
            positive regulation of TOR signaling + 81
            regulation of TOR signaling + 164
Path 2
Term Annotations click to browse term
  biological_process 20535
    biological regulation 13817
      regulation of biological process 13372
        signaling 7808
          signal transduction 7250
            intracellular signal transduction 3149
              TOR signaling 194
                TORC1 signaling + 118
                TORC2 signaling + 22
                negative regulation of TOR signaling + 75
                positive regulation of TOR signaling + 81
                regulation of TOR signaling + 164
paths to the root