Srms (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites) - Rat Genome Database

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Gene: Srms (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites) Rattus norvegicus
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Symbol: Srms
Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
RGD ID: 1306602
Description: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; innate immune response; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC296472; MGC109505; tyrosine-protein kinase Srms
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,696,070 - 188,702,474 (-)NCBIGRCr8
mRatBN7.23168,318,511 - 168,324,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,318,512 - 168,324,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,699,340 - 172,705,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,658,443 - 181,664,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,319,462 - 178,325,866 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,709,742 - 176,716,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,709,743 - 176,716,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,419,924 - 180,426,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,347,942 - 170,354,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,253,978 - 170,260,382 (-)NCBI
Celera3164,260,970 - 164,267,374 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:23822091   PMID:25897081   PMID:29496907  


Genomics

Comparative Map Data
Srms
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,696,070 - 188,702,474 (-)NCBIGRCr8
mRatBN7.23168,318,511 - 168,324,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,318,512 - 168,324,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,699,340 - 172,705,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,658,443 - 181,664,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,319,462 - 178,325,866 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,709,742 - 176,716,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,709,743 - 176,716,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,419,924 - 180,426,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,347,942 - 170,354,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,253,978 - 170,260,382 (-)NCBI
Celera3164,260,970 - 164,267,374 (+)NCBICelera
Cytogenetic Map3q43NCBI
SRMS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,538,489 - 63,547,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,538,489 - 63,547,749 (-)EnsemblGRCh38hg38GRCh38
GRCh372062,169,842 - 62,179,102 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,642,607 - 61,649,301 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,642,606 - 61,649,301NCBI
Celera2058,852,519 - 58,859,217 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,902,368 - 58,909,062 (-)NCBIHuRef
CHM1_12062,073,171 - 62,079,865 (-)NCBICHM1_1
T2T-CHM13v2.02065,351,086 - 65,360,346 (-)NCBIT2T-CHM13v2.0
Srms
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,847,356 - 180,854,964 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,847,355 - 180,854,978 (-)EnsemblGRCm39 Ensembl
GRCm382181,205,563 - 181,213,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,205,562 - 181,213,185 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,940,268 - 180,947,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,134,970 - 181,142,578 (-)NCBIMGSCv36mm8
Celera2185,288,382 - 185,295,958 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.62NCBI
Srms
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528677,628 - 684,340 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528677,332 - 685,903 (+)NCBIChiLan1.0ChiLan1.0
SRMS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,343,774 - 69,351,250 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,334,043 - 69,343,256 (-)NCBINHGRI_mPanPan1
PanPan1.12061,464,318 - 61,473,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,465,539 - 61,473,057 (-)Ensemblpanpan1.1panPan2
SRMS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,131,914 - 47,139,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,133,911 - 47,139,537 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,330,614 - 46,338,315 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02448,101,329 - 48,108,493 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.02447,241,060 - 47,248,754 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,979,092 - 47,986,798 (-)NCBIUU_Cfam_GSD_1.0
Srms
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,382,288 - 195,392,095 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,836,156 - 10,843,303 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,835,931 - 10,843,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRMS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,548,182 - 62,556,975 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,549,025 - 62,555,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SRMS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12657,315 - 664,883 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2657,623 - 664,064 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605048,216,450 - 48,225,224 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srms
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,195,599 - 29,202,285 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,194,227 - 29,205,752 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srms
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:179
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000017668
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 2 8 25 14 14 14 54 29 9 11
Below cutoff 1 33 25 21 4 21 8 11 20 6 23 8

Sequence


RefSeq Acc Id: ENSRNOT00000017668   ⟹   ENSRNOP00000017668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,318,512 - 168,324,915 (-)Ensembl
Rnor_6.0 Ensembl3176,709,743 - 176,716,146 (-)Ensembl
RefSeq Acc Id: NM_001011961   ⟹   NP_001011961
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,696,070 - 188,702,474 (-)NCBI
mRatBN7.23168,318,511 - 168,324,915 (-)NCBI
Rnor_6.03176,709,742 - 176,716,146 (-)NCBI
Rnor_5.03180,419,924 - 180,426,328 (-)NCBI
RGSC_v3.43170,347,942 - 170,354,346 (-)RGD
Celera3164,260,970 - 164,267,374 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001011961 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH90006 (Get FASTA)   NCBI Sequence Viewer  
  EDL88741 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017668
  ENSRNOP00000017668.5
RefSeq Acc Id: NP_001011961   ⟸   NM_001011961
- UniProtKB: Q5FVG7 (UniProtKB/TrEMBL),   F6Y6E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017668   ⟸   ENSRNOT00000017668
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVG7-F1-model_v2 AlphaFold Q5FVG7 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306602 AgrOrtholog
BioCyc Gene G2FUF-46301 BioCyc
Ensembl Genes ENSRNOG00000013003 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017668 ENTREZGENE
  ENSRNOT00000017668.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323399 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:296472 UniProtKB/TrEMBL
MGC_CLONE MGC:109505 IMAGE-MGC_LOAD
NCBI Gene 296472 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE SRMS UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PhenoGen Srms PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013003 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt F6Y6E1 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVG7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Srms  src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites  Srms_predicted  src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Srms_predicted  src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (predicted)      Symbol and Name status set to approved 70820 APPROVED