Dgkq (diacylglycerol kinase, theta) - Rat Genome Database

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Gene: Dgkq (diacylglycerol kinase, theta) Rattus norvegicus
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Symbol: Dgkq
Name: diacylglycerol kinase, theta
RGD ID: 2320722
Description: Enables ATP-dependent diacylglycerol kinase activity. Predicted to be involved in several processes, including regulation of cellular biosynthetic process; regulation of protein phosphorylation; and response to purine-containing compound. Located in nuclear matrix and nuclear speck. Orthologous to human DGKQ (diacylglycerol kinase theta); PARTICIPATES IN glycerolipid metabolic pathway; glycerophospholipid metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 17beta-estradiol; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DAG kinase theta; DGKtheta; diacylglycerol kinase theta; LOC100361138
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,059,125 - 1,073,131 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,059,170 - 1,073,131 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14959,068 - 973,029 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,260,846 - 2,274,807 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014957,541 - 971,502 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,069,409 - 2,083,370 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,069,409 - 2,083,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,064,851 - 2,078,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,600,280 - 1,614,154 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera141,098,511 - 1,112,472 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Nuclear diacylglycerol kinase-theta is activated in response to nerve growth factor stimulation of PC12 cells. Tabellini G, etal., Cell Signal. 2004 Nov;16(11):1263-71.
Additional References at PubMed
PMID:10066731   PMID:11309392   PMID:12799190   PMID:15632090   PMID:15632189   PMID:17664281   PMID:22627129   PMID:22732145   PMID:23091060   PMID:23610160   PMID:23767959   PMID:24369117  
PMID:26748701  


Genomics

Comparative Map Data
Dgkq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,059,125 - 1,073,131 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,059,170 - 1,073,131 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14959,068 - 973,029 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,260,846 - 2,274,807 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014957,541 - 971,502 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,069,409 - 2,083,370 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,069,409 - 2,083,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,064,851 - 2,078,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,600,280 - 1,614,154 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera141,098,511 - 1,112,472 (+)NCBICelera
Cytogenetic Map14p22NCBI
DGKQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384958,887 - 973,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4958,887 - 986,895 (-)EnsemblGRCh38hg38GRCh38
GRCh374952,675 - 967,357 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364942,675 - 957,344 (-)NCBINCBI36Build 36hg18NCBI36
Build 344942,505 - 957,174NCBI
Celera4889,584 - 904,387 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef4924,040 - 936,230 (-)NCBIHuRef
CHM1_14952,456 - 967,132 (-)NCBICHM1_1
T2T-CHM13v2.04956,995 - 971,678 (-)NCBIT2T-CHM13v2.0
Dgkq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,794,910 - 108,808,696 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5108,794,559 - 108,817,538 (-)EnsemblGRCm39 Ensembl
GRCm385108,647,044 - 108,660,830 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,646,693 - 108,669,672 (-)EnsemblGRCm38mm10GRCm38
MGSCv375109,076,063 - 109,089,788 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365108,887,346 - 108,901,071 (-)NCBIMGSCv36mm8
Celera5105,768,622 - 105,782,348 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.24NCBI
Dgkq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514453,886 - 464,978 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955514452,548 - 475,240 (-)NCBIChiLan1.0ChiLan1.0
DGKQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan141,255,455 - 1,270,606 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,075,133 - 1,090,081 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14993,261 - 1,009,414 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4994,985 - 1,007,724 (-)Ensemblpanpan1.1panPan2
DGKQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,544,350 - 91,554,494 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,544,219 - 91,554,565 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha394,009,425 - 94,019,552 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0392,541,158 - 92,551,573 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl392,540,425 - 92,551,567 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1391,714,767 - 91,724,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0391,767,739 - 91,777,865 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0392,151,558 - 92,161,686 (+)NCBIUU_Cfam_GSD_1.0
Dgkq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,523,999 - 68,537,133 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647722,225,618 - 22,238,803 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647722,225,624 - 22,238,825 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGKQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8313,329 - 325,095 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18313,325 - 325,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DGKQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,804,904 - 47,819,291 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,805,017 - 47,817,583 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236668089,565 - 24,022 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgkq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475526,179,162 - 26,189,901 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475526,179,099 - 26,197,764 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dgkq
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:469
Count of miRNA genes:247
Interacting mature miRNAs:296
Transcripts:ENSRNOT00000032056
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 35 19 19 19 74 35 37 11
Low 41 22 22 22 8 11 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032056   ⟹   ENSRNOP00000036466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,059,170 - 1,073,131 (+)Ensembl
Rnor_6.0 Ensembl142,069,409 - 2,083,370 (+)Ensembl
RefSeq Acc Id: NM_001198804   ⟹   NP_001185733
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,170 - 1,073,131 (+)NCBI
Rnor_6.0142,069,409 - 2,083,370 (+)NCBI
Rnor_5.0142,064,851 - 2,078,913 (+)NCBI
Celera141,098,511 - 1,112,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091544   ⟹   XP_038947472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,127 - 1,073,130 (+)NCBI
RefSeq Acc Id: XM_039091545   ⟹   XP_038947473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,126 - 1,073,130 (+)NCBI
RefSeq Acc Id: XM_039091546   ⟹   XP_038947474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,126 - 1,073,130 (+)NCBI
RefSeq Acc Id: XM_039091547   ⟹   XP_038947475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,127 - 1,073,130 (+)NCBI
RefSeq Acc Id: XM_039091548   ⟹   XP_038947476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,557 - 1,073,130 (+)NCBI
RefSeq Acc Id: XM_039091549   ⟹   XP_038947477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,127 - 1,073,130 (+)NCBI
RefSeq Acc Id: XM_039091550   ⟹   XP_038947478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,125 - 1,068,316 (+)NCBI
RefSeq Acc Id: XM_039091551   ⟹   XP_038947479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,126 - 1,068,274 (+)NCBI
RefSeq Acc Id: XM_039091552   ⟹   XP_038947480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,059,126 - 1,069,420 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001185733   ⟸   NM_001198804
- UniProtKB: D3ZEY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036466   ⟸   ENSRNOT00000032056
RefSeq Acc Id: XP_038947478   ⟸   XM_039091550
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038947473   ⟸   XM_039091545
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038947474   ⟸   XM_039091546
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038947480   ⟸   XM_039091552
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038947479   ⟸   XM_039091551
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038947472   ⟸   XM_039091544
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038947475   ⟸   XM_039091547
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038947477   ⟸   XM_039091549
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038947476   ⟸   XM_039091548
- Peptide Label: isoform X5
Protein Domains
DAGKc   Ras-associating

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEY4-F1-model_v2 AlphaFold D3ZEY4 1-937 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320722 AgrOrtholog
BioCyc Gene G2FUF-16683 BioCyc
Ensembl Genes ENSRNOG00000024112 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000036466 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032056 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.40 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
InterPro ATP-NAD_kinase_N UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  DGK UniProtKB/Swiss-Prot
  Diacylglycerol_kin_accessory UniProtKB/Swiss-Prot
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  RA_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:100361138 UniProtKB/Swiss-Prot
NCBI Gene 100361138 ENTREZGENE
PANTHER DIACYLGLYCEROL KINASE THETA UniProtKB/Swiss-Prot
  PTHR11255 UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  DAGK_acc UniProtKB/Swiss-Prot
  DAGK_cat UniProtKB/Swiss-Prot
  PF00788 UniProtKB/Swiss-Prot
PhenoGen Dgkq PhenoGen
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot
PROSITE DAGK UniProtKB/Swiss-Prot
  PS50200 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
SMART DAGKa UniProtKB/Swiss-Prot
  DAGKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00314 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
UniProt D3ZEY4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-10 Dgkq  diacylglycerol kinase, theta  LOC100361138  diacylglycerol kinase, theta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361138  diacylglycerol kinase, theta      Symbol and Name status set to provisional 70820 PROVISIONAL