Prkacb (protein kinase cAMP-activated catalytic subunit beta) - Rat Genome Database

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Gene: Prkacb (protein kinase cAMP-activated catalytic subunit beta) Rattus norvegicus
Analyze
Symbol: Prkacb
Name: protein kinase cAMP-activated catalytic subunit beta
RGD ID: 1310574
Description: Enables cAMP-dependent protein kinase activity. Involved in negative regulation of meiotic cell cycle; protein phosphorylation; and response to clozapine. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-dependent protein kinase catalytic subunit beta; LOC310986; PKA C-beta; protein kinase, cAMP dependent, catalytic, beta; protein kinase, cAMP-dependent, beta catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22235,636,878 - 235,726,928 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2235,636,885 - 235,726,198 (-)Ensembl
Rnor_6.02252,602,197 - 252,691,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,605,307 - 252,691,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02271,129,418 - 271,218,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,949,303 - 245,035,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2227,617,114 - 227,701,913 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androstane-3,17-diol  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cannabidiol  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
colforsin daropate hydrochloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diclofenac  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
haloperidol  (EXP)
heptanal  (ISO)
hexanal  (ISO)
hydrogen cyanide  (ISO)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
Kemptide  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
Methylazoxymethanol acetate  (EXP)
motexafin gadolinium  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nitrates  (EXP)
nonanal  (ISO)
octanal  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
propanal  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium fluoride  (ISO)
sulindac  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

References

Additional References at PubMed
PMID:1610898   PMID:9368018   PMID:9521123   PMID:12420224   PMID:12628924   PMID:18385332   PMID:19197368   PMID:21399614   PMID:21423175   PMID:21880142   PMID:22007132   PMID:23376485  
PMID:23533145   PMID:32357304  


Genomics

Comparative Map Data
Prkacb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22235,636,878 - 235,726,928 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2235,636,885 - 235,726,198 (-)Ensembl
Rnor_6.02252,602,197 - 252,691,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,605,307 - 252,691,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02271,129,418 - 271,218,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,949,303 - 245,035,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2227,617,114 - 227,701,913 (-)NCBICelera
Cytogenetic Map2q44NCBI
PRKACB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38184,078,079 - 84,238,498 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl184,078,062 - 84,238,498 (+)EnsemblGRCh38hg38GRCh38
GRCh37184,543,762 - 84,704,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36184,316,333 - 84,476,769 (+)NCBINCBI36hg18NCBI36
Celera182,787,965 - 82,948,395 (+)NCBI
Cytogenetic Map1p31.1NCBI
HuRef182,654,090 - 82,814,484 (+)NCBIHuRef
CHM1_1184,658,575 - 84,819,019 (+)NCBICHM1_1
Prkacb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393146,435,334 - 146,518,701 (-)NCBIGRCm39mm39
GRCm39 Ensembl3146,435,329 - 146,518,745 (-)Ensembl
GRCm383146,729,579 - 146,812,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3146,729,574 - 146,812,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv373146,392,543 - 146,475,910 (-)NCBIGRCm37mm9NCBIm37
MGSCv363146,666,965 - 146,750,316 (-)NCBImm8
Celera3153,182,525 - 153,265,941 (-)NCBICelera
Cytogenetic Map3H2NCBI
Prkacb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554239,629,378 - 9,747,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554239,630,308 - 9,747,820 (-)NCBIChiLan1.0ChiLan1.0
PRKACB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1185,574,094 - 85,647,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl185,487,681 - 85,644,253 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01116,625,640 - 116,786,396 (+)NCBIMhudiblu_PPA_v0panPan3
PRKACB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1663,615,445 - 63,729,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl663,618,323 - 63,730,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha666,263,759 - 66,377,569 (-)NCBI
ROS_Cfam_1.0664,155,572 - 64,269,668 (-)NCBI
ROS_Cfam_1.0 Ensembl664,155,572 - 64,269,867 (-)Ensembl
UMICH_Zoey_3.1663,683,378 - 63,796,798 (-)NCBI
UNSW_CanFamBas_1.0663,652,236 - 63,766,014 (-)NCBI
UU_Cfam_GSD_1.0664,158,621 - 64,272,439 (-)NCBI
Prkacb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505894,841,492 - 94,952,128 (+)NCBI
SpeTri2.0NW_0049366081,353,905 - 1,464,636 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKACB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6129,519,962 - 129,635,517 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16129,520,397 - 129,636,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26119,719,887 - 119,778,443 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKACB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12049,109,774 - 49,273,200 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2049,108,425 - 49,178,806 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603368,486,789 - 68,652,007 (+)NCBIVero_WHO_p1.0
Prkacb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474213,243,248 - 13,357,873 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH133906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,975,550 - 181,975,757 (+)MAPPERmRatBN7.2
Rnor_6.01198,801,547 - 198,801,753NCBIRnor6.0
Rnor_5.01205,799,940 - 205,800,146UniSTSRnor5.0
RGSC_v3.41186,620,151 - 186,620,357UniSTSRGSC3.4
Celera1179,628,164 - 179,628,370UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map2q44UniSTS
X61434  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,639,593 - 235,639,757 (+)MAPPERmRatBN7.2
Rnor_6.02252,605,036 - 252,605,199NCBIRnor6.0
Rnor_5.02271,132,135 - 271,132,298UniSTSRnor5.0
RGSC_v3.42244,949,032 - 244,949,195UniSTSRGSC3.4
Celera2227,616,843 - 227,617,006UniSTS
Cytogenetic Map2q44UniSTS
RH139283  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,640,477 - 235,640,719 (+)MAPPERmRatBN7.2
Rnor_6.02252,605,920 - 252,606,161NCBIRnor6.0
Rnor_5.02271,133,019 - 271,133,260UniSTSRnor5.0
RGSC_v3.42244,949,916 - 244,950,157UniSTSRGSC3.4
Celera2227,617,727 - 227,617,968UniSTS
Cytogenetic Map2q44UniSTS
BF417257  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,702,694 - 235,702,787 (+)MAPPERmRatBN7.2
Rnor_6.02252,668,523 - 252,668,615NCBIRnor6.0
Rnor_5.02271,195,622 - 271,195,714UniSTSRnor5.0
RGSC_v3.42245,011,907 - 245,011,999UniSTSRGSC3.4
Celera2227,678,543 - 227,678,635UniSTS
Cytogenetic Map2q44UniSTS
Prkacb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,655,423 - 235,656,709 (+)MAPPERmRatBN7.2
mRatBN7.21181,975,264 - 181,975,344 (+)MAPPERmRatBN7.2
Rnor_6.01198,801,261 - 198,801,340NCBIRnor6.0
Rnor_6.02252,620,866 - 252,622,151NCBIRnor6.0
Rnor_5.02271,147,965 - 271,149,250UniSTSRnor5.0
Rnor_5.01205,799,654 - 205,799,733UniSTSRnor5.0
RGSC_v3.41186,619,865 - 186,619,944UniSTSRGSC3.4
RGSC_v3.42244,964,862 - 244,966,147UniSTSRGSC3.4
Celera2227,632,322 - 227,633,607UniSTS
Celera1179,627,878 - 179,627,957UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map2q44UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87hepatic copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000068739
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 55 39 19 39 8 10 74 35 35 11 8
Low 1 2 2 2 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000068739   ⟹   ENSRNOP00000062228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,726,198 (-)Ensembl
Rnor_6.0 Ensembl2252,605,307 - 252,691,886 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109432   ⟹   ENSRNOP00000085004
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,668,313 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117576   ⟹   ENSRNOP00000092040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,681,232 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119870   ⟹   ENSRNOP00000097634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,666,414 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119887   ⟹   ENSRNOP00000086804
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,693,675 (-)Ensembl
RefSeq Acc Id: NM_001077645   ⟹   NP_001071113
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,639,865 - 235,726,052 (-)NCBI
Rnor_6.02252,605,307 - 252,691,886 (-)NCBI
Rnor_5.02271,129,418 - 271,218,985 (-)NCBI
RGSC_v3.42244,949,303 - 245,035,266 (-)RGD
Celera2227,617,114 - 227,701,913 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233451   ⟹   XP_006233513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,636,878 - 235,693,469 (-)NCBI
Rnor_6.02252,602,197 - 252,659,842 (-)NCBI
Rnor_5.02271,129,418 - 271,218,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233452   ⟹   XP_006233514
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,636,878 - 235,681,193 (-)NCBI
Rnor_6.02252,602,197 - 252,648,734 (-)NCBI
Rnor_5.02271,129,418 - 271,218,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233453   ⟹   XP_006233515
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,636,878 - 235,680,776 (-)NCBI
Rnor_6.02252,602,197 - 252,646,399 (-)NCBI
Rnor_5.02271,129,418 - 271,218,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101884   ⟹   XP_038957812
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,719,433 - 235,726,928 (-)NCBI
RefSeq Acc Id: XM_039101885   ⟹   XP_038957813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,667,297 - 235,726,928 (-)NCBI
RefSeq Acc Id: XM_039101886   ⟹   XP_038957814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,667,297 - 235,726,928 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001071113   ⟸   NM_001077645
- UniProtKB: P68182 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233513   ⟸   XM_006233451
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006233514   ⟸   XM_006233452
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006233515   ⟸   XM_006233453
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000062228   ⟸   ENSRNOT00000068739
RefSeq Acc Id: XP_038957814   ⟸   XM_039101886
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038957813   ⟸   XM_039101885
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038957812   ⟸   XM_039101884
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000086804   ⟸   ENSRNOT00000119887
RefSeq Acc Id: ENSRNOP00000097634   ⟸   ENSRNOT00000119870
RefSeq Acc Id: ENSRNOP00000085004   ⟸   ENSRNOT00000109432
RefSeq Acc Id: ENSRNOP00000092040   ⟸   ENSRNOT00000117576
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68182-F1-model_v2 AlphaFold P68182 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310574 AgrOrtholog
BioCyc Gene G2FUF-50889 BioCyc
Ensembl Genes ENSRNOG00000004978 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000062228 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000085004 ENTREZGENE
  ENSRNOP00000086804 ENTREZGENE
  ENSRNOP00000092040 ENTREZGENE
Ensembl Transcript ENSRNOT00000068739 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000109432 ENTREZGENE
  ENSRNOT00000117576 ENTREZGENE
  ENSRNOT00000119887 ENTREZGENE
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_PKA UniProtKB/Swiss-Prot
KEGG Report rno:293508 UniProtKB/Swiss-Prot
NCBI Gene 293508 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Prkacb PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt KAPCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P05206 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkacb  protein kinase cAMP-activated catalytic subunit beta  Prkacb  protein kinase, cAMP-dependent, beta catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkacb  protein kinase, cAMP-dependent, beta catalytic subunit  Prkacb  protein kinase, cAMP dependent, catalytic, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-08-18 Prkacb  protein kinase, cAMP dependent, catalytic, beta  Prkacb_predicted  protein kinase, cAMP dependent, catalytic, beta (predicted)  gene changed from predicted status to normal gene status 1299863 APPROVED
2005-01-12 Prkacb_predicted  protein kinase, cAMP dependent, catalytic, beta (predicted)      Symbol and Name status set to approved 70820 APPROVED