Tsc2_v1 (TSC complex subunit 2, variant 1) - Rat Genome Database

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Gene: Tsc2_v1 (TSC complex subunit 2, variant 1) Rattus norvegicus
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Symbol: Tsc2_v1
Name: TSC complex subunit 2, variant 1
RGD ID: 728308
Description: ENCODES an splice that exhibits phosphatase binding (ortholog); INVOLVED IN cell projection organization; negative regulation of cell size; regulation of postsynapse organization; PARTICIPATES IN mTOR signaling pathway; FOUND IN glutamatergic synapse; cytosol (ortholog); lysosomal membrane (ortholog)
Type: splice  of Tsc2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISS)
glutamatergic synapse  (IDA,IMP)
lysosomal membrane  (IEA,ISS)
lysosome  (IEA)
membrane  (IEA)
synapse  (IEA)
TSC1-TSC2 complex  (IBA,IEA,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. Goncharova E, etal., J Cell Biol. 2004 Dec 20;167(6):1171-82.
3. cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model. Kobayashi T, etal., Nucleic Acids Res 1995 Jul 25;23(14):2608-13.
4. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
5. GOA pipeline RGD automated data pipeline
6. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Tavazoie SF, etal., Nat Neurosci. 2005 Dec;8(12):1727-34. Epub 2005 Nov 6.
7. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex. Yasuda S, etal., Sci Rep. 2014 Jun 3;4:5155. doi: 10.1038/srep05155.

Genomics


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide U24150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49816-F1-model_v2 AlphaFold P49816 1-1809 view protein structure


Additional Information

Database Acc Id Source(s)
UniProt P49816


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Tsc2_v1  tuberous sclerosis 2, variant 1      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression RT-PCR analysis revealed expression in the heart and the brain 625610
gene_transcript has 126 bp insert 625610