Wdr24 (WD repeat domain 24) - Rat Genome Database

Name: Wdr24
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Wdr24 (WD repeat domain 24) Rattus norvegicus

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Symbol:

Wdr24

Name:

WD repeat domain 24

RGD ID:

1304803

Description:

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein K6-linked ubiquitination. Predicted to act upstream of or within positive regulation of protein kinase activity. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol and vacuolar membrane. Orthologous to human WDR24 (WD repeat domain 24); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GATOR complex protein WDR24; GATOR2 complex protein WDR24; LOC360497; MGC112842; RGD1304803; similar to Hypothetical protein MGC47001; WD repeat-containing protein 24

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WDR24 (WD repeat domain 24)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Wdr24 (WD repeat domain 24)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Wdr24 (WD repeat domain 24)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WDR24 (WD repeat domain 24)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WDR24 (WD repeat domain 24)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wdr24 (WD repeat domain 24)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WDR24 (WD repeat domain 24)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WDR24 (WD repeat domain 24)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wdr24 (WD repeat domain 24)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	WDR24 (WD repeat domain 24)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Wdr24 (WD repeat domain 24)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wdr24 (WD repeat domain 24)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y32H12A.8	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Wdr24	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RTC1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	wdr24	Alliance	DIOPT (OMA\|OrthoFinder)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,346,835 - 15,353,384 (+)	NCBI		GRCr8
mRatBN7.2	10	14,844,089 - 14,848,871 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,843,728 - 14,848,864 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,583,098 - 19,587,880 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	19,071,974 - 19,076,756 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,572,254 - 14,577,036 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	15,191,078 - 15,195,860 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	15,191,078 - 15,195,860 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	15,004,021 - 15,008,803 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,089,474 - 15,094,256 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,089,637 - 15,094,113 (+)	NCBI
Celera	10	14,513,031 - 14,517,813 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive spinocerebellar ataxia 16 (ISO)

cerebellar ataxia type 48 (ISO)

epilepsy (ISO)

idiopathic generalized epilepsy (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

tuberous sclerosis 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP)

acrylamide (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

caffeine (ISO)

Dibutyl phosphate (ISO)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

methapyrilene (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

thioacetamide (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid starvation (IBA,ISO)

cellular response to nutrient levels (ISO)

positive regulation of macroautophagy (IBA)

positive regulation of protein kinase activity (ISO)

positive regulation of TOR signaling (ISO)

positive regulation of TORC1 signaling (IBA,ISO)

protein K6-linked ubiquitination (ISO)

regulation of autophagy (ISO)

Cellular Component

cytosol (IBA,ISO)

GATOR2 complex (IBA,ISO)

intracellular membrane-bounded organelle (ISO)

lysosomal membrane (ISO)

vacuolar membrane (IBA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

ubiquitin protein ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of mTORC1 by amino acids.	Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:23723238	PMID:25931508	PMID:27166823	PMID:28199306

Genomics

Comparative Map Data

Wdr24
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,346,835 - 15,353,384 (+)	NCBI		GRCr8
mRatBN7.2	10	14,844,089 - 14,848,871 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,843,728 - 14,848,864 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,583,098 - 19,587,880 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	19,071,974 - 19,076,756 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,572,254 - 14,577,036 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	15,191,078 - 15,195,860 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	15,191,078 - 15,195,860 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	15,004,021 - 15,008,803 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,089,474 - 15,094,256 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,089,637 - 15,094,113 (+)	NCBI
Celera	10	14,513,031 - 14,517,813 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

WDR24
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	684,622 - 690,398 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	684,622 - 690,444 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	734,622 - 740,398 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	674,703 - 680,401 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	674,702 - 680,401	NCBI
Celera	16	934,859 - 940,557 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	656,579 - 662,277 (-)	NCBI		HuRef
CHM1_1	16	734,676 - 740,374 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	688,697 - 694,473 (-)	NCBI		T2T-CHM13v2.0

Wdr24
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	26,042,601 - 26,047,704 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	26,042,601 - 26,047,704 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	25,823,627 - 25,828,730 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	25,823,627 - 25,828,730 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	25,960,572 - 25,965,675 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	25,551,316 - 25,556,324 (+)	NCBI		MGSCv36	mm8
Celera	17	26,356,450 - 26,361,553 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.92	NCBI

Wdr24
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	16,513,448 - 16,519,296 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	16,513,074 - 16,519,296 (+)	NCBI	ChiLan1.0	ChiLan1.0

WDR24
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	925,834 - 931,678 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	4,709,701 - 4,715,567 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	699,007 - 704,844 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	699,142 - 704,869 (-)	Ensembl	panpan1.1		panPan2

WDR24
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	39,887,968 - 39,891,633 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	39,887,667 - 39,891,588 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	41,151,453 - 41,155,872 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,229,968 - 40,234,399 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	40,229,769 - 40,234,385 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	39,918,559 - 39,922,977 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	39,878,768 - 39,883,172 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,357,890 - 40,362,310 (+)	NCBI		UU_Cfam_GSD_1.0

Wdr24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	112,224,001 - 112,229,124 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	321,924 - 327,253 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	321,877 - 326,984 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WDR24
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	41,085,463 - 41,090,610 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	41,085,415 - 41,090,628 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,387,148 - 41,392,349 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WDR24
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	604,412 - 610,665 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	604,545 - 610,359 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	30,526,690 - 30,532,746 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wdr24
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	1,496,029 - 1,501,800 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	1,496,029 - 1,501,822 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Wdr24
7 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	69
Count of miRNA genes:	60
Interacting mature miRNAs:	62
Transcripts:	ENSRNOT00000026697
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat

Markers in Region

RH134746

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	14,848,589 - 14,848,776 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	15,195,579 - 15,195,765	NCBI	Rnor6.0
Rnor_5.0	10	15,008,522 - 15,008,708	UniSTS	Rnor5.0
RGSC_v3.4	10	15,093,975 - 15,094,161	UniSTS	RGSC3.4
Celera	10	14,517,532 - 14,517,718	UniSTS
RH 3.4 Map	10	156.6	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026697 ⟹ ENSRNOP00000026697

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	14,843,728 - 14,848,864 (+)	Ensembl
Rnor_6.0 Ensembl	10	15,191,078 - 15,195,860 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117508 ⟹ ENSRNOP00000097366

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	14,843,751 - 14,848,862 (+)	Ensembl

RefSeq Acc Id:

NM_001191084 ⟹ NP_001178013

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,348,602 - 15,353,384 (+)	NCBI
mRatBN7.2	10	14,844,089 - 14,848,871 (+)	NCBI
Rnor_6.0	10	15,191,078 - 15,195,860 (+)	NCBI
Rnor_5.0	10	15,004,021 - 15,008,803 (+)	NCBI
Celera	10	14,513,031 - 14,517,813 (+)	NCBI

Sequence:

show sequence

GGATTAATCAAATAGAATCTGGAGACGTCAGATATGGTGCTGACGAACCTCAGGTTAGCTCTGG
AGCCCATGAATTTGAACCCTCCTGTGACAATGATTGACTGATGGACCATCTCAGGCCGAAGGTT
CGAGAGGACTGAACCTGAACTATTAGGACACCATGACTGACCAGGCCAGCACACTTCACTGACA
TCCTCCTACCCCTGATTACCTGTGCAGCCATGGAAAAGATGTCCCGAGTTACCACAGCCCTGAG
TGGCAGTGCACTGACAGGCCGAACCATGCACTGCCACCTGGATGCACCAGCTAATGCCATCAGT
GTGTGCCGAGATGCAGCCCAGGTTGTTGTGGCTGGCCGAAGCATCTTCAAGATTTATGCCATTG
AAGAGGAGCAGTTTGTAGAGAAGCTGAATTTACGTGTGGGCCGGAAACCCTCACTCAACCTGAG
CTGTGCTGATGTGGTCTGGCACCAGATGGATGAGAATCTGCTGGCCACAGCAGCCACCAATGGT
GTGGTGGTTACTTGGAACCTAGGCCGGCCATCCCGCAACAAACAGGATCAGCTGTTCACAGAAC
ACAAGCGCACAGTGAACAAAGTCTGTTTCCATCCCACTGAGGCCCATGTGCTGCTCAGTGGCTC
TCAAGATGGCTTTATGAAGTGCTTTGATCTCCGAAGGAAGGACTCTGTCAGCACCTTCTCTGGC
CAGTCTGAGAGCGTGCGGGACGTGCAGTTCAGTATTCGTGACTACTTTACCTTTGCTTCCACCT
TTGAGAACGGCAATGTGCAGCTCTGGGACATCCGCCGTCCCGACCGGTGTGAAAGGATGTTCAC
AGCCCACAATGGGCCTGTCTTCTGCTGTGACTGGCACCCAGAGGACAGGGGCTGGTTGGCCACG
GGTGGACGAGACAAGATGGTTAAGGTCTGGGACATGACCACACATCGTGCCAAGGAGATACACT
GTGTGCAGACCATCGCTTCAGTGGCCCGAGTCAAATGGCGTCCTGAGTGCCGCCACCACCTGGC
CACGTGCTCCATGATGGTGGACCATAACATCTATGTATGGGATGTACGCCGGCCCTTTGTGCCA
GCTGCTATGTTCGAAGAGCACCGTGATGTCACGACAGGCATTGCCTGGCGCCATCCACATGACC
CCTCTTTCCTCCTCTCCGGCTCCAAGGACAGCACATTATGCCAGCACCTGTTTCGGGATGCCAG
TCAGCCTGTTGAGCGTGCCAACCCTGAGGGTCTCTGTTACGGACTCTTTGGGGACCTGGCCTTT
GCTGTCAAAGAAAGCCTGGTGGCCGCTGAATCTGGACGTAAACCCTATGCTGGTGATCGGCGTC
ACCCCATCTTCTTCAAGCGCAAGTTGGACCCTGCAGAACCTTTTTCTGGCCTTGCTTCCAGTGC
ACTCAGCGTCTTTGAGACTGAGTCTGGTGGTGGCAGCATGAGCTGGTTCGTGGATACAGCTGAA
CGCTATGCTCTGGCTGGTCGGCCACTAGCCGAGCTCTGTGATCACAATGCAAAAGTGGCTCGGG
AGCTCGGCCGCAACCAGGTGGCCCAGACATGGACCATGTTACGGATTATCTACTGCAGCCCTGG
CTTGGTGTCCTCTGCCAATCTCAACCACAGCGTCGGCAAAGGCAGCTCCTGCAGCCTACCCCTC
ATGAACAGCTTCAATCTGAAGGATATGGGCCCAGGGCTGGGCAGCGAGACGCGGCTGGATCGCA
GCAAAGGGGACACACGGAGCGACACGGTTCTGCTCGACTCTTCAGCCACACTCATCACCAATGA
GGATAACGAGGAGACTGAGGGGAGTGACGTACCCGCTGACTACCTGCTGGGTGACGTAGAAGGA
GAGGAGGATGAGCTATACCCACTGGACACAGAGCATGTGCACCCGGAGGAGCCTGAGTATGTGC
TGCCGCAGGAGGCATTCCCACTGCGTCACGAGATTGTGGACACACCTTCGGGCCCCGAGCACCT
GCAGGACAAGGCCGACTCTCCACATGTGAGCGGCAACGAGGCAGACACAGCTTCATTAGCCCCG
GTGGATTCCTCCTCCTCCCTCCTGTCCGTCTCCCACGCGCTCTATGACAGCCGCCTGCCACCGG
ACTTCTTCAGTGTTTTGGTCCGGGACATGTTGCACTTCTACGCTGAGCAGGGCGACGTGCAGAT
GGCTGTGTCTGTTCTCATCGTGCTGGGTGAGAGAGTACGAAAGGACATCGACGAGCAGACTCAG
GAGCACTGGTACACATCCTACATCGATCTGCTGCAGCGCTTCTGCCTTTGGAATGTGTCCAATG
AGGTGGTGAAGCTGAGCACCAGCAGGGCCGTGAGCTGCCTCAACCAAGCCTCCACCACCCTGCA
TGTCAACTGTAGTCACTGCAAACGGCCCATGAGCAGCCGAGGCTGGGTCTGCGACAGGTGCCGC
CGCTGTGCCAGCATGTGTGCCGTCTGCCATCATGTGGTTAAAGGTCTGTTCGTATGGTGTCAAG
GTTGCAGTCATGGTGGCCATCTTCAGCACATCATGAAATGGCTGGAAGGCAGCTCCCACTGCCC
TGCAGGCTGCGGCCATCTCTGTGAATACTCCTGACCTGGCCTTCCCAAAAGCTAATGCAGCTTC
CTCAGCTTAATCCCGATGTCCACCGGACTAGGCTGACCGCTCACCATCCGGTTTACCAGGATGG
AAGGTGGCTGCAACCTGTTAACCCAATAAAAATCAAGAACTGCTGTTTGG

hide sequence

RefSeq Acc Id:

XM_063269315 ⟹ XP_063125385

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,346,835 - 15,353,377 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178013	(Get FASTA)	NCBI Sequence Viewer
	XP_063125385	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98800	(Get FASTA)	NCBI Sequence Viewer
	EDM03963	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026697.4
	ENSRNOP00000097366.1

RefSeq Acc Id:

NP_001178013 ⟸ NM_001191084

- UniProtKB:

G3V8L0 (UniProtKB/TrEMBL), A6HD58 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEKMSRVTTALSGSALTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLN
LRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCF
HPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWD
IRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEIHCVQTIASVAR
VKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKD
STLCQHLFRDASQPVERANPEGLCYGLFGDLAFAVKESLVAAESGRKPYAGDRRHPIFFKRKLD
PAEPFSGLASSALSVFETESGGGSMSWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQT
WTMLRIIYCSPGLVSSANLNHSVGKGSSCSLPLMNSFNLKDMGPGLGSETRLDRSKGDTRSDTV
LLDSSATLITNEDNEETEGSDVPADYLLGDVEGEEDELYPLDTEHVHPEEPEYVLPQEAFPLRH
EIVDTPSGPEHLQDKADSPHVSGNEADTASLAPVDSSSSLLSVSHALYDSRLPPDFFSVLVRDM
LHFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFCLWNVSNEVVKLSTSRA
VSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCRRCASMCAVCHHVVKGLFVWCQGCSHGGHLQH
IMKWLEGSSHCPAGCGHLCEYS

hide sequence

Ensembl Acc Id:

ENSRNOP00000026697 ⟸ ENSRNOT00000026697

Ensembl Acc Id:

ENSRNOP00000097366 ⟸ ENSRNOT00000117508

RefSeq Acc Id:	XP_063125385 ⟸ XM_063269315
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AND7 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V8L0-F1-model_v2	AlphaFold	G3V8L0	1-790	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304803	AgrOrtholog
BioCyc Gene	G2FUF-25753	BioCyc
Ensembl Genes	ENSRNOG00000019713	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026697.6	UniProtKB/TrEMBL
	ENSRNOT00000117508.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	WDR24	UniProtKB/TrEMBL
KEGG Report	rno:360497	UniProtKB/TrEMBL
NCBI Gene	360497	ENTREZGENE
PANTHER	GATOR COMPLEX PROTEIN WDR24	UniProtKB/TrEMBL
	PTHR46200	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Wdr24	PhenoGen
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019713	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A0A8I6AND7	ENTREZGENE, UniProtKB/TrEMBL
	A6HD58	ENTREZGENE, UniProtKB/TrEMBL
	G3V8L0	ENTREZGENE, UniProtKB/TrEMBL
	Q4KM48_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Wdr24	WD repeat domain 24	RGD1304803	similar to Hypothetical protein MGC47001	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1304803	similar to Hypothetical protein MGC47001	RGD1304803_predicted	similar to Hypothetical protein MGC47001 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1304803_predicted	similar to Hypothetical protein MGC47001 (predicted)	LOC360497_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC360497_predicted	similar to Hypothetical protein MGC47001 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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