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Gene: Lamtor5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5) Rattus norvegicus

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Symbol:

Lamtor5

Name:

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

RGD ID:

1305005

Description:

Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including positive regulation of interleukin-8 production; positive regulation of intracellular signal transduction; and positive regulation of protein localization to nucleus. Predicted to be located in cytosol. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Orthologous to human LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Hbxip; hepatitis B virus x interacting protein; LOC295357; ragulator complex protein LAMTOR5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	197,588,242 - 197,593,598 (+)	NCBI		GRCr8
mRatBN7.2	2	194,900,038 - 194,905,394 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	194,900,038 - 194,905,395 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	202,549,499 - 202,554,860 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	200,426,547 - 200,431,892 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	195,243,475 - 195,248,820 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	210,034,095 - 210,039,451 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	210,034,095 - 210,039,451 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	229,503,095 - 229,508,451 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	202,753,681 - 202,759,037 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	202,716,491 - 202,721,792 (+)	NCBI
Celera	2	187,559,751 - 187,565,109 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Breast Neoplasms (ISO)

developmental and epileptic encephalopathy 32 (ISO)

glucose intolerance (ISO)

hereditary spastic paraplegia 63 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,6-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

all-trans-retinoic acid (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

citalopram (EXP)

clobetasol (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

dexamethasone (ISO)

diallyl trisulfide (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

escitalopram (EXP)

finasteride (EXP)

folic acid (ISO)

FR900359 (ISO)

indometacin (ISO)

ivermectin (ISO)

methylparaben (ISO)

nitrates (ISO)

paracetamol (EXP)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid stimulus (IBA,ISO)

negative regulation of apoptotic process (IEA,ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of gene expression (ISO)

positive regulation of interleukin-8 production (ISO)

positive regulation of protein localization to nucleus (ISO)

positive regulation of TOR signaling (ISO)

positive regulation of TORC1 signaling (IBA,ISO)

protein localization to lysosome (ISO)

regulation of cell size (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

FNIP-folliculin RagC/D GAP (ISO)

lysosomal membrane (ISO)

lysosome (IBA,IEA,ISO)

protein-containing complex (ISO)

Ragulator complex (IBA,IEA,ISO)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA,ISO)

molecular adaptor activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of mTORC1 by amino acids.	Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12773388	PMID:21343296	PMID:22980980

Genomics

Comparative Map Data

Lamtor5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	197,588,242 - 197,593,598 (+)	NCBI		GRCr8
mRatBN7.2	2	194,900,038 - 194,905,394 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	194,900,038 - 194,905,395 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	202,549,499 - 202,554,860 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	200,426,547 - 200,431,892 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	195,243,475 - 195,248,820 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	210,034,095 - 210,039,451 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	210,034,095 - 210,039,451 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	229,503,095 - 229,508,451 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	202,753,681 - 202,759,037 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	202,716,491 - 202,721,792 (+)	NCBI
Celera	2	187,559,751 - 187,565,109 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

LAMTOR5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	110,401,253 - 110,407,924 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	110,401,249 - 110,407,942 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	110,943,875 - 110,950,546 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	110,745,398 - 110,752,069 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	110,655,917 - 110,662,588	NCBI
Celera	1	109,191,059 - 109,197,730 (-)	NCBI		Celera
Cytogenetic Map	1	p13.3	NCBI
HuRef	1	108,815,555 - 108,822,229 (-)	NCBI		HuRef
CHM1_1	1	111,059,183 - 111,065,854 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	110,416,405 - 110,423,069 (-)	NCBI		T2T-CHM13v2.0

Lamtor5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	107,186,174 - 107,191,398 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	107,186,174 - 107,191,398 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	107,278,858 - 107,284,082 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	107,278,858 - 107,284,082 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	107,081,776 - 107,087,000 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	107,406,914 - 107,415,958 (+)	NCBI		MGSCv36	mm8
Celera	3	109,610,764 - 109,615,988 (+)	NCBI		Celera
Cytogenetic Map	3	F2.3	NCBI
cM Map	3	46.79	NCBI

Lamtor5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	13,896,320 - 13,900,754 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	13,896,320 - 13,900,742 (-)	NCBI	ChiLan1.0	ChiLan1.0

LAMTOR5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	116,632,096 - 116,638,776 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	115,779,705 - 115,786,389 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	113,050,671 - 113,057,368 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	127,285,553 - 127,292,235 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	127,285,553 - 127,292,233 (+)	Ensembl	panpan1.1		panPan2

LAMTOR5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	41,591,332 - 41,595,913 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	44,367,794 - 44,372,569 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	41,922,322 - 41,927,100 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	41,922,362 - 41,927,092 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	41,642,461 - 41,647,238 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	41,613,475 - 41,618,046 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	42,048,597 - 42,053,349 (+)	NCBI		UU_Cfam_GSD_1.0

Lamtor5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	18,270,271 - 18,283,679 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936704	1,830,470 - 1,835,994 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936704	1,830,470 - 1,835,966 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LAMTOR5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	109,722,913 - 109,728,257 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	109,722,664 - 109,728,278 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	120,122,172 - 120,123,255 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LAMTOR5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	23,134,847 - 23,140,527 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	23,134,843 - 23,138,934 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	35,319,202 - 35,326,284 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lamtor5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624772	6,132,459 - 6,137,182 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lamtor5
17 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	40
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000024473
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	122609194	206936711	Rat
61458	Bp10	Blood pressure QTL 10	3.42		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189020722	215287351	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	184114274	202447032	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	185876309	219753474	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1298083	Bp158	Blood pressure QTL 158	2.62		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189020722	215287351	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	189599258	218414891	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	162765032	207765032	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	160564068	205564068	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	174930955	213594495	Rat

Markers in Region

RH128508

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	194,904,963 - 194,905,183 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	210,039,021 - 210,039,240	NCBI	Rnor6.0
Rnor_5.0	2	229,508,021 - 229,508,240	UniSTS	Rnor5.0
RGSC_v3.4	2	202,758,607 - 202,758,826	UniSTS	RGSC3.4
Celera	2	187,564,679 - 187,564,898	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC113635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024473 ⟹ ENSRNOP00000024473

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	194,900,038 - 194,905,394 (+)	Ensembl
Rnor_6.0 Ensembl	2	210,034,095 - 210,039,451 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095818 ⟹ ENSRNOP00000086672

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	194,900,309 - 194,905,395 (+)	Ensembl

RefSeq Acc Id:

NM_001106462 ⟹ NP_001099932

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	197,588,242 - 197,593,598 (+)	NCBI
mRatBN7.2	2	194,900,038 - 194,905,394 (+)	NCBI
Rnor_6.0	2	210,034,095 - 210,039,451 (+)	NCBI
Rnor_5.0	2	229,503,095 - 229,508,451 (+)	NCBI
RGSC_v3.4	2	202,753,681 - 202,759,037 (+)	RGD
Celera	2	187,559,751 - 187,565,109 (+)	RGD

Sequence:

show sequence

TGAAGGCCCATTACACCGAATCAAATGCCAGCTAATGCCGGTTCTGTAGTGGTAGCTATGTCTT
TTCGTAAAGAGTGCGAACGCGGCGCCACGATGAATTTGTTCCCTCTGGAGACGCCGTCCGCGCG
CCCGCCTCGGTCAAGTCACGTGACCGAGGCTTGCTGTGAAGGAGGAAGTGTTTTGCCGAGGGGT
CTTGGGCTGGGGCGGACAGTGTACGGGATGGAGGCGACTTTGGAGCAGCATTTGGAGGACACAA
TGAAGAATCCATCCATTGTTGGAGTCCTATGCACAGATTCACAAGGACTTAATCTGGGCTGCCG
TGGTACCCTGTCGGATGAGCATGCTGGAGTGATATCTGTTCTCGCCCAGCAGGCAGCTAAGCTG
ACCTCTGACCCCACCGACATCCCTGTAGTGTGTTTAGAGTCAGATAACGGGAATGTTATGATCC
AGAAACACGATGGCATCACAGTGGCTGTGCACAAAATGGCCTCTTGACATCTGATGCCAGCTCT
CCAGTGGTCTCCCACCGGGATTCAGTCATGCCTGTCTCAGTTAACTTGTAAAACTATTAAAGTT
CCAGAAATCGGGCCATTCACTTAATGTCCAATGTGGACTTCTTATTAATATGACAGTCAGTTAC
CAAGACGTCAGTTAGGAGTGTGGTGGCCTTGTCTGGGCTTTTGTCACTCTGCTCTTTGGTGACA
GCCACTGTAGTCCAGGATCATATCCCTCATGGCCTAGAACTGTGTAGCCCAGGCTGACTTCAAA
TTTATGGTCTTCCTGCTTCAAACTCCTATATCCTGGGATTTAGCATTTGTCATGGTCTAGGTCA
CTTTGTATATAGAACTTTGTTGTGGTCAATAAACCTATTCTGAGGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099932	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL81871	(Get FASTA)	NCBI Sequence Viewer
	EDL81872	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024473
	ENSRNOP00000024473.5
	ENSRNOP00000086672.1

RefSeq Acc Id:	NP_001099932 ⟸ NM_001106462
- UniProtKB:	D3ZF11 (UniProtKB/TrEMBL), A6HUT5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPANAGSVVVAMSFRKECERGATMNLFPLETPSARPPRSSHVTEACCEGGSVLPRGLGLGRTVY GMEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAAKLTSDPTDIP VVCLESDNGNVMIQKHDGITVAVHKMAS hide sequence

Ensembl Acc Id:

ENSRNOP00000024473 ⟸ ENSRNOT00000024473

Ensembl Acc Id:

ENSRNOP00000086672 ⟸ ENSRNOT00000095818

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZF11-F1-model_v2	AlphaFold	D3ZF11	1-156	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691658

Promoter ID:

EPDNEW_R2183

Type:

initiation region

Name:

Lamtor5_1

Description:

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	210,034,021 - 210,034,081	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305005	AgrOrtholog
BioCyc Gene	G2FUF-51679	BioCyc
Ensembl Genes	ENSRNOG00000018186	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024473	ENTREZGENE
	ENSRNOT00000024473.6	UniProtKB/TrEMBL
	ENSRNOT00000095818.1	UniProtKB/TrEMBL
Gene3D-CATH	Dynein light chain 2a, cytoplasmic	UniProtKB/TrEMBL
InterPro	Hepatitis_HBXIP	UniProtKB/TrEMBL
KEGG Report	rno:295357	UniProtKB/TrEMBL
NCBI Gene	295357	ENTREZGENE
PANTHER	PTHR13342	UniProtKB/TrEMBL
	RAGULATOR COMPLEX PROTEIN LAMTOR5	UniProtKB/TrEMBL
Pfam	LAMTOR5	UniProtKB/TrEMBL
PhenoGen	Lamtor5	PhenoGen
PRINTS	HEPBVIRUSXIP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018186	RatGTEx
UniProt	A0A8I6GE99_RAT	UniProtKB/TrEMBL
	A6HUT5	ENTREZGENE, UniProtKB/TrEMBL
	D3ZF11	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-05	Lamtor5	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Hbxip	hepatitis B virus x interacting protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Hbxip	hepatitis B virus x interacting protein	Hbxip_predicted	hepatitis B virus x interacting protein (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Hbxip_predicted	hepatitis B virus x interacting protein (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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