LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5) - Rat Genome Database

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Gene: LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5) Sus scrofa
Analyze
Symbol: LAMTOR5
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
RGD ID: 14053465
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); positive regulation of gene expression (ortholog); positive regulation of TOR signaling (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Breast Neoplasms (ortholog); developmental and epileptic encephalopathy 32 (ortholog); FOUND IN lysosomal membrane (ortholog); lysosome (ortholog); Ragulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HBXIP; hepatitis B virus x interacting protein; Hepatitis B virus X-interacting protein homolog; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5; ragulator complex protein LAMTOR5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,722,913 - 109,728,257 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,722,664 - 109,728,278 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,122,172 - 120,123,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LAMTOR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,722,913 - 109,728,257 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,722,664 - 109,728,278 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,122,172 - 120,123,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LAMTOR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,401,253 - 110,407,924 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,401,249 - 110,407,942 (-)EnsemblGRCh38hg38GRCh38
GRCh371110,943,875 - 110,950,546 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,745,398 - 110,752,069 (-)NCBINCBI36Build 36hg18NCBI36
Build 341110,655,917 - 110,662,588NCBI
Celera1109,191,059 - 109,197,730 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,815,555 - 108,822,229 (-)NCBIHuRef
CHM1_11111,059,183 - 111,065,854 (-)NCBICHM1_1
T2T-CHM13v2.01110,416,405 - 110,423,069 (-)NCBIT2T-CHM13v2.0
Lamtor5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,186,174 - 107,191,398 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,186,174 - 107,191,398 (+)EnsemblGRCm39 Ensembl
GRCm383107,278,858 - 107,284,082 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,278,858 - 107,284,082 (+)EnsemblGRCm38mm10GRCm38
MGSCv373107,081,776 - 107,087,000 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,406,914 - 107,415,958 (+)NCBIMGSCv36mm8
Celera3109,610,764 - 109,615,988 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.79NCBI
Lamtor5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,588,242 - 197,593,598 (+)NCBIGRCr8
mRatBN7.22194,900,038 - 194,905,394 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,900,038 - 194,905,395 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,549,499 - 202,554,860 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,426,547 - 200,431,892 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,243,475 - 195,248,820 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,034,095 - 210,039,451 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,034,095 - 210,039,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,503,095 - 229,508,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,753,681 - 202,759,037 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,716,491 - 202,721,792 (+)NCBI
Celera2187,559,751 - 187,565,109 (+)NCBICelera
Cytogenetic Map2q34NCBI
Lamtor5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,896,320 - 13,900,754 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,896,320 - 13,900,742 (-)NCBIChiLan1.0ChiLan1.0
LAMTOR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,632,096 - 116,638,776 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,779,705 - 115,786,389 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,050,671 - 113,057,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,285,553 - 127,292,235 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,285,553 - 127,292,233 (+)Ensemblpanpan1.1panPan2
LOC102156380
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1953,420,574 - 53,421,161 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha952,616,260 - 52,616,550 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0954,317,193 - 54,317,483 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1953,094,581 - 53,094,871 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0953,415,822 - 53,416,112 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0953,508,320 - 53,508,610 (+)NCBIUU_Cfam_GSD_1.0
Lamtor5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,270,271 - 18,283,679 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,830,470 - 1,835,994 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367041,830,470 - 1,835,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMTOR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,134,847 - 23,140,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2023,134,843 - 23,138,934 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603835,319,202 - 35,326,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lamtor5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247726,132,459 - 6,137,182 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LAMTOR5
150 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 22 2 3 3
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000061729   ⟹   ENSSSCP00000053110
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4109,722,913 - 109,728,257 (+)Ensembl
RefSeq Acc Id: XM_013997277   ⟹   XP_013852731
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14109,722,664 - 109,728,278 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013852731   ⟸   XM_013997277
- Sequence:
RefSeq Acc Id: ENSSSCP00000053110   ⟸   ENSSSCT00000061729


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040889 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005024260 UniProtKB/TrEMBL
  ENSSSCG00015073917 UniProtKB/TrEMBL
  ENSSSCG00025064045 UniProtKB/TrEMBL
  ENSSSCG00030038710 UniProtKB/TrEMBL
  ENSSSCG00035036010 UniProtKB/TrEMBL
  ENSSSCG00045035024 UniProtKB/TrEMBL
  ENSSSCG00050055790 UniProtKB/TrEMBL
  ENSSSCG00055027712 UniProtKB/TrEMBL
  ENSSSCG00060023500 UniProtKB/Swiss-Prot
  ENSSSCG00065046470 UniProtKB/TrEMBL
  ENSSSCG00070008010 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061729.2 UniProtKB/TrEMBL
  ENSSSCT00000061729.3 UniProtKB/Swiss-Prot
  ENSSSCT00005038522.1 UniProtKB/TrEMBL
  ENSSSCT00015099657.1 UniProtKB/TrEMBL
  ENSSSCT00025087827.1 UniProtKB/TrEMBL
  ENSSSCT00030053885.1 UniProtKB/TrEMBL
  ENSSSCT00035047719.1 UniProtKB/TrEMBL
  ENSSSCT00045060223.1 UniProtKB/TrEMBL
  ENSSSCT00050076125.1 UniProtKB/TrEMBL
  ENSSSCT00055054879.1 UniProtKB/TrEMBL
  ENSSSCT00060031869.1 UniProtKB/Swiss-Prot
  ENSSSCT00065063579.1 UniProtKB/TrEMBL
  ENSSSCT00070015470.1 UniProtKB/TrEMBL
Gene3D-CATH Dynein light chain 2a, cytoplasmic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LAMTOR5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:448965 UniProtKB/Swiss-Prot
NCBI Gene LAMTOR5 ENTREZGENE
PANTHER PTHR13342 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAGULATOR COMPLEX PROTEIN LAMTOR5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LAMTOR5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEPBVIRUSXIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Roadblock/LC7 domain UniProtKB/Swiss-Prot
UniProt A0A4X1TBJ7_PIG UniProtKB/TrEMBL
  A0A5S6I704_PIG UniProtKB/TrEMBL
  A0A8D0JHL6_PIG UniProtKB/TrEMBL
  A0A8D0Q3Z2_PIG UniProtKB/TrEMBL
  LTOR5_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:109634 ENTREZGENE