RGD Reference Report - Regulation of mTORC1 by amino acids. - Rat Genome Database

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Regulation of mTORC1 by amino acids.

Authors: Bar-Peled, L  Sabatini, DM 
Citation: Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
RGD ID: 11535043
Pubmed: PMID:24698685   (View Abstract at PubMed)
PMCID: PMC4074565   (View Article at PubMed Central)
DOI: DOI:10.1016/j.tcb.2014.03.003   (Journal Full-text)

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the lysosomal surface, its site of activation. How amino acid levels are communicated to mTORC1 is only recently coming to light by the discovery of a lysosome-based signaling system composed of Rags (Ras-related GTPases) and Ragulator v-ATPase, GATOR (GAP activity towards Rags), and folliculin (FLCN) complexes. Increased understanding of this pathway will not only provide insight into growth control but also into the human pathologies triggered by its deregulation.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DEPDC5HumanmTOR signaling pathway   TAS  RGD 
Depdc5RatmTOR signaling pathway   ISODEPDC5 (Homo sapiens) RGD 
Depdc5MousemTOR signaling pathway   ISODEPDC5 (Homo sapiens) RGD 
LAMTOR1HumanmTOR signaling pathway   TAS  RGD 
LAMTOR2HumanmTOR signaling pathway   TAS  RGD 
LAMTOR3HumanmTOR signaling pathway   TAS  RGD 
LAMTOR4HumanmTOR signaling pathway   TAS  RGD 
LAMTOR5HumanmTOR signaling pathway   TAS  RGD 
Lamtor1RatmTOR signaling pathway   ISOLAMTOR1 (Homo sapiens) RGD 
Lamtor1MousemTOR signaling pathway   ISOLAMTOR1 (Homo sapiens) RGD 
Lamtor2MousemTOR signaling pathway   ISOLAMTOR2 (Homo sapiens) RGD 
Lamtor2RatmTOR signaling pathway   ISOLAMTOR2 (Homo sapiens) RGD 
Lamtor3RatmTOR signaling pathway   ISOLAMTOR3 (Homo sapiens) RGD 
Lamtor3MousemTOR signaling pathway   ISOLAMTOR3 (Homo sapiens) RGD 
Lamtor4RatmTOR signaling pathway   ISOLAMTOR4 (Homo sapiens) RGD 
Lamtor4MousemTOR signaling pathway   ISOLAMTOR4 (Homo sapiens) RGD 
Lamtor5RatmTOR signaling pathway   ISOLAMTOR5 (Homo sapiens) RGD 
Lamtor5MousemTOR signaling pathway   ISOLAMTOR5 (Homo sapiens) RGD 
MIOSHumanmTOR signaling pathway   TAS  RGD 
MiosRatmTOR signaling pathway   ISOMIOS (Homo sapiens) RGD 
MiosMousemTOR signaling pathway   ISOMIOS (Homo sapiens) RGD 
NPRL2HumanmTOR signaling pathway   TAS  RGD 
NPRL3HumanmTOR signaling pathway   TAS  RGD 
Nprl2RatmTOR signaling pathway   ISONPRL2 (Homo sapiens) RGD 
Nprl2MousemTOR signaling pathway   ISONPRL2 (Homo sapiens) RGD 
Nprl3RatmTOR signaling pathway   ISONPRL3 (Homo sapiens) RGD 
Nprl3MousemTOR signaling pathway   ISONPRL3 (Homo sapiens) RGD 
RRAGAHumanmTOR signaling pathway   TAS  RGD 
RRAGBHumanmTOR signaling pathway   TAS  RGD 
RRAGCHumanmTOR signaling pathway   TAS  RGD 
RRAGDHumanmTOR signaling pathway   TAS  RGD 
RragaRatmTOR signaling pathway   ISORRAGA (Homo sapiens) RGD 
RragaMousemTOR signaling pathway   ISORRAGA (Homo sapiens) RGD 
RragbRatmTOR signaling pathway   ISORRAGB (Homo sapiens) RGD 
RragbMousemTOR signaling pathway   ISORRAGB (Homo sapiens) RGD 
RragcRatmTOR signaling pathway   ISORRAGC (Homo sapiens) RGD 
RragcMousemTOR signaling pathway   ISORRAGC (Homo sapiens) RGD 
RragdRatmTOR signaling pathway   ISORRAGD (Homo sapiens) RGD 
RragdMousemTOR signaling pathway   ISORRAGD (Homo sapiens) RGD 
WDR24HumanmTOR signaling pathway   TAS  RGD 
WDR59HumanmTOR signaling pathway   TAS  RGD 
Wdr24RatmTOR signaling pathway   ISOWDR24 (Homo sapiens) RGD 
Wdr24MousemTOR signaling pathway   ISOWDR24 (Homo sapiens) RGD 
Wdr59MousemTOR signaling pathway   ISOWDR59 (Homo sapiens) RGD 
Wdr59RatmTOR signaling pathway   ISOWDR59 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Depdc5  (DEP domain containing 5, GATOR1 subcomplex subunit)
Lamtor1  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)
Lamtor2  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2)
Lamtor3  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)
Lamtor4  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)
Lamtor5  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5)
Mios  (meiosis regulator for oocyte development)
Nprl2  (NPR2-like, GATOR1 complex subunit)
Nprl3  (NPR3-like, GATOR1 complex subunit)
Rraga  (Ras-related GTP binding A)
Rragb  (Ras-related GTP binding B)
Rragc  (Ras-related GTP binding C)
Rragd  (Ras-related GTP binding D)
Wdr24  (WD repeat domain 24)
Wdr59  (WD repeat domain 59)

Genes (Mus musculus)
Depdc5  (DEP domain containing 5)
Lamtor1  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)
Lamtor2  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2)
Lamtor3  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)
Lamtor4  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)
Lamtor5  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5)
Mios  (meiosis regulator for oocyte development)
Nprl2  (NPR2 like, GATOR1 complex subunit)
Nprl3  (nitrogen permease regulator-like 3)
Rraga  (Ras-related GTP binding A)
Rragb  (Ras-related GTP binding B)
Rragc  (Ras-related GTP binding C)
Rragd  (Ras-related GTP binding D)
Wdr24  (WD repeat domain 24)
Wdr59  (WD repeat domain 59)

Genes (Homo sapiens)
DEPDC5  (DEP domain containing 5, GATOR1 subcomplex subunit)
LAMTOR1  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)
LAMTOR2  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2)
LAMTOR3  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)
LAMTOR4  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)
LAMTOR5  (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5)
MIOS  (meiosis regulator for oocyte development)
NPRL2  (NPR2 like, GATOR1 complex subunit)
NPRL3  (NPR3 like, GATOR1 complex subunit)
RRAGA  (Ras related GTP binding A)
RRAGB  (Ras related GTP binding B)
RRAGC  (Ras related GTP binding C)
RRAGD  (Ras related GTP binding D)
WDR24  (WD repeat domain 24)
WDR59  (WD repeat domain 59)


Additional Information