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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:platycodin D
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Accession:CHEBI:70436 term browser browse the term
Definition:A triterpenoid saponin that has formula C57H92O28.
Synonyms:related_synonym: Formula=C57H92O28;   InChI=1S/C57H92O28/c1-23-40(81-45-39(72)41(28(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)27(63)17-77-48(42)85-50(74)57-12-11-51(2,3)13-25(57)24-7-8-30-52(4)14-26(62)44(84-47-37(70)35(68)34(67)29(16-58)80-47)55(19-59,20-60)31(52)9-10-53(30,5)54(24,6)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25-,26-,27-,28+,29+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48-,49-,52+,53+,54+,56+,57+/m0/s1;   InChIKey=CYBWUNOAQPMRBA-NDTOZIJESA-N;   Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1->3)-O-beta-D-xylopyranosyl-(1->4)-O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-;   SMILES=[H][C@]1(O[C@@H](C)[C@]([H])(O[C@@H]2OC[C@@H](O)[C@]([H])(O[C@@H]3OC[C@](O)(CO)[C@H]3O)[C@H]2O)[C@@H](O)[C@H]1O)O[C@@H]1[C@@H](O)[C@@H](O)CO[C@H]1OC(=O)[C@]12CCC(C)(C)C[C@@]1([H])C1=CC[C@]3([H])[C@@]4(C)C[C@H](O)[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(CO)(CO)[C@]4([H])CC[C@@]3(C)[C@]1(C)C[C@H]2O
 xref: CAS:58479-68-8;   KEGG:C17410
 xref_mesh: MESH:C108953
 xref: PMID:20939516


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platycodin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [platycodin D co-treated with Imatinib Mesylate] results in decreased expression of ABL1 protein CTD PMID:29552859 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO platycodin D results in increased phosphorylation of ACACA protein CTD PMID:22872592 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases activity ISO platycodin D results in decreased activity of ACAT1 protein CTD PMID:16626693 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects expression
multiple interactions
decreases expression
decreases phosphorylation
decreases activity
increases phosphorylation		 ISO
EXP		 platycodin D affects the expression of AKT1 protein modified form
platycodin D inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
platycodin D results in decreased expression of AKT1 protein modified form
platycodin D results in decreased phosphorylation of AKT1 protein
platycodin D results in decreased activity of AKT1 protein
[platycodin D co-treated with Imatinib Mesylate] results in decreased phosphorylation of and results in decreased expression of AKT1 protein; [platycodin D results in decreased activity of AKT1 protein] which results in decreased phosphorylation of and results in decreased localization of TERT protein
platycodin D results in increased phosphorylation of AKT1 protein		 CTD PMID:18093727 PMID:21847688 PMID:24048756 PMID:25250884 PMID:25532840 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg3 autophagy related 3 increases expression ISO platycodin D results in increased expression of ATG3 protein CTD PMID:26078792 NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO platycodin D results in increased expression of ATG7 protein CTD PMID:26078792 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Axin1 axin 1 decreases expression ISO platycodin D results in decreased expression of AXIN1 protein CTD PMID:21798269 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO platycodin D results in increased expression of BAK1 protein CTD PMID:23236765 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO platycodin D results in increased expression of BAX protein CTD PMID:20412017 PMID:23236765 PMID:24641402 PMID:25532840 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO platycodin D results in decreased expression of BCL2 protein CTD PMID:20412017 PMID:23236765 PMID:24048756 PMID:25532840 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO platycodin D results in decreased expression of BCL2L1 protein CTD PMID:23236765 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 increases expression ISO platycodin D results in increased expression of BECN1 protein CTD PMID:26078792 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist increases activity ISO platycodin D results in increased activity of BID protein CTD PMID:20412017 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO Everolimus promotes the reaction [platycodin D results in decreased expression of BIRC5 protein]; platycodin D promotes the reaction [Everolimus results in decreased expression of BIRC5 protein] CTD PMID:24641402 PMID:28711525 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases phosphorylation ISO platycodin D results in increased phosphorylation of CAMK2A protein CTD PMID:23319015 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO [MK 2206 co-treated with platycodin D] results in increased activity of CASP3 protein; [platycodin D co-treated with Imatinib Mesylate] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [platycodin D results in increased activity of CASP3 protein]
platycodin D results in increased cleavage of CASP3 protein		 CTD PMID:16631160 PMID:18804340 PMID:23236765 PMID:24048756 PMID:25532840 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases activity ISO platycodin D results in increased activity of CASP4 protein CTD PMID:22784044 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [MK 2206 co-treated with platycodin D] results in increased activity of CASP7 protein CTD PMID:27897231 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO platycodin D results in increased activity of CASP8 protein CTD PMID:16631160 PMID:20412017 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage		 ISO [platycodin D co-treated with Imatinib Mesylate] results in increased cleavage of CASP9 protein
platycodin D results in increased activity of CASP9 protein
platycodin D results in increased cleavage of CASP9 protein		 CTD PMID:20412017 PMID:23236765 PMID:24048756 PMID:29552859 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO platycodin D inhibits the reaction [Ethanol results in decreased activity of CAT protein] CTD PMID:25927324 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL17 mRNA] CTD PMID:24854572 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO platycodin D inhibits the reaction [IL1B protein results in increased secretion of CCL5 protein] CTD PMID:27743553 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP platycodin D results in decreased expression of CCN2 protein CTD PMID:29595072 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO CTNNB1 affects the reaction [platycodin D results in increased expression of CCND1 mRNA] CTD PMID:21798269 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd14 CD14 molecule multiple interactions EXP platycodin D inhibits the reaction [Ethanol results in increased expression of CD14 protein] CTD PMID:28852734 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd274 CD274 molecule multiple interactions
increases expression		 ISO Chlorpromazine inhibits the reaction [platycodin D results in decreased expression of and results in increased secretion of CD274 protein]; platycodin D results in decreased expression of and results in increased secretion of CD274 protein
platycodin D results in increased expression of CD274 mRNA		 CTD PMID:31150782 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone decreases expression ISO platycodin D results in decreased expression of CDC37 protein CTD PMID:28711525 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO platycodin D results in decreased expression of CDK6 protein CTD PMID:28711525 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO platycodin D results in increased expression of CDKN1A protein CTD PMID:25431082 PMID:27432230 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO platycodin D results in increased expression of CDKN1B protein CTD PMID:25431082 PMID:27432230 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
multiple interactions		 ISO platycodin D results in decreased expression of CEBPA mRNA; platycodin D results in decreased expression of CEBPA protein
CTNNB1 affects the reaction [platycodin D results in decreased expression of CEBPA protein]		 CTD PMID:21798269 PMID:22872592 PMID:26244589 PMID:30599906 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation ISO platycodin D results in decreased phosphorylation of CREB1 protein CTD PMID:21995379 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO CTNNB1 affects the reaction [platycodin D results in decreased expression of CEBPA protein]; CTNNB1 affects the reaction [platycodin D results in decreased expression of FABP4 protein]; CTNNB1 affects the reaction [platycodin D results in increased expression of CCND1 mRNA]; CTNNB1 affects the reaction [platycodin D results in increased expression of PPARG mRNA]; platycodin D results in increased expression of and results in increased localization of CTNNB1 protein CTD PMID:21798269 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO platycodin D results in increased expression of DDIT3 mRNA CTD PMID:22784044 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 increases expression ISO platycodin D results in increased expression of DVL2 mRNA; platycodin D results in increased expression of DVL2 protein CTD PMID:21798269 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions		 ISO platycodin D results in decreased expression of EGFR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [platycodin D results in decreased expression of EGFR protein]; platycodin D inhibits the reaction [Everolimus results in increased expression of EGFR protein]; platycodin D inhibits the reaction [MK 2206 results in increased expression of EGFR protein]		 CTD PMID:23867902 PMID:27897231 PMID:28711525 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions		 ISO platycodin D results in increased expression of EGR1 mRNA
Acetylcysteine inhibits the reaction [platycodin D results in increased expression of EGR1 mRNA]		 CTD PMID:18804340 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO platycodin D results in increased phosphorylation of EIF2A protein CTD PMID:22784044 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO platycodin D results in increased phosphorylation of EIF2AK3 protein CTD PMID:22784044 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation
decreases expression		 ISO [platycodin D co-treated with MK 2206] results in decreased phosphorylation of EIF4EBP1 protein; Everolimus promotes the reaction [platycodin D results in decreased phosphorylation of EIF4EBP1 protein]; platycodin D promotes the reaction [Everolimus results in decreased phosphorylation of EIF4EBP1 protein]
platycodin D results in decreased expression of EIF4EBP1 protein modified form		 CTD PMID:26078792 PMID:27897231 PMID:28711525 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression
multiple interactions		 ISO platycodin D results in decreased expression of ERBB2 protein
platycodin D inhibits the reaction [MK 2206 results in increased expression of ERBB2 protein]		 CTD PMID:27897231 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO platycodin D results in decreased expression of ESR1 protein CTD PMID:23867902 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
decreases expression		 ISO CTNNB1 affects the reaction [platycodin D results in decreased expression of FABP4 protein]
platycodin D results in decreased expression of FABP4 mRNA; platycodin D results in decreased expression of FABP4 protein		 CTD PMID:20024897 PMID:21798269 PMID:22872592 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of FAS mRNA]]; dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of FAS protein]]; platycodin D inhibits the reaction [Glucose results in increased expression of FAS mRNA]; platycodin D inhibits the reaction [Glucose results in increased expression of FAS protein]; STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of FAS mRNA]]
platycodin D results in increased expression of FAS protein		 CTD PMID:16631160 PMID:23319015 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO platycodin D results in increased expression of FASLG mRNA; platycodin D results in increased expression of FASLG protein CTD PMID:16631160 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO platycodin D results in decreased expression of FASN mRNA CTD PMID:22872592 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP platycodin D results in decreased expression of FGF2 protein CTD PMID:29595072 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO platycodin D affects the expression of and affects the localization of FOS protein CTD PMID:26184636 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo3 forkhead box O3 increases expression
decreases expression
multiple interactions		 ISO platycodin D results in increased expression of FOXO3 protein
platycodin D results in decreased expression of FOXO3 protein modified form
MDM2 protein inhibits the reaction [platycodin D results in increased expression of FOXO3 protein]		 CTD PMID:25431082 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO platycodin D inhibits the reaction [Alloxan results in decreased expression of FOXP3 protein]; platycodin D inhibits the reaction [TGFB1 protein results in decreased expression of FOXP3 protein] CTD PMID:25887267 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression EXP platycodin D results in decreased expression of GATA4 protein modified form CTD PMID:29595072 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO platycodin D results in increased expression of GDF15 protein CTD PMID:18804340 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO platycodin D results in increased expression of and results in increased activity of HMOX1 protein CTD PMID:24854572 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO platycodin D results in increased expression of HSPA5 mRNA CTD PMID:22784044 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma multiple interactions ISO platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL17 mRNA]; platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein] CTD PMID:24854572 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [platycodin D results in decreased expression of IGF1R protein]; platycodin D inhibits the reaction [Everolimus results in increased expression of IGF1R protein] CTD PMID:28711525 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases activity ISO platycodin D results in increased activity of IKBKB protein CTD PMID:16631160 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO platycodin D inhibits the reaction [Alloxan results in decreased expression of and results in decreased secretion of IL10 protein]; platycodin D inhibits the reaction [TGFB1 protein results in decreased expression of and results in decreased secretion of IL10 protein] CTD PMID:25887267 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of and results in increased secretion of IL17A protein]; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL17A protein] CTD PMID:25887267 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL1B protein]; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein]; platycodin D inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of IL1B protein]
platycodin D inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
platycodin D inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; platycodin D inhibits the reaction [IL1B protein results in increased expression of NR1H3 protein]; platycodin D inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; platycodin D inhibits the reaction [IL1B protein results in increased secretion of CCL5 protein]; platycodin D inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; platycodin D inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]; platycodin D inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]		 CTD PMID:25887267 PMID:25927324 PMID:27743553 PMID:29375565 PMID:30562685 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL6 protein]; platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of and results in increased secretion of IL17A protein]; platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of RORC protein]; platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased phosphorylation of STAT3 protein]; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]; platycodin D inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of IL6 protein]
platycodin D inhibits the reaction [Ethanol results in increased expression of IL6 protein]; platycodin D inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:25887267 PMID:25927324 PMID:28852734 PMID:29375565 PMID:30562685 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO platycodin D results in decreased phosphorylation of JAK2 protein CTD PMID:25250884 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kdr kinase insert domain receptor decreases phosphorylation
affects binding		 ISO platycodin D results in decreased phosphorylation of KDR protein
platycodin D binds to KDR protein		 CTD PMID:25250884 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Klf2 KLF transcription factor 2 increases expression
multiple interactions		 ISO platycodin D results in increased expression of KLF2 mRNA
KLF2 affects the reaction [platycodin D results in decreased activity of PPARG protein]; KLF2 affects the reaction [platycodin D results in decreased expression of PPARG mRNA]		 CTD PMID:20024897 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Lpl lipoprotein lipase decreases expression ISO platycodin D results in decreased expression of LPL mRNA CTD PMID:20024897 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions EXP platycodin D inhibits the reaction [Ethanol results in increased expression of LY96 mRNA] CTD PMID:28852734 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions
increases expression		 ISO U 0126 inhibits the reaction [platycodin D results in increased expression of MAP1LC3A protein] CTD PMID:25592318 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO platycodin D results in increased expression of MAP1LC3B mRNA; platycodin D results in increased expression of MAP1LC3B protein CTD PMID:26078792 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases expression EXP platycodin D results in decreased expression of MAP2K5 protein modified form CTD PMID:29595072 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Acetylcysteine inhibits the reaction [platycodin D affects the phosphorylation of and results in increased activity of MAP3K5 protein]; platycodin D affects the phosphorylation of and results in increased activity of MAP3K5 protein CTD PMID:22784044 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
increases activity
increases phosphorylation
multiple interactions		 ISO
EXP		 platycodin D results in decreased phosphorylation of MAPK1 protein
platycodin D results in increased activity of MAPK1 protein
platycodin D results in increased phosphorylation of MAPK1 protein
platycodin D inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
U 0126 inhibits the reaction [platycodin D results in increased phosphorylation of MAPK1 protein]		 CTD PMID:20412017 PMID:25592318 PMID:26078792 PMID:27739107 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
increases phosphorylation
decreases phosphorylation
multiple interactions		 ISO
EXP		 platycodin D results in increased activity of MAPK3 protein
platycodin D results in increased phosphorylation of MAPK3 protein
platycodin D results in decreased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [platycodin D results in increased phosphorylation of MAPK3 protein]
platycodin D inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:20412017 PMID:25592318 PMID:26078792 PMID:27739107 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO platycodin D results in increased activity of MAPK8 protein CTD PMID:20412017 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases activity ISO platycodin D results in increased activity of MAPK9 protein CTD PMID:20412017 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression
multiple interactions		 ISO platycodin D results in decreased expression of MDM2 protein
MDM2 protein inhibits the reaction [platycodin D results in increased expression of FOXO3 protein]		 CTD PMID:25431082 PMID:27432230 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mdm4 MDM4 regulator of p53 decreases expression ISO platycodin D results in decreased expression of MDM4 protein CTD PMID:27432230 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO platycodin D inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein] CTD PMID:27743553 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO platycodin D inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein] CTD PMID:27743553 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP platycodin D results in decreased expression of MMP2 protein CTD PMID:29595072 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression		 ISO
EXP		 platycodin D results in decreased activity of MMP9 protein
platycodin D results in decreased expression of MMP9 mRNA
platycodin D results in decreased expression of MMP9 protein		 CTD PMID:23867902 PMID:29595072 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase decreases activity EXP platycodin D results in decreased activity of MPO protein CTD PMID:29770154 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO platycodin D results in decreased phosphorylation of MTOR protein
[platycodin D co-treated with Imatinib Mesylate] results in decreased phosphorylation of and results in decreased expression of MTOR protein		 CTD PMID:23867902 PMID:29552859 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO platycodin D inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC mRNA] CTD PMID:25590691 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO platycodin D results in decreased expression of and results in decreased activity of MYC protein CTD PMID:18093727 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP platycodin D inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:28852734 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO
EXP		 platycodin D affects the expression of and affects the localization of NFATC1 protein
platycodin D inhibits the reaction [TNFSF11 protein results in increased expression of and results in increased activity of NFATC1 protein]		 CTD PMID:26184636 PMID:27739107 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 decreases expression EXP platycodin D results in decreased expression of NFATC3 protein CTD PMID:29595072 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases localization ISO platycodin D results in increased localization of NFE2L2 protein CTD PMID:24854572 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16631160 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation		 ISO platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; platycodin D inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]
platycodin D results in increased degradation of NFKBIA protein		 CTD PMID:16631160 PMID:24854572 PMID:27743553 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO platycodin D results in decreased expression of NOS2 protein
platycodin D inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; platycodin D inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:15748625 PMID:23116642 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppb natriuretic peptide B decreases expression EXP platycodin D results in decreased expression of NPPB protein CTD PMID:29595072 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO platycodin D inhibits the reaction [IL1B protein results in increased expression of NR1H3 protein] CTD PMID:27743553 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases activity ISO platycodin D results in decreased activity of NR1H4 protein CTD PMID:16626693 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases activity		 ISO platycodin D results in increased cleavage of PARP1 protein
[platycodin D co-treated with Imatinib Mesylate] results in increased cleavage of and results in decreased expression of PARP1 protein
platycodin D results in increased activity of PARP1 protein		 CTD PMID:18804340 PMID:20412017 PMID:23236765 PMID:24048756 PMID:24641402 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression EXP platycodin D results in decreased expression of PLAU protein CTD PMID:29595072 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plcg1 phospholipase C, gamma 1 decreases phosphorylation ISO platycodin D results in decreased phosphorylation of PLCG1 protein CTD PMID:25250884 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
decreases activity		 ISO platycodin D results in decreased expression of PPARG protein
platycodin D results in decreased expression of PPARG mRNA; platycodin D results in decreased expression of PPARG protein
CTNNB1 affects the reaction [platycodin D results in increased expression of PPARG mRNA]; KLF2 affects the reaction [platycodin D results in decreased activity of PPARG protein]; KLF2 affects the reaction [platycodin D results in decreased expression of PPARG mRNA]		 CTD PMID:20024897 PMID:21798269 PMID:22872592 PMID:26244589 PMID:30599906 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO platycodin D results in increased expression of PPARGC1A protein CTD PMID:26244589 PMID:30599906 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions
increases phosphorylation		 ISO platycodin D results in increased phosphorylation of and results in increased activity of PRKAA1 protein
platycodin D results in increased phosphorylation of PRKAA1 protein		 CTD PMID:22872592 PMID:30599906 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO platycodin D results in increased phosphorylation of and results in increased activity of PRKAA2 protein CTD PMID:30599906 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 platycodin D inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
platycodin D inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; platycodin D inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]		 CTD PMID:11458457 PMID:15748625 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO platycodin D results in decreased phosphorylation of PTK2 protein CTD PMID:25250884 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity
multiple interactions
increases localization		 ISO
EXP		 platycodin D results in decreased activity of RELA protein
platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL1B protein]; platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL6 protein]; platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of TNF protein]; platycodin D inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RELA protein]
platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; platycodin D inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]
platycodin D results in increased localization of RELA protein
platycodin D inhibits the reaction [Ethanol results in increased expression of RELA protein modified form]; platycodin D inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]		 CTD PMID:16631160 PMID:23867902 PMID:24854572 PMID:27739107 PMID:27743553 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of RORC protein]; platycodin D inhibits the reaction [Alloxan results in increased expression of RORC protein] CTD PMID:25887267 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO platycodin D results in decreased expression of RPS6KB1 protein modified form CTD PMID:26078792 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL1B protein]; platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL6 protein]; platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of TNF protein] CTD PMID:30562685 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL1B protein]; platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL6 protein]; platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of TNF protein] CTD PMID:30562685 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO platycodin D results in increased expression of SLC2A4 protein CTD PMID:21847688 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; [platycodin D co-treated with osthol] results in decreased expression of SMAD2 mRNA; [platycodin D co-treated with osthol] results in decreased expression of SMAD2 protein CTD PMID:23603464 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; [platycodin D co-treated with osthol] results in decreased expression of SMAD3 mRNA; [platycodin D co-treated with osthol] results in decreased expression of SMAD3 protein CTD PMID:23603464 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO [platycodin D co-treated with osthol] results in decreased expression of SMAD4 mRNA; [platycodin D co-treated with osthol] results in decreased expression of SMAD4 protein CTD PMID:23603464 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO platycodin D results in decreased expression of and results in decreased activity of SP1 protein CTD PMID:18093727 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO platycodin D results in decreased phosphorylation of SRC protein CTD PMID:25250884 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]; dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]; Niacinamide inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]; platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]; platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]] CTD PMID:23319015 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein] CTD PMID:24854572 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased phosphorylation of STAT3 protein] CTD PMID:25887267 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tert telomerase reverse transcriptase decreases expression
multiple interactions		 ISO platycodin D results in decreased expression of TERT mRNA
[platycodin D results in decreased activity of AKT1 protein] which results in decreased phosphorylation of and results in decreased localization of TERT protein		 CTD PMID:18093727 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
platycodin D results in decreased expression of TGFB1 protein
platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of and results in increased secretion of IL17A protein]; platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of RORC protein]; platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased phosphorylation of STAT3 protein]; platycodin D inhibits the reaction [TGFB1 protein results in decreased expression of and results in decreased secretion of IL10 protein]; platycodin D inhibits the reaction [TGFB1 protein results in decreased expression of FOXP3 protein]		 CTD PMID:23603464 PMID:25887267 PMID:29595072 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO [platycodin D co-treated with osthol] results in decreased expression of TGFBR2 mRNA; [platycodin D co-treated with osthol] results in decreased expression of TGFBR2 protein CTD PMID:23603464 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP platycodin D inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA]; platycodin D inhibits the reaction [Lipopolysaccharides affects the localization of TLR4 protein] CTD PMID:28852734 PMID:29375565 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of TNF protein]; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]; platycodin D inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of TNF protein]
platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL17 mRNA]; platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; platycodin D inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
platycodin D inhibits the reaction [Ethanol results in increased expression of TNF protein]; platycodin D inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:24854572 PMID:25887267 PMID:25927324 PMID:28852734 PMID:29375565 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP
ISO		 platycodin D inhibits the reaction [TNFSF11 protein results in increased expression of and results in increased activity of NFATC1 protein]; platycodin D inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; platycodin D inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; platycodin D inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
platycodin D inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RELA protein]		 CTD PMID:27739107 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO platycodin D results in decreased expression of TP53 protein mutant form CTD PMID:27432230 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf6 TNF receptor associated factor 6 decreases expression
multiple interactions		 EXP platycodin D results in decreased expression of TRAF6 mRNA
platycodin D inhibits the reaction [Ethanol results in increased expression of TRAF6 mRNA]		 CTD PMID:28852734 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO platycodin D results in increased expression of UCP1 protein CTD PMID:30599906 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        biochemical role 19566
          metabolite 19533
            platycodin D 127
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbohydrates and carbohydrate derivatives 15283
                                    carbohydrate 15304
                                      carbohydrate derivative 14317
                                        glycosyl compound 13080
                                          glycoside 11832
                                            saponin 497
                                              triterpenoid saponin 424
                                                platycodin D 127
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