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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S100a8
Name: S100 calcium binding protein A8
Acc ID: CHEBI:70436
Term: platycodin D
Definition: A triterpenoid saponin that has formula C57H92O28.
Chemical ID: MESH:C108953
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S100a8multiple interactionsISOS100a8 (Mus musculus)6480464CTDplatycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL1B protein]; platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of IL6 protein]; platycodin D inhibits the reaction [[[S100A8 protein binds to S100A9 protein] which results in increased localization of and results in increased activity of RELA protein] which results in increased expression of TNF protein]PMID:30562685
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