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tanespimycin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tanespimycin
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Accession:CHEBI:64153 term browser browse the term
Definition:A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.
Synonyms:exact_synonym: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
 related_synonym: 17-(Allylamino)-17-demethoxygeldanamycin;   17-(Allylamino)geldanamycin;   17-AAG;   17-Demethoxy-17-allylamino geldanamycin;   17-N-allylamino-17-demethoxygeldanamycin;   17-allylaminogeldanamycin;   17-demethoxy-17-(2-propenylamino)geldanamycin;   17AAG;   Formula=C31H43N3O8;   InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1;   InChIKey=AYUNIORJHRXIBJ-TXHRRWQRSA-N;   NSC-330507;   SMILES=C=1C(C(=C2C(C1NC(=O)C(C)=CC=C[C@@H]([C@@H](OC(N)=O)C(C)=C[C@@H]([C@H]([C@H](C[C@@H](C2)C)OC)O)C)OC)=O)NCC=C)=O;   tanespimycina;   tanespimycine;   tanespimycinum
 alt_id: MESH:C112765
 xref: CAS:75747-14-7;   KEGG:D06650
 xref_mesh: MESH:C112765
 xref: PMID:20646760;   PMID:20652703;   PMID:20683637;   PMID:21219297;   PMID:21283735;   PMID:21454186;   PMID:21534941;   PMID:21558407;   PMID:21594721;   PMID:21670086;   PMID:21791475;   PMID:21856392;   PMID:22047770;   PMID:22209975;   PMID:22377218;   PMID:22621282;   PMID:23564374;   PMID:24317439;   PMID:25096912;   PMID:25633180;   PMID:25952464;   PMID:26277605;   PMID:26408708;   PMID:26872308;   PMID:26913406;   PMID:26922527;   PMID:27045471;   Reaxys:7402240;   Wikipedia:17-N-Allylamino-17-demethoxygeldanamycin

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tanespimycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11 abhydrolase domain containing 11 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ABHD11 protein CTD PMID:31370342 NCBI chr12:27,318,739...27,322,016
Ensembl chr12:21,682,202...21,685,398 		JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ACTR1A protein CTD PMID:31370342 NCBI chr 1:255,179,241...255,199,009
Ensembl chr 1:245,237,826...245,256,495 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO tanespimycin results in increased expression of ADAMTS1 mRNA CTD PMID:19514085 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions
increases expression		 ISO [tanespimycin co-treated with VER 155008] results in increased expression of AGR2 protein
tanespimycin analog results in increased expression of AGR2 protein; tanespimycin results in increased expression of AGR2 protein		 CTD PMID:31370342 NCBI chr 6:58,435,908...58,456,678
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin results in decreased expression of AHR protein] CTD PMID:37217010 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ak9 adenylate kinase 9 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of AK9 protein CTD PMID:31370342 NCBI chr20:46,307,100...46,523,537
Ensembl chr20:44,724,496...44,941,136 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
affects expression		 ISO
EXP		 Arsenic Trioxide promotes the reaction [tanespimycin results in decreased expression of AKT1 protein]; tanespimycin affects the reaction [Cannabidiol affects the expression of AKT1 protein]; tanespimycin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; tanespimycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
tanespimycin affects the expression of AKT1 protein		 CTD PMID:16923571 PMID:17157164 PMID:18566239 PMID:22810956 PMID:26504004 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO ALB protein binds to tanespimycin
ALB protein inhibits the reaction [Copper results in increased oxidation of tanespimycin analog]		 CTD PMID:18393300 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ALDH1A1 protein CTD PMID:31370342 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Alk ALK receptor tyrosine kinase decreases activity
decreases expression		 ISO tanespimycin results in decreased activity of ALK protein mutant form
tanespimycin results in decreased expression of ALK protein; tanespimycin results in decreased expression of ALK protein modified form		 CTD PMID:21030459 PMID:21502504 NCBI chr 6:28,631,431...29,351,321
Ensembl chr 6:22,880,625...23,598,034 		JBrowse link
G Anxa1 annexin A1 increases expression ISO tanespimycin results in increased expression of ANXA1 protein CTD PMID:31370342 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
increases expression		 ISO Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein] CTD PMID:19913524 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor decreases expression ISO tanespimycin results in decreased expression of AR protein CTD PMID:17010675 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ATP5F1A protein CTD PMID:31370342 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO tanespimycin analog results in decreased expression of ATP5F1B protein CTD PMID:31370342 NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tanespimycin results in decreased expression of BCL2 protein CTD PMID:16923571 PMID:28673683 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO tanespimycin results in decreased expression of BCL2L1 protein CTD PMID:16923571 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO tanespimycin results in increased expression of BCL2L11 protein CTD PMID:24784839 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase increases expression
decreases expression		 ISO
EXP		 tanespimycin analog results in increased expression of BRAF protein
tanespimycin results in decreased expression of BRAF protein		 CTD PMID:22810956 PMID:31370342 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO
EXP		 [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased activity of CASP3 protein]; tanespimycin results in increased cleavage of and results in increased activity of CASP3 protein
SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]
tanespimycin results in increased cleavage of CASP3 protein		 CTD PMID:15993848 PMID:17157164 PMID:18194434 PMID:19913524 PMID:22810956 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions		 ISO tanespimycin results in increased cleavage of CASP8 protein
[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein		 CTD PMID:17121904 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein
tanespimycin results in increased cleavage of CASP9 protein		 CTD PMID:17121904 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO tanespimycin results in decreased expression of CCND1 protein
[Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein		 CTD PMID:17121904 PMID:17157164 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CCT8 protein CTD PMID:31370342 NCBI chr11:40,196,619...40,208,328
Ensembl chr11:26,710,370...26,722,079 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression		 ISO
EXP		 [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein
tanespimycin results in decreased expression of CDC25C protein		 CTD PMID:21156818 PMID:22810956 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
affects expression		 ISO [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein; tanespimycin affects the reaction [Cannabidiol affects the expression of CDK1 protein]
tanespimycin results in decreased expression of CDK1 protein
tanespimycin affects the expression of CDK1 protein		 CTD PMID:21156818 PMID:24784839 PMID:26504004 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO tanespimycin results in decreased expression of CDK4 protein CTD PMID:17157164 PMID:28673683 PMID:34291863 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk8 cyclin-dependent kinase 8 decreases expression ISO tanespimycin results in decreased expression of CDK8 protein CTD PMID:17157164 NCBI chr12:8,737,198...8,805,026
Ensembl chr12:8,737,262...8,804,177 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO tanespimycin results in decreased expression of CEBPB protein CTD PMID:33609515 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO tanespimycin analog results in increased expression of CES1 protein CTD PMID:31370342 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Chp2 calcineurin-like EF hand protein 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CHP2 protein CTD PMID:31370342 NCBI chr 1:186,189,090...186,203,663
Ensembl chr 1:176,757,876...176,772,139 		JBrowse link
G Commd1 copper metabolism domain containing 1 multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr14:101,081,667...101,185,738
Ensembl chr14:96,880,463...96,984,501 		JBrowse link
G Csde1 cold shock domain containing E1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of CSDE1 protein CTD PMID:31370342 NCBI chr 2:193,234,546...193,271,301
Ensembl chr 2:190,554,980...190,582,784 		JBrowse link
G Cttn cortactin multiple interactions
increases expression		 ISO [tanespimycin co-treated with VER 155008] results in increased expression of CTTN protein
tanespimycin analog results in increased expression of CTTN protein		 CTD PMID:31370342 NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of tanespimycin CTD PMID:15718306 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of DARS1 protein CTD PMID:31370342 NCBI chr13:42,410,351...42,465,467
Ensembl chr13:39,857,936...39,913,116 		JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO tanespimycin results in increased expression of DHRS2 protein CTD PMID:31370342 NCBI chr15:32,658,855...32,673,591
Ensembl chr15:28,688,940...28,703,644 		JBrowse link
G Ebf2 EBF transcription factor 2 increases expression ISO tanespimycin analog results in increased expression of EBF2 protein CTD PMID:31370342 NCBI chr15:45,610,949...45,809,828
Ensembl chr15:41,435,509...41,634,403 		JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ECHDC3 protein CTD PMID:31370342 NCBI chr17:76,980,112...77,002,934
Ensembl chr17:72,070,668...72,093,516 		JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions
decreases expression		 ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EEF1G protein
tanespimycin analog results in decreased expression of EEF1G protein		 CTD PMID:31370342 NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:205,860,698...205,872,382 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions		 ISO tanespimycin analog results in increased expression of EEF2 protein; tanespimycin results in increased expression of EEF2 protein
[tanespimycin co-treated with VER 155008] results in increased expression of EEF2 protein		 CTD PMID:31370342 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions		 ISO tanespimycin analog results in decreased expression of EGFR protein; tanespimycin results in decreased expression of EGFR protein
tanespimycin results in increased degradation of and results in decreased expression of EGFR protein		 CTD PMID:16061882 PMID:17010675 PMID:22810956 PMID:31370342 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression
multiple interactions		 ISO tanespimycin results in decreased expression of EIF3I protein
[tanespimycin co-treated with VER 155008] results in decreased expression of EIF3I protein		 CTD PMID:31370342 NCBI chr 5:147,219,457...147,226,910
Ensembl chr 5:141,935,044...141,942,676 		JBrowse link
G Eif4b eukaryotic translation initiation factor 4B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of EIF4B protein CTD PMID:31370342 NCBI chr 7:135,085,259...135,107,054 JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EIF4H protein CTD PMID:31370342 NCBI chr12:27,719,527...27,736,350
Ensembl chr12:22,082,835...22,099,876 		JBrowse link
G Eml5 EMAP like 5 multiple interactions
increases expression		 ISO [tanespimycin co-treated with VER 155008] results in increased expression of EML5 protein
tanespimycin analog results in increased expression of EML5 protein		 CTD PMID:31370342 NCBI chr 6:123,775,269...123,905,585
Ensembl chr 6:118,046,655...118,175,831 		JBrowse link
G Eno1 enolase 1 increases expression ISO tanespimycin analog results in increased expression of ENO1 protein CTD PMID:31370342 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression		 ISO tanespimycin results in increased degradation of and results in decreased expression of ERBB2 protein
tanespimycin results in decreased expression of ERBB2 protein		 CTD PMID:16061882 PMID:24784839 PMID:34291863 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Eri1 exoribonuclease 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ERI1 protein CTD PMID:31370342 NCBI chr16:63,427,412...63,447,521
Ensembl chr16:56,724,115...56,744,226 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ERP29 protein CTD PMID:31370342 NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta multiple interactions
increases expression		 ISO [tanespimycin co-treated with VER 155008] results in increased expression of FARSB protein
tanespimycin analog results in increased expression of FARSB protein; tanespimycin results in increased expression of FARSB protein		 CTD PMID:31370342 NCBI chr 9:87,336,321...87,395,546
Ensembl chr 9:79,887,842...79,947,045 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FGF1 protein CTD PMID:31370342 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions ISO tanespimycin results in increased degradation of and results in decreased expression of FGFR3 protein CTD PMID:16061882 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO tanespimycin results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Fubp1 far upstream element binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FUBP1 protein CTD PMID:31370342 NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:241,159,512...241,186,602 		JBrowse link
G Gcfc2 GC-rich sequence DNA-binding factor 2 increases expression ISO tanespimycin analog results in increased expression of GCFC2 protein CTD PMID:31370342 NCBI chr 4:114,481,613...114,519,268
Ensembl chr 4:114,481,607...114,519,962 		JBrowse link
G Gls glutaminase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GLS protein CTD PMID:31370342 NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:49,344,781...49,416,900 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanespimycin results in decreased expression of GSK3B protein modified form CTD PMID:20090934 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression ISO tanespimycin analog results in increased expression of GTF2A2 protein CTD PMID:31370342 NCBI chr 8:79,542,682...79,556,484
Ensembl chr 8:70,662,428...70,675,569 		JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GTF2IRD1 protein CTD PMID:31370342 NCBI chr12:27,890,594...27,997,506
Ensembl chr12:22,254,221...22,361,040 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HINT1 protein CTD PMID:31370342 NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression
multiple interactions		 ISO tanespimycin analog results in decreased expression of HSD17B10 protein; tanespimycin results in decreased expression of HSD17B10 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSD17B10 protein		 CTD PMID:31370342 NCBI chr  X:24,568,551...24,571,012
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization
multiple interactions
increases activity		 ISO tanespimycin affects the localization of HSF1 protein
[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
tanespimycin results in increased activity of HSF1 protein		 CTD PMID:20090934 PMID:34170685 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
decreases expression
affects binding		 ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HSP90AA1 protein; N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]
tanespimycin results in decreased expression of HSP90AA1 protein		 CTD PMID:18830594 PMID:22895790 PMID:31370342 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding ISO tanespimycin binds to HSP90AB1 protein CTD PMID:22895790 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression		 ISO [tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
tanespimycin analog results in increased expression of HSPA1A protein		 CTD PMID:20090934 PMID:31370342 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of HSPA1B protein CTD PMID:31370342 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions		 ISO tanespimycin results in increased expression of HSPA4 protein
[tanespimycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin		 CTD PMID:16311509 NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO tanespimycin results in increased expression of HSPA5 protein CTD PMID:16357177 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of HSPA6 protein CTD PMID:31370342 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression
multiple interactions		 ISO tanespimycin results in decreased expression of HSPD1 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSPD1 protein		 CTD PMID:23144451 PMID:31370342 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression
decreases expression		 ISO
EXP		 tanespimycin affects the expression of IGF1R protein
tanespimycin results in decreased expression of IGF1R protein		 CTD PMID:22810956 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ILF3 protein CTD PMID:31370342 NCBI chr 8:28,198,454...28,236,634
Ensembl chr 8:19,922,460...19,960,350 		JBrowse link
G Kcnv2 potassium voltage-gated channel modifier subfamily V member 2 decreases expression
multiple interactions		 ISO tanespimycin analog results in decreased expression of KCNV2 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of KCNV2 protein		 CTD PMID:31370342 NCBI chr 1:234,409,067...234,485,894
Ensembl chr 1:224,999,552...225,014,062 		JBrowse link
G Kdm3a lysine demethylase 3A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of KDM3A protein CTD PMID:31370342 NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:103,630,908...103,675,073 		JBrowse link
G Kdr kinase insert domain receptor affects expression
decreases expression		 ISO
EXP		 tanespimycin affects the expression of KDR protein
tanespimycin results in decreased expression of KDR protein		 CTD PMID:22810956 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions		 ISO
EXP		 tanespimycin results in decreased expression of KIT protein
tanespimycin results in increased degradation of and results in decreased expression of KIT protein		 CTD PMID:16061882 PMID:16213582 PMID:22810956 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Larp7 La ribonucleoprotein 7, transcriptional regulator increases expression ISO tanespimycin analog results in increased expression of LARP7 protein CTD PMID:31370342 NCBI chr 2:218,672,145...218,687,332
Ensembl chr 2:215,997,649...216,012,865 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 increases expression
multiple interactions		 ISO tanespimycin analog results in increased expression of LCP1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of LCP1 protein		 CTD PMID:31370342 NCBI chr15:56,846,375...56,954,090
Ensembl chr15:50,488,149...50,544,680 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LDHA protein CTD PMID:31370342 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldhb lactate dehydrogenase B increases expression ISO tanespimycin analog results in increased expression of LDHB protein CTD PMID:31370342 NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Lmna lamin A/C multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of LMNA protein CTD PMID:31370342 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LRPPRC protein CTD PMID:31370342 NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:9,859,867...9,942,293 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein] CTD PMID:30796972 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
affects expression		 ISO
EXP		 tanespimycin results in decreased phosphorylation of MAPK1 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK1 protein
tanespimycin affects the reaction [Cannabidiol affects the expression of MAPK1 protein]
tanespimycin affects the expression of MAPK1 protein		 CTD PMID:17157164 PMID:20090934 PMID:21502504 PMID:22810956 PMID:24784839 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
affects expression		 ISO
EXP		 tanespimycin results in decreased phosphorylation of MAPK3 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK3 protein
tanespimycin affects the reaction [Cannabidiol affects the expression of MAPK3 protein]
tanespimycin affects the expression of MAPK3 protein		 CTD PMID:17157164 PMID:20090934 PMID:21502504 PMID:22810956 PMID:24784839 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO tanespimycin results in decreased expression of MCL1 protein CTD PMID:16923571 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases degradation ISO tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression EXP
ISO		 tanespimycin results in decreased expression of MET protein CTD PMID:22810956 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions
decreases expression		 ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MIF protein
tanespimycin results in decreased expression of MIF protein		 CTD PMID:31370342 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Mllt10 MLLT10, histone lysine methyltransferase DOT1L cofactor multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MLLT10 protein CTD PMID:31370342 NCBI chr17:85,729,964...85,857,791
Ensembl chr17:80,822,556...80,949,345 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP2 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP2 mRNA] CTD PMID:21401309 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP9 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP9 mRNA] CTD PMID:21401309 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Msn moesin increases expression ISO tanespimycin analog results in increased expression of MSN protein CTD PMID:31370342 NCBI chr  X:65,005,546...65,073,512
Ensembl chr  X:60,995,951...61,065,628 		JBrowse link
G Mtap methylthioadenosine phosphorylase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MTAP protein CTD PMID:31370342 NCBI chr 5:108,990,270...109,036,494
Ensembl chr 5:103,873,020...103,939,406 		JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO tanespimycin results in increased expression of MTSS1 mRNA CTD PMID:19514085 NCBI chr 7:92,378,228...92,517,444
Ensembl chr 7:90,488,754...90,627,968 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NAMPT protein CTD PMID:31370342 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nans N-acetylneuraminate synthase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NANS protein CTD PMID:31370342 NCBI chr 5:65,575,970...65,593,164
Ensembl chr 5:60,780,392...60,814,950 		JBrowse link
G Ncl nucleolin multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NCL protein CTD PMID:31370342 NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:86,998,019...87,008,136 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
decreases phosphorylation		 EXP
ISO		 tanespimycin results in increased expression of NFKBIA protein
tanespimycin results in decreased phosphorylation of NFKBIA protein		 CTD PMID:11835313 PMID:22810956 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [tanespimycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases abundance
increases reduction
increases response to substance		 ISO [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin metabolite; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased susceptibility to tanespimycin; [NQO1 protein results in increased reduction of tanespimycin] which results in increased chemical synthesis of tanespimycin metabolite; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
NQO1 protein results in increased abundance of tanespimycin; NQO1 protein results in increased abundance of tanespimycin metabolite
NQO1 protein results in increased susceptibility to tanespimycin		 CTD PMID:10564678 PMID:21156818 PMID:24552538 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of OAT protein CTD PMID:31370342 NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions
increases expression		 ISO [tanespimycin co-treated with VER 155008] results in increased expression of PA2G4 protein
tanespimycin analog results in increased expression of PA2G4 protein; tanespimycin results in increased expression of PA2G4 protein		 CTD PMID:31370342 NCBI chr 7:1,569,326...1,576,794
Ensembl chr 7:983,971...992,331 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage EXP
ISO		 tanespimycin results in increased cleavage of PARP1 protein CTD PMID:22810956 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 increases expression ISO tanespimycin analog results in increased expression of PARP2 protein CTD PMID:31370342 NCBI chr15:26,494,722...26,517,893
Ensembl chr15:24,034,106...24,044,338 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO
EXP		 tanespimycin results in decreased expression of PDGFRB protein CTD PMID:22810956 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PDIA4 protein CTD PMID:31370342 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pfn1 profilin 1 increases expression ISO tanespimycin analog results in increased expression of PFN1 protein CTD PMID:31370342 NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,365,262...55,527,631 		JBrowse link
G Pgr progesterone receptor decreases expression ISO tanespimycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PIP4K2C protein CTD PMID:31370342 NCBI chr 7:64,905,322...64,920,380
Ensembl chr 7:63,020,000...63,035,078 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO tanespimycin results in decreased expression of PKM protein CTD PMID:31370342 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pnn pinin, desmosome associated protein increases expression ISO tanespimycin results in increased expression of PNN mRNA CTD PMID:19514085 NCBI chr 6:82,493,032...82,501,345
Ensembl chr 6:76,758,117...76,766,889 		JBrowse link
G Prkrip1 PRKR interacting protein 1 increases expression ISO tanespimycin analog results in increased expression of PRKRIP1 protein CTD PMID:31370342 NCBI chr12:26,107,422...26,128,404
Ensembl chr12:20,470,820...20,489,115 		JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PRPS2 protein CTD PMID:31370342 NCBI chr  X:30,592,845...30,630,127
Ensembl chr  X:26,976,061...27,013,181 		JBrowse link
G Psma6 proteasome 20S subunit alpha 6 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PSMA6 protein CTD PMID:31370342 NCBI chr 6:78,500,676...78,531,693
Ensembl chr 6:72,765,473...72,796,554 		JBrowse link
G Psma7 proteasome 20S subunit alpha 7 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PSMA7 protein CTD PMID:31370342 NCBI chr 3:187,514,901...187,521,289
Ensembl chr 3:167,137,263...167,143,672 		JBrowse link
G Rab17 RAB17, member RAS oncogene family multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RAB17 protein CTD PMID:31370342 NCBI chr 9:99,001,044...99,014,340
Ensembl chr 9:91,553,464...91,566,451 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO tanespimycin results in decreased expression of RAF1 protein CTD PMID:10564678 PMID:34291863 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions		 ISO tanespimycin results in decreased phosphorylation of RB1 protein
[tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein		 CTD PMID:17121904 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rdx radixin increases expression
multiple interactions		 ISO tanespimycin analog results in increased expression of RDX protein
[tanespimycin co-treated with VER 155008] results in increased expression of RDX protein		 CTD PMID:31370342 NCBI chr 8:61,275,792...61,348,260
Ensembl chr 8:52,379,494...52,437,678 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RPLP0 protein CTD PMID:31370342 NCBI chr12:46,715,121...46,718,390
Ensembl chr12:41,054,179...41,057,632 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
decreases expression		 ISO tanespimycin results in decreased phosphorylation of RPS6 protein
tanespimycin results in decreased expression of RPS6 protein		 CTD PMID:17121904 PMID:27255535 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Runx1 RUNX family transcription factor 1 decreases expression ISO tanespimycin results in decreased expression of RUNX1 protein mutant form CTD PMID:33609515 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression ISO tanespimycin results in decreased expression of RUNX1T1 protein mutant form CTD PMID:33609515 NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:27,187,551...27,335,592 		JBrowse link
G Selenbp1 selenium binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of SELENBP1 protein CTD PMID:31370342 NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:182,493,978...182,504,594 		JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO tanespimycin results in increased expression of SERPINB5 mRNA CTD PMID:19514085 NCBI chr13:23,500,203...23,520,401
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 decreases expression ISO tanespimycin analog results in decreased expression of SHMT2 protein CTD PMID:31370342 NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Sod2 superoxide dismutase 2 increases abundance
increases response to substance		 ISO SOD2 protein results in increased abundance of tanespimycin metabolite
SOD2 protein results in increased susceptibility to tanespimycin		 CTD PMID:21156818 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 increases expression
multiple interactions		 ISO tanespimycin analog results in increased expression of SRCIN1 protein; tanespimycin results in increased expression of SRCIN1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of SRCIN1 protein		 CTD PMID:31370342 NCBI chr10:82,999,295...83,066,359
Ensembl chr10:82,504,393...82,571,040 		JBrowse link
G Tagln2 transgelin 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of TAGLN2 protein CTD PMID:31370342 NCBI chr13:87,499,350...87,506,328
Ensembl chr13:84,967,009...84,973,972 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO tanespimycin results in increased expression of TIMP3 mRNA CTD PMID:19514085 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein CTD PMID:15993848 NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO tanespimycin results in decreased expression of TP53 protein CTD PMID:10564678 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 increases expression ISO tanespimycin analog results in increased expression of TPTE2 protein CTD PMID:31370342 NCBI chr16:76,361,330...76,455,664
Ensembl chr16:69,658,875...69,752,949 		JBrowse link
G Tymp thymidine phosphorylase decreases expression
multiple interactions		 ISO tanespimycin results in decreased expression of TYMP mRNA; tanespimycin results in decreased expression of TYMP protein
[salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]; [tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]]; tanespimycin inhibits the reaction [salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]		 CTD PMID:30796972 NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Tyms thymidylate synthetase decreases expression ISO tanespimycin results in decreased expression of TYMS protein CTD PMID:18830594 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO tanespimycin analog results in increased expression of UGDH protein; tanespimycin results in increased expression of UGDH protein CTD PMID:31370342 NCBI chr14:43,202,480...43,226,002
Ensembl chr14:42,848,854...42,872,354 		JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 decreases expression ISO tanespimycin results in decreased expression of UGP2 protein CTD PMID:31370342 NCBI chr14:99,657,637...99,698,573
Ensembl chr14:95,456,330...95,496,830 		JBrowse link
G Vil1 villin 1 increases expression ISO tanespimycin analog results in increased expression of VIL1 protein CTD PMID:31370342 NCBI chr 9:83,440,248...83,467,963
Ensembl chr 9:75,991,141...76,018,858 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein CTD PMID:15993848 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of YARS1 protein CTD PMID:31370342 NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:141,535,759...141,563,833 		JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator multiple interactions
increases expression		 ISO [tanespimycin co-treated with VER 155008] results in increased expression of ZYG11B protein
tanespimycin analog results in increased expression of ZYG11B protein		 CTD PMID:31370342 NCBI chr 5:122,985,548...123,042,735
Ensembl chr 5:122,992,147...123,042,736 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        antimicrobial agent 18257
          geldanamycin 485
            tanespimycin 144
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              lactam 8392
                                                ansamycin 869
                                                  geldanamycin 485
                                                    tanespimycin 144
paths to the root