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Gene: Parp2 (poly (ADP-ribose) polymerase 2) Rattus norvegicus

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Symbol:

Parp2

Name:

poly (ADP-ribose) polymerase 2

RGD ID:

1310568

Description:

Predicted to enable several functions, including pentosyltransferase activity; poly-ADP-D-ribose binding activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Involved in hippocampal neuron apoptotic process; positive regulation of cell growth involved in cardiac muscle cell development; and response to oxygen-glucose deprivation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleolus and site of DNA damage. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; base excision repair pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,4-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2; Adprtl2; LOC290027; poly (ADP-ribose) polymerase family, member 2; poly [ADP-ribose] polymerase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PARP2 (poly(ADP-ribose) polymerase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Parp2 (poly (ADP-ribose) polymerase family, member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Parp2 (poly(ADP-ribose) polymerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PARP2 (poly(ADP-ribose) polymerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PARP2 (poly(ADP-ribose) polymerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Parp2 (poly(ADP-ribose) polymerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PARP2 (poly(ADP-ribose) polymerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PARP2 (poly(ADP-ribose) polymerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Parp2 (poly(ADP-ribose) polymerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	KLHL20 (kelch like family member 20)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Parp2 (poly (ADP-ribose) polymerase family, member 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PARP2 (poly(ADP-ribose) polymerase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	parp2 (poly (ADP-ribose) polymerase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	parp-2	Alliance	DIOPT (Ensembl Compara\|OMA)
Xenopus tropicalis (tropical clawed frog):	parp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	26,494,722 - 26,517,893 (+)	NCBI		GRCr8
mRatBN7.2	15	24,034,069 - 24,044,340 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	24,034,106 - 24,044,338 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	26,805,300 - 26,815,532 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	27,764,036 - 27,774,257 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	26,013,838 - 26,024,070 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	27,739,416 - 27,749,650 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	27,739,251 - 27,749,648 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	31,571,841 - 31,582,075 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	26,790,296 - 26,801,086 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	26,806,027 - 26,816,785 (+)	NCBI
Celera	15	24,353,597 - 24,363,829 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (IEP)

lipodystrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

3-aminobenzamide (ISO)

4,4'-sulfonyldiphenol (ISO)

antimycin A (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

cisplatin (ISO)

clofibrate (EXP)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

cypermethrin (ISO)

DDE (ISO)

deguelin (ISO)

diarsenic trioxide (ISO)

dioxygen (ISO)

Enterolactone (ISO)

fenpyroximate (ISO)

FR900359 (ISO)

fulvestrant (ISO)

furan (EXP)

gemcitabine (ISO)

glyphosate (ISO)

lead(0) (ISO)

leflunomide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N-methyl-N-nitrosourea (ISO)

niraparib (ISO)

nitrates (ISO)

olaparib (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

phorbol 13-acetate 12-myristate (ISO)

resveratrol (EXP,ISO)

rucaparib (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

talazoparib (ISO)

tanespimycin (ISO)

tebufenpyrad (ISO)

testosterone (ISO)

topotecan (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

veliparib (ISO)

vincristine (ISO)

XAV939 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (ISO)

decidualization (ISO)

DNA ADP-ribosylation (ISO)

DNA damage response (IEA,ISO)

DNA repair (IEA,ISO)

DNA repair-dependent chromatin remodeling (ISO)

double-strand break repair (IBA)

extrinsic apoptotic signaling pathway (ISO)

hippocampal neuron apoptotic process (IMP)

positive regulation of cell growth involved in cardiac muscle cell development (IMP)

protein auto-ADP-ribosylation (ISO)

protein poly-ADP-ribosylation (ISO)

response to oxygen-glucose deprivation (IMP)

Cellular Component

chromosome (IEA)

cytosol (ISO)

nucleolus (IBA,ISO)

nucleoplasm (ISO)

nucleus (IEA,ISO)

site of DNA damage (ISO)

Molecular Function

chromatin binding (ISO)

damaged DNA binding (ISO)

glycosyltransferase activity (IEA)

NAD DNA ADP-ribosyltransferase activity (ISO)

NAD+ poly-ADP-ribosyltransferase activity (IBA,IEA,ISO)

NAD+-protein mono-ADP-ribosyltransferase activity (ISO)

NAD+-protein-aspartate ADP-ribosyltransferase activity (ISO)

NAD+-protein-glutamate ADP-ribosyltransferase activity (ISO)

NAD+-protein-serine ADP-ribosyltransferase activity (ISO)

nucleosome binding (ISO)

nucleotidyltransferase activity (IEA)

poly-ADP-D-ribose binding (ISO)

poly-ADP-D-ribose modification-dependent protein binding (ISO)

protein binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ADP-ribosylation pathway, mono and poly-ribosylation (ISO)

base excision repair pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation.	Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1.	Geng B, etal., Biochem Biophys Res Commun. 2013 Jan 18;430(3):944-50. doi: 10.1016/j.bbrc.2012.11.132. Epub 2012 Dec 19.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.	Moroni F, etal., Br J Pharmacol. 2009 Jul;157(5):854-62. doi: 10.1111/j.1476-5381.2009.00232.x. Epub 2009 May 5.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1.	Zhang L, etal., Eur J Pharmacol. 2014 Dec 5;744:203-10. doi: 10.1016/j.ejphar.2014.09.037. Epub 2014 Sep 30.

Additional References at PubMed

PMID:10364231	PMID:11948190	PMID:12065591	PMID:12477932	PMID:15615785	PMID:25043379	PMID:27471034	PMID:28190768	PMID:30077797	PMID:30541899	PMID:32939087	PMID:38281279

Genomics

Comparative Map Data

Parp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	26,494,722 - 26,517,893 (+)	NCBI		GRCr8
mRatBN7.2	15	24,034,069 - 24,044,340 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	24,034,106 - 24,044,338 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	26,805,300 - 26,815,532 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	27,764,036 - 27,774,257 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	26,013,838 - 26,024,070 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	27,739,416 - 27,749,650 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	27,739,251 - 27,749,648 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	31,571,841 - 31,582,075 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	26,790,296 - 26,801,086 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	26,806,027 - 26,816,785 (+)	NCBI
Celera	15	24,353,597 - 24,363,829 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

PARP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	20,343,635 - 20,357,904 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	20,343,615 - 20,357,904 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	20,811,794 - 20,826,063 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	19,881,613 - 19,895,903 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	672,919 - 687,220 (+)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	933,616 - 947,915 (+)	NCBI		HuRef
CHM1_1	14	20,813,199 - 20,827,472 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	14,540,530 - 14,554,811 (+)	NCBI		T2T-CHM13v2.0

Parp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	51,045,347 - 51,058,758 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	51,045,298 - 51,058,758 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	50,807,897 - 50,821,301 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	50,807,841 - 50,821,301 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	51,427,621 - 51,440,975 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	49,729,897 - 49,743,251 (+)	NCBI		MGSCv36	mm8
Celera	14	47,099,033 - 47,112,197 (+)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	26.25	NCBI

Parp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955550	1,140,460 - 1,151,491 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955550	1,138,976 - 1,152,293 (+)	NCBI	ChiLan1.0	ChiLan1.0

PARP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	21,850,677 - 21,864,950 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	21,067,164 - 21,081,440 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	1,215,727 - 1,230,006 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	19,268,986 - 19,282,960 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	19,269,046 - 19,282,853 (+)	Ensembl	panpan1.1		panPan2

PARP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	17,705,966 - 17,716,743 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	17,705,975 - 17,716,094 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	18,191,050 - 18,201,770 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	17,964,896 - 17,975,837 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	17,964,862 - 17,975,138 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	17,647,938 - 17,657,915 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	17,702,653 - 17,713,344 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	17,831,425 - 17,842,255 (+)	NCBI		UU_Cfam_GSD_1.0

Parp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	77,573,779 - 77,583,748 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936877	554,473 - 564,903 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936877	554,969 - 564,905 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PARP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	78,535,076 - 78,551,375 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	78,535,072 - 78,551,393 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	83,563,415 - 83,579,720 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PARP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	20,862,787 - 20,877,752 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	20,863,380 - 20,877,644 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	25,544,206 - 25,558,652 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Parp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624825	4,313,217 - 4,325,968 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624825	4,312,243 - 4,326,058 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Parp2
19 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	84
Count of miRNA genes:	66
Interacting mature miRNAs:	69
Transcripts:	ENSRNOT00000011840
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
10755503	Bp391	Blood pressure QTL 391	2.37		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	20248600	37896129	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
5685002	Bss103	Bone structure and strength QTL 103	2.8		tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	15	14481165	28469888	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	19856566	34924750	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat

Markers in Region

UniSTS:492996

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	24,033,659 - 24,033,963 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	27,738,970 - 27,739,273	NCBI	Rnor6.0
Rnor_5.0	15	31,571,395 - 31,571,698	UniSTS	Rnor5.0
RGSC_v3.4	15	26,789,850 - 26,790,153	UniSTS	RGSC3.4
Celera	15	24,353,151 - 24,353,454	UniSTS
Cytogenetic Map	15	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006251856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010057803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011840 ⟹ ENSRNOP00000011840

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	24,034,106 - 24,044,338 (+)	Ensembl
Rnor_6.0 Ensembl	15	27,739,251 - 27,749,648 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105596 ⟹ ENSRNOP00000076757

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	24,035,238 - 24,041,402 (+)	Ensembl

RefSeq Acc Id:

NM_001106030 ⟹ NP_001099500

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,507,659 - 26,517,891 (+)	NCBI
mRatBN7.2	15	24,034,106 - 24,044,338 (+)	NCBI
Rnor_6.0	15	27,739,416 - 27,749,648 (+)	NCBI
Rnor_5.0	15	31,571,841 - 31,582,075 (+)	NCBI
RGSC_v3.4	15	26,790,296 - 26,801,086 (+)	RGD
Celera	15	24,353,597 - 24,363,829 (+)	RGD

Sequence:

show sequence

CGGCAAAGGGTGATGACGTCGTCCTTCAAGCGCTATGGCGCCGCGGCGGCGGAGATCTGGCTGT
GGAAGACGAGTGCTAAATGAAGCCAAGAGAGTTGATAATGGCAACAGAGCAACAGATGACTCTC
CTCCTGGCAAGAAAGTGCGCACGTGCCAGAAAAAGGGGCCTGCGGCTGGAGGGGAGGACACAGA
CAGGACAAAAGGCAAGCAAGACTCTGTGAAGACCCTGCTCGTAAAGGGCCGAGCTCCTGTGGAC
CCAGAGTGCACATCCAAGGTCGGAAAGGCTCATGTGTATTGTGAAGGAGATGATGTCTATGACG
TCATGTTAAATCAAACCAATCTCCAGTTCAACAACAACAAGTACTACCTTATCCAGCTGTTAGA
AGATGATGCCCAGCAGAACTTCAGTGTGTGGATGAGGTGGGGCCGAGTTGGGAAAACAGGGCAG
CACAGCTTGGTGGCTTGTTCTGGTGACCTCAACAAAGCAAAAGAAATATTTCAGAAAAAATTCC
TTGACAAAACTAAAAACAATTGGGAGGATCGTGAGAACTTTGAGAAAGTACCTGGAAAATACGA
CATGTTGCAGATGGACTATGCTGCCAGCACTGAGGATGAAAATAAAACAAAACAAGAGGAAACT
TCGAAGCCAGAGTCACAGCTGGATCTTCGAGTCCAGGAGCTGCTAAAGTTGATCTGTAACGTGC
AGACCATGGAAGAGATGATGATTGAGATGAAGTATGACACCAAGAGGGCCCCACTCGGAAAACT
GACAGTGGCGCAGATCAAGGCAGGCTACCAGTCTCTCAAGAAGATTGAGGATTGTATCCGTGCT
GGCCAGCATGGGCGAGCGCTTGTTGAGGCATGTAATGAATTCTACACCAGGATCCCTCATGACT
TTGGACTCTCCATCCCTCCTGTAATCCGGACAGAGAAAGAACTGTCAGACAAAGTAAAACTGCT
GGAGGCATTGGGAGACATTGAAATTGCCCTTAAGCTGGTGAAGTCAGAGCGCCAAGGCCTAGAA
CACCCACTGGACCAACACTATAGAAACCTACGTTGTGCTTTGCGTCCTCTGGACCATGAAAGTC
ATGAGTTCAAAGTGATTTCCCAGTACTTACAGTCTACCCATGCTCCTACACATAAGGACTATAC
TATGACCTTGCTGGAAGTTTTCGAAGTAGAGAAGGAAGGGGAGAAAGAGGCCTTCAGAAAGGAC
CTTCCTAACAGGATGCTGCTCTGGCATGGTTCCAGGCTGAGTAACTGGGTGGGGATCCTGAGCC
ACGGACTTAGAGTCGCCCCACCTGAGGCTCCCATCACAGGTTATATGTTTGGGAAAGGAATCTA
CTTTGCTGACATGTCGTCCAAGAGTGCCAATTACTGCTTTGCTTCTCGCCTGAAGAATACAGGA
TTGCTTCTTCTGTCAGAGGTAGCTCTGGGTCAGTGTAATGAACTGCTGGAGGCCAACCCTAAGG
CAGAAGGATTGCTTCAGGGCAAGCATAGCACCAAGGGGATGGGAAAGATGGCTCCCAGCCCTGC
CCACTTCATCACCCTGAATGGGAGTACAGTGCCCTTAGGACCAGCAAGTGACACAGGAATTCTC
AATCCAGAGGGGTACACCCTCAACTACAATGAGTTTATTGTTTATAGCCCCAGCCAGGTCCATA
TGCGATACCTTCTAAAGATTCAATTTAATTTTCTGCAGCTGTGGTGAATGTTGATCAAACAAGC
CAGAGAGAATCTCATCTTCAAACAAAAACCAAGCAATACTTTGTTCTTAAACTTTTTGATATTT
TGTTTAATAAAATCGTATAAATCTT

hide sequence

RefSeq Acc Id:

XM_006251856 ⟹ XP_006251918

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,509,162 - 26,517,893 (+)	NCBI
mRatBN7.2	15	24,035,606 - 24,044,340 (+)	NCBI
Rnor_6.0	15	27,742,063 - 27,749,650 (+)	NCBI
Rnor_5.0	15	31,571,841 - 31,582,075 (+)	NCBI

Sequence:

show sequence

CACCATCGTCCAGTTGACAGTGTGATTTTGATGATAAACTACCATGGAATGGCATGAGTTACTG
ATGGAGGGGAAACGGTTAGAAGGATCTCGAAACAAGCCTACTTAGAAAGCAGGTTTACTCTGAG
GCTCATGTGTATTGTGAAGGAGATGATGTCTATGACGTCATGTTAAATCAAACCAATCTCCAGT
TCAACAACAACAAGTACTACCTTATCCAGCTGTTAGAAGATGATGCCCAGCAGAACTTCAGTGT
GTGGATGAGGTGGGGCCGAGTTGGGAAAACAGGGCAGCACAGCTTGGTGGCTTGTTCTGGTGAC
CTCAACAAAGCAAAAGAAATATTTCAGAAAAAATTCCTTGACAAAACTAAAAACAATTGGGAGG
ATCGTGAGAACTTTGAGAAAGTACCTGGAAAATACGACATGTTGCAGATGGACTATGCTGCCAG
CACTGAGGATGAAAATAAAACAAAACAAGAGGAAACTTCGAAGCCAGAGTCACAGCTGGATCTT
CGAGTCCAGGAGCTGCTAAAGTTGATCTGTAACGTGCAGACCATGGAAGAGATGATGATTGAGA
TGAAGTATGACACCAAGAGGGCCCCACTCGGAAAACTGACAGTGGCGCAGATCAAGGCAGGCTA
CCAGTCTCTCAAGAAGATTGAGGATTGTATCCGTGCTGGCCAGCATGGGCGAGCGCTTGTTGAG
GCATGTAATGAATTCTACACCAGGATCCCTCATGACTTTGGACTCTCCATCCCTCCTGTAATCC
GGACAGAGAAAGAACTGTCAGACAAAGTAAAACTGCTGGAGGCATTGGGAGACATTGAAATTGC
CCTTAAGCTGGTGAAGTCAGAGCGCCAAGGCCTAGAACACCCACTGGACCAACACTATAGAAAC
CTACGTTGTGCTTTGCGTCCTCTGGACCATGAAAGTCATGAGTTCAAAGTGATTTCCCAGTACT
TACAGTCTACCCATGCTCCTACACATAAGGACTATACTATGACCTTGCTGGAAGTTTTCGAAGT
AGAGAAGGAAGGGGAGAAAGAGGCCTTCAGAAAGGACCTTCCTAACAGGATGCTGCTCTGGCAT
GGTTCCAGGCTGAGTAACTGGGTGGGGATCCTGAGCCACGGACTTAGAGTCGCCCCACCTGAGG
CTCCCATCACAGGTTATATGTTTGGGAAAGGAATCTACTTTGCTGACATGTCGTCCAAGAGTGC
CAATTACTGCTTTGCTTCTCGCCTGAAGAATACAGGATTGCTTCTTCTGTCAGAGGTAGCTCTG
GGTCAGTGTAATGAACTGCTGGAGGCCAACCCTAAGGCAGAAGGATTGCTTCAGGGCAAGCATA
GCACCAAGGGGATGGGAAAGATGGCTCCCAGCCCTGCCCACTTCATCACCCTGAATGGGAGTAC
AGTGCCCTTAGGACCAGCAAGTGACACAGGAATTCTCAATCCAGAGGGGTACACCCTCAACTAC
AATGAGTTTATTGTTTATAGCCCCAGCCAGGTCCATATGCGATACCTTCTAAAGATTCAATTTA
ATTTTCTGCAGCTGTGGTGAATGTTGATCAAACAAGCCAGAGAGAATCTCATCTTCAAACAAAA
ACCAAGCAATACTTTGTTCTTAAACTTTTTGATATTTTGTTTAATAAAATCGTATAAATCTTAA

hide sequence

RefSeq Acc Id:

XM_039093103 ⟹ XP_038949031

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,507,584 - 26,517,893 (+)	NCBI
mRatBN7.2	15	24,034,069 - 24,044,340 (+)	NCBI

RefSeq Acc Id:

XM_039093104 ⟹ XP_038949032

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,512,494 - 26,517,893 (+)	NCBI
mRatBN7.2	15	24,038,927 - 24,044,340 (+)	NCBI

RefSeq Acc Id:

XM_063274097 ⟹ XP_063130167

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,494,722 - 26,517,893 (+)	NCBI

RefSeq Acc Id:

XM_063274098 ⟹ XP_063130168

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,507,582 - 26,517,893 (+)	NCBI

RefSeq Acc Id:

XM_063274099 ⟹ XP_063130169

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,507,580 - 26,517,893 (+)	NCBI

RefSeq Acc Id:

XR_010057803

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	26,506,322 - 26,517,157 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099500	(Get FASTA)	NCBI Sequence Viewer
	XP_006251918	(Get FASTA)	NCBI Sequence Viewer
	XP_038949031	(Get FASTA)	NCBI Sequence Viewer
	XP_038949032	(Get FASTA)	NCBI Sequence Viewer
	XP_063130167	(Get FASTA)	NCBI Sequence Viewer
	XP_063130168	(Get FASTA)	NCBI Sequence Viewer
	XP_063130169	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61972	(Get FASTA)	NCBI Sequence Viewer
	EDL88414	(Get FASTA)	NCBI Sequence Viewer
	EDL88415	(Get FASTA)	NCBI Sequence Viewer
	EDL88416	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011840
	ENSRNOP00000011840.5
	ENSRNOP00000076757.1
	ENSRNOP00000099105

RefSeq Acc Id:

NP_001099500 ⟸ NM_001106030

- UniProtKB:

G3V749 (UniProtKB/TrEMBL), A6KEA9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPRRRRSGCGRRVLNEAKRVDNGNRATDDSPPGKKVRTCQKKGPAAGGEDTDRTKGKQDSVKT
LLVKGRAPVDPECTSKVGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQQNFSVWM
RWGRVGKTGQHSLVACSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGKYDMLQMDYAASTE
DENKTKQEETSKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKRAPLGKLTVAQIKAGYQS
LKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTEKELSDKVKLLEALGDIEIALK
LVKSERQGLEHPLDQHYRNLRCALRPLDHESHEFKVISQYLQSTHAPTHKDYTMTLLEVFEVEK
EGEKEAFRKDLPNRMLLWHGSRLSNWVGILSHGLRVAPPEAPITGYMFGKGIYFADMSSKSANY
CFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGMGKMAPSPAHFITLNGSTVP
LGPASDTGILNPEGYTLNYNEFIVYSPSQVHMRYLLKIQFNFLQLW

hide sequence

RefSeq Acc Id:

XP_006251918 ⟸ XM_006251856

- Peptide Label:

isoform X5

- Sequence:

show sequence

MLNQTNLQFNNNKYYLIQLLEDDAQQNFSVWMRWGRVGKTGQHSLVACSGDLNKAKEIFQKKFL
DKTKNNWEDRENFEKVPGKYDMLQMDYAASTEDENKTKQEETSKPESQLDLRVQELLKLICNVQ
TMEEMMIEMKYDTKRAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDF
GLSIPPVIRTEKELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLRCALRPLDHESH
EFKVISQYLQSTHAPTHKDYTMTLLEVFEVEKEGEKEAFRKDLPNRMLLWHGSRLSNWVGILSH
GLRVAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKA
EGLLQGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSPSQVHM
RYLLKIQFNFLQLW

hide sequence

Ensembl Acc Id:

ENSRNOP00000011840 ⟸ ENSRNOT00000011840

RefSeq Acc Id:	XP_038949031 ⟸ XM_039093103
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038949032 ⟸ XM_039093104
- Peptide Label:	isoform X6

Ensembl Acc Id:

ENSRNOP00000076757 ⟸ ENSRNOT00000105596

RefSeq Acc Id:	XP_063130167 ⟸ XM_063274097
- Peptide Label:	isoform X1
- UniProtKB:	A6KEA9 (UniProtKB/TrEMBL), G3V749 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063130169 ⟸ XM_063274099
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063130168 ⟸ XM_063274098
- Peptide Label:	isoform X2

Protein Domains

PARP alpha-helical PARP catalytic WGR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V749-F1-model_v2	AlphaFold	G3V749	1-558	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699622

Promoter ID:

EPDNEW_R10144

Type:

multiple initiation site

Name:

Parp2_1

Description:

poly (ADP-ribose) polymerase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	27,739,427 - 27,739,487	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310568	AgrOrtholog
BioCyc Gene	G2FUF-14057	BioCyc
Ensembl Genes	ENSRNOG00000008892	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011840	ENTREZGENE
	ENSRNOT00000011840.7	UniProtKB/TrEMBL
	ENSRNOT00000105596.1	UniProtKB/TrEMBL
	ENSRNOT00000123945	ENTREZGENE
Gene3D-CATH	1.20.142.10	UniProtKB/TrEMBL
	3.90.228.10	UniProtKB/TrEMBL
	WGR domain	UniProtKB/TrEMBL
InterPro	ARTD/PARP	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_cat_dom	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_reg_dom	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_reg_dom_sf	UniProtKB/TrEMBL
	WGR_dom_sf	UniProtKB/TrEMBL
	WGR_domain	UniProtKB/TrEMBL
KEGG Report	rno:290027	UniProtKB/TrEMBL
NCBI Gene	290027	ENTREZGENE
PANTHER	DNA LIGASE	UniProtKB/TrEMBL
	POLY [ADP-RIBOSE] POLYMERASE 2	UniProtKB/TrEMBL
Pfam	PARP	UniProtKB/TrEMBL
	PARP_reg	UniProtKB/TrEMBL
	WGR	UniProtKB/TrEMBL
PhenoGen	Parp2	PhenoGen
PROSITE	PARP_ALPHA_HD	UniProtKB/TrEMBL
	PARP_CATALYTIC	UniProtKB/TrEMBL
	WGR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008892	RatGTEx
SMART	WGR	UniProtKB/TrEMBL
Superfamily-SCOP	ADP-ribosylation	UniProtKB/TrEMBL
	PARP_reg	UniProtKB/TrEMBL
	SSF142921	UniProtKB/TrEMBL
UniProt	A0A8I5Y6B5_RAT	UniProtKB/TrEMBL
	A6KEA9	ENTREZGENE, UniProtKB/TrEMBL
	B1WC20_RAT	UniProtKB/TrEMBL
	G3V749	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-11-17	Parp2	poly (ADP-ribose) polymerase 2	Parp2	poly (ADP-ribose) polymerase family, member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Parp2	poly (ADP-ribose) polymerase family, member 2	Parp2_predicted	poly (ADP-ribose) polymerase family, member 2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Parp2_predicted	poly (ADP-ribose) polymerase family, member 2 (predicted)	Adprtl2_predicted	ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Adprtl2_predicted	ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)