Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | PARP2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | PARP2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. | Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1. | Geng B, etal., Biochem Biophys Res Commun. 2013 Jan 18;430(3):944-50. doi: 10.1016/j.bbrc.2012.11.132. Epub 2012 Dec 19. |
4. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
5. | Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. | Moroni F, etal., Br J Pharmacol. 2009 Jul;157(5):854-62. doi: 10.1111/j.1476-5381.2009.00232.x. Epub 2009 May 5. |
6. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
7. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
8. | Comprehensive gene review and curation | RGD comprehensive gene curation |
9. | Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. | Zhang L, etal., Eur J Pharmacol. 2014 Dec 5;744:203-10. doi: 10.1016/j.ejphar.2014.09.037. Epub 2014 Sep 30. |
PMID:10364231 | PMID:11948190 | PMID:12065591 | PMID:12477932 | PMID:15615785 | PMID:25043379 | PMID:27471034 | PMID:28190768 | PMID:30077797 | PMID:30541899 | PMID:32939087 |
Parp2 (Rattus norvegicus - Norway rat) |
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PARP2 (Homo sapiens - human) |
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Parp2 (Mus musculus - house mouse) |
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Parp2 (Chinchilla lanigera - long-tailed chinchilla) |
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PARP2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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PARP2 (Canis lupus familiaris - dog) |
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Parp2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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PARP2 (Sus scrofa - pig) |
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PARP2 (Chlorocebus sabaeus - green monkey) |
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Parp2 (Heterocephalus glaber - naked mole-rat) |
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Variants in Parp2
19 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
UniSTS:492996 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 28 | 45 | 29 | 19 | 29 | 68 | 33 | 41 | 11 | |||
Low | 15 | 12 | 12 | 12 | 8 | 11 | 6 | 2 | 8 | ||||
Below cutoff |
RefSeq Transcripts | NM_001106030 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006251856 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039093103 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039093104 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063274097 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063274098 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063274099 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_010057803 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC126900 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC161972 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474040 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000015 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000011840 ⟹ ENSRNOP00000011840 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000105596 ⟹ ENSRNOP00000076757 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001106030 ⟹ NP_001099500 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006251856 ⟹ XP_006251918 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039093103 ⟹ XP_038949031 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039093104 ⟹ XP_038949032 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063274097 ⟹ XP_063130167 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063274098 ⟹ XP_063130168 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063274099 ⟹ XP_063130169 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_010057803 | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001099500 | (Get FASTA) | NCBI Sequence Viewer |
XP_006251918 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038949031 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038949032 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063130167 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063130168 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063130169 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAI61972 | (Get FASTA) | NCBI Sequence Viewer |
EDL88414 | (Get FASTA) | NCBI Sequence Viewer | |
EDL88415 | (Get FASTA) | NCBI Sequence Viewer | |
EDL88416 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000011840 | ||
ENSRNOP00000011840.5 | |||
ENSRNOP00000076757.1 |
RefSeq Acc Id: | NP_001099500 ⟸ NM_001106030 |
- UniProtKB: | G3V749 (UniProtKB/TrEMBL), A6KEA9 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006251918 ⟸ XM_006251856 |
- Peptide Label: | isoform X5 |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000011840 ⟸ ENSRNOT00000011840 |
RefSeq Acc Id: | XP_038949031 ⟸ XM_039093103 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | XP_038949032 ⟸ XM_039093104 |
- Peptide Label: | isoform X6 |
RefSeq Acc Id: | ENSRNOP00000076757 ⟸ ENSRNOT00000105596 |
RefSeq Acc Id: | XP_063130167 ⟸ XM_063274097 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | XP_063130169 ⟸ XM_063274099 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_063130168 ⟸ XM_063274098 |
- Peptide Label: | isoform X2 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-G3V749-F1-model_v2 | AlphaFold | G3V749 | 1-558 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13699622 | ||||||||
Promoter ID: | EPDNEW_R10144 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Parp2_1 | ||||||||
Description: | poly (ADP-ribose) polymerase 2 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1310568 | AgrOrtholog |
BioCyc Gene | G2FUF-14057 | BioCyc |
Ensembl Genes | ENSRNOG00000008892 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000011840 | ENTREZGENE |
ENSRNOT00000011840.7 | UniProtKB/TrEMBL | |
ENSRNOT00000105596.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.20.142.10 | UniProtKB/TrEMBL |
3.90.228.10 | UniProtKB/TrEMBL | |
WGR domain | UniProtKB/TrEMBL | |
InterPro | Poly(ADP-ribose)pol_cat_dom | UniProtKB/TrEMBL |
Poly(ADP-ribose)pol_reg_dom | UniProtKB/TrEMBL | |
Poly(ADP-ribose)pol_reg_dom_sf | UniProtKB/TrEMBL | |
WGR_dom_sf | UniProtKB/TrEMBL | |
WGR_domain | UniProtKB/TrEMBL | |
KEGG Report | rno:290027 | UniProtKB/TrEMBL |
NCBI Gene | 290027 | ENTREZGENE |
PANTHER | DNA LIGASE | UniProtKB/TrEMBL |
POLY [ADP-RIBOSE] POLYMERASE 2 | UniProtKB/TrEMBL | |
Pfam | PARP | UniProtKB/TrEMBL |
PARP_reg | UniProtKB/TrEMBL | |
WGR | UniProtKB/TrEMBL | |
PhenoGen | Parp2 | PhenoGen |
PROSITE | PARP_ALPHA_HD | UniProtKB/TrEMBL |
PARP_CATALYTIC | UniProtKB/TrEMBL | |
WGR | UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000008892 | RatGTEx |
SMART | WGR | UniProtKB/TrEMBL |
Superfamily-SCOP | ADP-ribosylation | UniProtKB/TrEMBL |
PARP_reg | UniProtKB/TrEMBL | |
SSF142921 | UniProtKB/TrEMBL | |
UniProt | A0A8I5Y6B5_RAT | UniProtKB/TrEMBL |
A6KEA9 | ENTREZGENE, UniProtKB/TrEMBL | |
B1WC20_RAT | UniProtKB/TrEMBL | |
G3V749 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2008-11-17 | Parp2 | poly (ADP-ribose) polymerase 2 | Parp2 | poly (ADP-ribose) polymerase family, member 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-04-30 | Parp2 | poly (ADP-ribose) polymerase family, member 2 | Parp2_predicted | poly (ADP-ribose) polymerase family, member 2 (predicted) | 'predicted' is removed | 2292626 | APPROVED |
2006-03-30 | Parp2_predicted | poly (ADP-ribose) polymerase family, member 2 (predicted) | Adprtl2_predicted | ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2 (predicted) | Symbol and Name updated | 1299863 | APPROVED |
2005-01-12 | Adprtl2_predicted | ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2 (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |