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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:geldanamycin
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Accession:CHEBI:5292 term browser browse the term
Definition:An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Synonyms:exact_synonym: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
 related_synonym: Formula=C29H40N2O9;   InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1;   InChIKey=QTQAWLPCGQOSGP-KSRBKZBZSA-N;   SMILES=CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\\C(C)=C\\C=C/[C@H](OC)[C@@H](OC(N)=O)\\C(C)=C\\[C@H](C)[C@H]1O)C2=O
 alt_id: CHEBI:42670
 xref: CAS:30562-34-6;   KEGG:C11222;   KNApSAcK:C00018795
 xref_mesh: MESH:C001277
 xref: PDBeChem:GDM;   PMID:21983172;   PMID:21985437;   PMID:22050565;   PMID:22136518;   PMID:22138446;   PMID:22215907;   PMID:22277058;   PMID:22361388;   Reaxys:14205884;   Wikipedia:Geldanamycin


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geldanamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 increases expression ISO geldanamycin results in increased expression of ACAP2 mRNA CTD PMID:26705709 NCBI chr11:69,538,487...69,654,156
Ensembl chr11:69,538,546...69,654,151
JBrowse link
G Actr2 actin related protein 2 increases expression ISO geldanamycin results in increased expression of ACTR2 mRNA CTD PMID:26705709 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524
JBrowse link
G Aff3 AF4/FMR2 family, member 3 increases expression ISO geldanamycin results in increased expression of AFF3 mRNA CTD PMID:26705709 NCBI chr 9:40,399,109...40,856,716
Ensembl chr 9:40,404,375...40,857,247
JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression ISO geldanamycin results in increased expression of AFF4 mRNA CTD PMID:26705709 NCBI chr10:37,498,825...37,579,751
Ensembl chr10:37,498,825...37,579,751
JBrowse link
G Agfg1 ArfGAP with FG repeats 1 increases expression ISO geldanamycin results in increased expression of AGFG1 mRNA CTD PMID:26705709 NCBI chr 9:84,124,878...84,178,149
Ensembl chr 9:84,125,120...84,178,128
JBrowse link
G Ahr aryl hydrocarbon receptor increases localization
decreases expression
increases degradation
multiple interactions
ISO geldanamycin results in increased localization of AHR protein
geldanamycin results in decreased expression of AHR protein
geldanamycin results in increased degradation of AHR protein; geldanamycin results in increased degradation of AHR protein mutant form
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; geldanamycin results in increased localization of and results in increased degradation of AHR protein; lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]
CTD PMID:9664232 PMID:12237327 PMID:12606767 PMID:16226227 PMID:20057149 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of AKT1 protein; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased expression of AKT1 protein
CTD PMID:15781649 PMID:17293044 PMID:19167484 PMID:24211270 PMID:24450340 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt3 AKT serine/threonine kinase 3 increases expression ISO geldanamycin results in increased expression of AKT3 mRNA CTD PMID:26705709 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Amotl1 angiomotin-like 1 increases expression ISO geldanamycin results in increased expression of AMOTL1 mRNA CTD PMID:26705709 NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
JBrowse link
G Angpt1 angiopoietin 1 increases expression ISO geldanamycin results in increased expression of ANGPT1 mRNA CTD PMID:26705709 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO geldanamycin results in decreased expression of ANGPTL1 mRNA CTD PMID:26705709 NCBI chr13:68,963,198...68,969,742
Ensembl chr13:68,962,991...68,992,570
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO geldanamycin results in increased expression of ANKRD1 mRNA CTD PMID:26705709 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Ap5m1 adaptor related protein complex 5 subunit mu 1 increases expression ISO geldanamycin results in increased expression of AP5M1 mRNA CTD PMID:26705709 NCBI chr15:22,355,478...22,385,222
Ensembl chr15:22,355,500...22,377,750
JBrowse link
G Apela apelin receptor early endogenous ligand increases expression ISO geldanamycin results in increased expression of APELA mRNA CTD PMID:26705709 NCBI chr16:24,694,231...24,703,466 JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 increases expression ISO geldanamycin results in increased expression of APPL2 mRNA CTD PMID:26705709 NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO geldanamycin results in increased expression of ARFIP1 mRNA CTD PMID:26705709 NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142
JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO geldanamycin results in increased expression of ASPM mRNA CTD PMID:26705709 NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
JBrowse link
G Atp11b ATPase phospholipid transporting 11B (putative) increases expression ISO geldanamycin results in increased expression of ATP11B mRNA CTD PMID:26705709 NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232
JBrowse link
G Atp11c ATPase phospholipid transporting 11C increases expression ISO geldanamycin results in increased expression of ATP11C mRNA CTD PMID:26705709 NCBI chr  X:138,564,459...138,752,116
Ensembl chr  X:138,565,836...138,751,204
JBrowse link
G Atp13a3 ATPase 13A3 increases expression ISO geldanamycin results in increased expression of ATP13A3 mRNA CTD PMID:26705709 NCBI chr11:70,364,998...70,442,005
Ensembl chr11:70,365,322...70,441,235
JBrowse link
G Atp13a5 ATPase 13A5 increases expression ISO geldanamycin results in increased expression of ATP13A5 mRNA CTD PMID:26705709 NCBI chr11:71,376,388...71,515,789
Ensembl chr11:71,376,422...71,515,789
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO geldanamycin results in increased expression of ATRX mRNA CTD PMID:26705709 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Atxn7l3b ataxin 7-like 3B increases expression ISO geldanamycin results in increased expression of ATXN7L3B mRNA CTD PMID:26705709 NCBI chr 7:48,322,451...48,325,975
Ensembl chr 7:48,321,755...48,328,878
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2 protein
geldanamycin results in decreased expression of BCL2 protein
CTD PMID:15781649 PMID:28673683 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
multiple interactions
ISO BCL2L1 protein results in decreased susceptibility to geldanamycin
[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2L1 protein
CTD PMID:15781649 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcor BCL6 co-repressor increases expression ISO geldanamycin results in increased expression of BCOR mRNA CTD PMID:26705709 NCBI chr  X:10,609,756...10,729,613
Ensembl chr  X:10,687,732...10,729,613
JBrowse link
G Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB increases expression ISO geldanamycin results in increased expression of BDP1 mRNA CTD PMID:26705709 NCBI chr 2:31,457,523...31,470,119
Ensembl chr 2:31,378,924...31,470,119
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of BIRC2 protein CTD PMID:15781649 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 increases expression ISO geldanamycin results in increased expression of BOD1L1 mRNA CTD PMID:26705709 NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490
JBrowse link
G Cab39 calcium binding protein 39 increases expression ISO geldanamycin results in increased expression of CAB39 mRNA CTD PMID:26705709 NCBI chr 9:86,463,008...86,524,545
Ensembl chr 9:86,463,095...86,524,544
JBrowse link
G Cald1 caldesmon 1 increases expression ISO geldanamycin results in increased expression of CALD1 mRNA CTD PMID:26705709 NCBI chr 4:63,265,781...63,446,936
Ensembl chr 4:63,265,942...63,446,932
JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase increases expression ISO geldanamycin results in increased expression of CASK mRNA CTD PMID:26705709 NCBI chr  X:8,899,500...9,243,014
Ensembl chr  X:8,899,833...9,238,694
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein] CTD PMID:12115584 PMID:12530016 PMID:14576064 PMID:24998639 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein] CTD PMID:24998639 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions ISO geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein] CTD PMID:16311509 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO geldanamycin results in increased expression of CBL mRNA CTD PMID:26705709 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
JBrowse link
G Ccdc186 coiled-coil domain containing 186 increases expression ISO geldanamycin results in increased expression of CCDC186 mRNA CTD PMID:26705709 NCBI chr 1:255,831,663...255,871,954
Ensembl chr 1:255,839,595...255,871,935
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of CCND1 protein
geldanamycin results in decreased expression of CCND1 mRNA; geldanamycin results in decreased expression of CCND1 protein
CTD PMID:15781649 PMID:17959518 PMID:24211270 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO geldanamycin results in increased expression of CCND2 mRNA CTD PMID:26705709 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne2 cyclin E2 increases expression ISO geldanamycin results in increased expression of CCNE2 mRNA CTD PMID:26705709 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccnk cyclin K increases expression ISO geldanamycin results in increased expression of CCNK mRNA CTD PMID:26705709 NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
JBrowse link
G Cdc27 cell division cycle 27 increases expression ISO geldanamycin results in increased expression of CDC27 mRNA CTD PMID:26705709 NCBI chr10:89,400,931...89,449,823
Ensembl chr10:89,400,940...89,449,736
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein] CTD PMID:17223712 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO geldanamycin results in increased expression of CDCA2 mRNA CTD PMID:26705709 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh4 cadherin 4 increases expression ISO geldanamycin results in increased expression of CDH4 mRNA CTD PMID:26705709 NCBI chr 3:166,525,098...167,003,380
Ensembl chr 3:166,525,099...167,003,371
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO geldanamycin results in increased expression of CDK13 mRNA CTD PMID:26705709 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
JBrowse link
G Cdk14 cyclin-dependent kinase 14 increases expression ISO geldanamycin results in increased expression of CDK14 mRNA CTD PMID:26705709 NCBI chr 4:28,666,688...29,258,865
Ensembl chr 4:28,666,843...29,258,861
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO geldanamycin results in decreased expression of CDK4 protein CTD PMID:28673683 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO geldanamycin results in increased expression of CDK6 mRNA CTD PMID:26705709 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cenpj centromere protein J increases expression ISO geldanamycin results in increased expression of CENPJ mRNA CTD PMID:26705709 NCBI chr15:30,626,946...30,690,384
Ensembl chr15:30,627,224...30,686,791
JBrowse link
G Cep89 centrosomal protein 89 increases expression ISO geldanamycin results in increased expression of CEP89 mRNA CTD PMID:26705709 NCBI chr 1:88,058,211...88,100,114
Ensembl chr 1:88,058,227...88,100,112
JBrowse link
G Cep95 centrosomal protein 95 increases expression ISO geldanamycin results in increased expression of CEP95 mRNA CTD PMID:26705709 NCBI chr10:91,732,111...91,760,095
Ensembl chr10:91,732,111...91,760,092
JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO geldanamycin results in increased expression of CERS6 mRNA CTD PMID:26705709 NCBI chr 3:53,630,636...53,879,692
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases degradation ISO geldanamycin results in increased degradation of CHUK protein CTD PMID:15930313 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 increases expression ISO geldanamycin results in increased expression of CLIP1 mRNA CTD PMID:26705709 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884
JBrowse link
G Clk4 CDC-like kinase 4 increases expression ISO geldanamycin results in increased expression of CLK4 mRNA CTD PMID:26705709 NCBI chr10:35,523,382...35,541,387
Ensembl chr10:35,524,755...35,541,352
JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL12A1 mRNA CTD PMID:26705709 NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686
JBrowse link
G Col25a1 collagen type XXV alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL25A1 mRNA CTD PMID:26705709 NCBI chr 2:218,755,152...219,154,348
Ensembl chr 2:218,755,691...219,153,501
JBrowse link
G Col8a1 collagen type VIII alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL8A1 mRNA CTD PMID:26705709 NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424
JBrowse link
G Cpne3 copine 3 increases expression ISO geldanamycin results in increased expression of CPNE3 mRNA CTD PMID:26705709 NCBI chr 5:33,014,658...33,064,004
Ensembl chr 5:33,016,307...33,063,934
JBrowse link
G Crcp CGRP receptor component increases expression ISO geldanamycin results in increased expression of CRCP mRNA CTD PMID:26705709 NCBI chr12:26,623,968...26,659,756
Ensembl chr12:26,623,976...26,768,225
JBrowse link
G Csk C-terminal Src kinase multiple interactions
decreases activity
ISO geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]
geldanamycin results in decreased activity of CSK protein
CTD PMID:9664232 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO geldanamycin results in increased expression of CSNK2A1 mRNA CTD PMID:26705709 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Ctdspl2 CTD small phosphatase like 2 increases expression ISO geldanamycin results in increased expression of CTDSPL2 mRNA CTD PMID:26705709 NCBI chr 3:108,914,650...108,970,620
Ensembl chr 3:108,915,280...108,967,227
JBrowse link
G Ctnna1 catenin alpha 1 increases expression ISO geldanamycin results in increased expression of CTNNA1 mRNA CTD PMID:26705709 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] CTD PMID:17024233 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cul5 cullin 5 increases expression ISO geldanamycin results in increased expression of CUL5 mRNA CTD PMID:26705709 NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO geldanamycin results in increased expression of CYP17A1 mRNA CTD PMID:15711029 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:12237327 PMID:20057149 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 increases expression ISO geldanamycin results in increased expression of DDR2 mRNA CTD PMID:26705709 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression ISO geldanamycin results in increased expression of DDX17 mRNA CTD PMID:26705709 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked increases expression
increases degradation
ISO geldanamycin results in increased expression of DDX3X mRNA
geldanamycin results in increased degradation of DDX3X protein
CTD PMID:26705709 PMID:30821613 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Ddx42 DEAD-box helicase 42 increases expression ISO geldanamycin results in increased expression of DDX42 mRNA CTD PMID:26705709 NCBI chr10:91,148,926...91,180,940
Ensembl chr10:91,148,254...91,180,939
JBrowse link
G Ddx6 DEAD-box helicase 6 increases expression ISO geldanamycin results in increased expression of DDX6 mRNA CTD PMID:26705709 NCBI chr 8:44,931,127...44,967,773
Ensembl chr 8:44,931,974...44,964,405
JBrowse link
G Dhx9 DExH-box helicase 9 increases expression ISO geldanamycin results in increased expression of DHX9 mRNA CTD PMID:26705709 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Dip2a disco-interacting protein 2 homolog A increases expression ISO geldanamycin results in increased expression of DIP2A mRNA CTD PMID:26705709 NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression ISO geldanamycin results in increased expression of DLG1 mRNA CTD PMID:26705709 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Dmd dystrophin increases expression ISO geldanamycin results in increased expression of DMD mRNA CTD PMID:26705709 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 increases expression ISO geldanamycin results in increased expression of DNAJC13 mRNA CTD PMID:26705709 NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:104,767,788...104,877,317
JBrowse link
G Dst dystonin increases expression ISO geldanamycin results in increased expression of DST mRNA CTD PMID:26705709 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO geldanamycin results in increased expression of E2F3 mRNA CTD PMID:26705709 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 increases expression ISO geldanamycin results in increased expression of EDIL3 mRNA CTD PMID:26705709 NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
JBrowse link
G Edn1 endothelin 1 increases expression ISO geldanamycin results in increased expression of EDN1 mRNA CTD PMID:26705709 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eea1 early endosome antigen 1 increases expression ISO geldanamycin results in increased expression of EEA1 mRNA CTD PMID:26705709 NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487
JBrowse link
G Egf epidermal growth factor multiple interactions EXP
ISO
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431 PMID:9664232 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO
EXP
geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]
geldanamycin results in decreased expression of EGFR protein
CTD PMID:9605431 PMID:9664232 PMID:20007406 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Ehbp1 EH domain binding protein 1 increases expression ISO geldanamycin results in increased expression of EHBP1 mRNA CTD PMID:26705709 NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332
JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 increases expression ISO geldanamycin results in increased expression of EHMT1 mRNA CTD PMID:26705709 NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 increases degradation ISO geldanamycin results in increased degradation of EIF4A1 protein CTD PMID:30821613 NCBI chr10:54,384,345...54,389,853
Ensembl chr10:54,384,347...54,389,858
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO geldanamycin results in increased expression of ELL2 mRNA CTD PMID:26705709 NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
JBrowse link
G Epb41l5 erythrocyte membrane protein band 4.1 like 5 increases expression ISO geldanamycin results in increased expression of EPB41L5 mRNA CTD PMID:26705709 NCBI chr13:30,673,052...30,770,213
Ensembl chr13:30,669,764...30,768,360
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression ISO geldanamycin results in increased expression of EPRS1 mRNA CTD PMID:26705709 NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases degradation
multiple interactions
decreases expression
ISO geldanamycin results in increased degradation of ERBB2 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]
geldanamycin results in decreased expression of ERBB2 protein
CTD PMID:8617772 PMID:11071886 PMID:17959518 PMID:18655187 PMID:24450340 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Ercc6l2 ERCC excision repair 6 like 2 increases expression ISO geldanamycin results in increased expression of ERCC6L2 mRNA CTD PMID:26705709 NCBI chr17:1,076,486...1,311,281
Ensembl chr17:1,216,428...1,310,275
JBrowse link
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 increases expression ISO geldanamycin results in increased expression of ESCO1 mRNA CTD PMID:26705709 NCBI chr18:1,630,560...1,686,803
Ensembl chr18:1,631,954...1,686,942
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression ISO geldanamycin results in increased expression of ESCO2 mRNA CTD PMID:26705709 NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
decreases stability
increases degradation
ISO geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]
geldanamycin results in decreased expression of ESR1 protein
geldanamycin results in decreased stability of ESR1 protein
CTD PMID:11448926 PMID:16037132 PMID:24211270 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression ISO geldanamycin results in increased expression of ETS1 mRNA CTD PMID:26705709 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Evi5 ecotropic viral integration site 5 increases expression ISO geldanamycin results in increased expression of EVI5 mRNA CTD PMID:26705709 NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678
JBrowse link
G Fam126a family with sequence similarity 126, member A increases expression ISO geldanamycin results in increased expression of FAM126A mRNA CTD PMID:26705709 NCBI chr 4:11,132,224...11,239,120
Ensembl chr 4:11,132,385...11,239,113
JBrowse link
G Fam172a family with sequence similarity 172, member A increases expression ISO geldanamycin results in increased expression of FAM172A mRNA CTD PMID:26705709 NCBI chr 2:7,553,873...8,018,183
Ensembl chr 2:7,553,891...8,018,162
JBrowse link
G Fancb FA complementation group B increases expression ISO geldanamycin results in increased expression of FANCB mRNA CTD PMID:26705709 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192
JBrowse link
G Fancm FA complementation group M increases expression ISO geldanamycin results in increased expression of FANCM mRNA CTD PMID:26705709 NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO geldanamycin results in increased expression of FBN1 mRNA CTD PMID:26705709 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein] CTD PMID:14656992 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression ISO geldanamycin results in increased expression of FLT1 mRNA CTD PMID:26705709 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fn1 fibronectin 1 increases expression ISO geldanamycin results in increased expression of FN1 mRNA CTD PMID:26705709 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fryl FRY like transcription coactivator increases expression ISO geldanamycin results in increased expression of FRYL mRNA CTD PMID:26705709 NCBI chr14:34,956,623...35,189,738
Ensembl chr14:34,956,620...35,190,222
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO geldanamycin results in increased expression of G3BP1 mRNA CTD PMID:26705709 NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268
JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 increases expression ISO geldanamycin results in increased expression of GALNT5 mRNA CTD PMID:26705709 NCBI chr 3:42,573,622...42,619,881
Ensembl chr 3:42,573,622...42,619,881
JBrowse link
G Gls glutaminase increases expression ISO geldanamycin results in increased expression of GLS mRNA CTD PMID:26705709 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Gng12 G protein subunit gamma 12 increases expression ISO geldanamycin results in increased expression of GNG12 mRNA CTD PMID:26705709 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
JBrowse link
G Golim4 golgi integral membrane protein 4 increases expression ISO geldanamycin results in increased expression of GOLIM4 mRNA CTD PMID:26705709 NCBI chr 2:160,640,932...160,733,475
Ensembl chr 2:160,640,938...160,733,253
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression ISO geldanamycin results in increased expression of GRIA3 mRNA CTD PMID:26705709 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096
JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 increases expression ISO geldanamycin results in increased expression of GTF2A1 mRNA CTD PMID:26705709 NCBI chr 6:110,488,891...110,521,059
Ensembl chr 6:110,488,931...110,521,511
JBrowse link
G H4f3 H1.3 linker histone, cluster member increases expression ISO geldanamycin results in increased expression of H1-3 mRNA CTD PMID:26705709 NCBI chr17:41,528,576...41,554,586
Ensembl chr17:41,529,667...41,552,334
JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 increases expression ISO geldanamycin results in increased expression of HACD2 mRNA CTD PMID:26705709 NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 increases expression ISO geldanamycin results in increased expression of HCN1 mRNA CTD PMID:26705709 NCBI chr 2:49,495,771...49,899,702
Ensembl chr 2:49,495,771...49,899,774
JBrowse link
G Heatr1 HEAT repeat containing 1 increases expression ISO geldanamycin results in increased expression of HEATR1 mRNA CTD PMID:26705709 NCBI chr17:58,051,700...58,093,895
Ensembl chr17:58,051,700...58,093,948
JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 increases expression ISO geldanamycin results in increased expression of HECTD1 mRNA CTD PMID:26705709 NCBI chr 6:69,181,429...69,267,803
Ensembl chr 6:69,181,436...69,268,053
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases degradation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]
geldanamycin results in decreased expression of HIF1A protein
CTD PMID:11980636 PMID:12811834 PMID:14726529 PMID:15319539 PMID:16432534 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein] CTD PMID:25645596 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein] CTD PMID:15680906 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein CTD PMID:10632574 PMID:25645596 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 affects binding
multiple interactions
EXP
ISO
geldanamycin binds to HSP90AA1 protein
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]
CTD PMID:12775586 PMID:17223712 PMID:18655187 PMID:21749116 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding
increases expression
EXP
ISO
geldanamycin binds to HSP90AB1 protein
geldanamycin results in increased expression of HSP90AB1 mRNA
CTD PMID:21749116 PMID:26705709 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 affects binding
multiple interactions
ISO geldanamycin binds to HSP90B1 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]
CTD PMID:8617772 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
EXP
ISO
geldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A protein
[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to Gentamicins
CTD PMID:11448926 PMID:19723345 PMID:25477506
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
ISO geldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 protein
[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509 PMID:26705709 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
affects expression
ISO Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]
geldanamycin affects the expression of HSPA5 protein
CTD PMID:14576064 PMID:15141013 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO geldanamycin results in increased expression of HSPD1 mRNA CTD PMID:26705709 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Htt huntingtin multiple interactions ISO geldanamycin inhibits the reaction [HTT protein binds to HTT protein] CTD PMID:11406612 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070
JBrowse link
G Ice2 interactor of little elongation complex ELL subunit 2 increases expression ISO geldanamycin results in increased expression of ICE2 mRNA CTD PMID:26705709 NCBI chr 8:70,043,419...70,085,217
Ensembl chr 8:70,043,424...70,084,995
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]
CTD PMID:12571865 PMID:15808840 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 multiple interactions ISO IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 multiple interactions ISO geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] CTD PMID:12571865 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression ISO geldanamycin results in increased expression of IL6ST mRNA CTD PMID:26705709 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO geldanamycin results in increased expression of INHBA mRNA CTD PMID:26705709 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A increases expression ISO geldanamycin results in increased expression of INPP5A mRNA CTD PMID:26705709 NCBI chr 1:194,190,086...194,380,429
Ensembl chr 1:194,190,393...194,380,428
JBrowse link
G Ipo8 importin 8 increases expression ISO geldanamycin results in increased expression of IPO8 mRNA CTD PMID:26705709 NCBI chr 4:181,729,216...181,793,673 JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO geldanamycin results in increased expression of IQGAP1 mRNA CTD PMID:26705709 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
JBrowse link
G Itga1 integrin subunit alpha 1 increases expression ISO geldanamycin results in increased expression of ITGA1 mRNA CTD PMID:26705709 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
JBrowse link
G Itgb3 integrin subunit beta 3 increases expression ISO geldanamycin results in increased expression of ITGB3 mRNA CTD PMID:26705709 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itprid2 ITPR interacting domain containing 2 increases expression ISO geldanamycin results in increased expression of ITPRID2 mRNA CTD PMID:26705709 NCBI chr 3:64,536,707...64,573,978
Ensembl chr 3:64,536,707...64,573,978
JBrowse link
G Jmjd1c jumonji domain containing 1C increases expression ISO geldanamycin results in increased expression of JMJD1C mRNA CTD PMID:26705709 NCBI chr20:21,332,147...21,494,220
Ensembl chr20:21,332,147...21,463,122
JBrowse link
G Kat6a lysine acetyltransferase 6A increases expression ISO geldanamycin results in increased expression of KAT6A mRNA CTD PMID:26705709 NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606
JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 increases expression ISO geldanamycin results in increased expression of KBTBD2 mRNA CTD PMID:26705709 NCBI chr 4:86,027,947...86,050,266
Ensembl chr 4:86,027,947...86,050,211
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects localization
decreases activity
increases degradation
multiple interactions
decreases expression
ISO geldanamycin affects the localization of KCNH2 protein
geldanamycin results in decreased activity of KCNH2 protein
geldanamycin results in increased degradation of KCNH2 protein
geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]
geldanamycin results in decreased expression of KCNH2 protein modified form
CTD PMID:12775586 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kdm6a lysine demethylase 6A increases expression ISO geldanamycin results in increased expression of KDM6A mRNA CTD PMID:26705709 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062
JBrowse link
G Kirrel1 kirre like nephrin family adhesion molecule 1 increases expression ISO geldanamycin results in increased expression of KIRREL1 mRNA CTD PMID:26705709 NCBI chr 2:172,521,644...172,615,057
Ensembl chr 2:172,525,245...172,615,299
JBrowse link
G Klf12 Kruppel-like factor 12 increases expression ISO geldanamycin results in increased expression of KLF12 mRNA CTD PMID:26705709 NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO geldanamycin results in increased expression of KLHL24 mRNA CTD PMID:26705709 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Kmt2a lysine methyltransferase 2A increases expression ISO geldanamycin results in increased expression of KMT2A mRNA CTD PMID:26705709 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Knl1 kinetochore scaffold 1 increases expression ISO geldanamycin results in increased expression of KNL1 mRNA CTD PMID:26705709 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
JBrowse link
G Lama4 laminin subunit alpha 4 increases expression ISO geldanamycin results in increased expression of LAMA4 mRNA CTD PMID:26705709 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
JBrowse link
G Larp1b La ribonucleoprotein 1B increases expression ISO geldanamycin results in increased expression of LARP1B mRNA CTD PMID:26705709 NCBI chr 2:123,936,074...123,969,254
Ensembl chr 2:123,935,983...123,968,896
JBrowse link
G Larp4 La ribonucleoprotein 4 increases expression ISO geldanamycin results in increased expression of LARP4 mRNA CTD PMID:26705709 NCBI chr 7:131,104,470...131,152,692 JBrowse link
G Lars1 leucyl-tRNA synthetase 1 increases expression ISO geldanamycin results in increased expression of LARS1 mRNA CTD PMID:26705709 NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
JBrowse link
G Lima1 LIM domain and actin binding 1 increases expression ISO geldanamycin results in increased expression of LIMA1 mRNA CTD PMID:26705709 NCBI chr 7:130,901,717...131,001,573
Ensembl chr 7:130,901,717...131,001,473
JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component increases expression ISO geldanamycin results in increased expression of LIN7A mRNA CTD PMID:26705709 NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression ISO geldanamycin results in increased expression of LMAN1 mRNA CTD PMID:26705709 NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO geldanamycin results in increased expression of LMO7 mRNA CTD PMID:26705709 NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma increases expression ISO geldanamycin results in increased expression of LPP mRNA CTD PMID:26705709 NCBI chr11:75,787,326...76,426,646
Ensembl chr11:75,797,078...76,422,597
JBrowse link
G Lrrc58 leucine rich repeat containing 58 increases expression ISO geldanamycin results in increased expression of LRRC58 mRNA CTD PMID:26705709 NCBI chr11:62,850,507...62,862,829
Ensembl chr11:62,847,562...62,862,829
JBrowse link
G Lsm14b LSM family member 14B increases expression ISO geldanamycin results in increased expression of LSM14B mRNA CTD PMID:26705709 NCBI chr 3:167,125,633...167,136,417
Ensembl chr 3:167,125,628...167,136,432
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 increases expression ISO geldanamycin results in increased expression of MAN1A2 mRNA CTD PMID:26705709 NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO geldanamycin results in increased expression of MAP1B mRNA CTD PMID:26705709 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
geldanamycin results in decreased phosphorylation of MAP2K1 protein
CTD PMID:8816498 PMID:19167484 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases phosphorylation ISO geldanamycin results in decreased phosphorylation of MAP2K2 protein CTD PMID:19167484 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO geldanamycin results in increased expression of MAP3K1 mRNA CTD PMID:26705709 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases expression ISO geldanamycin results in increased expression of MAP3K5 mRNA CTD PMID:26705709 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 increases expression ISO geldanamycin results in increased expression of MAP4K5 mRNA CTD PMID:26705709 NCBI chr 6:88,284,094...88,377,118
Ensembl chr 6:88,284,094...88,376,799
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]
geldanamycin results in decreased expression of MAPK1 mRNA
geldanamycin results in decreased phosphorylation of MAPK1 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484 PMID:30166341 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]
geldanamycin results in decreased phosphorylation of MAPK3 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression ISO geldanamycin results in increased expression of MAPKAPK2 mRNA CTD PMID:26705709 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Matr3 matrin 3 increases expression ISO geldanamycin results in increased expression of MATR3 mRNA CTD PMID:26705709 NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 increases expression ISO geldanamycin results in increased expression of MBNL1 mRNA CTD PMID:26705709 NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368
JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 increases expression ISO geldanamycin results in increased expression of MBNL2 mRNA CTD PMID:26705709 NCBI chr15:97,385,238...97,542,924
Ensembl chr15:97,385,244...97,542,937
JBrowse link
G Mbtd1 mbt domain containing 1 increases expression ISO geldanamycin results in increased expression of MBTD1 mRNA CTD PMID:26705709 NCBI chr10:78,839,140...78,895,413
Ensembl chr10:78,839,036...78,893,720
JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO geldanamycin results in increased expression of MCAM mRNA CTD PMID:26705709 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO geldanamycin results in increased expression of MCM4 mRNA CTD PMID:26705709 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
JBrowse link
G Mdfic MyoD family inhibitor domain containing increases expression ISO geldanamycin results in increased expression of MDFIC mRNA CTD PMID:26705709 NCBI chr 4:43,972,310...44,052,162
Ensembl chr 4:43,972,507...44,052,161
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Med13 mediator complex subunit 13 increases expression ISO geldanamycin results in increased expression of MED13 mRNA CTD PMID:26705709 NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242
JBrowse link
G Med7 mediator complex subunit 7 increases expression ISO geldanamycin results in increased expression of MED7 mRNA CTD PMID:26705709 NCBI chr10:30,842,330...30,857,873
Ensembl chr10:30,842,292...30,859,220
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO geldanamycin results in increased expression of MET mRNA CTD PMID:26705709 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mettl16 methyltransferase like 16 increases expression ISO geldanamycin results in increased expression of METTL16 mRNA CTD PMID:26705709 NCBI chr10:59,640,915...59,697,291
Ensembl chr10:59,640,972...59,687,061
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO geldanamycin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mier1 MIER1 transcriptional regulator increases expression ISO geldanamycin results in increased expression of MIER1 mRNA CTD PMID:26705709 NCBI chr 5:117,876,012...117,927,592
Ensembl chr 5:117,870,382...117,927,589
JBrowse link
G Mir21 microRNA 21 increases expression ISO geldanamycin results in increased expression of MIR21 mRNA CTD PMID:26705709 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mis18bp1 MIS18 binding protein 1 increases expression ISO geldanamycin results in increased expression of MIS18BP1 mRNA CTD PMID:26705709 NCBI chr 6:83,182,497...83,231,978
Ensembl chr 6:83,182,499...83,231,383
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
decreases expression
ISO [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA
geldanamycin results in decreased expression of MMP1 mRNA
CTD PMID:12724357 PMID:26705709 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO geldanamycin results in increased expression of MMP16 mRNA CTD PMID:26705709 NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 increases expression ISO geldanamycin results in increased expression of ND6 mRNA CTD PMID:26705709 Ensembl chr MT:13,543...14,061 JBrowse link
G Myo5a myosin VA increases expression ISO geldanamycin results in increased expression of MYO5A mRNA CTD PMID:26705709 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918
JBrowse link
G Myocd myocardin increases expression ISO geldanamycin results in increased expression of MYOCD mRNA CTD PMID:26705709 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Mzt1 mitotic spindle organizing protein 1 increases expression ISO geldanamycin results in increased expression of MZT1 mRNA CTD PMID:26705709 NCBI chr15:75,786,992...75,797,631 JBrowse link
G Nasp nuclear autoantigenic sperm protein increases expression ISO geldanamycin results in increased expression of NASP mRNA CTD PMID:26705709 NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928
JBrowse link
G Nbas NBAS subunit of NRZ tethering complex increases expression ISO geldanamycin results in increased expression of NBAS mRNA CTD PMID:26705709 NCBI chr 6:36,048,357...36,353,206
Ensembl chr 6:36,048,191...36,352,984
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 increases expression ISO geldanamycin results in increased expression of NCOA2 mRNA CTD PMID:26705709 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO geldanamycin results in increased expression of NEDD9 mRNA CTD PMID:26705709 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nes nestin increases expression ISO geldanamycin results in increased expression of NES mRNA CTD PMID:26705709 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nf1 neurofibromin 1 increases expression ISO geldanamycin results in increased expression of NF1 mRNA CTD PMID:26705709 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Nf2 neurofibromin 2 increases expression ISO geldanamycin results in increased expression of NF2 mRNA CTD PMID:26705709 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO geldanamycin results in increased expression of NFAT5 mRNA CTD PMID:26705709 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
JBrowse link
G Nipbl NIPBL, cohesin loading factor increases expression ISO geldanamycin results in increased expression of NIPBL mRNA CTD PMID:26705709 NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899
JBrowse link
G Nktr natural killer cell triggering receptor increases expression ISO geldanamycin results in increased expression of NKTR mRNA CTD PMID:26705709 NCBI chr 8:121,380,010...121,420,495
Ensembl chr 8:121,382,436...121,418,314
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP geldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313 PMID:15583003 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npr3 natriuretic peptide receptor 3 increases expression ISO geldanamycin results in increased expression of NPR3 mRNA CTD PMID:26705709 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction ISO NQO1 protein results in increased reduction of geldanamycin CTD PMID:16825487 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 increases expression ISO geldanamycin results in increased expression of NR2C2 mRNA CTD PMID:26705709 NCBI chr 4:124,610,216...124,666,813
Ensembl chr 4:124,608,960...124,661,902
JBrowse link
G Nrk Nik related kinase increases expression ISO geldanamycin results in increased expression of NRK mRNA CTD PMID:26705709 NCBI chr  X:102,365,747...102,462,957
Ensembl chr  X:102,365,765...102,459,657
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO geldanamycin results in increased expression of OSBPL8 mRNA CTD PMID:26705709 NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
JBrowse link
G Otud4 OTU deubiquitinase 4 increases expression ISO geldanamycin results in increased expression of OTUD4 mRNA CTD PMID:26705709 NCBI chr19:28,236,713...28,279,815
Ensembl chr19:28,236,713...28,279,815
JBrowse link
G Oxtr oxytocin receptor increases expression ISO geldanamycin results in increased expression of OXTR mRNA CTD PMID:26705709 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions EXP geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
JBrowse link
G Pappa1 pappalysin 1 increases expression ISO geldanamycin results in increased expression of PAPPA mRNA CTD PMID:26705709 NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases degradation
ISO geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein] CTD PMID:16311509 PMID:17293044 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcbp2 poly(rC) binding protein 2 increases expression ISO geldanamycin results in increased expression of PCBP2 mRNA CTD PMID:26705709 NCBI chr 7:133,605,480...133,631,312
Ensembl chr 7:133,605,573...133,629,863
JBrowse link
G Pcm1 pericentriolar material 1 increases expression ISO geldanamycin results in increased expression of PCM1 mRNA CTD PMID:26705709 NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO geldanamycin results in increased expression of PDE4DIP mRNA CTD PMID:26705709 NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression ISO geldanamycin results in increased expression of PDGFA mRNA CTD PMID:26705709 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO geldanamycin results in increased expression of PEG10 mRNA CTD PMID:26705709 NCBI chr 4:32,842,394...32,855,641 JBrowse link
G Pgr progesterone receptor decreases expression ISO geldanamycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phactr2 phosphatase and actin regulator 2 increases expression ISO geldanamycin results in increased expression of PHACTR2 mRNA CTD PMID:26705709 NCBI chr 1:7,591,254...7,860,431
Ensembl chr 1:7,597,927...7,860,289
JBrowse link
G Phldb2 pleckstrin homology-like domain, family B, member 2 increases expression ISO geldanamycin results in increased expression of PHLDB2 mRNA CTD PMID:26705709 NCBI chr11:54,859,173...55,078,212
Ensembl chr11:54,859,135...55,078,467
JBrowse link
G Phtf2 putative homeodomain transcription factor 2 increases expression ISO geldanamycin results in increased expression of PHTF2 mRNA CTD PMID:26705709 NCBI chr 4:14,215,190...14,330,513
Ensembl chr 4:14,215,263...14,330,513
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO geldanamycin results in increased expression of PIK3CA mRNA CTD PMID:26705709 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO geldanamycin results in increased expression of PIK3R1 mRNA CTD PMID:26705709 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA CTD PMID:12724357 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plppr4 phospholipid phosphatase related 4 increases expression ISO geldanamycin results in increased expression of PLPPR4 mRNA CTD PMID:26705709 NCBI chr 2:205,371,317...205,412,302
Ensembl chr 2:205,371,322...205,412,302
JBrowse link
G Plxna2 plexin A2 increases expression ISO geldanamycin results in increased expression of PLXNA2 mRNA CTD PMID:26705709 NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979
JBrowse link
G Polr2b RNA polymerase II subunit B decreases expression ISO geldanamycin results in decreased expression of POLR2B mRNA CTD PMID:30166341 NCBI chr14:30,797,228...30,834,916
Ensembl chr14:30,797,228...30,834,916
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K increases expression ISO geldanamycin results in increased expression of PPM1K mRNA CTD PMID:26705709 NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 increases expression ISO geldanamycin results in increased expression of PRKG1 mRNA CTD PMID:26705709 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Prmt2 protein arginine methyltransferase 2 increases expression ISO geldanamycin results in increased expression of PRMT2 mRNA CTD PMID:26705709 NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643
JBrowse link
G Prpf6 pre-mRNA processing factor 6 increases expression ISO geldanamycin results in increased expression of PRPF6 mRNA CTD PMID:26705709 NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991
JBrowse link
G Prr14l proline rich 14-like increases expression ISO geldanamycin results in increased expression of PRR14L mRNA CTD PMID:26705709 NCBI chr14:77,869,848...77,937,141
Ensembl chr14:77,869,799...77,936,521
JBrowse link
G Prrc2c proline-rich coiled-coil 2C increases expression ISO geldanamycin results in increased expression of PRRC2C mRNA CTD PMID:26705709 NCBI chr13:75,003,995...75,073,701 JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO geldanamycin results in increased expression of PSME4 mRNA CTD PMID:26705709 NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408
JBrowse link
G Ptar1 protein prenyltransferase alpha subunit repeat containing 1 increases expression ISO geldanamycin results in increased expression of PTAR1 mRNA CTD PMID:26705709 NCBI chr 1:221,283,306...221,326,861
Ensembl chr 1:221,283,415...221,327,073
JBrowse link
G Ptbp3 polypyrimidine tract binding protein 3 increases expression ISO geldanamycin results in increased expression of PTBP3 mRNA CTD PMID:26705709 NCBI chr 5:74,313,536...74,399,439
Ensembl chr 5:74,315,101...74,399,791
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO geldanamycin results in decreased expression of PTGS1 mRNA CTD PMID:26705709 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:11133817 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions ISO [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA; [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA CTD PMID:12724357 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptk2 protein tyrosine kinase 2 increases degradation
decreases phosphorylation
ISO geldanamycin results in increased degradation of PTK2 protein
geldanamycin results in decreased phosphorylation of PTK2 protein
CTD PMID:9973544 PMID:12811834 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases expression ISO geldanamycin results in increased expression of PTPN11 mRNA CTD PMID:26705709 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 increases expression ISO geldanamycin results in increased expression of PTPN12 mRNA CTD PMID:26705709 NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A increases expression ISO geldanamycin results in increased expression of PTPRA mRNA CTD PMID:26705709 NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D increases expression ISO geldanamycin results in increased expression of PTPRD mRNA CTD PMID:26705709 NCBI chr 5:90,046,993...90,698,977
Ensembl chr 5:90,048,966...92,369,396
JBrowse link
G Pygo1 pygopus family PHD finger 1 increases expression ISO geldanamycin results in increased expression of PYGO1 mRNA CTD PMID:26705709 NCBI chr 8:73,666,467...73,684,641
Ensembl chr 8:73,665,593...73,684,869
JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO geldanamycin results in increased expression of RAB3B mRNA CTD PMID:26705709 NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
JBrowse link
G Rabep1 rabaptin, RAB GTPase binding effector protein 1 increases expression ISO geldanamycin results in increased expression of RABEP1 mRNA CTD PMID:26705709 NCBI chr10:55,566,156...55,667,595
Ensembl chr10:55,566,185...55,665,973
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression
decreases expression
multiple interactions
ISO geldanamycin results in increased expression of RAF1 protein
geldanamycin results in decreased expression of RAF1 protein
geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein
CTD PMID:8816498 PMID:19167484 PMID:24450340 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 increases expression ISO geldanamycin results in increased expression of RAPGEF2 mRNA CTD PMID:26705709 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247
JBrowse link
G Rassf8 Ras association domain family member 8 increases expression ISO geldanamycin results in increased expression of RASSF8 mRNA CTD PMID:26705709 NCBI chr 4:178,716,110...178,798,042
Ensembl chr 4:178,719,992...178,796,690
JBrowse link
G Rbak RB-associated KRAB zinc finger increases expression ISO geldanamycin results in increased expression of RBAK mRNA CTD PMID:26705709 NCBI chr12:11,375,314...11,388,937
Ensembl chr12:11,375,318...11,388,934
JBrowse link
G Rbm26 RNA binding motif protein 26 increases expression ISO geldanamycin results in increased expression of RBM26 mRNA CTD PMID:26705709 NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118
JBrowse link
G Rbms3 RNA binding motif, single stranded interacting protein 3 increases expression ISO geldanamycin results in increased expression of RBMS3 mRNA CTD PMID:26705709 NCBI chr 8:116,308,360...117,625,730
Ensembl chr 8:116,309,882...117,625,423
JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression ISO geldanamycin results in increased expression of RCAN1 mRNA CTD PMID:26705709 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Rdh10 retinol dehydrogenase 10 increases expression ISO geldanamycin results in increased expression of RDH10 mRNA CTD PMID:26705709 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572
JBrowse link
G Resf1 retroelement silencing factor 1 increases expression ISO geldanamycin results in increased expression of RESF1 mRNA CTD PMID:26705709 NCBI chr 4:182,325,913...182,362,054
Ensembl chr 4:182,335,454...182,362,054
JBrowse link
G Rfx7 regulatory factor X, 7 increases expression ISO geldanamycin results in increased expression of RFX7 mRNA CTD PMID:26705709 NCBI chr 8:73,254,051...73,339,209
Ensembl chr 8:73,254,051...73,339,209
JBrowse link
G RGD1306502 similar to hypothetical protein FLJ11193 increases expression ISO geldanamycin results in increased expression of C5ORF22 mRNA CTD PMID:26705709 NCBI chr 2:61,848,716...61,864,762
Ensembl chr 2:61,849,363...61,864,738
JBrowse link
G RGD1307929 similar to CG14967-PA increases expression ISO geldanamycin results in increased expression of KIAA0100 mRNA CTD PMID:26705709 NCBI chr10:63,155,999...63,185,213
Ensembl chr10:63,156,044...63,191,141
JBrowse link
G RGD1566359 similar to RIKEN cDNA B230219D22 increases expression ISO geldanamycin results in increased expression of C5ORF24 mRNA CTD PMID:26705709 NCBI chr17:8,923,041...8,932,927 JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase increases expression
decreases expression
ISO geldanamycin results in increased expression of RNGTT mRNA
geldanamycin results in decreased expression of RNGTT protein
CTD PMID:26705709 PMID:30166341 NCBI chr 5:47,706,929...47,913,297
Ensembl chr 5:47,706,799...47,913,295
JBrowse link
G Ro60 Ro60, Y RNA binding protein increases expression ISO geldanamycin results in increased expression of RO60 mRNA CTD PMID:26705709 NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression ISO geldanamycin results in increased expression of ROCK2 mRNA CTD PMID:26705709 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 decreases expression ISO geldanamycin results in decreased expression of RPLP0 mRNA CTD PMID:30166341 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Rttn rotatin increases expression ISO geldanamycin results in increased expression of RTTN mRNA CTD PMID:26705709 NCBI chr18:82,220,999...82,398,334
Ensembl chr18:82,221,050...82,398,333
JBrowse link
G Rufy2 RUN and FYVE domain containing 2 increases expression ISO geldanamycin results in increased expression of RUFY2 mRNA CTD PMID:26705709 NCBI chr20:25,626,958...25,658,157
Ensembl chr20:25,621,999...25,658,186
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO geldanamycin results in decreased expression of S100A4 mRNA CTD PMID:26705709 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Samd5 sterile alpha motif domain containing 5 increases expression ISO geldanamycin results in increased expression of SAMD5 mRNA CTD PMID:26705709 NCBI chr 1:4,041,547...4,090,909
Ensembl chr 1:3,677,784...4,091,120
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B increases expression ISO geldanamycin results in increased expression of SAR1B mRNA CTD PMID:26705709 NCBI chr10:36,024,443...36,054,067
Ensembl chr10:36,024,382...36,054,066
JBrowse link
G Scrn3 secernin 3 increases expression ISO geldanamycin results in increased expression of SCRN3 mRNA CTD PMID:26705709 NCBI chr 3:58,188,820...58,213,623
Ensembl chr 3:58,188,889...58,213,623
JBrowse link
G Scyl2 SCY1 like pseudokinase 2 increases expression ISO geldanamycin results in increased expression of SCYL2 mRNA CTD PMID:26705709 NCBI chr 7:24,064,404...24,117,338
Ensembl chr 7:24,064,404...24,117,305
JBrowse link
G Sema3d semaphorin 3D increases expression ISO geldanamycin results in increased expression of SEMA3D mRNA CTD PMID:26705709 NCBI chr 4:22,316,769...22,505,930
Ensembl chr 4:22,316,779...22,505,930
JBrowse link
G Senp1 SUMO specific peptidase 1 increases expression ISO geldanamycin results in increased expression of SENP1 mRNA CTD PMID:26705709 NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO geldanamycin results in increased expression of SERPINE1 mRNA CTD PMID:26705709 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sesn3 sestrin 3 increases expression ISO geldanamycin results in increased expression of SESN3 mRNA CTD PMID:26705709 NCBI chr 8:11,133,822...11,189,436
Ensembl chr 8:11,133,678...11,185,842
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase increases expression ISO geldanamycin results in increased expression of SETD2 mRNA CTD PMID:26705709 NCBI chr 8:110,511,808...110,597,489
Ensembl chr 8:110,511,772...110,597,489
JBrowse link
G Setx senataxin increases expression ISO geldanamycin results in increased expression of SETX mRNA CTD PMID:26705709 NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803
JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO geldanamycin results in increased expression of SFPQ mRNA CTD PMID:26705709 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sgms2 sphingomyelin synthase 2 increases expression ISO geldanamycin results in increased expression of SGMS2 mRNA CTD PMID:26705709 NCBI chr 2:219,889,809...219,967,704
Ensembl chr 2:219,893,572...219,967,546
JBrowse link
G Sike1 suppressor of IKBKE 1 increases expression ISO geldanamycin results in increased expression of SIKE1 mRNA CTD PMID:26705709 NCBI chr 2:190,518,002...190,525,833
Ensembl chr 2:190,518,002...190,525,832
JBrowse link
G Slain2 SLAIN motif family, member 2 increases expression ISO geldanamycin results in increased expression of SLAIN2 mRNA CTD PMID:26705709 NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678
JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression ISO geldanamycin results in increased expression of SLC16A1 mRNA CTD PMID:26705709 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc16a7 solute carrier family 16 member 7 increases expression ISO geldanamycin results in increased expression of SLC16A7 mRNA CTD PMID:26705709 NCBI chr 7:61,043,667...61,211,547
Ensembl chr 7:61,051,167...61,154,994
JBrowse link
G Slc2a13 solute carrier family 2 member 13 increases expression ISO geldanamycin results in increased expression of SLC2A13 mRNA CTD PMID:26705709 NCBI chr 7:122,399,329...122,726,605
Ensembl chr 7:122,399,330...122,726,605
JBrowse link
G Slc38a1 solute carrier family 38, member 1 increases expression ISO geldanamycin results in increased expression of SLC38A1 mRNA CTD PMID:26705709 NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218
JBrowse link
G Slc39a6 solute carrier family 39 member 6 increases expression ISO geldanamycin results in increased expression of SLC39A6 mRNA CTD PMID:26705709 NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417
JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression ISO geldanamycin results in increased expression of SLC8A1 mRNA CTD PMID:26705709 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Slfn5 schlafen family member 5 increases expression ISO geldanamycin results in increased expression of SLFN5 mRNA CTD PMID:26705709 NCBI chr10:67,881,068...67,895,013
Ensembl chr10:67,880,009...67,893,109
JBrowse link
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 increases expression ISO geldanamycin results in increased expression of SMARCA2 mRNA CTD PMID:26705709 NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684
JBrowse link
G Smc1a structural maintenance of chromosomes 1A increases expression ISO geldanamycin results in increased expression of SMC1A mRNA CTD PMID:26705709 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 increases expression ISO geldanamycin results in increased expression of SMCHD1 mRNA CTD PMID:26705709 NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 increases expression ISO geldanamycin results in increased expression of SOS2 mRNA CTD PMID:26705709 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
JBrowse link
G Sp4 Sp4 transcription factor increases expression ISO geldanamycin results in increased expression of SP4 mRNA CTD PMID:26705709 NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 increases expression ISO geldanamycin results in increased expression of SPTBN1 mRNA CTD PMID:26705709 NCBI chr14:103,842,684...104,008,507
Ensembl chr14:103,842,684...104,008,507
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO
EXP
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein]
CTD PMID:10401681 PMID:17223712 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srpra SRP receptor subunit alpha increases expression ISO geldanamycin results in increased expression of SRPR mRNA CTD PMID:26705709 NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression ISO geldanamycin results in increased expression of SRRM2 mRNA CTD PMID:26705709 NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751
JBrowse link
G Srrt serrate, RNA effector molecule increases expression ISO geldanamycin results in increased expression of SRRT mRNA CTD PMID:26705709 NCBI chr12:19,392,578...19,406,098 JBrowse link
G Strn4 striatin 4 decreases expression ISO geldanamycin results in decreased expression of STRN4 mRNA CTD PMID:30166341 NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein] CTD PMID:16037132 PMID:25645596 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
JBrowse link
G Supt16h SPT16 homolog, facilitates chromatin remodeling subunit increases expression ISO geldanamycin results in increased expression of SUPT16H mRNA CTD PMID:26705709 NCBI chr15:24,867,697...24,904,818
Ensembl chr15:24,866,489...24,904,846
JBrowse link
G Tead1 TEA domain transcription factor 1 increases expression ISO geldanamycin results in increased expression of TEAD1 mRNA CTD PMID:26705709 NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 increases expression ISO geldanamycin results in increased expression of TET2 mRNA CTD PMID:26705709 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO geldanamycin results in increased expression of TFPI mRNA CTD PMID:26705709 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO geldanamycin results in increased expression of TGFB2 mRNA CTD PMID:26705709 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO geldanamycin results in increased expression of THBS1 mRNA CTD PMID:26705709 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tle4 TLE family member 4, transcriptional corepressor increases expression ISO geldanamycin results in increased expression of TLE4 mRNA CTD PMID:26705709 NCBI chr 1:211,661,738...211,798,458
Ensembl chr 1:211,661,746...211,797,862
JBrowse link
G Tlk1 tousled-like kinase 1 increases expression ISO geldanamycin results in increased expression of TLK1 mRNA CTD PMID:26705709 NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968
JBrowse link
G Tll1 tolloid-like 1 increases expression ISO geldanamycin results in increased expression of TLL1 mRNA CTD PMID:26705709 NCBI chr16:25,509,146...25,710,330
Ensembl chr16:25,509,146...25,709,543
JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO geldanamycin results in increased expression of TLR4 mRNA CTD PMID:26705709 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmem33 transmembrane protein 33 increases expression ISO geldanamycin results in increased expression of TMEM33 mRNA CTD PMID:26705709 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715
JBrowse link
G Tmod3 tropomodulin 3 increases expression ISO geldanamycin results in increased expression of TMOD3 mRNA CTD PMID:26705709 NCBI chr 8:76,248,978...76,310,855
Ensembl chr 8:76,248,979...76,310,977
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 increases expression ISO geldanamycin results in increased expression of TMTC3 mRNA CTD PMID:26705709 NCBI chr 7:35,264,886...35,310,010
Ensembl chr 7:35,264,892...35,310,385
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:11472980 PMID:12571865 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 increases expression ISO geldanamycin results in increased expression of TNFRSF10D mRNA CTD PMID:26705709 NCBI chr 1:198,802,513...198,824,049
Ensembl chr 1:198,802,971...198,823,418
JBrowse link
G Tnfsf15 TNF superfamily member 15 decreases expression ISO geldanamycin results in decreased expression of TNFSF15 mRNA CTD PMID:26705709 NCBI chr 5:77,140,099...77,156,142
Ensembl chr 5:77,139,878...77,156,228
JBrowse link
G Tnks2 tankyrase 2 increases expression ISO geldanamycin results in increased expression of TNKS2 mRNA CTD PMID:26705709 NCBI chr 1:234,567,888...234,621,079
Ensembl chr 1:234,567,858...234,621,079
JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression ISO geldanamycin results in increased expression of TOB2 mRNA CTD PMID:26705709 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688
JBrowse link
G Tp53 tumor protein p53 affects localization
affects expression
multiple interactions
ISO geldanamycin affects the localization of TP53 protein
geldanamycin affects the expression of TP53 protein
Tretinoin inhibits the reaction [geldanamycin affects the localization of TP53 protein]
CTD PMID:17293044 PMID:24211270 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO geldanamycin results in increased expression of TP53BP1 mRNA CTD PMID:26705709 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Tpm4 tropomyosin 4 increases expression ISO geldanamycin results in increased expression of TPM4 mRNA CTD PMID:26705709 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
JBrowse link
G Tpp2 tripeptidyl peptidase 2 increases expression ISO geldanamycin results in increased expression of TPP2 mRNA CTD PMID:26705709 NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO geldanamycin results in increased expression of TPR mRNA CTD PMID:26705709 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Trim59 tripartite motif-containing 59 increases expression ISO geldanamycin results in increased expression of TRIM59 mRNA CTD PMID:26705709 NCBI chr 2:153,269,210...153,281,185
Ensembl chr 2:153,268,584...153,281,031
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression ISO geldanamycin results in increased expression of TRPC6 mRNA CTD PMID:26705709 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP geldanamycin affects the reaction [Capsaicin results in increased activity of TRPV1] CTD PMID:11930156 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 increases expression ISO geldanamycin results in increased expression of TTC3 mRNA CTD PMID:26705709 NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975
JBrowse link
G Ttc37 tetratricopeptide repeat domain 37 increases expression ISO geldanamycin results in increased expression of TTC37 mRNA CTD PMID:26705709 NCBI chr 2:5,631,544...5,783,643
Ensembl chr 2:5,631,635...5,751,626
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO geldanamycin results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:130,113,214...130,116,880 JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H increases expression ISO geldanamycin results in increased expression of UBE2H mRNA CTD PMID:26705709 NCBI chr 4:58,834,674...58,930,156
Ensembl chr 4:58,834,674...58,930,156
JBrowse link
G Ubn2 ubinuclein 2 increases expression ISO geldanamycin results in increased expression of UBN2 mRNA CTD PMID:26705709 NCBI chr 4:67,165,278...67,251,562
Ensembl chr 4:67,166,346...67,230,491
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO geldanamycin results in increased expression of UGCG mRNA CTD PMID:26705709 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 increases expression ISO geldanamycin results in increased expression of UGGT1 mRNA CTD PMID:26705709 NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467
JBrowse link
G Uhmk1 U2AF homology motif kinase 1 increases expression ISO geldanamycin results in increased expression of UHMK1 mRNA CTD PMID:26705709 NCBI chr13:82,396,646...82,416,292
Ensembl chr13:82,401,187...82,416,292
JBrowse link
G Usp10 ubiquitin specific peptidase 10 increases expression ISO geldanamycin results in increased expression of USP10 mRNA CTD PMID:26705709 NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897
JBrowse link
G Usp12 ubiquitin specific peptidase 12 increases expression ISO geldanamycin results in increased expression of USP12 mRNA CTD PMID:26705709 NCBI chr12:8,309,845...8,363,686
Ensembl chr12:8,309,750...8,363,656
JBrowse link
G Usp25 ubiquitin specific peptidase 25 increases expression ISO geldanamycin results in increased expression of USP25 mRNA CTD PMID:26705709 NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348
JBrowse link
G Usp36 ubiquitin specific peptidase 36 increases expression ISO geldanamycin results in increased expression of USP36 mRNA CTD PMID:26705709 NCBI chr10:103,497,349...103,528,877
Ensembl chr10:103,497,349...103,528,877
JBrowse link
G Vapb VAMP associated protein B and C increases expression ISO geldanamycin results in increased expression of VAPB mRNA CTD PMID:26705709 NCBI chr 3:162,536,090...162,578,738
Ensembl chr 3:162,535,905...162,573,763
JBrowse link
G Vdac3 voltage-dependent anion channel 3 decreases expression ISO geldanamycin results in decreased expression of VDAC3 mRNA CTD PMID:30166341 NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO geldanamycin results in increased expression of VMP1 mRNA CTD PMID:26705709 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007
JBrowse link
G Vps50 VPS50 subunit of EARP/GARPII complex increases expression ISO geldanamycin results in increased expression of VPS50 mRNA CTD PMID:26705709 NCBI chr 4:31,484,424...31,585,617
Ensembl chr 4:31,484,463...31,585,617
JBrowse link
G Zbed6 zinc finger, BED-type containing 6 increases expression ISO geldanamycin results in increased expression of ZBED6 mRNA CTD PMID:26705709 NCBI chr13:45,107,489...45,113,141 JBrowse link
G Zc3h11a zinc finger CCCH-type containing 11A increases expression ISO geldanamycin results in increased expression of ZC3H11A mRNA CTD PMID:26705709 NCBI chr13:45,073,422...45,113,901
Ensembl chr13:45,071,718...45,114,009
JBrowse link
G Zfhx4 zinc finger homeobox 4 increases expression ISO geldanamycin results in increased expression of ZFHX4 mRNA CTD PMID:26705709 NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO geldanamycin results in decreased expression of ZNF207 mRNA CTD PMID:30166341 NCBI chr10:65,385,823...65,397,591
Ensembl chr10:65,385,740...65,397,386
JBrowse link
G Zfp326 zinc finger protein 326 increases expression ISO geldanamycin results in increased expression of ZNF326 mRNA CTD PMID:26705709 NCBI chr14:3,941,210...3,980,419
Ensembl chr14:3,941,958...3,980,384
JBrowse link
G Zfp518a zinc finger protein 518A increases expression ISO geldanamycin results in increased expression of ZNF518A mRNA CTD PMID:26705709 NCBI chr 1:239,719,305...239,744,978
Ensembl chr 1:239,719,505...239,744,979
JBrowse link
G Zfp638 zinc finger protein 638 increases expression ISO geldanamycin results in increased expression of ZNF638 mRNA CTD PMID:26705709 NCBI chr 4:116,355,934...116,479,845
Ensembl chr 4:116,402,428...116,479,845
JBrowse link
G Zfp655 zinc finger protein 655 increases expression ISO geldanamycin results in increased expression of ZNF655 mRNA CTD PMID:26705709 NCBI chr12:9,349,985...9,375,449
Ensembl chr12:9,357,639...9,374,569
JBrowse link
G Zfp704 zinc finger protein 704 increases expression ISO geldanamycin results in increased expression of ZNF704 mRNA CTD PMID:26705709 NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282
JBrowse link
G Zfp711 zinc finger protein 711 increases expression ISO geldanamycin results in increased expression of ZNF711 mRNA CTD PMID:26705709 NCBI chr  X:77,646,300...77,679,398
Ensembl chr  X:77,646,558...77,678,045
JBrowse link
G Zfp770 zinc finger protein 770 increases expression ISO geldanamycin results in increased expression of ZNF770 mRNA CTD PMID:26705709 NCBI chr 3:100,963,430...100,971,215
Ensembl chr 3:100,963,427...100,971,684
JBrowse link
G Zfr zinc finger RNA binding protein increases expression ISO geldanamycin results in increased expression of ZFR mRNA CTD PMID:26705709 NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
JBrowse link
G Zfx zinc finger protein X-linked increases expression ISO geldanamycin results in increased expression of ZFX mRNA CTD PMID:26705709 NCBI chr  X:58,804,690...58,853,155
Ensembl chr  X:58,804,691...58,853,265
JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 increases expression ISO geldanamycin results in increased expression of ZMYND11 mRNA CTD PMID:26705709 NCBI chr17:60,542,669...60,631,913
Ensembl chr17:60,543,077...60,631,902
JBrowse link
G Znf660 zinc finger protein 660 increases expression ISO geldanamycin results in increased expression of ZNF660 mRNA CTD PMID:26705709 NCBI chr 8:122,523,881...122,537,581
Ensembl chr 8:122,524,324...122,536,247
JBrowse link
G Zxdc ZXD family zinc finger C increases expression ISO geldanamycin results in increased expression of ZXDC mRNA CTD PMID:26705709 NCBI chr 4:122,882,389...122,914,486
Ensembl chr 4:122,882,336...122,916,496
JBrowse link
tanespimycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11 abhydrolase domain containing 11 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ABHD11 protein CTD PMID:31370342 NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398
JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ACTR1A protein CTD PMID:31370342 NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO tanespimycin results in increased expression of ADAMTS1 mRNA CTD PMID:19514085 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of AGR2 protein
tanespimycin analog results in increased expression of AGR2 protein; tanespimycin results in increased expression of AGR2 protein
CTD PMID:31370342 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Ak9 adenylate kinase 9 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of AK9 protein CTD PMID:31370342 NCBI chr20:44,724,494...44,941,135
Ensembl chr20:44,724,496...44,941,136
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects expression
decreases expression
ISO
EXP
Arsenic Trioxide promotes the reaction [tanespimycin results in decreased expression of AKT1 protein]; tanespimycin affects the reaction [Cannabidiol affects the expression of AKT1 protein]; tanespimycin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; tanespimycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
tanespimycin affects the expression of AKT1 protein
CTD PMID:16923571 PMID:17157164 PMID:18566239 PMID:22810956 PMID:26504004 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO ALB protein binds to tanespimycin
ALB protein inhibits the reaction [Copper results in increased oxidation of tanespimycin analog]
CTD PMID:18393300 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ALDH1A1 protein CTD PMID:31370342 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Alk ALK receptor tyrosine kinase decreases activity
decreases expression
ISO tanespimycin results in decreased activity of ALK protein mutant form
tanespimycin results in decreased expression of ALK protein; tanespimycin results in decreased expression of ALK protein modified form
CTD PMID:21030459 PMID:21502504 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034
JBrowse link
G Anxa1 annexin A1 increases expression ISO tanespimycin results in increased expression of ANXA1 protein CTD PMID:31370342 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
increases expression
ISO Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein] CTD PMID:19913524 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Ar androgen receptor decreases expression ISO tanespimycin results in decreased expression of AR protein CTD PMID:17010675 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ATP5F1A protein CTD PMID:31370342 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO tanespimycin analog results in decreased expression of ATP5F1B protein CTD PMID:31370342 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tanespimycin results in decreased expression of BCL2 protein CTD PMID:16923571 PMID:28673683 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO tanespimycin results in decreased expression of BCL2L1 protein CTD PMID:16923571 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO tanespimycin results in increased expression of BCL2L11 protein CTD PMID:24784839 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase increases expression
decreases expression
ISO
EXP
tanespimycin analog results in increased expression of BRAF protein
tanespimycin results in decreased expression of BRAF protein
CTD PMID:22810956 PMID:31370342 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
[tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased activity of CASP3 protein]; tanespimycin results in increased cleavage of and results in increased activity of CASP3 protein
tanespimycin results in increased cleavage of CASP3 protein
SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]
CTD PMID:15993848 PMID:17157164 PMID:18194434 PMID:19913524 PMID:22810956 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO tanespimycin results in increased cleavage of CASP8 protein
[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein
CTD PMID:17121904 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein
tanespimycin results in increased cleavage of CASP9 protein
CTD PMID:17121904 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of CCND1 protein
[Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein
CTD PMID:17121904 PMID:17157164 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CCT8 protein CTD PMID:31370342 NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO
EXP
[tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein
tanespimycin results in decreased expression of CDC25C protein
CTD PMID:21156818 PMID:22810956 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
affects expression
decreases expression
ISO [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein; tanespimycin affects the reaction [Cannabidiol affects the expression of CDK1 protein]
tanespimycin affects the expression of CDK1 protein
tanespimycin results in decreased expression of CDK1 protein
CTD PMID:21156818 PMID:24784839 PMID:26504004 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO tanespimycin results in decreased expression of CDK4 protein CTD PMID:17157164 PMID:28673683 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk8 cyclin-dependent kinase 8 decreases expression ISO tanespimycin results in decreased expression of CDK8 protein CTD PMID:17157164 NCBI chr12:8,737,198...8,805,026 JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO tanespimycin analog results in increased expression of CES1 protein CTD PMID:31370342 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Chp2 calcineurin-like EF hand protein 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CHP2 protein CTD PMID:31370342 NCBI chr 1:176,757,945...176,772,443
Ensembl chr 1:176,757,876...176,772,139
JBrowse link
G Commd1 copper metabolism domain containing 1 multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501
JBrowse link
G Csde1 cold shock domain containing E1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of CSDE1 protein CTD PMID:31370342 NCBI chr 2:190,546,015...190,582,790
Ensembl chr 2:190,554,980...190,582,784
JBrowse link
G Cttn cortactin multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of CTTN protein
tanespimycin analog results in increased expression of CTTN protein
CTD PMID:31370342 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of tanespimycin CTD PMID:15718306 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of DARS1 protein CTD PMID:31370342 NCBI chr13:39,857,936...39,913,055
Ensembl chr13:39,857,936...39,913,116
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO tanespimycin results in increased expression of DHRS2 protein CTD PMID:31370342 NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
JBrowse link
G Ebf2 EBF transcription factor 2 increases expression ISO tanespimycin analog results in increased expression of EBF2 protein CTD PMID:31370342 NCBI chr15:41,435,509...41,634,403
Ensembl chr15:41,435,509...41,634,403
JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ECHDC3 protein CTD PMID:31370342 NCBI chr17:72,070,697...72,093,519
Ensembl chr17:72,070,668...72,093,516
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EEF1G protein
tanespimycin analog results in decreased expression of EEF1G protein
CTD PMID:31370342 NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of EEF2 protein; tanespimycin results in increased expression of EEF2 protein
[tanespimycin co-treated with VER 155008] results in increased expression of EEF2 protein
CTD PMID:31370342 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of EGFR protein; tanespimycin results in decreased expression of EGFR protein
tanespimycin results in increased degradation of and results in decreased expression of EGFR protein
CTD PMID:16061882 PMID:17010675 PMID:22810956 PMID:31370342 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of EIF3I protein
[tanespimycin co-treated with VER 155008] results in decreased expression of EIF3I protein
CTD PMID:31370342 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of EIF4B protein CTD PMID:31370342 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EIF4H protein CTD PMID:31370342 NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
JBrowse link
G Eml5 EMAP like 5 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of EML5 protein
tanespimycin analog results in increased expression of EML5 protein
CTD PMID:31370342 NCBI chr 6:118,046,655...118,175,831
Ensembl chr 6:118,046,655...118,175,831
JBrowse link
G Eno1 enolase 1 increases expression ISO tanespimycin analog results in increased expression of ENO1 protein CTD PMID:31370342 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO tanespimycin results in increased degradation of and results in decreased expression of ERBB2 protein
tanespimycin results in decreased expression of ERBB2 protein
CTD PMID:16061882 PMID:24784839 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Eri1 exoribonuclease 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ERI1 protein CTD PMID:31370342 NCBI chr16:56,724,101...56,744,228
Ensembl chr16:56,724,115...56,744,226
JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ERP29 protein CTD PMID:31370342 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of FARSB protein
tanespimycin analog results in increased expression of FARSB protein; tanespimycin results in increased expression of FARSB protein
CTD PMID:31370342 NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FGF1 protein CTD PMID:31370342 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions ISO tanespimycin results in increased degradation of and results in decreased expression of FGFR3 protein CTD PMID:16061882 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO tanespimycin results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Fubp1 far upstream element binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FUBP1 protein CTD PMID:31370342 NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
JBrowse link
G Gcfc2 GC-rich sequence DNA-binding factor 2 increases expression ISO tanespimycin analog results in increased expression of GCFC2 protein CTD PMID:31370342 NCBI chr 4:114,481,613...114,519,268
Ensembl chr 4:114,481,607...114,519,962
JBrowse link
G Gls glutaminase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GLS protein CTD PMID:31370342 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanespimycin results in decreased expression of GSK3B protein modified form CTD PMID:20090934 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression ISO tanespimycin analog results in increased expression of GTF2A2 protein CTD PMID:31370342 NCBI chr 8:70,662,395...70,675,576
Ensembl chr 8:70,662,428...70,675,569
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GTF2IRD1 protein CTD PMID:31370342 NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HINT1 protein CTD PMID:31370342 NCBI chr10:38,989,516...38,993,259 JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of HSD17B10 protein; tanespimycin results in decreased expression of HSD17B10 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSD17B10 protein
CTD PMID:31370342 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization
multiple interactions
ISO tanespimycin affects the localization of HSF1 protein
[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
CTD PMID:20090934 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
affects binding
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HSP90AA1 protein; N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]
tanespimycin results in decreased expression of HSP90AA1 protein
CTD PMID:18830594 PMID:22895790 PMID:31370342 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding ISO tanespimycin binds to HSP90AB1 protein CTD PMID:22895790 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
ISO [tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
tanespimycin analog results in increased expression of HSPA1A protein
CTD PMID:20090934 PMID:31370342
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of HSPA1B protein CTD PMID:31370342 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
ISO tanespimycin results in increased expression of HSPA4 protein
[tanespimycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO tanespimycin results in increased expression of HSPA5 protein CTD PMID:16357177 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of HSPD1 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSPD1 protein
CTD PMID:23144451 PMID:31370342 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression
decreases expression
ISO
EXP
tanespimycin affects the expression of IGF1R protein
tanespimycin results in decreased expression of IGF1R protein
CTD PMID:22810956 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ILF3 protein CTD PMID:31370342 NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350
JBrowse link
G Kcnv2 potassium voltage-gated channel modifier subfamily V member 2 decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of KCNV2 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of KCNV2 protein
CTD PMID:31370342 NCBI chr 1:224,999,552...225,014,062
Ensembl chr 1:224,999,552...225,014,062
JBrowse link
G Kdm3a lysine demethylase 3A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of KDM3A protein CTD PMID:31370342 NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073
JBrowse link
G Kdr kinase insert domain receptor affects expression
decreases expression
ISO
EXP
tanespimycin affects the expression of KDR protein
tanespimycin results in decreased expression of KDR protein
CTD PMID:22810956 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions
ISO
EXP
tanespimycin results in decreased expression of KIT protein
tanespimycin results in increased degradation of and results in decreased expression of KIT protein
CTD PMID:16061882 PMID:16213582 PMID:22810956 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Larp7 La ribonucleoprotein 7, transcriptional regulator increases expression ISO tanespimycin analog results in increased expression of LARP7 protein CTD PMID:31370342 NCBI chr 2:215,997,641...216,012,833
Ensembl chr 2:215,997,649...216,012,865
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of LCP1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of LCP1 protein
CTD PMID:31370342 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LDHA protein CTD PMID:31370342 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ldhb lactate dehydrogenase B increases expression ISO tanespimycin analog results in increased expression of LDHB protein CTD PMID:31370342 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Lmna lamin A/C multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of LMNA protein CTD PMID:31370342 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of HSPA6 protein CTD PMID:31370342 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LRPPRC protein CTD PMID:31370342 NCBI chr 6:9,859,867...9,942,294
Ensembl chr 6:9,859,867...9,942,293
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein] CTD PMID:30796972 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
affects expression
multiple interactions
ISO
EXP
tanespimycin results in decreased phosphorylation of MAPK1 protein
tanespimycin affects the expression of MAPK1 protein
tanespimycin affects the reaction [Cannabidiol affects the expression of MAPK1 protein]
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK1 protein
CTD PMID:17157164 PMID:20090934 PMID:21502504 PMID:22810956 PMID:24784839 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
affects expression
multiple interactions
ISO
EXP
tanespimycin results in decreased phosphorylation of MAPK3 protein
tanespimycin affects the expression of MAPK3 protein
tanespimycin affects the reaction [Cannabidiol affects the expression of MAPK3 protein]
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK3 protein
CTD PMID:17157164 PMID:20090934 PMID:21502504 PMID:22810956 PMID:24784839 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO tanespimycin results in decreased expression of MCL1 protein CTD PMID:16923571 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mdm2 MDM2 proto-oncogene increases degradation ISO tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression EXP
ISO
tanespimycin results in decreased expression of MET protein CTD PMID:22810956 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MIF protein
tanespimycin results in decreased expression of MIF protein
CTD PMID:31370342 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mllt10 MLLT10, histone lysine methyltransferase DOT1L cofactor multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MLLT10 protein CTD PMID:31370342 NCBI chr17:80,821,870...80,949,349
Ensembl chr17:80,822,556...80,949,345
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP2 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP2 mRNA] CTD PMID:21401309 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP9 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP9 mRNA] CTD PMID:21401309 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msn moesin increases expression ISO tanespimycin analog results in increased expression of MSN protein CTD PMID:31370342 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Mtap methylthioadenosine phosphorylase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MTAP protein CTD PMID:31370342 NCBI chr 5:103,873,020...103,939,406
Ensembl chr 5:103,873,020...103,939,406
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO tanespimycin results in increased expression of MTSS1 mRNA CTD PMID:19514085 NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NAMPT protein CTD PMID:31370342 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nans N-acetylneuraminate synthase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NANS protein CTD PMID:31370342 NCBI chr 5:60,780,441...60,797,583
Ensembl chr 5:60,780,392...60,814,950
JBrowse link
G Ncl nucleolin multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NCL protein CTD PMID:31370342 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
decreases phosphorylation
EXP
ISO
tanespimycin results in increased expression of NFKBIA protein
tanespimycin results in decreased phosphorylation of NFKBIA protein
CTD PMID:11835313 PMID:22810956 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [tanespimycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
increases reduction
increases abundance
ISO [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin metabolite; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased susceptibility to tanespimycin; [NQO1 protein results in increased reduction of tanespimycin] which results in increased chemical synthesis of tanespimycin metabolite; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
NQO1 protein results in increased susceptibility to tanespimycin
NQO1 protein results in increased abundance of tanespimycin; NQO1 protein results in increased abundance of tanespimycin metabolite
CTD PMID:10564678 PMID:21156818 PMID:24552538 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of OAT protein CTD PMID:31370342 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of PA2G4 protein
tanespimycin analog results in increased expression of PA2G4 protein; tanespimycin results in increased expression of PA2G4 protein
CTD PMID:31370342 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage EXP
ISO
tanespimycin results in increased cleavage of PARP1 protein CTD PMID:22810956 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 increases expression ISO tanespimycin analog results in increased expression of PARP2 protein CTD PMID:31370342 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO
EXP
tanespimycin results in decreased expression of PDGFRB protein CTD PMID:22810956 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PDIA4 protein CTD PMID:31370342 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pfn1 profilin 1 increases expression ISO tanespimycin analog results in increased expression of PFN1 protein CTD PMID:31370342 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Pgr progesterone receptor decreases expression ISO tanespimycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PIP4K2C protein CTD PMID:31370342 NCBI chr 7:63,020,004...63,035,086
Ensembl chr 7:63,020,000...63,035,078
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO tanespimycin results in decreased expression of PKM protein CTD PMID:31370342 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pnn pinin, desmosome associated protein increases expression ISO tanespimycin results in increased expression of PNN mRNA CTD PMID:19514085 NCBI chr 6:76,758,138...76,766,451
Ensembl chr 6:76,758,117...76,766,889
JBrowse link
G Prkrip1 PRKR interacting protein 1 increases expression ISO tanespimycin analog results in increased expression of PRKRIP1 protein CTD PMID:31370342 NCBI chr12:20,470,802...20,491,789
Ensembl chr12:20,470,820...20,489,115
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PRPS2 protein CTD PMID:31370342 NCBI chr  X:26,975,915...27,013,184
Ensembl chr  X:26,976,061...27,013,181
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PSMA6 protein CTD PMID:31370342 NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554
JBrowse link
G Psma7 proteasome 20S subunit alpha 7 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PSMA7 protein CTD PMID:31370342 NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672
JBrowse link
G Rab17 RAB17, member RAS oncogene family multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RAB17 protein CTD PMID:31370342 NCBI chr 9:91,552,924...91,566,759
Ensembl chr 9:91,553,464...91,566,451
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO tanespimycin results in decreased expression of RAF1 protein CTD PMID:10564678 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO tanespimycin results in decreased phosphorylation of RB1 protein
[tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein
CTD PMID:17121904 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rdx radixin increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of RDX protein
[tanespimycin co-treated with VER 155008] results in increased expression of RDX protein
CTD PMID:31370342 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RPLP0 protein CTD PMID:31370342 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
decreases expression
ISO tanespimycin results in decreased phosphorylation of RPS6 protein
tanespimycin results in decreased expression of RPS6 protein
CTD PMID:17121904 PMID:27255535 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Selenbp1 selenium binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of SELENBP1 protein CTD PMID:31370342
G Serpinb5 serpin family B member 5 increases expression ISO tanespimycin results in increased expression of SERPINB5 mRNA CTD PMID:19514085 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 decreases expression ISO tanespimycin analog results in decreased expression of SHMT2 protein CTD PMID:31370342 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
JBrowse link
G Sod2 superoxide dismutase 2 increases abundance
increases response to substance
ISO SOD2 protein results in increased abundance of tanespimycin metabolite
SOD2 protein results in increased susceptibility to tanespimycin
CTD PMID:21156818 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of SRCIN1 protein; tanespimycin results in increased expression of SRCIN1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of SRCIN1 protein
CTD PMID:31370342 NCBI chr10:82,511,101...82,568,706
Ensembl chr10:82,504,393...82,571,040
JBrowse link
G Tagln2 transgelin 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of TAGLN2 protein CTD PMID:31370342 NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO tanespimycin results in increased expression of TIMP3 mRNA CTD PMID:19514085 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein CTD PMID:15993848 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO tanespimycin results in decreased expression of TP53 protein CTD PMID:10564678 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 increases expression ISO tanespimycin analog results in increased expression of TPTE2 protein CTD PMID:31370342 NCBI chr16:69,658,874...69,756,571
Ensembl chr16:69,658,875...69,752,949
JBrowse link
G Tymp thymidine phosphorylase decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of TYMP mRNA; tanespimycin results in decreased expression of TYMP protein
[salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]; [tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]]; tanespimycin inhibits the reaction [salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]
CTD PMID:30796972 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO tanespimycin results in decreased expression of TYMS protein CTD PMID:18830594 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO tanespimycin analog results in increased expression of UGDH protein; tanespimycin results in increased expression of UGDH protein CTD PMID:31370342 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 decreases expression ISO tanespimycin results in decreased expression of UGP2 protein CTD PMID:31370342 NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830
JBrowse link
G Vil1 villin 1 increases expression ISO tanespimycin analog results in increased expression of VIL1 protein CTD PMID:31370342 NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein CTD PMID:15993848 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of YARS1 protein CTD PMID:31370342 NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of ZYG11B protein
tanespimycin analog results in increased expression of ZYG11B protein
CTD PMID:31370342 NCBI chr 5:122,985,548...123,042,735
Ensembl chr 5:122,992,147...123,042,736
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          geldanamycin 479
            alvespimycin 0
            retaspimycin 0
            tanespimycin 140
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                lactam 8307
                                                  ansamycin 850
                                                    geldanamycin 479
                                                      alvespimycin 0
                                                      retaspimycin 0
                                                      tanespimycin 140
paths to the root