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ONTOLOGY REPORT - ANNOTATIONS

Term:dendritic spine development
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Accession:GO:0060996 term browser browse the term
Definition:The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


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dendritic spine development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 IMP RGD PMID:19166906 RGD:2312805 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Arf4 ADP-ribosylation factor 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23050017)
MGI:3879059 (PMID:23050017)
GO_REF:0000107		 RGD
Ensembl		 PMID:23050017 GO_REF:0000107 NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261 		JBrowse link
G Arid1b AT-rich interaction domain 1B acts_upstream_of_or_within ISO (PMID:26937011) RGD PMID:26937011 NCBI chr 1:45,567,991...45,923,644
Ensembl chr 1:45,563,623...45,923,493 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28130356)		 UniProt
Ensembl
RGD		 PMID:28130356 GO_REF:0000024 GO_REF:0000107 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO MGI:2677631 (PMID:23074245), (PMID:25951243) RGD PMID:23074245 PMID:25951243 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027 		JBrowse link
G Ephb1 Eph receptor B1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IGI		 GO_REF:0000024
(PMID:14691139)
PMID:17310244		 UniProt
RGD		 PMID:14691139 PMID:17310244 PMID:17310244 GO_REF:0000024, RGD:10047256, RGD:10047256 NCBI chr 8:102,507,549...102,944,839
Ensembl chr 8:102,507,549...102,944,839 		JBrowse link
G Ephb2 Eph receptor B2 involved_in ISO (PMID:14691139) RGD PMID:14691139 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Ephb3 Eph receptor B3 involved_in ISO (PMID:14691139) RGD PMID:14691139 NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 acts_upstream_of_or_within ISO MGI:1339656|MGI:1339975|MGI:1339984|MGI:1917834 (PMID:23509247) RGD PMID:23509247 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr10:62,342,082...62,356,379
Ensembl chr10:62,342,299...62,356,373 		JBrowse link
G Iqsec1 IQ motif and Sec7 domain ArfGEF 1 involved_in ISO (PMID:31607425) RGD PMID:31607425 NCBI chr 4:123,168,719...123,488,300
Ensembl chr 4:123,168,719...123,488,172 		JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO MGI:4414794 (PMID:30936556) RGD PMID:30936556 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 acts_upstream_of_or_within ISO MGI:95564 (PMID:23509247) RGD PMID:23509247 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 acts_upstream_of_or_within ISO MGI:95564 (PMID:23509247) RGD PMID:23509247 NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 acts_upstream_of_or_within ISO MGI:95564 (PMID:23509247) RGD PMID:23509247 NCBI chr  X:107,116,308...107,374,342
Ensembl chr  X:107,260,898...107,368,314 		JBrowse link
G Pak4 p21 (RAC1) activated kinase 4 acts_upstream_of_or_within ISO MGI:95564 (PMID:23509247) RGD PMID:23509247 NCBI chr 1:83,849,904...83,889,188
Ensembl chr 1:83,849,904...83,859,413 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 involved_in IDA
IEA
ISO		 PMID:22345354
GO_REF:0000107
(PMID:24668262)		 Ensembl
RGD		 PMID:24668262 PMID:22345354 GO_REF:0000107, RGD:10449516 NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 acts_upstream_of_or_within ISO MGI:3604561 (PMID:24035762) RGD PMID:24035762 NCBI chr  X:134,430,677...134,486,747
Ensembl chr  X:134,420,756...134,485,375 		JBrowse link
G Spire1 spire-type actin nucleation factor 1 acts_upstream_of_or_within ISO MGI:4310183 (PMID:24345451) RGD PMID:24345451 NCBI chr18:61,041,914...61,171,670
Ensembl chr18:61,041,290...61,171,899 		JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22559944)		 UniProt
RGD		 PMID:22559944 GO_REF:0000024 NCBI chr13:42,745,956...42,967,091
Ensembl chr13:42,745,947...42,967,058 		JBrowse link
G Uba6 ubiquitin-like modifier activating enzyme 6 acts_upstream_of_or_within ISO MGI:2176173|MGI:5509054 (PMID:23499007) RGD PMID:23499007 NCBI chr14:21,884,039...21,947,857
Ensembl chr14:21,884,039...21,947,857 		JBrowse link
G Ulk4 unc-51 like kinase 4 acts_upstream_of_or_within ISO (PMID:35522199) RGD PMID:35522199 NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924 		JBrowse link
dendritic spine morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 involved_in ISS
ISO		 GO_REF:0000024
(PMID:25851601)		 UniProt
RGD		 PMID:25851601 GO_REF:0000024 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Ctnnd2 catenin delta 2 involved_in ISO
IEA		 (PMID:25807484)
GO_REF:0000107		 RGD
Ensembl		 PMID:25807484 GO_REF:0000107 NCBI chr 2:81,168,525...82,016,495
Ensembl chr 2:81,167,117...82,015,764 		JBrowse link
G Dip2a disco-interacting protein 2 homolog A involved_in ISO (PMID:31600191) RGD PMID:31600191 NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 involved_in IMP
ISO
IEA		 PMID:21525273
(PMID:20952458)
GO_REF:0000107		 RGD
Ensembl		 PMID:20952458 PMID:21525273 GO_REF:0000107, RGD:8554095 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dock10 dedicator of cytokinesis 10 involved_in ISO (PMID:25851601) RGD PMID:25851601 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 involved_in IGI PMID:21670302 ParkinsonsUK-UCL PMID:21670302 RGD:10449514 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Epha5 EPH receptor A5 involved_in IDA PMID:20824214 UniProt PMID:20824214 RGD:8554330 NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317 		JBrowse link
G Ephb1 Eph receptor B1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:14691139)
(PMID:17310244)		 UniProt
RGD		 PMID:14691139 PMID:17310244 GO_REF:0000024 NCBI chr 8:102,507,549...102,944,839
Ensembl chr 8:102,507,549...102,944,839 		JBrowse link
G Ephb2 Eph receptor B2 acts_upstream_of_or_within
involved_in		 ISO (PMID:17310244)
(PMID:14691139)		 RGD PMID:14691139 PMID:17310244 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Ephb3 Eph receptor B3 involved_in ISO (PMID:14691139) RGD PMID:14691139 NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370 		JBrowse link
G Hdac6 histone deacetylase 6 acts_upstream_of_or_within ISO (PMID:24113571) RGD PMID:24113571 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Myo5b myosin Vb IMP RGD PMID:18984164 RGD:11533643 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:25851601)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:25851601 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:107,116,308...107,374,342
Ensembl chr  X:107,260,898...107,368,314 		JBrowse link
G Prmt3 protein arginine methyltransferase 3 IMP RGD PMID:20647003 RGD:9491824 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435 		JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:18082964), (PMID:21411674) RGD PMID:18082964 PMID:21411674 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Septin7 septin 7 acts_upstream_of_or_within ISO (PMID:24113571) RGD PMID:24113571 NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18272690)		 BHF-UCL
RGD		 PMID:18272690 GO_REF:0000024 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 GO_REF:0000024
(PMID:21167025), (PMID:21423165), (PMID:21558424)
MGI:5056336 (PMID:21558424)
GO_REF:0000107		 BHF-UCL
RGD
Ensembl		 PMID:21167025 PMID:21423165 PMID:21558424 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Wasl WASP like actin nucleation promoting factor involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:25851601)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:25851601 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022 		JBrowse link
G Wnt7a Wnt family member 7A involved_in ISO (PMID:21670302)
UniProtKB:Q9WVB9 (PMID:21670302)		 RGD PMID:21670302 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981 		JBrowse link
G Zfp365 zinc finger protein 365 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:25983680)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:25983680 GO_REF:0000024 GO_REF:0000107 NCBI chr20:20,666,240...20,689,734
Ensembl chr20:20,666,240...20,691,238 		JBrowse link
negative regulation of dendritic spine development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E acts_upstream_of_or_within ISO (PMID:24328732) RGD PMID:24328732 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23050017)		 Ensembl
RGD		 PMID:23050017 GO_REF:0000107 NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754 		JBrowse link
G Fstl4 follistatin-like 4 acts_upstream_of_or_within ISO (PMID:24573299) RGD PMID:24573299 NCBI chr10:36,911,422...37,344,545
Ensembl chr10:36,911,420...37,338,588 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A involved_in IDA PMID:24297929 UniProt PMID:24297929 RGD:42721994 NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085 		JBrowse link
G Hdac2 histone deacetylase 2 IMP RGD PMID:23485013 RGD:9590265 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IMP RGD PMID:24636259 RGD:12789709 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Ngfr nerve growth factor receptor IMP RGD PMID:22548193 RGD:10413901 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Plk2 polo-like kinase 2 IMP RGD PMID:18723513 RGD:7241135 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22519304)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22519304 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947 		JBrowse link
negative regulation of dendritic spine morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnm3 dynamin 3 IDA RGD PMID:17880892 RGD:8553820 NCBI chr13:74,359,043...74,838,135
Ensembl chr13:74,359,213...74,838,108 		JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 IMP
IDA		 RGD PMID:20531346 PMID:20531346 RGD:11251757, RGD:11251757 NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661 		JBrowse link
G Efna1 ephrin A1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17143272)		 UniProt
RGD		 PMID:17143272 GO_REF:0000024 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Ngef neuronal guanine nucleotide exchange factor involved_in ISS
ISO		 GO_REF:0000024
(PMID:17143272)		 UniProt
RGD		 PMID:17143272 GO_REF:0000024 NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914 		JBrowse link
G Nlgn1 neuroligin 1 involved_in ISO
IEA
ISS		 UniProtKB:Q99K10 (PMID:23143522)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:23143522 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nlgn3 neuroligin 3 involved_in ISO (PMID:21808020) RGD PMID:21808020 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876 		JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:16675393) RGD PMID:16675393 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ube3a ubiquitin protein ligase E3A IMP RGD PMID:25867122 RGD:11079590 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250 		JBrowse link
positive regulation of dendritic spine development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24328732)
GO_REF:0000107		 RGD
Ensembl		 PMID:24328732 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arf1 ADP-ribosylation factor 1 IMP RGD PMID:23889934 RGD:8553918 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G C11h21orf91 similar to human chromosome 21 open reading frame 91 involved_in ISO (PMID:27404227) RGD PMID:27404227 NCBI chr11:17,229,129...17,262,307
Ensembl chr11:17,229,138...17,262,483 		JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I involved_in ISO
IEA
ISS		 (PMID:18184567)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:18184567 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081 		JBrowse link
G Cdkl5 cyclin-dependent kinase-like 5 IMP RGD PMID:23671101 RGD:12791021 NCBI chr  X:33,757,605...33,988,075
Ensembl chr  X:33,821,257...33,986,582 		JBrowse link
G Cfl1 cofilin 1 IMP RGD PMID:25723479 RGD:11570400 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 involved_in ISO (PMID:22153079) RGD PMID:22153079 NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560 		JBrowse link
G Crebbp CREB binding protein IMP RGD PMID:32206715 RGD:126848802 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 involved_in ISO (PMID:25232112) RGD PMID:25232112 NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837 		JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 IMP RGD PMID:22514323 RGD:10755512 NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18539120)		 UniProt
RGD		 PMID:18539120 GO_REF:0000024 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Foxo6 forkhead box O6 involved_in ISO (PMID:23222102) RGD PMID:23222102 NCBI chr 5:133,856,087...133,876,387
Ensembl chr 5:133,856,072...133,876,573 		JBrowse link
G Grn granulin precursor IMP RGD PMID:21813674 RGD:5509044 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K IMP RGD PMID:24990929 RGD:10002784 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Il2 interleukin 2 IDA RGD PMID:20225203 RGD:5147914 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Itsn1 intersectin 1 IMP RGD PMID:19258322 RGD:13461864 NCBI chr11:30,978,590...31,160,645
Ensembl chr11:30,978,590...31,160,645 		JBrowse link
G Llph LLP homolog, long-term synaptic facilitation factor involved_in ISO (PMID:26961175) RGD PMID:26961175 NCBI chr 7:55,735,317...55,740,341
Ensembl chr 7:55,735,400...55,740,339 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IDA RGD PMID:16638019 RGD:2317707 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 acts_upstream_of_or_within ISO MGI:1333110 (PMID:22508986) RGD PMID:22508986 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 acts_upstream_of_or_within ISO MGI:1354946|MGI:2680287 (PMID:22508986) RGD PMID:22508986 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IMP RGD PMID:24188180 RGD:12789443 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:21683721 RGD:10040994 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 involved_in ISO (PMID:22153079) RGD PMID:22153079 NCBI chr 1:246,066,830...246,152,890
Ensembl chr 1:246,067,100...246,152,903 		JBrowse link
G Nlgn1 neuroligin 1 involved_in IMP
ISO
IEA
IDA		 (PMID:23143522)
GO_REF:0000107
PMID:17582332
UniProtKB:Q99K10 (PMID:23143522)		 RGD
Ensembl		 PMID:23143522 PMID:15681343 PMID:17582332 GO_REF:0000107, RGD:8553420, RGD:8553502 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nlgn2 neuroligin 2 IMP RGD PMID:15681343 RGD:8553420 NCBI chr10:54,544,461...54,557,854
Ensembl chr10:54,544,588...54,558,434 		JBrowse link
G Nlgn3 neuroligin 3 IMP RGD PMID:15681343 RGD:8553420 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:22509272 RGD:7174739 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Palm paralemmin involved_in ISO (PMID:18287537) RGD PMID:18287537 NCBI chr 7:9,886,634...9,912,389
Ensembl chr 7:9,886,643...9,912,555 		JBrowse link
G Pbrm1 polybromo 1 IMP RGD PMID:31723243 RGD:150340632 NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780 		JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:12052877 RGD:1299363 NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (PMID:21951279) RGD PMID:21951279 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO MGI:2685385 (PMID:25865668) RGD PMID:25865668 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 involved_in IDA PMID:18287537 UniProt PMID:18287537 RGD:8553517 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in ISS
ISO
IEA		 PMID:21795692
(PMID:21795692)
GO_REF:0000107		 RGD
Ensembl		 PMID:21795692 PMID:21795692 GO_REF:0000107, RGD:7349315 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:16595860 RGD:11568665 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 IMP RGD PMID:24117785 RGD:8554267 NCBI chr 3:154,528,917...154,629,532
Ensembl chr 3:154,529,043...154,628,463 		JBrowse link
positive regulation of dendritic spine morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 IMP RGD PMID:23441206 RGD:11530033 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524 		JBrowse link
G Actr3 actin related protein 3 IMP RGD PMID:23441206 RGD:11530033 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Afdn afadin, adherens junction formation factor IMP RGD PMID:22948147 RGD:13838731 NCBI chr 1:53,905,344...54,034,216
Ensembl chr 1:53,905,373...54,034,216 		JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 IMP RGD PMID:15673667 RGD:9684988 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta involved_in IMP PMID:12873385 UniProt PMID:12873385 RGD:8553829 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Caprin1 cell cycle associated protein 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:20516077)		 UniProt
Ensembl
RGD		 PMID:20516077 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502 		JBrowse link
G Caprin2 caprin family member 2 involved_in ISO (PMID:20516077) RGD PMID:20516077 NCBI chr 4:181,806,105...181,860,754
Ensembl chr 4:181,806,575...181,860,830 		JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase IMP RGD PMID:18606847 RGD:11576294 NCBI chr  X:8,899,500...9,243,014
Ensembl chr  X:8,899,833...9,238,694 		JBrowse link
G Cux2 cut-like homeobox 2 involved_in ISO (PMID:20510857) RGD PMID:20510857 NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806 		JBrowse link
G Dbn1 drebrin 1 involved_in IMP
IEA
ISS
IBA
ISO		 GO_REF:0000107
GO_REF:0000024
GO_REF:0000033
(PMID:25865831)		 Ensembl
UniProt
GO_Central
RGD		 PMID:25865831 PMID:19174472 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:10398809 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984 		JBrowse link
G Dbnl drebrin-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155 		JBrowse link
G Dhx36 DEAH-box helicase 36 involved_in IMP PMID:23651854 UniProt PMID:23651854 RGD:13792545 NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572 		JBrowse link
G Dnm1l dynamin 1-like IMP RGD PMID:19605646 RGD:7800727 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase IMP RGD PMID:20427644 RGD:10401235 NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164 		JBrowse link
G Ephb2 Eph receptor B2 IMP RGD PMID:21364901 RGD:127285794 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Gprasp3 G protein-coupled receptor associated sorting protein family member 3 involved_in ISO (PMID:21199326) RGD PMID:21199326 NCBI chr  X:98,847,591...98,854,949
Ensembl chr  X:98,817,593...98,854,545 		JBrowse link
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 involved_in ISO (PMID:21940441) RGD PMID:21940441 NCBI chr  X:51,371,969...52,876,726
Ensembl chr  X:51,378,215...52,876,772 		JBrowse link
G Itpka inositol-trisphosphate 3-kinase A acts_upstream_of_or_within IMP PMID:19890013 MGI PMID:19890013 RGD:8553536 NCBI chr 3:106,726,036...106,734,601
Ensembl chr 3:106,726,036...106,734,600 		JBrowse link
G Kalrn kalirin, RhoGEF kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4358076 (PMID:19625617)		 Ensembl
RGD		 PMID:19625617 GO_REF:0000107 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610 		JBrowse link
G Lrp8 LDL receptor related protein 8 involved_in ISO (PMID:21852430) RGD PMID:21852430 NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate IMP RGD PMID:16202710 RGD:9685333 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mfn1 mitofusin 1 IMP RGD PMID:19605646 RGD:7800727 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:19605646 RGD:7800727 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IMP RGD PMID:19605646 RGD:7800727 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 involved_in ISO (PMID:23483716) RGD PMID:23483716 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 IMP RGD PMID:18481281 RGD:7775053 NCBI chr  X:107,116,308...107,374,342
Ensembl chr  X:107,260,898...107,368,314 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D involved_in IEA
ISO		 GO_REF:0000107
(PMID:21940441)		 Ensembl
RGD		 PMID:21940441 GO_REF:0000107 NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396 		JBrowse link
G Reln reelin involved_in IEA
ISO		 GO_REF:0000107
(PMID:21664258), (PMID:21852430)		 Ensembl
RGD		 PMID:21664258 PMID:21852430 GO_REF:0000107 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 IMP RGD PMID:25319628 RGD:11057402 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Stau2 staufen double-stranded RNA binding protein 2 IMP RGD PMID:16418534 RGD:10043163 NCBI chr 5:2,840,741...3,084,935
Ensembl chr 5:2,840,765...3,084,929 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 IMP RGD PMID:16474385 RGD:10043325 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
regulation of dendritic spine development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf6 ADP-ribosylation factor 6 involved_in IMP
ISO
IBA		 PMID:16672654
(PMID:16325184)
GO_REF:0000033		 RGD
GO_Central		 PMID:16325184 PMID:16672654 GO_REF:0000033, RGD:8554141 NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114 		JBrowse link
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 involved_in ISO (PMID:24155305) RGD PMID:24155305 NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560 		JBrowse link
G Disc1 DISC1 scaffold protein IMP RGD PMID:20139976 RGD:5509795 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in ISO
ISS		 (PMID:16631377)
GO_REF:0000024		 RGD
UniProt		 PMID:16631377 GO_REF:0000024 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Kif1a kinesin family member 1A involved_in IMP PMID:30021165 UniProt PMID:30021165 RGD:14995321 NCBI chr 9:93,563,033...93,647,412
Ensembl chr 9:93,563,045...93,647,480 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(PMID:18599438)		 UniProt
RGD		 PMID:18599438 GO_REF:0000024 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Ppfia2 PTPRF interacting protein alpha 2 involved_in ISO (PMID:30021165) RGD PMID:30021165 NCBI chr 7:41,765,716...42,240,104
Ensembl chr 7:41,765,575...42,239,599 		JBrowse link
G Sdk1 sidekick cell adhesion molecule 1 acts_upstream_of_or_within ISO (PMID:24449909) RGD PMID:24449909 NCBI chr12:12,378,074...13,363,934
Ensembl chr12:12,380,524...13,363,976 		JBrowse link
G Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 involved_in IMP PMID:30021165 UniProt PMID:30021165 RGD:14995321 NCBI chr10:90,553,124...90,873,477
Ensembl chr10:90,553,002...90,868,756 		JBrowse link
regulation of dendritic spine morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 involved_in ISO (PMID:15572692) RGD PMID:15572692 NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699 		JBrowse link
G Abi3bp ABI family member 3 binding protein involved_in IMP PMID:22485184 ARUK-UCL PMID:22485184 RGD:42721990 NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 IMP RGD PMID:22328515 RGD:13703034 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein involved_in IGI PMID:15537891 ARUK-UCL PMID:15537891 RGD:13210528 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Arhgap33 Rho GTPase activating protein 33 IMP RGD PMID:24003235 RGD:13508596 NCBI chr 1:85,776,112...85,789,767
Ensembl chr 1:85,776,108...85,789,678 		JBrowse link
G Arhgap44 Rho GTPase activating protein 44 involved_in IBA
ISO		 GO_REF:0000033
(PMID:24352656)		 GO_Central
RGD		 PMID:24352656 GO_REF:0000033 NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:17143272)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:17143272 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17143272)		 UniProt
RGD		 PMID:17143272 GO_REF:0000024 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cfl1 cofilin 1 involved_in ISO
ISS		 (PMID:24464040)
GO_REF:0000024		 RGD
ParkinsonsUK-UCL		 PMID:24464040 GO_REF:0000024 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Dnm3 dynamin 3 IMP RGD PMID:15741233 RGD:8554738 NCBI chr13:74,359,043...74,838,135
Ensembl chr13:74,359,213...74,838,108 		JBrowse link
G Epha4 Eph receptor A4 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17143272)		 UniProt
RGD		 PMID:17143272 GO_REF:0000024 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Kif1a kinesin family member 1A involved_in IMP PMID:30021165 UniProt PMID:30021165 RGD:14995321 NCBI chr 9:93,563,033...93,647,412
Ensembl chr 9:93,563,045...93,647,480 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO
ISS		 (PMID:21168496)
UniProtKB:P23528 (PMID:24464040)
GO_REF:0000024		 RGD
ParkinsonsUK-UCL		 PMID:21168496 PMID:24464040 GO_REF:0000024 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lzts3 leucine zipper tumor suppressor family member 3 involved_in IMP
IBA		 PMID:27252646
GO_REF:0000033		 GO_Central PMID:27252646 GO_REF:0000033, RGD:13210540 NCBI chr 3:117,850,286...117,861,132
Ensembl chr 3:117,851,702...117,860,081 		JBrowse link
G Nlgn3 neuroligin 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:21808020)		 BHF-UCL
RGD		 PMID:21808020 PMID:21808020 GO_REF:0000024, RGD:8553412 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876 		JBrowse link
G Pdlim5 PDZ and LIM domain 5 involved_in IDA PMID:19900557 UniProt PMID:19900557 RGD:8554803 NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275 		JBrowse link
G Ppfia2 PTPRF interacting protein alpha 2 involved_in ISO (PMID:30021165) RGD PMID:30021165 NCBI chr 7:41,765,716...42,240,104
Ensembl chr 7:41,765,575...42,239,599 		JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:15473970 RGD:10043779 NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:21795692)		 Ensembl
RGD		 PMID:21795692 PMID:21795692 GO_REF:0000107, RGD:7349315 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 involved_in IDA PMID:11502259 UniProt PMID:11502259 RGD:8554032 NCBI chr 6:101,839,351...102,118,408
Ensembl chr 6:101,839,404...102,116,950 		JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 involved_in ISO
IBA
IEA
ISS		 (PMID:19146815)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:19146815 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:82,502,911...82,569,882
Ensembl chr10:82,504,393...82,571,040 		JBrowse link
G Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 involved_in IMP
IBA		 PMID:30021165
GO_REF:0000033		 GO_Central PMID:30021165 GO_REF:0000033, RGD:14995321 NCBI chr10:90,553,124...90,873,477
Ensembl chr10:90,553,002...90,868,756 		JBrowse link
G Zdhhc15 zinc finger DHHC-type palmitoyltransferase 15 involved_in IMP PMID:31189538 UniProt PMID:31189538 RGD:25671406 NCBI chr  X:69,568,086...69,701,756
Ensembl chr  X:69,574,124...69,701,756 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20052
    developmental process 7036
      anatomical structure development 6542
        dendritic spine development 136
          dendritic spine morphogenesis + 77
          negative regulation of dendritic spine development + 17
          positive regulation of dendritic spine development + 67
          regulation of dendritic spine development + 87
Path 2
Term Annotations click to browse term
  biological_process 20052
    developmental process 7036
      anatomical structure development 6542
        multicellular organism development 5283
          system development 4567
            nervous system development 2842
              neurogenesis 2104
                generation of neurons 1803
                  neuron differentiation 1719
                    neuron development 1415
                      neuron projection development 1240
                        dendrite development 332
                          dendritic spine development 136
                            dendritic spine morphogenesis + 77
                            negative regulation of dendritic spine development + 17
                            positive regulation of dendritic spine development + 67
                            regulation of dendritic spine development + 87
paths to the root